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Results for "

PB-2

" in MedChemExpress (MCE) Product Catalog:

11

Inhibitors & Agonists

1

Fluorescent Dye

2

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-138649
    PB2

    		Others Neurological Disease
    PB2 is a tris(2-carboxyethyl)phosphine (TCEP) analogue increasing retinal ganglion (RGCs) cells survival after axotomy in vitro at nanomolar and picomolar concentrations. PB2 is substantially more permeable than TCEP. PB2, as a reducing agent, is highly neuroprotective for RGCs .
    PB2
  • HY-12353A
    Pimodivir
    5 Publications Verification

    VX-787

    		 Influenza Virus Infection
    Pimodivir (VX-787) is an orally bioavailable inhibitor of influenza A virus polymerases through interaction with the viral PB2 subunit.
    Pimodivir
  • HY-163617
    c-PB2(OH)2

    		HIV Infection
    c-PB2(OH)2 is a 4-carboxyphenyl / 4-hydroxyphenyl meso-substituted porphyrin compound. c-PB2(OH)2 shows anti HIV-1 activity under non-photodynamic and photodynamic conditions .
    c-PB2(OH)2
  • HY-156440
    7-51A

    		Influenza Virus Infection
    7-51A 是一种有效的 PB2 抑制剂，经 ITC 测定的 KD 值为 1.64 nM。PB2 是流感 RNA 依赖性 RNA 聚合酶 (RdRP) 的重要亚基。
    7-51A
  • HY-12353B
    Pimodivir hydrochlorid hemihydrate

    VX-787 hydrochlorid hemihydrate

    		 Influenza Virus Infection
    Pimodivir hydrochlorid hemihydrate (VX-787) is an orally bioavailable inhibitor of influenza A virus polymerases through interaction with the viral PB2 subunit.
    Pimodivir hydrochlorid hemihydrate
  • HY-N7647
    Methyl brevifolincarboxylate

    Brevifolincarboxylic acid methyl ester

    		 Influenza Virus Infection Cardiovascular Disease Inflammation/Immunology
    Methyl brevifolincarboxylate (Brevifolincarboxylic acid methyl ester) is a potent influenza virus PB2 cap-binding inhibitor. Methyl brevifolincarboxylate has anti-oxidant activity. Methyl brevifolincarboxylate also inhibits platelet aggregation, lipid metabolism and inflammation [2] .
    Methyl brevifolincarboxylate
  • HY-149263
    HAA-09

    		Influenza Virus Virus Protease Infection
    HAA-09 is an orally active and potent anti-influenza agent, targeting the influenza PB2_cap binding domain. HAA-09 displays potent anti-influenza A virus activity, with an EC50 of 0.03 μM. HAA-09 shows polymerase inhibition, with an IC50 of 0.06±0.004 μM. HAA-09 blocks virus replication without causing obvious cytotoxicity .
    HAA-09
  • HY-100858
    PP7

    		Influenza Virus Infection
    PP7 is a potent PB1-PB2 interaction inhibitor with an IC50 of 8.6 μM, and their inhibition against viral polymerase activity (IC50=9.5 μM). PP7 shows antiviral activities against influenza A virus (IAV), including A(H1N1)pdm09 (EC50=1.4 μM), A(H7N9) and A(H9N2) subtypes .
    PP7
  • HY-N12110
    SMU-CX1

    		Toll-like Receptor (TLR) SARS-CoV Infection
    SMU-CX1 is a specific TLR3 inhibitor (IC50: 0.11 μM) with IC50 ranging from 0.14-0.33 μM against multiple influenza A virus subtypes. SMU-CX1 inhibits the viral PB2 and NP proteins with an IC50 of 0.43 μM for SARS-CoV-2 activity. SMU-CX1 also inhibits inflammatory factors in host cells, including IFN-β, IP-10, and CCL-5 .
    SMU-CX1
  • HY-136894
    Rhod-5N

    		Fluorescent Dye Others
    Rhod-5N is a calcium-binding fluorescent dye composed of a BAPTA chelating group and a rhodamine fluorophore. Rhod-5N is often added to MOPS buffer to complex and indicate cation content. The selectivity of Rhod-5N for Cd 2+ is higher than other interfering cations ((Na+, K+, Mg 2+, Ca 2+, Zn 2+) except Pb 2+), and the detection limit is 3.1 μg/L [2].
    Rhod-5N
  • HY-D1551
    10-(4-(Bis(2-hydroxyethyl)amino)phenyl)-5,5-difluoro-1,3,7,9-tetramethyl-5H-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-4-ium-5-uide

    		Fluorescent Dye Others
    10-(4-(Bis(2-hydroxyethyl)amino)phenyl)-5,5-difluoro-1,3,7,9-tetramethyl-5H-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-4-ium-5-uide, a BODIPY derivative, is a fluorescent indicator for detecting Pb 2+ (Ex=504 nM, Em=510 nM) [2].
    10-(4-(Bis(2-hydroxyethyl)amino)phenyl)-5,5-difluoro-1,3,7,9-tetramethyl-5H-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-4-ium-5-uide

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