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Isoforms Recommended:	Na_v1.8

Results for "

Nav1.8

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Calcium Channel (1) GABA Receptor (1) Potassium Channel (4) Sodium Channel (40)
By Research Areas:	Cancer (2) Cardiovascular Disease (4) Infection (2) Inflammation/Immunology (5) Neurological Disease (35)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-155635

Nav1.8-IN-4	Sodium Channel	Infection
Nav1.8-IN-4 (compound 9a) is a *Nav1.8* channel inhibitor (IC₅₀=0.014 μM). Nav1.8-IN-4 can be used for research on pain-related diseases .

HY-160588

Nav1.8-IN-7	Sodium Channel Potassium Channel	Neurological Disease
Nav1.8-IN-7 (Example 116) is a selective *Nav1.8* inhibitor. Nav1.8-IN-7 shows an inhibition of >50% with 100 nM for Nav1.8. Nav1.8-IN-7 inhibits hERG with an IC₅₀ of 15.6 μM. Nav1.8-IN-7 has the potential for pain research .

HY-160591

Nav1.8-IN-10	Sodium Channel	Neurological Disease
Nav1.8-IN-10 (Compound 6) is a *Nav1.8* channel inhibitor. When the concentration is 4 nM, the percentage blocking rate of Nav1.8 channel is 79.4%. Nav1.8-IN-10 can be used in the study of pain disorders .

HY-160593

Nav1.8-IN-12	Sodium Channel	Neurological Disease
Nav1.8-IN-12 (Compound 23 R) is a *Nav1.8* channel inhibitor. Nav1.8-IN-12 can be used in the study of pain-related diseases .

HY-160592

Nav1.8-IN-11	Sodium Channel	Neurological Disease
Nav1.8-IN-11 (Example 1) is a *Nav1.8* channel inhibitor with a IC₅₀ value of 0.1 nM. Nav1.8-IN-11 can be used in the study of pain disorders .

HY-160589

Nav1.8-IN-8	Sodium Channel	Neurological Disease
Nav1.8-IN-8 (Compound A11) is a *Nav1.8* channel inhibitor. Nav1.8-IN-8 may prevent associated diseases mediated by sodium ion channels (NaV) .

HY-158979

Nav1.8-IN-14	Sodium Channel	Neurological Disease
Nav1.8-IN-14 (compound 20) is a potent and selective *Nav1.8* inhibitor. Nav1.8-IN-14 can be used in the study of pain-related diseases .

HY-143481

Nav1.8-IN-2	Sodium Channel	Neurological Disease
Nav1.8-IN-2 (compound 35A) is a potent *Na_v1.8* inhibitor with an IC₅₀ value of 0.4 nM. Nav1.8-IN-2 can be used for researching pain disorders, cough disorders, and acute and chronic itch disorders .

HY-161572

Nav1.8-IN-13	Sodium Channel	Cardiovascular Disease
Nav1.8-IN-13 (compound 16) is a Nav1.8 inhibitor (pIC₅₀=7.9) .

HY-159094

Nav1.8-IN-15	Sodium Channel	Neurological Disease
Nav1.8-IN-15 (compound 6) is a potent *Nav1.8* inhibitor. Nav1.8-IN-15 shows analgesic effect. Nav1.8-IN-15 has the potential for the research of chronic pain .

HY-162246

Nav1.8-IN-5	Sodium Channel	Cardiovascular Disease Neurological Disease
Nav1.8-IN-5 (Example 1) is a voltage-gated sodium channel *Nav1.8* inhibitor. Nav1.8-IN-5 can be used for Nav1.8-mediated diseases, such as pain and pain-related disorders, as well as cardiovascular diseases (such as atrial fibrillation) research .

HY-132133

Nav1.8-IN-1	Sodium Channel	Neurological Disease Inflammation/Immunology
Nav1.8-IN-1 (Compound 31) is a potent inhibitor of Na(v)1.8 sodium channel. Nav1.8-IN-1 has the potential for the research of inflammatory and neuropathic pain .

HY-161272

Nav1.8-IN-6	Sodium Channel	Neurological Disease
Nav1.8-IN-6 (Compound 2j) is a novel pyridinone amide Nav1.8 channel inhibitor. The IC₅₀ values in the resting state and semi-activated state are 513.33 and 471.81 nM, respectively. Nav1.8-IN-6 has analgesic activity .

HY-149944

Analgesic agent-2	Sodium Channel	Inflammation/Immunology
Analgesic agent-2 is a selective and orally active NaV1.8 Channel inhibitor, with an IC₅₀ of 50.18 nM in HEK293 cells stably expressing human NaV1.8 channel. Analgesic agent-2 has analgesic activity .

HY-114301A

PF-06305591 dihydrate	Sodium Channel	Neurological Disease
PF-06305591 dihydrate is a potent and highly selective voltage gated sodium channel *NaV1.8* blocker, with an IC₅₀ of 15 nM. An excellent preclinical in vitro ADME and safety profile .

HY-146069

ABBV-318	Sodium Channel	Neurological Disease
ABBV-318 is a potent **Nav1.7/ Nav1.8 blocker, with IC₅₀s of 2.8 μM and 3.8 μM for hNav1.7 and hNav1.8**, respectively. ABBV-318 can be used for the research of pain .

HY-101383

PF-01247324 1 Publications Verification	Sodium Channel	Neurological Disease
PF-01247324 is a selective and orally bioavailable *Na_v1.8* channel blocker with an IC₅₀ of 196 nM for recombinant human Na_v1.8 channel.

HY-148800

Suzetrigine 1 Publications Verification VX-548	Sodium Channel	Neurological Disease
Suzetrigine (VX-548) is an orally active and highly selective *Na_V1.8* inhibitor that acts as an analgesic. Suzetrigine is also a blocker of sodium channel protein type 10 subunit alpha. Suzetrigine is promising for research of acute pain after abdominoplasty and bunionectomy .

HY-105283

PF 04531083	Sodium Channel	Neurological Disease
PF 04531083 is a selective *Na_V1.8* blocker, and used for the research of neuropathic/inflammatory pain.

HY-163855

KGP-25	Sodium Channel GABA Receptor	Neurological Disease
KGP-25 is an inhibitor of voltage-gated sodium channel 1.8 (Nav1.8), which can be used for analgesia by targeting *Nav1.8* in the peripheral nervous system (PNS). KGP-25 can also target γ-aminobutyric acid subtype A receptor (GABA_A) in the central nervous system (CNS) for general anesthesia .

HY-11079

A-803467 2 Publications Verification	Sodium Channel	Neurological Disease Inflammation/Immunology Cancer
A-803467 is a potent and selective tetrodotoxin-resistant Na_v1.8 sodium channel blocker (IC₅₀=8 nM). A-803467 has shown significant anti-nociception in neuropathic and inflammatory pain models. A-803467 enhances the chemosensitivity of conventional anticancer agents through interaction with the ATP-binding cassette subfamily G member 2 (ABCG2) transporter .

HY-157802

LTGO-33	Sodium Channel	Neurological Disease
LTGO-33 is a potent and selective voltage-gated sodium channel *NaV1.8* inhibitor. LTGO-33 inhibits NaV1.8 in the nM potency range and exhibits over 600-fold selectivity against human NaV1.1-NaV1.7 and NaV1.9. LTGO-33 exhibits state-independent inhibition with similar potencies on channels in the closed and inactivated conformations. LTGO-33 inhibits native TTX-R NaV1.8 currents in non-human primate and human DRG neurons, where it reduces action potential firing. LTGO-33 can be used for pain disorders research .

HY-139346

VX-150	Sodium Channel	Neurological Disease
VX-150 is an orally active, highly selective *Na_V1.8* inhibitor. VX-150 has the potential for various pain indications research .

HY-114301

PF-06305591	Sodium Channel	Neurological Disease
PF-06305591 is a potent and highly selective voltage gated sodium channel *NaV1.8* blocker, with an IC₅₀ of 15 nM. An excellent preclinical in vitro ADME and safety profile .

HY-110325

PF-04885614	Sodium Channel	Neurological Disease
PF-04885614 is a potent *NaV1.8* inhibitor, extracted from patent US2018328915. PF-04885614 has potential for neurological and neurodevelopmental diseases treatment .

HY-157802A

(S)-LTGO-33	Sodium Channel	Neurological Disease
(S)-LTGO-33 is a small molecule inhibitor of voltage-gated sodium channel *NaV1.8*. (S)-LTGO-33 can be used in the treatment of pain disorders .

HY-160903

Suzetrigine phenol	Sodium Channel	Neurological Disease
Suzetrigine phenol is the phenolate form of the sodium channel modulator Suzetrigine (HY-148800). Suzetrigine (VX-548) is an orally active and highly selective inhibitor of NaV1.8 .

HY-B1837

Cyfluthrin	Sodium Channel	Infection
Cyfluthrin is a type II pyrethroid and has effects on various insects. Cyfluthrin is a modulator of Nav_1.8 sodium channels by repetitive stimulation. Cyfluthrin can be applied in agriculture,veterinary, insecticide,pyrethroid and stored product .

HY-16723

Funapide TV 45070; XEN402	Sodium Channel	Neurological Disease Inflammation/Immunology
Funapide (TV 45070; XEN402) is a potent inhibitor of the sodium channel *Nav1.7, Nav1.8* and other Nav channels expressed in the peripheral nervous system. Fornabil is an orally effective analgesic agent .

HY-16723A

(R)-Funapide (R)-TV 45070; (R)-XEN402	Sodium Channel	Neurological Disease Inflammation/Immunology
(R)-Funapide ((R)-TV 45070) is the less active R-enantiomer of Funapide. Funapide is a potent inhibitor of the sodium channel *Nav1.7, Nav1.8* and other Nav channels expressed in the peripheral nervous system. Fornabil is an orally effective analgesic agent .

HY-P5786

Heteropodatoxin-1	Potassium Channel Sodium Channel	Neurological Disease
Heteropodatoxin-1 (HpTx1), a spider peptide toxin, is a Kv4.2 current inhibitor. Heteropodatoxin-1 also inhibits *Nav1.7* and activates *Nav1.9* but does not affect Nav1.8 .

HY-N1847

3'-Methoxydaidzein	Sodium Channel	Neurological Disease
3'-Methoxydaidzein is a isoflavone and a Sodium Channel inhibitor. 3'-Methoxydaidzein inhibits subtypes NaV1.7, NaV1.8 and NaV1.3 with IC₅₀ of 181 nM, 397 nM, and 505 nM, respectively. 3'-Methoxydaidzein exerts analgesic activity by inhibiting voltage-gated sodium channels .

HY-P5916

VSTx-3 κ-Theraphotoxin-Gr4a; Kappa-TRTX-Gr4a; Voltage sensor toxin 3; Peptide F	Others Potassium Channel	Neurological Disease
VSTx-3 is a K_V channel blocker. VSTx-3 is demonstrated to be a potent, TTX-sensitive sodium channel blocker and especially, a potent blocker of NaV1.8 channels (IC₅₀ 0.19 μM for hNaV1.3, 0.43 μM for hNaV1.7 and 0.77 μM for hNaV1.8 channels).

HY-B0824

Bifenthrin 1 Publications Verification	Sodium Channel	Neurological Disease
Bifenthrin is a synthetic pyrethroid insecticide. Bifenthrin prolongs the opening time of Nav1.8 sodium channels, leading to membrane depolarization and conductance block in the insect nervous system, thereby disrupting neural function. Bifenthrin was effective in inhibiting A. gambiae (LD₅₀=0.15 ng/mg) and C. quinquefasciatus (LD₅₀=0.16 ng/mg). Bifenthrin has good lethality against susceptible and resistant mosquitoes and is very effective in inhibiting blood sucking and can be developed as a mosquito-removal netting material .

HY-16787

ICA-121431 2 Publications Verification	Sodium Channel	Cardiovascular Disease
ICA-121431 is a nanomolar potent and broad-spectrum voltage-gated sodium channel (Na_v) blocker, shows equipotent selectivity for human Na_v1.1 and Na_v1.3 subtypes with IC₅₀ values of 13 nM and 23 nM, respectively. ICA-121431 shows less potent inhibition of Na_v1.2 (IC₅₀=240 nM) and 1,000 fold selectivity against Na_v1.4, Na_v1.6, and the TTX-resistant human Na_v1.5 and Na_v1.8 channels (IC₅₀s >10 μM).

HY-B0824R

Bifenthrin (Standard)	Sodium Channel	Neurological Disease
Bifenthrin (Standard) is the analytical standard of Bifenthrin. This product is intended for research and analytical applications. Bifenthrin is a synthetic pyrethroid insecticide. Bifenthrin prolongs the opening time of Nav1.8 sodium channels, leading to membrane depolarization and conductance block in the insect nervous system, thereby disrupting neural function. Bifenthrin was effective in inhibiting A. gambiae (LD50=0.15 ng/mg) and C. quinquefasciatus (LD50=0.16 ng/mg). Bifenthrin has good lethality against susceptible and resistant mosquitoes and is very effective in inhibiting blood sucking and can be developed as a mosquito-removal netting material .

HY-P1441A

Mambalgin 1 TFA	Sodium Channel	Neurological Disease
Mambalgin 1 TFA is a selective ASIC1a inhibitor (IC₅₀ values are 192 and 72 nM for human ASIC1a and ASIC1a/1b dimer, respectively). Mambalgin 1 TFA binds to closed/inactive channel. Mambalgin 1 TFA is selective for ASIC1a over ASIC2a, ASIC3, TRPV1, P2X2, 5-HT3, Nav1.8, Cav3.2 and Kv1.2 channels. Mambalgin 1 TFA increases latency of withdrawal response in mouse tail-flick and paw-flick tests.

HY-125079

DSP-2230	Sodium Channel	Cardiovascular Disease Neurological Disease
DSP-2230 is a selective *Nav1.7/Nav1.8* blocker, can be used to improve neuropathic pain .

HY-100080

A-887826	Sodium Channel	Neurological Disease
A-887826 is a potent, selective, oral bioavailable and voltage-dependent Na(v)1.8 sodium channel blocker with an IC₅₀ of 11 nM . A-887826 attenuates neuropathic tactile allodynia in vivo .

HY-P1073

ProTx-I	Calcium Channel Sodium Channel Potassium Channel	Cancer
ProTx-I, a venom toxin of the tarantula Thrixopelma pruriens, is a potent, selective Ca_V3.1 channel blocker with IC₅₀ values of 0.2 μM and 31.8 μM for hCa_V3.1 and hCa_V3.2 respectively. ProTx-I is also a potent blocker for voltage-gated Na ⁺ channels and inhibits K_V 2.1 channels .

HY-P5811

Ceratotoxin-1 CcoTx1; β-TRTX-cm1a	Sodium Channel	Neurological Disease
Ceratotoxin-1 (CcoTx1), a peptide toxin, is an voltage-gated sodium channel subtypes inhibitor. Ceratotoxin-1 inhibits *Nav1.1/β1, Nav1.2/β1, Nav1.4/β1, and Nav1.5/β1* with IC₅₀ of 523 nM, 3 nM, 888 nM, and 323 nM, respectively. Ceratotoxin-1 also inhibits *Nav1.8/β1* .

Cat. No.	Product Name	Target	Research Area

HY-P1441A

Mambalgin 1 TFA	Sodium Channel	Neurological Disease
Mambalgin 1 TFA is a selective ASIC1a inhibitor (IC₅₀ values are 192 and 72 nM for human ASIC1a and ASIC1a/1b dimer, respectively). Mambalgin 1 TFA binds to closed/inactive channel. Mambalgin 1 TFA is selective for ASIC1a over ASIC2a, ASIC3, TRPV1, P2X2, 5-HT3, Nav1.8, Cav3.2 and Kv1.2 channels. Mambalgin 1 TFA increases latency of withdrawal response in mouse tail-flick and paw-flick tests.

HY-P5786

Heteropodatoxin-1	Potassium Channel Sodium Channel	Neurological Disease
Heteropodatoxin-1 (HpTx1), a spider peptide toxin, is a Kv4.2 current inhibitor. Heteropodatoxin-1 also inhibits *Nav1.7* and activates *Nav1.9* but does not affect Nav1.8 .

HY-P5916

VSTx-3 κ-Theraphotoxin-Gr4a; Kappa-TRTX-Gr4a; Voltage sensor toxin 3; Peptide F	Peptides Potassium Channel	Neurological Disease
VSTx-3 is a K_V channel blocker. VSTx-3 is demonstrated to be a potent, TTX-sensitive sodium channel blocker and especially, a potent blocker of NaV1.8 channels (IC₅₀ 0.19 μM for hNaV1.3, 0.43 μM for hNaV1.7 and 0.77 μM for hNaV1.8 channels).

HY-P1073

ProTx-I	Calcium Channel Sodium Channel Potassium Channel	Cancer
ProTx-I, a venom toxin of the tarantula Thrixopelma pruriens, is a potent, selective Ca_V3.1 channel blocker with IC₅₀ values of 0.2 μM and 31.8 μM for hCa_V3.1 and hCa_V3.2 respectively. ProTx-I is also a potent blocker for voltage-gated Na ⁺ channels and inhibits K_V 2.1 channels .

HY-P5811

Ceratotoxin-1 CcoTx1; β-TRTX-cm1a	Sodium Channel	Neurological Disease
Ceratotoxin-1 (CcoTx1), a peptide toxin, is an voltage-gated sodium channel subtypes inhibitor. Ceratotoxin-1 inhibits *Nav1.1/β1, Nav1.2/β1, Nav1.4/β1, and Nav1.5/β1* with IC₅₀ of 523 nM, 3 nM, 888 nM, and 323 nM, respectively. Ceratotoxin-1 also inhibits *Nav1.8/β1* .

Cat. No.	Compare	Product Name	Species	Source

HY-P703191

	SCN10A Protein, Human (HEK293, Flag, Strep) Sodium channel protein type 10 subunit alpha; Peripheral nerve sodium channel 3; PN3; hPN3; Sodium channel protein type X subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.8; SCN10A; Homo sapiens; Human; PN3; Ion channel; Sodium channel; Voltage-gated channel	Human	HEK293
	SCN10A Protein, Human (HEK293, Flag, Strep) is the recombinant human-derived SCN10A, expressed by HEK293 , with Strep, Flag labeled tag. ,

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Nav1.8

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