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Mfn2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (3) Mitochondrial Metabolism (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cardiovascular Disease (4) Neurological Disease (1)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

MFN2 agonist-1	Others	Others
MFN2 agonist-1 (B-A/l) potently stimulates mitochondrial fusion in mitofusin 2 (MFN2)-deficient cells. MFN2 agonist-1 reverses mitochondrial “clumping” (formation of static mitochondrial aggregates) and restores mitochondrial motility in cultured mouse neurons expressing the CMT2A mutant MFN2 T105M.

MASM7 1 Publications Verification	Others	Others
MASM7 is a mitofusin activator, and can achieve mitochondrial fusion via mitofusins. MASM7 can increase Mito AR with an EC₅₀ value of 75 nM in MEFs in concentration-responsively, and can promote mitochondrial fusion by directly activating MFN2 or MFN. MASM7 also demonstrates direct binding to the HR2 domain of MFN2 with K_d value of 1.1 μM .

Mabuterol	Adrenergic Receptor	Cardiovascular Disease
Mabuterol is a selective and orally active **beta-2 adrenergic receptor (ADRB2)** agonist. Mabuterol inhibits the proliferation and suppresses the increase of intracellular Ca2+ induced by PDGF-BB. Mabuterol suppresses the protein expressions of Drp-1, cyclinD1 and PCNA and enhanced the expression of Mfn-2 induced by PDGF-BB ^[2].

MFI8 2 Publications Verification	Mitochondrial Metabolism	Others
MFI8 is a small molecule inhibitor of mitochondrial .

AP39 3 Publications Verification	Others	Cardiovascular Disease Neurological Disease
AP39 is a triphenylphosphonium derivatised anethole dithiolethione and mitochondria-targeting hydrogen sulfide (H₂S) donor. AP39 increases intracellular H₂S levels. AP39 exerts cytoprotective effects and maintains mitochondrial DNA integrity under oxidative stress conditions. AP39 protects against myocardial reperfusion injury in mice model and has the potential for Alzheimer's disease research ^[2] .

MFN2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MFN2 Human Pre-designed siRNA Set A contains three designed siRNAs for MFN2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MFN2 Human Pre-designed siRNA Set A MFN2 Human Pre-designed siRNA Set A

Mabuterol hydrochloride	Adrenergic Receptor	Cardiovascular Disease
Mabuterol hydrochloride is a selective and orally active **beta-2 adrenergic receptor (ADRB2)** agonist. Mabuterol hydrochloride inhibits the proliferation and suppresses the increase of intracellular Ca2+ induced by PDGF-BB. Mabuterol hydrochloride suppresses the protein expressions of Drp-1, cyclinD1 and PCNA and enhanced the expression of Mfn-2 induced by PDGF-BB ^[2].

Mabuterol hydrochloride (Standard)	Adrenergic Receptor	Cardiovascular Disease
Mabuterol (hydrochloride) (Standard) is the analytical standard of Mabuterol (hydrochloride). This product is intended for research and analytical applications. Mabuterol hydrochloride is a selective and orally active beta-2 adrenergic receptor (ADRB2) agonist. Mabuterol hydrochloride inhibits the proliferation and suppresses the increase of intracellular Ca2+ induced by PDGF-BB. Mabuterol hydrochloride suppresses the protein expressions of Drp-1, cyclinD1 and PCNA and enhanced the expression of Mfn-2 induced by PDGF-BB ^[2].

Cat. No.	Compare	Product Name	Species	Source

	MFN2 Protein, Human (Cell-Free, His) Mitofusin-2; Transmembrane GTPase Mfn2	Human	E. coli Cell-free
	MFN2, a mitochondrial outer membrane GTPase, regulates mitochondrial dynamics, balancing fusion and fission for dynamic organelle morphology. Its overexpression forms extensive mitochondrial networks, highlighting its organizational role. Beyond shaping structure, MFN2 influences mitochondrial metabolism, impacting obesity and apoptosis. In vascular smooth muscle cells, it regulates proliferation. Crucial in mitochondrial quality control, MFN2 facilitates mitophagy and modulates the unfolded protein response during ER stress, emphasizing its diverse roles in cellular homeostasis and stress responses. MFN2 Protein, Human (Cell-Free, His) is the recombinant human-derived MFN2 protein, expressed by E. coli Cell-free, with N-10*His labeled tag. The total length of MFN2 Protein, Human (Cell-Free, His) is 757 a.a., with molecular weight of 87.9 kDa.

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MFN2 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
MFN2 Human Pre-designed siRNA Set A contains three designed siRNAs for MFN2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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