2. Antibody-drug Conjugate/ADC Related Metabolic Enzyme/Protease
  3. ADC Cytotoxin N-myristoyltransferase
  4. MYX1715

MYX1715 is an inhibitor of N-Myristoyltransferase (NMT) with a KD value of 0.09 nM. MYX1715 inhibits the proliferation of LU0884 and LU2511 with IC50 values of 44 nM and 9 nM. MYX1715 exhibits antitumor efficacy against neuroblastoma and gastric cancer in mouse models. MYX1715 can be used as ADC toxin.

For research use only. We do not sell to patients.

MYX1715 Chemical Structure

MYX1715 Chemical Structure

CAS No. : 2445448-66-6

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1 mg USD 465 In-stock
5 mg USD 1165 In-stock
10 mg USD 1860 In-stock
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Based on 1 publication(s) in Google Scholar

MYX1715 Related Antibodies

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Description

MYX1715 is an inhibitor of N-Myristoyltransferase (NMT) with a KD value of 0.09 nM. MYX1715 inhibits the proliferation of LU0884 and LU2511 with IC50 values of 44 nM and 9 nM. MYX1715 exhibits antitumor efficacy against neuroblastoma and gastric cancer in mouse models. MYX1715 can be used as ADC toxin[1][2].

In Vivo

MYX1715 (12.5 and 25 mg/kg, a single dose for 20 days) prevents tumour growth in a Th-MYCN GEMM model, in a DLBCL xenograft model and in a gastric cancer xenograft model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Th-MYCN GEMM mice model, DLBCL xenograft mice model and gastric cancer xenograft mice model[1]
Dosage: 12.5 and 25 mg/kg
Administration: a single dose for 20 days
Result: Inhibited tumour growth in mice bearing tumors.
Molecular Weight

480.99

Formula

C25H29ClN6O2
CAS No.
Appearance

Solid

Color

Yellow to brown

SMILES

O=C(N(C)C)C1=NN(C)C(C)=C1CCOC2=C(C3=CN4C(CCN)=CN=C4C=C3)C=CC(Cl)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (259.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0790 mL 10.3952 mL 20.7905 mL
5 mM 0.4158 mL 2.0790 mL 4.1581 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0790 mL 10.3952 mL 20.7905 mL 51.9761 mL
5 mM 0.4158 mL 2.0790 mL 4.1581 mL 10.3952 mL
10 mM 0.2079 mL 1.0395 mL 2.0790 mL 5.1976 mL
15 mM 0.1386 mL 0.6930 mL 1.3860 mL 3.4651 mL
20 mM 0.1040 mL 0.5198 mL 1.0395 mL 2.5988 mL
25 mM 0.0832 mL 0.4158 mL 0.8316 mL 2.0790 mL
30 mM 0.0693 mL 0.3465 mL 0.6930 mL 1.7325 mL
40 mM 0.0520 mL 0.2599 mL 0.5198 mL 1.2994 mL
50 mM 0.0416 mL 0.2079 mL 0.4158 mL 1.0395 mL
60 mM 0.0347 mL 0.1733 mL 0.3465 mL 0.8663 mL
80 mM 0.0260 mL 0.1299 mL 0.2599 mL 0.6497 mL
100 mM 0.0208 mL 0.1040 mL 0.2079 mL 0.5198 mL
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MYX1715 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MYX17152445448-66-6MYX 1715MYX-1715ADC CytotoxinN-myristoyltransferaseADC PayloadNMTNSCLCSNU-620LU0884LU2511neuroblastomagastric cancerInhibitorinhibitorinhibit

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