NMT

By Targets:	N-myristoyltransferase (4) ADC Cytotoxin (2) AMPK (1) Biochemical Assay Reagents (1) DNA/RNA Synthesis (2) Drug Metabolite (1) Endogenous Metabolite (2) Fungal (1) Parasite (3) PPAR (1) Small Interfering RNA (siRNA) (2)
By Research Areas:	Cancer (5) Cardiovascular Disease (1) Infection (7) Inflammation/Immunology (1) Neurological Disease (3)
Oligonucleotides:	Human Pre-designed siRNA Sets (2) siRNAs (2)

Targets Recommended: N-myristoyltransferase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-153021

NMT-IN-1	Parasite	Infection
NMT-IN-1 (compound 9) is a potent N-Myristoyltransferase (NMT) Inhibitor with IC₅₀ values of 31 and 66 μM for TbNMT and hNMT, respectively. NMT-IN-1 can be used in research of african trypanosomiasis .

HY-103056

DDD85646 IMP-366	DNA/RNA Synthesis Parasite	Infection
DDD85646 (IMP-366) is an orally active of trypanosoma brucei N-myristoyltransferase (TbNMT IC₅₀=2 nM; hNMT IC₅₀=4 nM). The enzyme N-myristoyltransferase (NMT) is a potential agent target for human African trypanosomiasis .

HY-158364

NMT-IN-3	Parasite	Infection
NMT-IN-3 is an inhibitor of N-myristoyltransferase (NMT). The IC₅₀ of NMT-IN-3 for Plasmodium vivax NMT is 38 mM .

HY-160945

NMT-IN-7	ADC Cytotoxin N-myristoyltransferase	Cancer
NMT-IN-7 is a N-myristoyl transferase (NMT) inhibitor, with IC₅₀s of 2.1 nM for HsNMT1M, 0.6 nM for SU-DHL-10 cell. NMT-IN-7 can be used as a ADC cytotoxin .

HY-RS09390

NMT2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
NMT2 Human Pre-designed siRNA Set A contains three designed siRNAs for NMT2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

NMT2 Human Pre-designed siRNA Set A NMT2 Human Pre-designed siRNA Set A

HY-RS09389

NMT1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
NMT1 Human Pre-designed siRNA Set A contains three designed siRNAs for NMT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

NMT1 Human Pre-designed siRNA Set A NMT1 Human Pre-designed siRNA Set A

HY-W721249

5-Methoxy NMT 5-MeO-NMT	Biochemical Assay Reagents	Neurological Disease
5-Methoxy NMT is an organic compound of the tryptamine class. 5-Methoxy NMT can be metabolized in the liver by the action of cytochrome p450 enzymes .

HY-168652

*4-PivO-NMT* chloride**	AMPK	Neurological Disease Inflammation/Immunology
4-PivO-NMT chloride is an indole-derived AMPK signaling pathway modulator that regulates neurogenesis or neurite outgrowth by modulating AMPK activity. 4-PivO-NMT chloride holds promise for research in the fields of neurological disorders, pain, and inflammation .

HY-122134

SC-58272	Fungal	Infection
SC-58272 is a potent and selective dipeptide N-myristoyltransferase (Nmt) inhibitor with an IC₅₀ of 56 nM for C. albicans (strain B311) Nmt. SC-58272 shows 250-fold selective for the fungal enzyme compared to human enzyme .

HY-W703869

*5-Hydroxy NMT* oxalate** N-Methylserotonin oxalate; 5-Hydroxy-N-methyl tryptamine oxalate	Drug Metabolite	Neurological Disease
5-Hydroxy NMT (N-Methylserotonin) oxalate is a metabolite of 5-HT and belongs to the tryptamine class of compounds. Elevated levels of 5-Hydroxy NMT oxalate in plasma are associated with cocaine addiction .

HY-126833

Myristoyl coenzyme A	Endogenous Metabolite	Infection Cancer
Myristoyl coenzyme A is a myristoylated coenzyme A (CoA). Myristoylation is an essential process in viruses and is generally controlled by N-myristoyltransferase (NMT). And NMT is more active in colon epithelial tumors than in normal cells. Reduced Ccoenzyme A (CoA) is known to be a key regulator of NMT activity, whereas oxidized CoA does not allow NMT to promote myristoylation. Myristoyl coenzyme A blocks the demyristoylation process and has potential anticancer and antiviral mechanisms.

HY-126833A

Myristoyl coenzyme A lithium 1 Publications Verification	Endogenous Metabolite	Infection Cancer
Myristoyl coenzyme A lithium is lithium-labeled myristoylated coenzyme A (CoA). Myristoylation is an essential process in viruses and is generally controlled by N-myristoyltransferase (NMT). And NMT is more active in colon epithelial tumors than in normal cells. Reduced Ccoenzyme A (CoA) is known to be a key regulator of NMT activity, whereas oxidized CoA does not allow NMT to promote myristoylation. Myristoyl coenzyme A blocks the demyristoylation process and has potential anticancer and antiviral mechanisms.

HY-147308

Zelenirstat 2 Publications Verification PCLX-001	N-myristoyltransferase	Cancer
Zelenirstat is an orally acitve, small-molecule, dual N-myristoyltransferase (NMT) inhibitor, with IC₅₀s of 5 nM (NMT1) and 8 nM (NMT2), respectively. Zelenirstat can induce cell apoptosis, has anti-cancer activity, inhibits early B cell receptor (BCR) signaling, and can be used to study malignant lymphoma .

HY-132211

3-Thiatetradecanoic acid	PPAR	Others
3-Thiatetradecanoic acid is a substrate of N-myristoyltransferase (NMT), which is involved in the metabolism of thiofatty acids .

HY-136625

LY134046	N-myristoyltransferase	Cardiovascular Disease
LY134046 is an inhibitor of norepinephrine N-methyltransferase (NMT) with cardiovascular activity. LY134046 causes sustained reductions in mean arterial blood pressure and heart rate, but no significant reductions in norepinephrine concentrations in the rat brain. LY134046 does not interact with adrenergic or cholinergic receptors, and its hypotensive and bradycardic effects do not require neurogenic tension. LY134046 (40 mg/kg/day) causes sustained and significant inhibition of hypothalamic and brainstem NMT activity, resulting in central norepinephrine depletion.

HY-112258

IMP-1088 4 Publications Verification	DNA/RNA Synthesis	Infection
IMP-1088 is a potent human N-myristoyltransferases NMT1 and *NMT2* dual inhibitor with IC₅₀s of <1 nM for HsNMT1 and HsNMT2. IMP-1088 has a K_d of <210 pM for HsNMT1. IMP-1088 efficiently blocks rhinovirus replication by blocking rhinovirus virus-encoded protein (VP0) N-myristoylation. IMP-1088 protects host cells from the cytotoxic effects of viral infection .

HY-164285

MYX1715	ADC Cytotoxin N-myristoyltransferase	Cancer
MYX1715 is an inhibitor of N-Myristoyltransferase (NMT) with a K_D value of 0.09 nM. MYX1715 inhibits the proliferation of LU0884 and LU2511 with IC₅₀ values of 44 nM and 9 nM. MYX1715 exhibits antitumor efficacy against neuroblastoma and gastric cancer in mouse models. MYX1715 can be used as ADC toxin .

Cat. No.	Product Name	Type

HY-126833

Myristoyl coenzyme A	Enzyme Substrates
Myristoyl coenzyme A is a myristoylated coenzyme A (CoA). Myristoylation is an essential process in viruses and is generally controlled by N-myristoyltransferase (NMT). And NMT is more active in colon epithelial tumors than in normal cells. Reduced Ccoenzyme A (CoA) is known to be a key regulator of NMT activity, whereas oxidized CoA does not allow NMT to promote myristoylation. Myristoyl coenzyme A blocks the demyristoylation process and has potential anticancer and antiviral mechanisms.

Myristoyl coenzyme A

Enzyme Substrates

Myristoyl coenzyme A is a myristoylated coenzyme A (CoA). Myristoylation is an essential process in viruses and is generally controlled by N-myristoyltransferase (NMT). And NMT is more active in colon epithelial tumors than in normal cells. Reduced Ccoenzyme A (CoA) is known to be a key regulator of NMT activity, whereas oxidized CoA does not allow NMT to promote myristoylation. Myristoyl coenzyme A blocks the demyristoylation process and has potential anticancer and antiviral mechanisms.

Cat. No.	Product Name	Target	Research Area

HY-P6028A

GSNKSKPK-NH2 TFA	Peptides	Others
GSNKSKPK-NH2 TFA is a model peptide based on a c-Src N-terminal peptide that can be used as NMT substrate .

HY-P6028

GSNKSKPK-NH2	Peptides	Others
GSNKSKPK-NH2 is a model peptide based on a c-Src N-terminal peptide that can be used as NMT substrate .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-126833A

Myristoyl coenzyme A lithium 1 Publications Verification	Infection Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
Myristoyl coenzyme A lithium is lithium-labeled myristoylated coenzyme A (CoA). Myristoylation is an essential process in viruses and is generally controlled by N-myristoyltransferase (NMT). And NMT is more active in colon epithelial tumors than in normal cells. Reduced Ccoenzyme A (CoA) is known to be a key regulator of NMT activity, whereas oxidized CoA does not allow NMT to promote myristoylation. Myristoyl coenzyme A blocks the demyristoylation process and has potential anticancer and antiviral mechanisms.

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81661

	NONO Antibody (YA1406) P54; NMT55; NRB54; P54NRB	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	NONO Antibody (YA1406) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1406), targeting NONO, with a predicted molecular weight of 54 kDa (observed band size: 54 kDa). NONO Antibody (YA1406) can be used for WB, IHC-F, IHC-P, ICC/IF experiment in human, mouse, rat background.

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Cat. No.	Product Name		Classification

HY-RS09390

NMT2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
NMT2 Human Pre-designed siRNA Set A contains three designed siRNAs for NMT2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS09389

NMT1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
NMT1 Human Pre-designed siRNA Set A contains three designed siRNAs for NMT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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