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Results for "

MTH1 inhibitor

" in MedChemExpress (MCE) Product Catalog:

15

Inhibitors & Agonists

1

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-112081
    BAY-707

    		DNA/RNA Synthesis Cancer
    BAY-707 is a substrate-competitive, highly potent and selective inhibitor of MTH1(NUDT1) with an IC50 of 2.3 nM. BAY-707 has a good pharmacokinetic (PK) profile to other MTH1 compounds and is well-tolerated in mice, but shows a clear lack of in vitro or in vivo anticancer efficacy .
    BAY-707
  • HY-100549
    (S)-Crizotinib

    		DNA/RNA Synthesis Apoptosis Cancer
    (S)-Crizotinib is a potent and selective MTH1 (mutT homologue) inhibitor with an IC50 of 330 nM. (S)-Crizotinib disrupts nucleotide pool homeostasis via MTH1 inhibition, induces an increase in DNA single strand breaks, activates DNA repair in human colon carcinoma cells, and effectively suppresses tumour growth in animal models .
    (S)-Crizotinib
  • HY-12814
    TH588
    2 Publications Verification

    		 DNA/RNA Synthesis Cancer
    TH588 is first-in-class nudix hydrolase family inhibitor that potently and selectively engage and inhibit the MTH1 (IC50= 5 nM).
    TH588
  • HY-16965
    TH287
    2 Publications Verification

    		 DNA/RNA Synthesis Cancer
    TH287 is a potent and selective inhibitor of MTH1, with an IC50 of 0.8 nM. TH287 is highly selective towards MTH1, with no relevant inhibition of MTH2, NUDT5, NUDT12, NUDT14, NUDT16, dCTPase, dUTPase and ITPA at 100 μM. TH287 could act as a chemotherapeutic agent for cancer research .
    TH287
  • HY-134725
    MTH1 degrader-1

    		DNA/RNA Synthesis Ligands for Target Protein for PROTAC Cancer
    MTH1 degrader-1, a MTH1 aTAG inhibitor, is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). MTH1 degrader-1 can be used for synthesis PROTAC aTAG 4531 (HY-163168) .
    MTH1 degrader-1
  • HY-120936
    IACS-4759

    		DNA/RNA Synthesis Cancer
    IACS-4759 is a potent and selective MTH1 (MutT homolog 1) inhibitor with an IC50 of 0.6 nM. IACS-4759 has anti-cancer effects .
    IACS-4759
  • HY-114939
    Phelorphan

    		DNA/RNA Synthesis Others
    Phelorphan is a purine MTH1 inhibitor identified through chemical array screening. Although it targets cellular MTH1, its cytotoxicity to cancer cells is weaker than that of other reported inhibitors. The cytotoxicity of MTH1 inhibitors may be attributed to off-target effects, and MTH1 is not essential for cancer cell survival.
    Phelorphan
  • HY-135967
    MTH1-IN-2

    		DNA/RNA Synthesis Cancer
    MTH1-IN-2 is a MutT homolog 1 (MTH1) inhibitor extracted from patent WO2016135138A1, Compound (6), MTH1-IN-2 can be used for the research of cancer. Anti-tumor activity .
    MTH1-IN-2
  • HY-163168
    aTAG 4531

    CFT-4531

    		 PROTACs DNA/RNA Synthesis Cancer
    aTAG 4531 (CFT-4531) is a potent, selective, and onmechanism tool degrader of MTH1 with DC50 value of 0.28 nM and Ki value of 1.8 nM. The degradation activity is due to the intricate formation of the ternary complex between the MTH1 aTAG, CRBN E3 ligase, and aTAG tool degrader. Red: MTH1 aTAG inhibitor (HY-134725), Blue: CRBN ligand (HY-126457), Black: linker (HY-108374) .
    aTAG 4531
  • HY-12814A
    TH588 hydrochloride

    		DNA/RNA Synthesis Cancer
    TH588 hydrochloride is first-in-class nudix hydrolase family inhibitor that potently and selectively engage and inhibit the MTH1 (IC50= 5 nM).
    TH588 hydrochloride
  • HY-16965A
    TH287 hydrochloride

    		DNA/RNA Synthesis Cancer
    TH287 hydrochloride is a potent and selective inhibitor of MTH1, with an IC50 of 0.8 nM. TH287 hydrochloride is highly selective towards MTH1, with no relevant inhibition of MTH2, NUDT5, NUDT12, NUDT14, NUDT16, dCTPase, dUTPase and ITPA at 100 μM. TH287 hydrochloride could act as a chemotherapeutic agent for cancer research .
    TH287 hydrochloride
  • HY-112081A
    BAY-707 acetate

    		DNA/RNA Synthesis Others
    BAY-707 acetate is a highly potent and selective substrate-competitive inhibitor of MTH1 with superior cellular target engagement and pharmacokinetic properties.
    BAY-707 acetate
  • HY-111094
    NPD7155

    		Endogenous Metabolite Cancer
    NPD7155 is a purine-based competitive inhibitor of MTH1, designed to target cancer cells while exhibiting off-target effects that contribute to its cytotoxicity.
    NPD7155
  • HY-N6845
    3-Isomangostin

    		DNA/RNA Synthesis Cancer
    3-Isomangostin, extracted from Garciniamangostana.L. shell, is a potent MutT homologue 1 (MTH1) inhibitor with an IC50 value of 52 nM. 3-Isomangostin would be an attractive chemical tool for the development of anticancer agents .
    3-Isomangostin
  • HY-125209A
    TH5427 hydrochloride

    		DNA/RNA Synthesis Cancer
    TH5427 hydrochloride is a potent, selective NUDT5 inhibitor (IC50=29 nM). TH5427 hydrochloride shows an apparent 690-fold selectivity for NUDT5 over MTH1. TH5427 hydrochloride blocks progestin-dependent, PAR-derived nuclear ATP synthesis and subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells .
    TH5427 hydrochloride

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