2. Metabolic Enzyme/Protease NF-κB Protein Tyrosine Kinase/RTK
  3. Phosphatase NF-κB c-Met/HGFR Anaplastic lymphoma kinase (ALK)
  4. MY10

MY10 is a potent and orally active receptor protein tyrosine phosphatase (RPTPβ/ζ) inhibitor. MY10 reduces NF-κB p65 expression. MY10 activates tyrosine phosphorylation of c-Met. MY10 prevents the alcohol-induced downregulation of Ptprz1 and Alk expression. MY10 attenuates binge-like ethanol consumption and ethanol reward. MY10 can be used in the study of neurological and vascular diseases.

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MY10 Chemical Structure

MY10 Chemical Structure

CAS No. : 2204270-73-3

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Based on 1 publication(s) in Google Scholar

MY10 Related Antibodies

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Description

MY10 is a potent and orally active receptor protein tyrosine phosphatase (RPTPβ/ζ) inhibitor. MY10 reduces NF-κB p65 expression. MY10 activates tyrosine phosphorylation of c-Met. MY10 prevents the alcohol-induced downregulation of Ptprz1 and Alk expression. MY10 attenuates binge-like ethanol consumption and ethanol reward. MY10 can be used in the study of neurological and vascular diseases[1][2][3][4][5].

IC50 & Target

receptor protein tyrosine phosphatase (RPTPβ/ζ)[1]
In Vitro

MY10 (0.1-10 μM, 24 h) decreases the viability of both SH-SY5Y neuroblastoma cells and BV2 microglial cells[2].
MY10 (10 μM) increases proliferation, migration, and tube formation of Ptprz1+/+ pulmonary microvascular endothelial cells (LMVECs)[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MY10 Related Antibodies
In Vivo

MY10 (100 mg/kg, p.o., 1 h before the voluntary alcohol consumption) reduces the alcohol consumption in rats[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Wistar rats (male, 375-440 g) in alcohol operant self- administration paradigm and Drinking In the Dark - Multiple Scheduled Access (DID-MSA) paradigm[5]
Dosage: 20, 60, 100 mg/kg (in 10% dehydrated ethanol, 20% polysorbate 80, and 70% PEG 300 vehicle)
Administration: Administered by oral gavage, once 1 hour before the voluntary alcohol consumption, for 3 days.
Result: Caused a significant 26.1% reduction in alcohol consumption at 100 mg/kg (in the alcohol operant self-administration paradigm).
Caused a 28.1% decrease in cumulative alcohol intake (in the DID-MSA paradigm).
Decreased the alcohol preference.
Had no effect on saccharin intake.
Prevented the alcohol-induced down-regulation of Prprzl and Alk gene expression.
Molecular Weight

384.36

Formula

C15H10F6OS2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

FC(SC1=CC=C(C=C1)COC2=CC=C(SC(F)(F)F)C=C2)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (130.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6017 mL 13.0086 mL 26.0173 mL
5 mM 0.5203 mL 2.6017 mL 5.2035 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6017 mL 13.0086 mL 26.0173 mL 65.0432 mL
5 mM 0.5203 mL 2.6017 mL 5.2035 mL 13.0086 mL
10 mM 0.2602 mL 1.3009 mL 2.6017 mL 6.5043 mL
15 mM 0.1734 mL 0.8672 mL 1.7345 mL 4.3362 mL
20 mM 0.1301 mL 0.6504 mL 1.3009 mL 3.2522 mL
25 mM 0.1041 mL 0.5203 mL 1.0407 mL 2.6017 mL
30 mM 0.0867 mL 0.4336 mL 0.8672 mL 2.1681 mL
40 mM 0.0650 mL 0.3252 mL 0.6504 mL 1.6261 mL
50 mM 0.0520 mL 0.2602 mL 0.5203 mL 1.3009 mL
60 mM 0.0434 mL 0.2168 mL 0.4336 mL 1.0841 mL
80 mM 0.0325 mL 0.1626 mL 0.3252 mL 0.8130 mL
100 mM 0.0260 mL 0.1301 mL 0.2602 mL 0.6504 mL
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MY10 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MY102204270-73-3MY 10MY-10PhosphataseNF-κBc-Met/HGFRAnaplastic lymphoma kinase (ALK)Nuclear factor-κBNuclear factor-kappaBAnaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246receptor protein tyrosine phosphataseRPTPβ/ζethanolInhibitorinhibitorinhibit

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