2. Signaling Pathways
  3. GPCR/G Protein
  4. Natriuretic Peptide Receptor (NPR)

Natriuretic Peptide Receptor (NPR)

Natriuretic Peptide Receptor; NPR; NPR-A; NPR-B; NPR-C

Natriuretic peptide receptors can be divided into three types: NPR-A, NPR-B (guanylate cyclase-A and guanylate cyclase-B) and NPR-C. All three receptors have an effect on biological second messengers. NPR-A and NPR-B are guanylate cyclase receptors, and their activation can lead to increased cGMP levels, while the activation of NPR-C can lead to the inhibition of adenylate cyclase activity and increased phospholipase C activity. Natriuretic peptide receptors play an important role in the regulation of blood pressure and cardiovascular homeostasis[1].

Natriuretic Peptide Receptor (NPR) Related Products (8):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P0003
    Nesiritide
    		Agonist 99.71%
    Nesiritide (Brain Natriuretic Peptide-32 human) is an agonist of natriuretic peptide receptors (NPRs), with Kd values of 7.3 and 13 pM for NPR-A and NPR-C, respectively. Nesiritide can be used for the research of heart failure.
    Nesiritide
  • HY-P10279
    Anaritide
    		98.83%
    Anaritide is a synthetic form of atrial natriuretic peptide (ANP) composed of 25 amino acids. Anaritide increases glomerular filtration rate by dilating into and contracting out the bulbar arterioles. Anaritide can be used to study the effects on patients with acute tubular necrosis, particularly in improving dialysis free survival.
    Anaritide
  • HY-P990921
    Imelciment
    HY-P990921 is an NPR1-targeting half-IG G4 -κ/h-CH2-CH3 type human antibody.
    Imelciment
  • HY-P990951
    Vixticibart
    HY-P990951 is an NPR1-targeting IgG4κ type human antibody, the recommed isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
    Vixticibart
  • HY-P1573A
    Brain Natriuretic Peptide-45, rat TFA
    Brain Natriuretic Peptide-45, rat TFA (BNP-45, rat TFA) is a circulating form of rat brain natriuretic peptide isolated from rat heart with potent hypotensive and natriuretic potency.
    Brain Natriuretic Peptide-45, rat TFA
  • HY-120521
    Urodilatin
    		Activator
    Urodilatin is an analogue of ANF-(99-126). Urodilatin is a diuretic-natriuretic regulatory peptide. Urodilatin can be used for research of acute renal failure, congestive heart failure, and bronchial asthma, etc.
    Urodilatin
  • HY-P3758
    BNP (1-21), Pro (Human)
    		Activator
    BNP (1-21), Pro (Human) is a peptide containg 21 amino acids. B-Type Natriuretic Peptide (BNP), a cardiac natriuretic hormone. BNP together with the highly homologous atrial natriuretic peptide, it forms a dual natriuretic peptide system of the heart. BNP is responsible for changes in the heart organogenesis and is associated with transition to extrauterine life.
    BNP (1-21), Pro (Human)
  • HY-P3759
    BNP (22-46), Pro (Human)
    		Activator
    BNP (22-46), Pro (Human) is an peptide . BNP (22-46), Pro (Human) can be used for the research of cardiac dysfunction.
    BNP (22-46), Pro (Human)