Search Result

Isoforms Recommended:	N-Ras

Results for "

NRAS

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Adrenergic Receptor (1) Akt (1) AMPK (1) Apoptosis (3) Autophagy (2) Dopamine Receptor (1) ERK (1) Eukaryotic Initiation Factor (eIF) (1) Farnesyl Transferase (4) Haspin Kinase (2) ICMT (2) MAGL (1) MEK (1) Molecular Glues (1) NF-κB (1) PARP (1) Phospholipase (1) Raf (5) Ras (6) Ribosomal S6 Kinase (RSK) (1) Small Interfering RNA (siRNA) (3) Src (1)
By Research Areas:	Cancer (19) Endocrinology (1) Infection (3) Inflammation/Immunology (1) Neurological Disease (1)
Oligonucleotides:	Pre-designed siRNA Sets (3) siRNAs (3)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-142161

ABD957 1 Publications Verification	MAGL	Cancer
ABD957 is a potent and selective covalent inhibitor of the ABHD17 family of depalmitoylases, with an IC₅₀ of 0.21 µM for ABHD17B. ABD957 can block N-Ras signaling and the growth of NRAS-mutant AML cells .

HY-156498

RMC-7977	Ras ERK Raf Ribosomal S6 Kinase (RSK) AMPK Apoptosis PARP	Cancer
RMC-7977 is an orally active triple-complex RAS inhibitor that can simultaneously bind to cyclophilin A (CYPA) (K_d = 195 nM) and KRAS (G12V) (K_d = 292 μM). It exhibits broad-spectrum inhibitory activity against KRAS, NRAS, and HRAS proteins and their various wild-type and mutant variants. RMC-7977 induces apoptosis by inhibiting the phosphorylation of ERK, CRAF, and RSK, as well as increasing PARP cleavage. This leads to tumor regression, reduces resistance in KRAS ^G12C cancer models, and demonstrates good tolerability across various RAS cancer models .

HY-122866

ZT-12-037-01	Ras	Cancer
ZT-12-037-01 is a STK19-targeted inhibitor, has a high-affinity interaction with STK19 protein and inhibits oncogenic NRAS-driven melanocyte malignant transformation. ZT-12-037-01 is an ATP-competitive inhibitor, inhibiting phosphorylation of NRAS (major isoform of Ras family) with an IC₅₀ of 24 nM .

HY-RS09558

NRAS Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
NRAS Human Pre-designed siRNA Set A contains three designed siRNAs for NRAS gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

NRAS Human Pre-designed siRNA Set A NRAS Human Pre-designed siRNA Set A

HY-RS09559

Nras Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Nras Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nras gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Nras Mouse Pre-designed siRNA Set A Nras Mouse Pre-designed siRNA Set A

HY-RS09560

Nras Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Nras Rat Pre-designed siRNA Set A contains three designed siRNAs for Nras gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Nras Rat Pre-designed siRNA Set A Nras Rat Pre-designed siRNA Set A

HY-163515

Anticancer agent 207	Ras	Cancer
Anticancer agent 207 (compound 10b) is a potent anticancer agent. Anticancer agent 207 bounds to the NRAS rG4 with a K_D value of 2.31 µM. Anticancer agent 207 shows cytotoxicity and decreases the expression of NRAS protein. Anticancer agent 207 shows antitumor activity .

HY-108887

Anticancer agent 124	Raf	Cancer
Anticancer agent 124 is an orally active, highly selective and potent pan RAF inhibitor. Anticancer agent 124 inhibits MAPK signalling in BRAF V600E, NRAS and KRAS mutant tumor cells .

HY-120911

Palmostatin B	Phospholipase	Cancer
Palmostatin B is an Acyl protein thioesterase 1 and 2 (APT-1, APT-2) inhibitor. Palmostatin B reduces cell viability in a panel of NRAS mutant melanoma cell lines. Palmostatin B inhibits Ras depalmitoylation in cells .

HY-101641

NRA-0160	Dopamine Receptor 5-HT Receptor Adrenergic Receptor	Neurological Disease Endocrinology
NRA-0160 is a selective dopamine D4 receptor antagonist, with a K_i value of 0.48 nM and with negligible affinity for dopamine D2 receptor (K_i: >10000 nM), D3 receptor (K_i: 39 nM), rat 5-HT2A receptor (K_i: 180 nM) and rat α1 adrenoceptor (K_i: 237 nM).

HY-107415

PLX7922	Raf	Cancer
PLX7922, a RAF inhibitor, can bind with BRAF ^V600E. PLX7922 inhibits pERK in BRAF ^V600E cell lines, and activates pERK in mutant NRAS cell lines .

HY-156228

RGB-1	Others	Cancer
RGB-1 is a polycyclic aromatic hydrocarbon molecule and a stabilizer of RNA G-quadruplexes. RGB-1 can promote the inhibition of RNA translation and reduce the expression of NRAS proto-oncogene in breast cancer cells .

HY-15879

LB42708	Farnesyl Transferase Apoptosis	Inflammation/Immunology
LB42708 is a potent, selective and orally active farnesyltransferase inhibitor. LB42708 inhibits farnesylation of H-Ras, *N-Ras* and K-Ras4B with IC₅₀s of 0.8 nM, 1.2 nM and 2.0 nM, respectively .

HY-15136

Lonafarnib Maximum Cited Publications 8 Publications Verification Sch66336	Farnesyl Transferase Ras Autophagy	Infection Cancer
Lonafarnib (Sch66336) is a potent and orally active farnesyl transferase (FTase) inhibitor. Lonafarnib inhibits the activities of H-ras, K-ras and *N-ras* with IC₅₀ values of 1.9 nM, 5.2 nM and 2.8 nM, respectively. Lonafarnib also has anti-hepatitis delta virus (HDV) activities.

HY-156500

ICMT-IN-1	ICMT	Cancer
ICMT-IN-1 (compound 75) is an inhibitor of ICMT (IC₅₀=0.0013 μM). ICMT-IN-1 dose-dependently induces ICMT accumulation in the cytoplasm of HCT-116 cells and inhibits the proliferation of multiple cancer cell lines expressing K-Ras and N-Ras .

HY-149705

ICMT-IN-7	ICMT	Cancer
ICMT-IN-7 (compound 74) is an inhibitor of ICMT (IC₅₀=0.015 μM). ICMT-IN-7 dose-dependently induces ICMT accumulation in the cytoplasm of HCT-116 cells and inhibits the proliferation of multiple cancer cell lines expressing K-Ras and N-Ras .

HY-164524

SBI-0640726	Eukaryotic Initiation Factor (eIF) Akt NF-κB	Cancer
SBI-0640726 is an eIF4G1 inhibitor with antiproliferative activity in melanoma. SBI-0640726 disrupts the eIF4F translation initiation complex by inhibiting AKT and NF-kB signaling pathways. SBI-0640726 inhibits the growth of NRAS and BRAF mutant melanoma in vitro .

HY-15136B

(Rac)-Lonafarnib Sch66336 racemate	Farnesyl Transferase	Infection Cancer
(Rac)-Lonafarnib (Sch66336 racemate) is the racemate of Lonafarnib. Lonafarnib is a potent and orally active farnesyl transferase (FTase) inhibitor. Lonafarnib inhibits the activities of H-ras, K-ras and *N-ras* with IC₅₀ values of 1.9 nM, 5.2 nM and 2.8 nM, respectively. Lonafarnib also has anti-hepatitis delta virus (HDV) activities .

HY-12847

CCT241161	Raf Src Apoptosis	Cancer
CCT241161 is an orally active pan-RAF inhibitor with IC₅₀s of 3, 6, 10, 15 and 30 nM for LCK, CRAF, SRC, V600E-BRAF and BRAF, respectively. CCT241161 shows good activity to in BRAF and *NRAS* mutant melanomas. CCT241161 also exhibits anticancer cell proliferative activity .

HY-15136R

Lonafarnib (Standard)	Farnesyl Transferase Ras Autophagy	Infection Cancer
Lonafarnib (Standard) is the analytical standard of Lonafarnib. This product is intended for research and analytical applications. Lonafarnib (Sch66336) is a potent and orally active farnesyl transferase (FTase) inhibitor. Lonafarnib inhibits the activities of H-ras, K-ras and *N-ras* with IC₅₀ values of 1.9 nM, 5.2 nM and 2.8 nM, respectively. Lonafarnib also has anti-hepatitis delta virus (HDV) activities.

HY-158115

NST-628	Molecular Glues Raf MEK	Cancer
NST-628 is a brain-permeable MAPK pathway molecule glue that inhibits RAF phosphorylation and MEK activation. NST-628 also binds RAF and prevents the formation of BRAF-CRAF and BRAF-ARAF heterodimers, effectively inhibiting the RAS-MAPK pathway. NST-628 inhibits RAS- and RAF-driven cancers and demonstrated potent inhibition in mutant KRAS, NRAS, BRAF class II/III, and NF1-mutant tumors .

HY-122862

RAS inhibitor Abd-7 1 Publications Verification	Ras	Cancer
RAS inhibitor Abd-7, a potent RAS-binding compound (K_d=51 nM), is a RAS-effector protein-protein interaction (PPI) inhibitor. RAS inhibitor Abd-7 interacts with RAS inside the cells, prevents RAS-effector interactions and inhibits endogenous RAS-dependent signaling. RAS inhibitor Abd-7 impairs the PPI of various mutant KRAS proteins with PI3K, CRAF and RALGDS as well as NRAS Q61H and HRAS G12V .

HY-15217

CHR-6494 5+ Cited Publications	Haspin Kinase	Cancer
CHR-6494 is a potent inhibitor of haspin, with an IC₅₀ of 2 nM. CHR-6494 inhibits histone H3T3 phosphorylation. CHR-6494 can be used in the research of cancer .

HY-110350

CHR-6494 TFA	Haspin Kinase	Cancer
CHR-6494 TFA is a potent inhibitor of haspin, with an IC₅₀ of 2 nM. CHR-6494 TFA inhibits histone H3T3 phosphorylation. CHR-6494 TFA induces the apoptosis of cancer cells, including melanoma and breast cancer. CHR-6494 TFA can be used in the research of cancer .

Species:	Human (2)
Tag:	His (2)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P73741

	NRAS Protein, Human (His, solution) 1 Publications Verification GTPase NRAS; Transforming protein N-Ras; NRAS; HRAS1	Human	E. coli
	NRAS protein is a member of the Ras family that binds GDP/GTP and has intrinsic GTPase activity. This property enables NRAS to actively regulate cellular processes by cycling between a GDP-bound inactive state and a GTP-bound active state. NRAS Protein, Human (His, solution) is the recombinant human-derived NRAS protein, expressed by E. coli , with N-His labeled tag. The total length of NRAS Protein, Human (His, solution) is 186 a.a., with molecular weight of ~24 kDa.

HY-P73741A

	NRAS Protein, Human (N-His) GTPase NRAS; Transforming protein N-Ras; NRAS; HRAS1	Human	E. coli
	NRAS protein is a member of the Ras family that binds GDP/GTP and has intrinsic GTPase activity. This property enables NRAS to actively regulate cellular processes by cycling between a GDP-bound inactive state and a GTP-bound active state. NRAS Protein, Human (N-His) is the recombinant human-derived NRAS protein, expressed by E. coli , with N-His labeled tag. The total length of NRAS Protein, Human (N-His) is 186 a.a., with molecular weight of ~23 kDa.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82085

	*GTPase NRAS* Antibody (YA1830)** NS6; CMNS; NCMS; ALPS4; N-ras; NRAS1	WB, IP	Human, Mouse, Rat
	GTPase NRAS Antibody (YA1830) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1830), targeting GTPase NRAS, with a predicted molecular weight of 21 kDa (observed band size: 21 kDa). GTPase NRAS Antibody (YA1830) can be used for WB, IP experiment in human, mouse, rat background.

HY-P82088

	GTPase HRAS Antibody (YA1833) NS6; CMNS; NCMS; ALPS4; N-ras; NRAS1	WB, ICC/IF, IP	Human, Mouse, Rat
	GTPase HRAS Antibody (YA1833) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1833), targeting GTPase HRAS, with a predicted molecular weight of 21 kDa (observed band size: 21 kDa). GTPase HRAS Antibody (YA1833) can be used for WB, ICC/IF, IP experiment in human, mouse, rat background.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-RS09558

NRAS Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
NRAS Human Pre-designed siRNA Set A contains three designed siRNAs for NRAS gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS09559

Nras Mouse Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Nras Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nras gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS09560

Nras Rat Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Nras Rat Pre-designed siRNA Set A contains three designed siRNAs for Nras gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: