2. Signaling Pathways
  3. GPCR/G Protein
  4. Natriuretic Peptide Receptor (NPR)

Natriuretic Peptide Receptor (NPR)

Natriuretic Peptide Receptor; NPR; NPR-A; NPR-B; NPR-C

Natriuretic peptide receptors can be divided into three types: NPR-A, NPR-B (guanylate cyclase-A and guanylate cyclase-B) and NPR-C. All three receptors have an effect on biological second messengers. NPR-A and NPR-B are guanylate cyclase receptors, and their activation can lead to increased cGMP levels, while the activation of NPR-C can lead to the inhibition of adenylate cyclase activity and increased phospholipase C activity. Natriuretic peptide receptors play an important role in the regulation of blood pressure and cardiovascular homeostasis[1].

Natriuretic Peptide Receptor (NPR) Related Products (18):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P0003
    Nesiritide
    		Agonist 99.71%
    Nesiritide (Brain Natriuretic Peptide-32 human) is an agonist of natriuretic peptide receptors (NPRs), with Kd values of 7.3 and 13 pM for NPR-A and NPR-C, respectively. Nesiritide can be used for the research of heart failure.
    Nesiritide
  • HY-P1419
    AP 811
    		Antagonist 98.07%
    AP 811 is a selective atrial natriuretic peptide clearance receptor (ANP-CR, NPR3) antagonist with a Ki of 0.48 nM. AP 811 displays >20000-fold selectivity for NPR3 over NPR1. AP 811 abolishes ANP-induced pump stimulation.
    AP 811
  • HY-P2026
    A 71915
    		Antagonist 99.95%
    A 71915 is a highly potent and competitive natriuretic peptide receptor A (ANP, NPRA) antagonist (pKi= 9.18). A 71915 displaces [125I]ANP dose dependently, with a Ki of 0.65 nM. A71915( pA2= 9.48) against rat ANP-induced cGMP production in NB-OK-1 cells.
    A 71915
  • HY-P2469
    Brain Natriuretic Peptide-45, mouse
    		98.05%
    Brain Natriuretic Peptide-45, mouse (BNP-45, mouse) is a circulating form of mouse brain natriuretic peptide isolated from mouse heart with potent hypotensive and natriuretic potency.
    Brain Natriuretic Peptide-45, mouse
  • HY-153650
    JS11
    		Inhibitor 99.22%
    JS11 is an inhibitor for natriuretic polypeptide receptor 1 (Npr1) with an IC50 of 1.9 μM for hNpr1. JS11 ameliorates the pruritus in mouse models.
    JS11
  • HY-P990921
    Imelciment
    HY-P990921 is an NPR1-targeting half-IG G4 -κ/h-CH2-CH3 type human antibody.
    Imelciment
  • HY-P990951
    Vixticibart
    HY-P990951 is an NPR1-targeting IgG4κ type human antibody, the recommed isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
    Vixticibart
  • HY-P1526
    ANP [Des18-22] 4-23 amide (rat)
    		Ligand
    ANP [Des18-22] 4-23 amide rat is a polypeptide fragment of rat atrial natriuretic peptide (ANP) that specifically binds NPR-C.
    ANP [Des18-22] 4-23 amide (rat)
  • HY-P10279
    Anaritide
    		98.83%
    Anaritide is a synthetic form of atrial natriuretic peptide (ANP) composed of 25 amino acids. Anaritide increases glomerular filtration rate by dilating into and contracting out the bulbar arterioles. Anaritide can be used to study the effects on patients with acute tubular necrosis, particularly in improving dialysis free survival.
    Anaritide
  • HY-P1573A
    Brain Natriuretic Peptide-45, rat TFA
    Brain Natriuretic Peptide-45, rat TFA (BNP-45, rat TFA) is a circulating form of rat brain natriuretic peptide isolated from rat heart with potent hypotensive and natriuretic potency.
    Brain Natriuretic Peptide-45, rat TFA
  • HY-P2687
    Ularitide
    Ularitide (Urodilatin), natriuretic peptide, is a vasodilator. Ularitide binds to and activates renal receptors. Ularitide also regulates renal dopamine metabolism Ularitide can be used in the research of heart failure.
    Ularitide
  • HY-120521
    Urodilatin
    		Activator
    Urodilatin is an analogue of ANF-(99-126). Urodilatin is a diuretic-natriuretic regulatory peptide. Urodilatin can be used for research of acute renal failure, congestive heart failure, and bronchial asthma, etc.
    Urodilatin
  • HY-P3758
    BNP (1-21), Pro (Human)
    		Activator
    BNP (1-21), Pro (Human) is a peptide containg 21 amino acids. B-Type Natriuretic Peptide (BNP), a cardiac natriuretic hormone. BNP together with the highly homologous atrial natriuretic peptide, it forms a dual natriuretic peptide system of the heart. BNP is responsible for changes in the heart organogenesis and is associated with transition to extrauterine life.
    BNP (1-21), Pro (Human)
  • HY-P5978
    Atriopeptin III (rat)
    Atriopeptin III (ANP 127-150) (rat), a 24-amino acid atrial peptide, is a potent vasodilator and natriuretic/diuretic agent. Atriopeptin III (rat) improves renal functions and decreases blood pressure in a ureter-obstructed rat kidney model. Atriopeptin III (rat) can be used for research of chronic renal failure.
    Atriopeptin III (rat)
  • HY-P3759
    BNP (22-46), Pro (Human)
    		Activator
    BNP (22-46), Pro (Human) is an peptide . BNP (22-46), Pro (Human) can be used for the research of cardiac dysfunction.
    BNP (22-46), Pro (Human)
  • HY-120147
    Ethiazide
    Ethiazide is a thiazole diuretic which inhibits renal reabsorption of sodium and water, thereby increasing urine excretion, reducing fluid retention, and lowering blood volume and blood pressure. Ethiazide can be used for cardiovascular research.
    Ethiazide
  • HY-P10869
    dCNP
    		Activator
    dCNP binds to NPR-B/C receptor, activates cGMP signaling pathway, and regulates vascular function. dCNP exhibits anti-hypoxia property through downregulation of hypoxia-related genes expressions like HIF1α and HIF2α. dCNP inhibits the induction of tumor stroma and exhibits anti-fibrosis activity. dCNP upregulates CTLs, NK cells, and conventional type 1 dendritic cells in tumors, and activates immune responses.
    dCNP
  • HY-P0003A
    Nesiritide acetate
    		Agonist
    Nesiritide (Brain Natriuretic Peptide-32 human) acetate is an agonist of natriuretic peptide receptors (NPRs), with Kd values of 7.3 and 13 pM for NPR-A and NPR-C, respectively. Nesiritide acetate can be used for the research of heart failure.
    Nesiritide acetate