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MY-10

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-123856
    MY10

    		Phosphatase NF-κB c-Met/HGFR Anaplastic lymphoma kinase (ALK) Cardiovascular Disease Neurological Disease
    MY10 is a potent and orally active receptor protein tyrosine phosphatase (RPTPβ/ζ) inhibitor. MY10 reduces NF-κB p65 expression. MY10 activates tyrosine phosphorylation of c-Met. MY10 prevents the alcohol-induced downregulation of Ptprz1 and Alk expression. MY10 attenuates binge-like ethanol consumption and ethanol reward. MY10 can be used in the study of neurological and vascular diseases .
    MY10
  • HY-170640
    FLT3-IN-29

    		FLT3 Reactive Oxygen Species Apoptosis Cancer
    FLT3-IN-29 (Compound MY-10) is a FLT3 inhibitor (IC50s: 6.5 and 10.3 nM for FLT3-ITD and FLT3-D835Y mutants). FLT3-IN-29 arrests cell cycle at the G0/G1 phase and efficiently induces Apoptosis. FLT3-IN-29 also reduces reactive oxygen species (ROS) production and mitochondrial membrane potential (MMP). FLT3-IN-29 displays antileukemic activity .
    FLT3-IN-29

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