2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. RMC-6236

RMC-6236 (Compound A122) is a potent RAS(ON)MULTI inhibitor and can be used for the research of cancer.

For research use only. We do not sell to patients.

RMC-6236 Chemical Structure

RMC-6236 Chemical Structure

CAS No. : 2765081-21-6

Size Price Stock Quantity
1 mg USD 140 In-stock
5 mg USD 350 In-stock
10 mg USD 550 In-stock
25 mg USD 950 In-stock
50 mg USD 1650 In-stock
100 mg USD 2650 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

RMC-6236 Related Antibodies

Top Publications Citing Use of Products

View All Ras Isoform Specific Products:

View All Isoforms
K-Ras H-Ras N-Ras Ras

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

RMC-6236 (Compound A122) is a potent RAS(ON)MULTI inhibitor and can be used for the research of cancer[1].

IC50 & Target[1]

KRas G12D

 

In Vitro

RMC-6236 (Compound A122) (5 days) inhibits cell viability with an IC50 of 1-10 μM against AsPC-1 (K-Ras G12D)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RMC-6236 Related Antibodies
Molecular Weight

811.05

Formula

C44H58N8O5S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(COC([C@H]1NN(C([C@H](CC2=NC3=CS2)NC([C@H]4C[C@@H]4C)=O)=O)CCC1)=O)(C)CC5=[C@@](N(CC)C6=C5C=C3C=C6)[C@@]7=C([C@H](C)OC)N=CC(N8CCN(C)CC8)=C7
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (123.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2330 mL 6.1648 mL 12.3297 mL
5 mM 0.2466 mL 1.2330 mL 2.4659 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.88%

COA (256 KB) HNMR (325 KB) LCMS (95 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2330 mL 6.1648 mL 12.3297 mL 30.8242 mL
5 mM 0.2466 mL 1.2330 mL 2.4659 mL 6.1648 mL
10 mM 0.1233 mL 0.6165 mL 1.2330 mL 3.0824 mL
15 mM 0.0822 mL 0.4110 mL 0.8220 mL 2.0549 mL
20 mM 0.0616 mL 0.3082 mL 0.6165 mL 1.5412 mL
25 mM 0.0493 mL 0.2466 mL 0.4932 mL 1.2330 mL
30 mM 0.0411 mL 0.2055 mL 0.4110 mL 1.0275 mL
40 mM 0.0308 mL 0.1541 mL 0.3082 mL 0.7706 mL
50 mM 0.0247 mL 0.1233 mL 0.2466 mL 0.6165 mL
60 mM 0.0205 mL 0.1027 mL 0.2055 mL 0.5137 mL
80 mM 0.0154 mL 0.0771 mL 0.1541 mL 0.3853 mL
100 mM 0.0123 mL 0.0616 mL 0.1233 mL 0.3082 mL
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RMC-6236 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RMC-62362765081-21-6RAS-IN-2RMC6236RMC 6236RasG12DK-RasAsPC-1Inhibitorinhibitorinhibit

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