SPSB2-iNOS inhibitory cyclic peptide-1

Cat. No.: HY-P10383 Purity: 99.81%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

SPSB2-iNOS inhibitory cyclic peptide-1 is an inhibitor for the interaction of SPRY domain and SOCS-box protein 2 (SPSB2) and iNOS, through binding SPSB2 on iNOS site with K_D of 4.4 nM. SPSB2-iNOS inhibitory cyclic peptide-1 is resistant to the proteases pepsin, trypsin and α-chymotrypsin. SPSB2-iNOS inhibitory cyclic peptide-1 is stable in human plasma and in oxidative environment.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

SPSB2-iNOS inhibitory cyclic peptide-1 Chemical Structure

CAS No. : 1621616-13-4

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of SPSB2-iNOS inhibitory cyclic peptide-1:

SPSB2-iNOS inhibitory cyclic peptide-1 TFA Get quote

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nNOS iNOS eNOS

Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

933.02

Formula

C₃₅H₅₆N₁₂O₁₄S₂

CAS No.

1621616-13-4

Appearance

Solid

Color

White to off-white

Sequence

Ac-Cys-Val-Asp-Ile-Asn-Asn-Asn-Cys-NH2 (Disulfide bridge: Cys1-Cys8)

Sequence Shortening

Ac-CVDINNNC-NH2 (Disulfide bridge: Cys1-Cys8)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (53.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0718 mL	5.3589 mL	10.7179 mL
5 mM	0.2144 mL	1.0718 mL	2.1436 mL
10 mM	0.1072 mL	0.5359 mL	1.0718 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.81%

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Data Sheet (284 KB) SDS (252 KB)

COA (266 KB) RP-HPLC (109 KB) MS (205 KB)

Handling Instructions (2659 KB)

References

[1]. Yap BK, et al., A potent cyclic peptide targeting SPSB2 protein as a potential anti-infective agent. J Med Chem. 2014 Aug 28;57(16):7006-15. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.0718 mL	5.3589 mL	10.7179 mL	26.7947 mL
	5 mM	0.2144 mL	1.0718 mL	2.1436 mL	5.3589 mL
	10 mM	0.1072 mL	0.5359 mL	1.0718 mL	2.6795 mL
	15 mM	0.0715 mL	0.3573 mL	0.7145 mL	1.7863 mL
	20 mM	0.0536 mL	0.2679 mL	0.5359 mL	1.3397 mL
	25 mM	0.0429 mL	0.2144 mL	0.4287 mL	1.0718 mL
	30 mM	0.0357 mL	0.1786 mL	0.3573 mL	0.8932 mL
	40 mM	0.0268 mL	0.1340 mL	0.2679 mL	0.6699 mL
	50 mM	0.0214 mL	0.1072 mL	0.2144 mL	0.5359 mL