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Results for "

NAE

" in MedChemExpress (MCE) Product Catalog:

By Targets:	NEDD8-activating Enzyme (7) Apoptosis (3) Biochemical Assay Reagents (1) Cannabinoid Receptor (2) E1/E2/E3 Enzyme (2) Isotope-Labeled Compounds (1) Microtubule/Tubulin (1) Reactive Oxygen Species (1) Small Interfering RNA (siRNA) (1) TRP Channel (1)
By Research Areas:	Cancer (12) Metabolic Disease (2) Neurological Disease (1)
Oligonucleotides:	siRNAs (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: NEDD8-activating Enzyme

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-115537

NAE-IN-M22	Apoptosis	Cancer
NAE-IN-M22 is a potent, selective and reversible inhibitor of NEDD8 activating enzyme (NAE), with potency in micromolar range. NAE-IN-M22 inhibits multiple cancer cell lines and induces apoptosis in A549 cells. NAE-IN-M22 also can inhibit tumor growth in vivo .

HY-128586

TAS4464 5 Publications Verification	NEDD8-activating Enzyme	Cancer
TAS4464 is a highly potent and selective inhibitor of NEDD8 activating enzyme (NAE), with an IC₅₀ of 0.955 nM .

HY-10484

Pevonedistat hydrochloride Maximum Cited Publications 137 Publications Verification MLN4924 hydrochloride	NEDD8-activating Enzyme	Cancer
Pevonedistat hydrochloride (MLN4924 hydrochloride) is a potent and selective NEDD8-activating enzyme (NAE) inhibitor, with an IC₅₀ of 4.7 nM .

HY-70062

Pevonedistat Maximum Cited Publications 137 Publications Verification MLN4924	NEDD8-activating Enzyme	Cancer
Pevonedistat (MLN4924) is a potent and selective NEDD8-activating enzyme (NAE) inhibitor with an IC₅₀ of 4.7 nM .

HY-161268

NAE-IN-1	Apoptosis NEDD8-activating Enzyme Reactive Oxygen Species	Cancer
NAE-IN-1 (compound X-10) is a potent *NAE1* inhibitor. NAE-IN-1 induces apoptosis and cell cycle arrest at the G2/M phase. NAE-IN-1 increases ROS levels and prevents cell migration. NAE-IN-1 shows anti-proliferation activity .

HY-163524

NAE-IN-2	Apoptosis	Cancer
NAE-IN-2 (compound III-26) is N2–(1-benzylpiperidin-4-yl)quinazoline-2,4-diamine derivative, and inhibits Cullin1 and Cullin3. NAE-IN-2 inhibits migration and induces cell apoptosis of gastric cancer cells .

HY-RS09007

NAE1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
NAE1 Human Pre-designed siRNA Set A contains three designed siRNAs for NAE1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

NAE1 Human Pre-designed siRNA Set A NAE1 Human Pre-designed siRNA Set A

HY-W747573

N-Linolenoylethanolamine 18:3 NAE; α-Linolenoyl ethanolamide	TRP Channel	Neurological Disease
N-Linolenoylethanolamine (18:3 NAE) is an endocannabinoid. N-Linolenoylethanolamine is a vanillin receptor (TRPV1) agonist .

HY-101790

ZM223	NEDD8-activating Enzyme	Cancer
ZM223 is a potent non-covalent NEDD8 activating enzyme (NAE) inhibitor, orally active .

HY-W127407

Glycerophospho-N-arachidonoyl ethanolamine	Biochemical Assay Reagents	Others
Glycerophospho-N-Arachidonoyl Ethanolamine is a N-acylated ethanolamines (NAEs). Most NAEs are naturally occurring lipids with diverse biological activities. Different types of NAE can be derived from glycerophosphate-linked precursors through the activity of glycerophosphodiesterase 1 (GDE1). Glycerophosphate-N-Arachidonoyl Ethanolamine is the precursor of Anandamide (AEA), also known as Anandamide. AEA is an endocannabinoid neurotransmitter that binds to central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. It inhibits the specific binding of [3H]-HU-243 to synaptosomal membranes with a Ki value of 52 nM compared to 46 nM for δ9-THC.

HY-101790A

ZM223 hydrochloride	NEDD8-activating Enzyme	Cancer
ZM223 hydrochloride is an orally active, potent non-covalent NEDD8 activating enzyme (NAE) inhibitor with excellent anticancer activity .

HY-128586A

TAS4464 hydrochloride 5 Publications Verification	NEDD8-activating Enzyme	Cancer
TAS4464 (hydrochloride) is a highly potent and selective inhibitor of NEDD8 activating enzyme (NAE), with an IC₅₀ of 0.955 nM . TAS4464 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-108702

ML-792 20+ Cited Publications	E1/E2/E3 Enzyme	Cancer
ML-792 is a potent and selective inhibitor of SAE/SUMO1 and SAE/SUMO2 in enzymatic assays (IC₅₀ values of 3 and 11 nM, respectively) compared with NAE/NEDD8 and UAE/ubiquitin (IC₅₀> values of 32 μM and >100 μM, respectively) .

HY-148266

UBA5-IN-1	E1/E2/E3 Enzyme	Cancer
UBA5-IN-1 (compound 8.5) is a selective UBA5 inhibitor with an IC₅₀ value of 4.0 μM. UBA5-IN-1 inhibits cell proliferation of Sk-Luci6 cancer cells with high expression levels of UBA5 .

HY-124089

Eicosapentaenoyl ethanolamide	Cannabinoid Receptor	Metabolic Disease
Eicosapentaenoyl ethanolamide, an omega-3 fatty acid, is one of N-acylethanolamines (NAEs). Eicosapentaenoyl ethanolamide is cannabinoid CB1/CB2 receptor agonist. Eicosapentaenoyl ethanolamide acts as a metabolic signal. Eicosapentaenoyl ethanolamide inhibits dietary restriction (DR)-induced lifespan extension in wild type animals and suppresses lifespan extension in a TOR pathway mutant .

HY-124089S

Eicosapentaenoyl ethanolamide-d4	Isotope-Labeled Compounds Cannabinoid Receptor	Metabolic Disease
Eicosapentaenoyl ethanolamide-d₄ is the deuterium labeled Eicosapentaenoyl ethanolamide. Eicosapentaenoyl ethanolamide, an omega-3 fatty acid, is one of N-acylethanolamines (NAEs). Eicosapentaenoyl ethanolamide is cannabinoid CB1/CB2 receptor agonist. Eicosapentaenoyl ethanolamide acts as a metabolic signal. Eicosapentaenoyl ethanolamide inhibits dietary restriction (DR)-induced lifespan extension in wild type animals and suppresses lifespan extension in a TOR pathway mutant[1][2].

HY-163105

Tubulin/NEDDylation-IN-1	Microtubule/Tubulin	Cancer
Tubulin/NEDDylation-IN-1 (compound C11) is a dual inhibitor of tubulin (Microtubule/Tubulin)-NEDDylation (IC₅₀ for tubulin=2.40 μM), which has strong anti-proliferative activity. Neddylation is a protein post-translational modification that covalently tags the ubiquitin-like protein NEDD8 to target proteins. Tubulin/NEDDylation-IN-1 forms hydrogen bonds with residues of tubulin and E1 NEDD8 activating enzyme (NAE) through methoxy and dithiocarbamate groups and inhibits NEDDylation and microtubulin in an ATP-dependent manner. tube polymerization .

Cat. No.	Product Name	Type

HY-W127407

Glycerophospho-N-arachidonoyl ethanolamine	Drug Delivery
Glycerophospho-N-Arachidonoyl Ethanolamine is a N-acylated ethanolamines (NAEs). Most NAEs are naturally occurring lipids with diverse biological activities. Different types of NAE can be derived from glycerophosphate-linked precursors through the activity of glycerophosphodiesterase 1 (GDE1). Glycerophosphate-N-Arachidonoyl Ethanolamine is the precursor of Anandamide (AEA), also known as Anandamide. AEA is an endocannabinoid neurotransmitter that binds to central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. It inhibits the specific binding of [3H]-HU-243 to synaptosomal membranes with a Ki value of 52 nM compared to 46 nM for δ9-THC.

Glycerophospho-N-arachidonoyl ethanolamine

Drug Delivery

Glycerophospho-N-Arachidonoyl Ethanolamine is a N-acylated ethanolamines (NAEs). Most NAEs are naturally occurring lipids with diverse biological activities. Different types of NAE can be derived from glycerophosphate-linked precursors through the activity of glycerophosphodiesterase 1 (GDE1). Glycerophosphate-N-Arachidonoyl Ethanolamine is the precursor of Anandamide (AEA), also known as Anandamide. AEA is an endocannabinoid neurotransmitter that binds to central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. It inhibits the specific binding of [3H]-HU-243 to synaptosomal membranes with a Ki value of 52 nM compared to 46 nM for δ9-THC.

Cat. No.	Product Name	Chemical Structure

HY-124089S

Eicosapentaenoyl ethanolamide-d4
Eicosapentaenoyl ethanolamide-d₄ is the deuterium labeled Eicosapentaenoyl ethanolamide. Eicosapentaenoyl ethanolamide, an omega-3 fatty acid, is one of N-acylethanolamines (NAEs). Eicosapentaenoyl ethanolamide is cannabinoid CB1/CB2 receptor agonist. Eicosapentaenoyl ethanolamide acts as a metabolic signal. Eicosapentaenoyl ethanolamide inhibits dietary restriction (DR)-induced lifespan extension in wild type animals and suppresses lifespan extension in a TOR pathway mutant[1][2].

Eicosapentaenoyl ethanolamide-d4

Eicosapentaenoyl ethanolamide-d₄ is the deuterium labeled Eicosapentaenoyl ethanolamide. Eicosapentaenoyl ethanolamide, an omega-3 fatty acid, is one of N-acylethanolamines (NAEs). Eicosapentaenoyl ethanolamide is cannabinoid CB1/CB2 receptor agonist. Eicosapentaenoyl ethanolamide acts as a metabolic signal. Eicosapentaenoyl ethanolamide inhibits dietary restriction (DR)-induced lifespan extension in wild type animals and suppresses lifespan extension in a TOR pathway mutant[1][2].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P83551

	NEDD8 Activating Enzyme E1C Antibody (YA3296) NAE2; UBE1C; hUBA3	WB	Human, Mouse
	NEDD8 Activating Enzyme E1C Antibody (YA3296) is a biotin-conjugated non-conjugated IgG antibody, targeting NEDD8 Activating Enzyme E1C, with a predicted molecular weight of 52 kDa (observed band size: 52 kDa). NEDD8 Activating Enzyme E1C Antibody (YA3296) can be used for WB experiment in human, mouse background.

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HY-RS09007

NAE1 Human Pre-designed siRNA Set A		siRNAs
NAE1 Human Pre-designed siRNA Set A contains three designed siRNAs for NAE1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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