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Isoforms Recommended:	NUAK1

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NUAK1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AMPK (7) CDK (2) JAK (3) LRRK2 (2) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (6) Inflammation/Immunology (1) Neurological Disease (3)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

10

Inhibitors & Agonists

1

Recombinant Proteins

3

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HTH-01-015 1 Publications Verification	AMPK	Cancer
HTH-01-015 is a selective *NUAK1/ARK5* inhibitor (IC₅₀ is 100 nM). HTH-01-015 inhibits NUAK1 with >100-fold higher potency than NUAK2 (IC50 of >10 μM).

WZ4003 5 Publications Verification	AMPK	Cancer
WZ4003 is the first potent and highly specific NUAK kinase inhibitor with IC₅₀ of 20 nM/100 nM for NUAK1 (ARK5)/NUAK2, without significant inhibition on other 139 kinases.

Nuak1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Nuak1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Nuak1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Nuak1 Rat Pre-designed siRNA Set A Nuak1 Rat Pre-designed siRNA Set A

Nuak1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Nuak1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nuak1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Nuak1 Mouse Pre-designed siRNA Set A Nuak1 Mouse Pre-designed siRNA Set A

NUAK1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
NUAK1 Human Pre-designed siRNA Set A contains three designed siRNAs for NUAK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

NUAK1 Human Pre-designed siRNA Set A NUAK1 Human Pre-designed siRNA Set A

NUAK1-IN-1	AMPK CDK	Neurological Disease Cancer
NUAK1-IN-1 (Compound 9) is a *NUAK1* (IC₅₀ of 5.012 nM) and CDK4 inhibitor. NUAK1-IN-1 can be used in cancer, neurodevelopmental disorders and Alzheimer's disease research ^[1].

NUAK1-IN-2	AMPK CDK	Neurological Disease Cancer
NUAK1-IN-2 (Compound 24) is a *NUAK1* (IC₅₀ of 3.162 nM) and CDK2/4/6 inhibitor. NUAK1-IN-2 can be used in cancer, neurodevelopmental disorders and Alzheimer's disease research ^[1].

*LRRK2/NUAK1/TYK2-IN-1*	LRRK2 JAK AMPK	Inflammation/Immunology
LRRK2/NUAK1/TYK2-IN-1 (conpound 226) shows inhibitory activity toward LRRK2 (Wt), LRRK2 (G2019), TYK2 and *NUAK1, with IC₅₀* values lower than 10 nM. LRRK2/NUAK1/TYK2-IN-1 can be used for autoimmune disease research ^[1].

LRRK2-IN-8	LRRK2 JAK AMPK	Neurological Disease Cancer
LRRK2-IN-8 is a LRRK2 inhibitor. LRRK2-IN-8 inhibits LRRK2 (wt) and LRRK2 (G2019) with IC₅₀s lower than 10 nM, and inhibits TYK2 and *NUAK1* with IC₅₀s of 10-100 nM ^[1].

UCB9386	AMPK JAK	Cancer
UCB9386 is the selective and brain penetrant inhibitor for *Nuak1* with a pIC₅₀ of 10.1. UCB9386 inhibits *Nuak2* and Kak2 with an inhibition rate of ca. 50% at 10 nM ^[1].

Cat. No.	Compare	Product Name	Species	Source

	NUAK1 Protein, Human (sf9, GST) NUAK1; NUAK family, SNF1-like kinase, 1; NUAK family SNF1-like kinase 1; AMP activated protein kinase family member 5; ARK5; KIAA0537; NUAK1; omphalocele kinase 1; AMPK-related protein kinase 5; AMP-activated protein kinase family member 5	Human	Sf9 insect cells
	NUAK1 Protein, Human (sf9, GST) is the recombinant human-derived NUAK1, expressed by Sf9 insect cells , with GST labeled tag. ,

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