Chebulinic acid

Name: Chebulinic acid
Brand: MedChemExpress
SKU: HY-N2033
Rating: 5.0 (2 reviews)

Cat. No.: HY-N2033 Purity: 99.68%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity.

For research use only. We do not sell to patients.

Chebulinic acid Chemical Structure

CAS No. : 18942-26-2

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 368	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 368	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	USD 90	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 220	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 350	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 2 publication(s) in Google Scholar

Other Forms of Chebulinic acid:

Chebulinic acid (Standard) Get quote

2 Publications Citing Use of MCE Chebulinic acid

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Biological Activity
Purity & Documentation
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Description

Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity.

IC₅₀ & Target

target: M. tuberculosis DNA gyrase[1], SMAD-3 phosphorylation[2], H+ K+-ATPase activity.[3] IC50: 65.01 μg/ml ( H+ K+-ATPase ) [3]

In Vitro

In vitro: binding of Chebulinic acid causes displacement of catalytic Tyr129 away from its target DNA-phosphate molecule. [1] Chebulinic acid reduce the expression and activity of MMP-2 at an ED50 value of 100 μM. EMT (Epithelial to Mesenchymal Transition) is found to be induced in ARPE-19 cells, through SMAD-3 phosphorylation and it is inhibited by CA. [2] chebulinic acid significantly inhibited H+ K+-ATPase activity in vitrowith IC50 of 65.01 μg/ml. [3]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

956.68

Formula

C₄₁H₃₂O₂₇

CAS No.

18942-26-2

Appearance

Solid

Color

White to off-white

SMILES

OC(C[C@H](C(O[C@@]([C@H](O[C@H]1OC(C2=CC(O)=C(O)C(O)=C2)=O)COC(C3=CC(O)=C(O)C(O)=C3)=O)([H])[C@@](OC(C4=CC(O)=C(O)C(O)=C4)=O)([H])[C@@]1([H])OC5=O)=O)[C@@]([C@H]6O)([H])C(C5=CC(O)=C7O)=C7OC6=O)=O

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (104.53 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0453 mL	5.2264 mL	10.4528 mL
5 mM	0.2091 mL	1.0453 mL	2.0906 mL
10 mM	0.1045 mL	0.5226 mL	1.0453 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.68%

Select Batch:

Data Sheet (287 KB) SDS (392 KB)

COA (270 KB) HNMR (331 KB) LCMS (93 KB)

Handling Instructions (2659 KB)

References

[1]. Patel K et al. Identification of chebulinic acid as potent natural inhibitor of M. tuberculosis DNA gyrase and molecular insights into its binding mode of action. Comput Biol Chem. 2015 Dec;59 Pt A:37-47. [Content Brief]

[2]. Sivasankar S et al. Aqueous and alcoholic extracts of Triphala and their active compounds chebulagic acid and chebulinic acidprevented epithelial to mesenchymal transition in retinal pigment epithelial cells, by inhibiting SMAD-3 phosphorylation. PLoS One. 2015 Mar 20 [Content Brief]

[3]. Mishra V et al. Anti-secretory and cyto-protective effects of chebulinic acid isolated from the fruits of Terminalia chebula on gastric ulcers. Phytomedicine. 2013 Apr 15;20(6):506-11. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.0453 mL	5.2264 mL	10.4528 mL	26.1320 mL
	5 mM	0.2091 mL	1.0453 mL	2.0906 mL	5.2264 mL
	10 mM	0.1045 mL	0.5226 mL	1.0453 mL	2.6132 mL
	15 mM	0.0697 mL	0.3484 mL	0.6969 mL	1.7421 mL
	20 mM	0.0523 mL	0.2613 mL	0.5226 mL	1.3066 mL
	25 mM	0.0418 mL	0.2091 mL	0.4181 mL	1.0453 mL
	30 mM	0.0348 mL	0.1742 mL	0.3484 mL	0.8711 mL
	40 mM	0.0261 mL	0.1307 mL	0.2613 mL	0.6533 mL
	50 mM	0.0209 mL	0.1045 mL	0.2091 mL	0.5226 mL
	60 mM	0.0174 mL	0.0871 mL	0.1742 mL	0.4355 mL
	80 mM	0.0131 mL	0.0653 mL	0.1307 mL	0.3267 mL
	100 mM	0.0105 mL	0.0523 mL	0.1045 mL	0.2613 mL

Chebulinic acid Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chebulinic acid18942-26-2DNA/RNA SynthesisTGF-beta/SmadProton PumpTransforming growth factor betaInhibitorinhibitorinhibit

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Chebulinic acid

Customer Review

Other Forms of Chebulinic acid:

Chebulinic acid Related Antibodies

2 Publications Citing Use of MCE Chebulinic acid

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

Chebulinic acid Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Chebulinic acid Related Classifications

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