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PD-1/PD-L1 inhibitory peptide C8

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Formyl Peptide Receptor (FPR) (1) Akt (2) Amino Acid Derivatives (2) Aminoacyl-tRNA Synthetase (1) Angiotensin Receptor (1) Angiotensin-converting Enzyme (ACE) (5) Antibiotic (2) Autophagy (4) Bacterial (7) Biochemical Assay Reagents (1) CaMK (6) CDK (2) CXCR (3) DNA/RNA Synthesis (1) Dynamin (4) G Protein-coupled Receptor Kinase (GRK) (1) GLP Receptor (1) Guanylate Cyclase (1) Histone Methyltransferase (1) HIV (1) Influenza Virus (1) Insulin Receptor (9) Integrin (3) MARCKS (1) Melanocortin Receptor (1) nAChR (1) NF-κB (2) NO Synthase (2) PAK (1) PD-1/PD-L1 (1) PKC (3) Ras (1) Ser/Thr Protease (2) Sodium Channel (1) STAT (2) TGF-beta/Smad (5) VEGFR (1)
By Research Areas:	Cancer (18) Cardiovascular Disease (11) Endocrinology (3) Infection (17) Inflammation/Immunology (5) Metabolic Disease (13) Neurological Disease (14)

By Targets:

Formyl Peptide Receptor (FPR) (1)

Akt (2)

Amino Acid Derivatives (2)

Aminoacyl-tRNA Synthetase (1)

Angiotensin Receptor (1)

Angiotensin-converting Enzyme (ACE) (5)

Antibiotic (2)

Autophagy (4)

Bacterial (7)

Biochemical Assay Reagents (1)

CaMK (6)

CDK (2)

CXCR (3)

DNA/RNA Synthesis (1)

Dynamin (4)

G Protein-coupled Receptor Kinase (GRK) (1)

GLP Receptor (1)

Guanylate Cyclase (1)

Histone Methyltransferase (1)

HIV (1)

Influenza Virus (1)

Insulin Receptor (9)

Integrin (3)

MARCKS (1)

Melanocortin Receptor (1)

nAChR (1)

NF-κB (2)

NO Synthase (2)

PAK (1)

PD-1/PD-L1 (1)

PKC (3)

Ras (1)

Ser/Thr Protease (2)

Sodium Channel (1)

STAT (2)

TGF-beta/Smad (5)

VEGFR (1)

By Research Areas:

Cancer (18)

Cardiovascular Disease (11)

Endocrinology (3)

Infection (17)

Inflammation/Immunology (5)

Metabolic Disease (13)

Neurological Disease (14)

Inhibitors & Agonists

Peptides

Natural
Products

Targets Recommended: Macrophage migration inhibitory factor (MIF) Natriuretic Peptide Receptor (NPR) Formyl Peptide Receptor (FPR) Peptide-Drug Conjugate (PDC) CGRP Receptor Amyloid-β

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P3579

*Gastric Inhibitory* Peptide, porcine** GIP (1-42), porcine	Insulin Receptor	Endocrinology
Gastric Inhibitory Peptide, porcine is a glucose-dependent insulinotropic polypeptide, is a 42 amino acid intestinal hormone with effects on fat and glucose metabolism .

HY-P10242

*Myostatin inhibitory* peptide 7**	TGF-beta/Smad	Others
Myostatin inhibitory peptide 7 is a 23 amino acids peptide, which is derived from amino acids 21 to 43 of the mouse myostatin prodomain. Myostatin inhibitory peptide 7 inhibits myostatin with K_d of 29.7 nM. Myostatin inhibitory peptide 7 can be used for researches of muscle atrophic disorders .

HY-P1083

Dynamin inhibitory peptide 1 Publications Verification	Dynamin	Neurological Disease
Dynamin inhibitory peptide competitively blocks binding of dynamin to amphiphysin, thus preventing endocytosis. Dynamin inhibitory peptide blocks the dopamine D3 effect on GABAA receptors .

HY-P1369

*DynaMin inhibitory* peptide, myristoylated**	Dynamin	Neurological Disease
DynaMin inhibitory peptide, myristoylated is a DynaMin inhibitor to interfere with the binding of amphiphysin with dynamin. DynaMin inhibitory peptide, myristoylated is a membrane-permeant form of the peptide that prevents endocytosis .

HY-P10476

*Myostatin inhibitory* peptide 2**	TGF-beta/Smad	Others
Myostatin inhibitory peptide 2 (compd 2) is a myostatin inhibitor with a K_d of 35.9 nM. Myostatin inhibitory peptide 2 can be used for researches of muscle atrophic disorders .

HY-P10242A

*Myostatin inhibitory* peptide 7 TFA**	TGF-beta/Smad	Others
Myostatin inhibitory peptide 7 TFA is a 23 amino acids peptide, which is derived from amino acids 21 to 43 of the mouse myostatin prodomain. Myostatin inhibitory peptide 7 TFA inhibits myostatin with K_d of 29.7 nM. Myostatin inhibitory peptide 7 TFA can be used for researches of muscle atrophic disorders .

HY-P10106

TAT-PAK18 inhibitory peptide	PAK	Cancer
TAT-PAK18 inhibitory peptide is a membrane-permeable PAK inhibitory peptide. TAT-PAK18 inhibitory peptide reduces F-actin clusters and occludes the effect of Shank3 knockdown .

HY-P2157

Ras Inhibitory Peptide	Ras	Cancer
Ras Inhibitory Peptide (VPPPVPPRRR) is a Ras inhibitor with antitumor activity .

HY-P1083A

*Dynamin inhibitory* peptide TFA**	Dynamin	Neurological Disease
Dynamin inhibitory peptide TFA competitively blocks binding of dynamin to amphiphysin, thus preventing endocytosis. Dynamin inhibitory peptide TFA blocks the dopamine D₃ effect on GABA_A receptors .

HY-P1369A

*DynaMin inhibitory* peptide, myristoylated TFA**	Dynamin	Neurological Disease
DynaMin inhibitory peptide, myristoylated TFA is a DynaMin inhibitor to interfere with the binding of amphiphysin with dynamin. DynaMin inhibitory peptide, myristoylated TFA is a membrane-permeant form of the peptide that prevents endocytosis .

HY-P10476A

*Myostatin inhibitory* peptide 2 TFA**	TGF-beta/Smad	Others
Myostatin inhibitory peptide 2 (compd 2) TFA is a myostatin inhibitor with a K_d of 35.9 nM. Myostatin inhibitory peptide 2 TFA can be used for researches of muscle atrophic disorders .

HY-P0215

*Autocamtide-2-related inhibitory* peptide, myristoylated**	CaMK Autophagy	Neurological Disease
Autocamtide-2-related inhibitory peptide, myristoylated is the myristoylated Autocamtide-2-related inhibitory peptide. Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of CaMKII with an IC₅₀ of 40 nM .

HY-P1847

IKKγ NBD Inhibitory Peptide	NF-κB	Cancer
IKKγ NBD Inhibitory Peptide is a highly specific inhibitor NF-κB inhibitor. IKKγ NBD Inhibitory Peptide acts by disrupting the interaction between IKKγ/NEMO-binding domain (NBD) with IKKα and IKKβ, thus blocking TNF-α-induced NF-kB activation. IKKγ NBD Inhibitory Peptide could significantly suppresses inflammation and ameliorate the cerebral ischemia-induced neurological deficits .

HY-114437

Fusion Inhibitory Peptide Z-D-Phe-Phe-Gly-OH; FIP; Virus Replication inhibitory peptide	Influenza Virus	Infection
Fusion Inhibitory Peptide (Z-D-Phe-Phe-Gly-OH, FIP, Virus Replication Inhibitory Peptide) is a potent inhibitor of the virus replication, by inhibiting the membrane fusing activity of a viral glycoprotein .

HY-P0215A

*Autocamtide-2-related inhibitory* peptide, myristoylated TFA**	CaMK Autophagy	Neurological Disease
Autocamtide-2-related inhibitory peptide, myristoylated TFA is the myristoylated Autocamtide-2-related inhibitory peptide. Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of CaMKII with an IC₅₀ of 40 nM .

HY-P1847A

*IKKγ NBD Inhibitory* Peptide TFA**	NF-κB	Inflammation/Immunology
IKKγ NBD Inhibitory Peptide TFA is a highly specific inhibitor NF-κB inhibitor. IKKγ NBD Inhibitory Peptide TFA acts by disrupting the interaction between IKKγ/NEMO-binding domain (NBD) with IKKα and IKKβ, thus blocking TNF-α-induced NF-kB activation. IKKγ NBD Inhibitory Peptide TFA could significantly suppresses inflammation and ameliorate the cerebral ischemia-induced neurological deficits .

HY-P10383

*SPSB2-iNOS inhibitory* cyclic peptide-1**	NO Synthase	Infection
SPSB2-iNOS inhibitory cyclic peptide-1 is an inhibitor for the interaction of SPRY domain and SOCS-box protein 2 (SPSB2) and iNOS, through binding SPSB2 on iNOS site with K_D of 4.4 nM. SPSB2-iNOS inhibitory cyclic peptide-1 is resistant to the proteases pepsin, trypsin and α-chymotrypsin. SPSB2-iNOS inhibitory cyclic peptide-1 is stable in human plasma and in oxidative environment .

HY-P0214

Autocamtide-2-related inhibitory peptide	CaMK Autophagy	Neurological Disease
Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of CaMKII with an IC₅₀ of 40 nM.

HY-P10384

*SPSB2-iNOS inhibitory* cyclic peptide-2**	NO Synthase	Infection
SPSB2-iNOS inhibitory cyclic peptide-2 (Compound CP2) is an inhibitor for the interaction of SPRY domain and SOCS-box protein 2 (SPSB2) and iNOS, through binding SPSB2 on iNOS site with K_D of 21 nM. SPSB2-iNOS inhibitory cyclic peptide-2 is reduction-resistant and oxidatively stable .

HY-P0214A

*Autocamtide-2-related inhibitory* peptide TFA** 2 Publications Verification	CaMK Autophagy	Neurological Disease
Autocamtide-2-related inhibitory peptide (TFA) is a highly specific and potent inhibitor of CaMKII with an IC₅₀ of 40 nM.

HY-P3577

*[Tyr0] Gastric Inhibitory* Peptide (23-42), human**	Insulin Receptor	Metabolic Disease
[Tyr0] Gastric Inhibitory Peptide (23-42), human, a glucose-dependent insulinotropic polypeptide (GIP), is a weak inhibitor of gastric acid secretion that also stimulates insulin secretion. [Tyr0] Gastric Inhibitory Peptide (23-42), human can be used in diabetes, obesity research .

HY-P3580

*Acetyl Gastric Inhibitory* Peptide (human)** Human N-acetyl GIP	Insulin Receptor	Metabolic Disease Endocrinology
Acetyl Gastric Inhibitory Peptide (human) is a fatty acid derivatized analog of glucose-dependent insulinotropic polypeptide with improved antihyperglycaemic and insulinotropic properties. Acetyl Gastric Inhibitory Peptide (human) can be used for research of diabetes, insulin resistance and obesity .

HY-P3730

*Cdk2/Cyclin Inhibitory* Peptide I**	CDK	Cancer
Cdk2/Cyclin Inhibitory Peptide I (Tat-LFG), a CDK2 inhibitor, kills U2OS osteosarcoma cells in a dose-dependent manner .

HY-P3731

*Cdk2/Cyclin Inhibitory* Peptide II**	CDK	Cancer
Cdk2/Cyclin Inhibitory Peptide II (Tat-LDL), a CDK2 inhibitor, kills U2OS osteosarcoma cells in a dose-dependent manner .

HY-P10071

*CaMKII inhibitory* peptide KIIN** Calmodulin Kinase IINtide; CaM-KIIN; CaM-KIINβ	CaMK	Others
CaMKII inhibitory peptide KIIN is a potent inhibitor of CaMKII .

HY-P3580A

*Acetyl Gastric Inhibitory* Peptide (human) (TFA)** Human N-acetyl GIP TFA	Insulin Receptor	Metabolic Disease Endocrinology
Acetyl Gastric Inhibitory Peptide (human) TFA is a fatty acid derivatized analog of glucose-dependent insulinotropic polypeptide with improved antihyperglycaemic and insulinotropic properties. Acetyl Gastric Inhibitory Peptide (human) TFA can be used for research of diabetes, insulin resistance and obesity .

HY-P10826

*PD-1/PD-L1 inhibitory* peptide C8**	PD-1/PD-L1	Cancer
PD-1/PD-L1 inhibitory peptide C8 is inhibits PD-1/PD-L1 interaction, promotes the activation of CD8+ and CD4+ T cells, and increases the IFN-γ secretion. PD-1/PD-L1 inhibitory peptide C8 exhibits antitumor efficacy in mouse model .

HY-P5525

AC3-I, myristoylated Autocamtide-3 Derived inhibitory peptide	CaMK	Others
AC3-I, myristoylated is a biological active peptide. (This is a myristoylated form of Autocamtide-3-Derived Inhibitory Peptide (AC3-I), a highly specific inhibitor of Calmodulin-Dependent Protein Kinase ll (CaMKII) that is resistant to proteolysis. AC3-I is derived from Autocamtide-3, a substrate for CaMKII, with the Thr-9 phosphorylation site substituted with Ala.)

HY-P5038

Cyclo(Gly-Arg-Gly-Asp-Ser-Pro) c(GRGDSP)	Integrin	Cancer
Cyclo(Gly-Arg-Gly-Asp-Ser-Pro) (c(GRGDSP)) is an RGD-containing inhibitory peptide. Cyclo(Gly-Arg-Gly-Asp-Ser-Pro) is a synthetic α5β1 integrin ligand that competitively inhibits the binding of invasin (Inv) to α5β1 integrin expressed on Caco-2 cells .

HY-P3584

(Pro3) GIP, human (Pro3) Gastric inhibitory peptide, human	Insulin Receptor	Metabolic Disease
(Pro3) GIP, human ((Pro3) Gastric Inhibitory Peptide, human) is an efficacious, stable and specific human GIP receptor (hGIPR) full agonist. (Pro3) GIP, human has high binding affinity for human GIPR with K_i/ K_d values of 0.90 nM. (Pro3) GIP, human can be used for the research of obesity-related diabetes .

HY-P4874

ACTH (7-38) (human)	Melanocortin Receptor	Metabolic Disease
ACTH (7-38) (human) is the 7-38 fragment of human ACTH (1-39). human ACTH (1-39), known as a corticotropin inhibitory peptide (CIP), is an antagonist of the ACTH receptor and has no any corticosteroid activity .

HY-P1115

AKTide-2T	Akt	Others
AKTide-2T is an excellent in vitro substrate for AKT and shows competitive inhibition of histone H2B phosphorylation with a K_i of 12 nM. AKTide-2T mimics the optimal phosphorylation sequence of Akt and is an inhibitory peptide with the wildtype AKTide lacking Thr in the S22 position .

HY-P1115A

AKTide-2T TFA	Akt	Others
AKTide-2T TFA is an excellent in vitro substrate for AKT and shows competitive inhibition of histone H2B phosphorylation with a K_i of 12 nM. AKTide-2T TFA mimics the optimal phosphorylation sequence of Akt and is an inhibitory peptide with the wildtype AKTide lacking Thr in the S22 position .

HY-P0276

GIP, human 1 Publications Verification Gastric inhibitory peptide (GIP), human	Insulin Receptor	Metabolic Disease
GIP, human, a peptide hormone consisting of 42 amino acids, is a stimulator of glucose-dependent insulin secretion and a weak inhibitor of gastric acid secretion. GIP, human acts as an incretin hormone released from intestinal K cells in response to nutrient ingestion .

HY-P0276A

GIP, human TFA 1 Publications Verification Gastric inhibitory peptide (GIP), human TFA	Insulin Receptor	Metabolic Disease
GIP, human TFA, a peptide hormone consisting of 42 amino acids, is a stimulator of glucose-dependent insulin secretion and a weak inhibitor of gastric acid secretion. GIP, human TFA acts as an incretin hormone released from intestinal K cells in response to nutrient ingestion .

HY-P3584A

(Pro3) GIP, human TFA (Pro3) Gastric inhibitory peptide, human TFA	Insulin Receptor	Metabolic Disease
(Pro3) GIP, human TFA is an efficacious, stable and specific human GIP receptor (hGIPR) full agonist. (Pro3) GIP, human TFA has high binding affinity for human GIPR with K_i/ K_d value of 0.90 nM. (Pro3) GIP, human TFA human can be used for the research of obesity-related diabetes .

HY-E70421

Butelase 1 ligase	Angiotensin Receptor	Others
Butelase 1 ligase can be used for the cyclization of food-derived angiotensin I converting enzyme (ACE) inhibitory peptides, and thus improves the stability and bioactivity of ACE inhibitory peptides .

HY-121610

FR-202306	Others	Others
FR-202306 is a compound with antibacterial and peptide deformylase inhibitory activities, isolated from microorganisms, which has an inhibitory effect on the peptide deformylase of Staphylococcus aureus and also has antibacterial activity.

HY-P10634

P17 Peptide	TGF-beta/Smad	Others
P17 Peptide is a human TGF-β1 inhibitory peptide. P17 Peptide can block woodchuck TGF-β1 activity .

HY-P4420

H-Lys-Trp-OH	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
H-Lys-Trp-OH (KW) is an ACE inhibitory peptide with an IC₅₀ of 7.8 μM .

HY-P10791

YYLLVR	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
YYLLVR is an angiotensin-converting enzyme (ACE) inhibitory peptide with an inhibitory rate of 89.10%. YYLLVR has a lower binding energy for ACE of -35.98 kcal/mol. YYLLVR can be used in the study of hypertensive diseases .

HY-P5737

ASP-1	Bacterial	Infection
ASP-1 is a strong antistaphylococcal peptide with minimum inhibitory concentrations (MICs) of the purified peptide against S. aureus and methicillin-resistant S. aureus (MRSA) ranged from 2 μg/mL to 64 μg/mL .

HY-P4810

Polyphemusin II-Derived Peptide T140	CXCR	Infection
Polyphemusin II-Derived Peptide (T140), a CXCR4 inhibitor, shows high inhibitory activity against HIV-1 entry and the inhibitory effect on the binding of an anti-CXCR4 monoclonal antibody (12G5) to CXCR4 .

HY-P0322

GRGDSPK EMD 56574	Integrin	Cardiovascular Disease Metabolic Disease
GRGDSPK (EMD 56574) is a peptide incluing Arg-Gly-Asp (RGD). GRGDSPK (EMD 56574) is an competitive and reversible inhibitory peptide for inhibiting integrin-fibronectin binding. GRGDSPK is used to study the role of integrins in bone formation and resorption .

HY-125341

Microginin 527	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Microginin 527 is a linear cyanobacterial peptide with potent angiotensin-converting enzyme (ACE) inhibitory activity. Microginin 527 also exhibits inhibitory effects on protein phosphatases and leucine aminopeptidase. With an IC50 value of 31 μM, Microginin 527 is the most active component in this class of compounds .

HY-W008876

Fmoc-Pen(Trt)-OH	Amino Acid Derivatives	Others
Fmoc-Pen(Trt)-OH is an amino acid derivative with an Fmoc protecting group that can be used to synthesize the inhibitory cystine knot (ICK) peptide ProTx-II .

HY-P10591

Olatorepatide Olatorepatidum	Insulin Receptor GLP Receptor	Metabolic Disease
Olatorepatide (Olatorepatidum) is a dual gastric inhibitory polypeptide (GIP) receptor and glucagon like peptide 1 (GLP-1) receptor agonist, with antidiabetic effect .

HY-P5483

Retro-indolicidin	Bacterial	Others
Retro-indolicidin is a biological active peptide. (Reverse peptide of indolicidin (Rev4) is a 13-amino acid residue peptide based on the sequence of indolicidin. Indolicidin, a member of the cathelicidin protein family, is a 13-amino acid residue cationic, antimicrobial peptide-amide isolated from the cytoplasmic granules of bovine neutrophils. The synthetic peptide Rev4 has been shown to possess strong antimicrobial as well as protease inhibitory activities in vitro.)

HY-P0322A

GRGDSPK TFA EMD 56574 TFA	Integrin	Cardiovascular Disease Metabolic Disease
GRGDSPK TFA (EMD 56574 TFA) is a peptide incluing Arg-Gly-Asp (RGD). GRGDSPK TFA is an competitive and reversible inhibitory peptide for inhibiting integrin-fibronectin binding. GRGDSPK TFA is used to study the role of integrins in bone formation and resorption .

HY-P10391

Ser-Ala-Pro	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Ser-Ala-Pro is an X-Pro structure specific angiotensin-converting enzyme (ACE) inhibitory peptide. Ser-Ala-Pro has the potential for hypertension research .

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