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Isoforms Recommended:	PKD2

Results for "

PKD2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (3) HSP (1) Pim (3) PKD (9) Small Interfering RNA (siRNA) (5)
By Research Areas:	Cancer (8) Cardiovascular Disease (1) Inflammation/Immunology (3) Metabolic Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (2) siRNAs (4)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-118052

BPKDi	PKD	Cardiovascular Disease
BPKDi is a potent bipyridyl *PKD* inhibitor with IC₅₀s of 1 nM, 9 nM and 1 nM for PKD1, PKD2 and PKD3, respectively. BPKDi blocks signal-dependent phosphorylation and nuclear export of class IIa HDACs in cardiomyocytes .

HY-12239

CID755673 Maximum Cited Publications 7 Publications Verification	PKD	Cancer
CID755673 is a potent *PKD* inhibitor with IC₅₀s of 182 nM, 280 nM and 227 nM for *PKD1, PKD2* and *PKD3*, respectively.

HY-15698A

CRT0066101 dihydrochloride 2 Publications Verification	PKD Pim Apoptosis	Inflammation/Immunology Cancer
CRT0066101 dihydrochloride is a potent and orally active *PKD* inhibitor with IC₅₀ values of 1 nM, 2.5 nM and 2 nM for *PKD1, PKD2, and PKD3, respectively . CRT0066101 dihydrochloride is also a potent PIM2* inhibitor with an IC₅₀ of ~135.7 nM. CRT0066101 dihydrochloride exhibits anti-inflammatory activity in mice LPS (HY-D1056)-induced lung injury models, and has anticancer effects ^[2] .

HY-15698

CRT0066101 2 Publications Verification	PKD Pim Apoptosis	Inflammation/Immunology Cancer
CRT0066101 is a potent and orally active *PKD* inhibitor with IC₅₀ values of 1 nM, 2.5 nM and 2 nM for *PKD1, PKD2, and PKD3, respectively . CRT0066101 is also a potent PIM2* inhibitor with an IC₅₀ of ~135.7 nM. CRT0066101 exhibits anti-inflammatory activity in mice LPS (HY-D1056)-induced lung injury models, and has anticancer effects ^[2] .

HY-RS16302

PKD2 Pig Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Metabolic Disease
PKD2 Pig Pre-designed siRNA Set A contains three designed siRNAs for PKD2 gene (Pig), as well as a negative control, a positive control, and a FAM-labeled negative control. Components PKD2 siRNA-1: 5 nmol (HPLC) PKD2 siRNA-2: 5 nmol (HPLC) PKD2 siRNA-3: 5 nmol (HPLC) siRNA Negative Control: 5 nmol (HPLC) FAM-labeled siRNA Negative Control: 5 nmol (HPLC) GAPDH siRNA Positive Control: 5 nmol (HPLC)

PKD2 Pig Pre-designed siRNA Set A

Small Interfering RNA (siRNA)

Metabolic Disease

PKD2 Pig Pre-designed siRNA Set A contains three designed siRNAs for PKD2 gene (Pig), as well as a negative control, a positive control, and a FAM-labeled negative control.

Components

PKD2 siRNA-1: 5 nmol (HPLC)

PKD2 siRNA-2: 5 nmol (HPLC)

PKD2 siRNA-3: 5 nmol (HPLC)

siRNA Negative Control: 5 nmol (HPLC)

FAM-labeled siRNA Negative Control: 5 nmol (HPLC)

GAPDH siRNA Positive Control: 5 nmol (HPLC)

PKD2 Pig Pre-designed siRNA Set A PKD2 Pig Pre-designed siRNA Set A

HY-RS10591

PKD2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PKD2 Human Pre-designed siRNA Set A contains three designed siRNAs for PKD2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PKD2 Human Pre-designed siRNA Set A PKD2 Human Pre-designed siRNA Set A

HY-RS10593

Pkd2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Pkd2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Pkd2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pkd2 Rat Pre-designed siRNA Set A Pkd2 Rat Pre-designed siRNA Set A

HY-RS10592

Pkd2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Pkd2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pkd2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pkd2 Mouse Pre-designed siRNA Set A Pkd2 Mouse Pre-designed siRNA Set A

HY-RS10594

PKD2L1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PKD2L1 Human Pre-designed siRNA Set A contains three designed siRNAs for PKD2L1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PKD2L1 Human Pre-designed siRNA Set A PKD2L1 Human Pre-designed siRNA Set A

HY-15698B

CRT0066101 trihydrochloride	PKD Pim Apoptosis	Inflammation/Immunology Cancer
CRT0066101 trihydrochloride is the trihydrochloride salt form of CRT0066101 (HY-15698). CRT0066101 trihydrochloride is an orally active *PKD* inhibitor with IC₅₀ values of 1 nM, 2.5 nM and 2 nM for *PKD1, PKD2, and PKD3, respectively. CRT0066101 trihydrochloride is also an inhibitor for PIM2* with an IC₅₀ of ~135.7 nM. CRT0066101 trihydrochloride exhibits anti-inflammatory activity in mice LPS (HY-D1056)-induced lung injury models, and has anticancer effects ^[2] .

HY-151374

3-IN-PP1	PKD	Cancer
3-IN-PP1 is a protein kinase D (PKD) inhibitor. 3-IN-PP1 has potent pan-PKD inhibitory activity for PKD1, PKD2 and PKD3 with IC₅₀ values of 108, 94 and 108 nM, respectively. 3-IN-PP1 also is a broad spectrum anticancer agent and has inhibition of several tumor cells growth. 3-IN-PP1 can be used for the research of cancer .

HY-15528

kb NB 142-70	PKD	Cancer
kb NB 142-70 is a potent *PKD* inhibitor, with IC₅₀s of 28.3, 58.7 and 53.2 nM for PKD1, PKD2, and PKD3, respectively. kb NB 142-70 also has antitumor activity.

HY-112547

CRT5 CRT0066051	PKD	Others
CRT5, a pyrazine benzamide, is a potent and selective inhibitor for all three isoforms of *PKD* in endothelial cells treated with VEGF (IC₅₀s = 1, 2, and 1.5 nM for PKD1, PKD2, and PKD3, respectively). CRT5 decreases VEGF-induced endothelial migration, proliferation and tubulogenesis .

HY-13454

CID 2011756	PKD	Cancer
CID 2011756 is an ATP competitive *PKD* inhibitor, with an IC₅₀ of 3.2 μM for PKD1 in cell free assay, and also shows cellular pan-PKD inhibitory activity against PKD2 and PKD3 (IC₅₀, 0.6 and 0.7 μM, respectively). CID 2011756 also has antitumor activity.

HY-117051

STA-2842	HSP	Cancer
STA-2842 is an inhibitor of heat shock protein HSP90 with potential to inhibit autosomal dominant polycystic kidney disease (ADPKD). ADPKD is caused by inherited mutations in the PKD1 or PKD2 genes that abnormally activate multiple signaling proteins and pathways that regulate cell proliferation. STA-2842 can significantly reduce initial renal cyst formation and kidney growth in mice, and slow disease progression in mice with existing cysts.

Cat. No.	Compare	Product Name	Species	Source

HY-P74615

	Protein Kinase D2/PRKD2 Protein, Human (sf9, His-GST) Serine/threonine-protein kinase D2; PRKD2; PKD2; HSPC187	Human	Sf9 insect cells
	Protein kinase D2 (PRKD2) is a serine/threonine protein kinase that mediates various cellular processes downstream of PKC. It affects cell proliferation through MAPK1/3 (ERK1/2) signaling, activates NF-kappa-B under oxidative stress, inhibits HDAC7 transcriptional repression, and regulates T cell antigen receptor (TCR) signaling, cytokine production, Golgi trafficking, angiogenesis, particle release, and cell adhesion. Protein Kinase D2/PRKD2 Protein, Human (sf9, His-GST) is the recombinant human-derived protein Kinase D2/PRKD2 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

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HY-P81985

	PKD2 Antibody (YA1730) PRKD2; PKD2; HSPC187; Serine/threonine-protein kinase D2; nPKC-D2	WB, IHC-P, ICC/IF, FC	Human, Mouse
	PKD2 Antibody (YA1730) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1730), targeting PKD2, with a predicted molecular weight of 97 kDa (observed band size: 105 kDa). PKD2 Antibody (YA1730) can be used for WB, IHC-P, ICC/IF, FC experiment in human, mouse background.

HY-P81917

	Phospho-PRKD2 (Ser876) Antibody (YA1662) PRKD2; PKD2; HSPC187; Serine/threonine-protein kinase D2; nPKC-D2	WB, IP	Human
	Phospho-PRKD2 (Ser876) Antibody (YA1662) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1662), targeting Phospho-PRKD2 (Ser876), with a predicted molecular weight of 97 kDa (observed band size: 105 kDa). Phospho-PRKD2 (Ser876) Antibody (YA1662) can be used for WB, IP experiment in human background.

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PKD2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
PKD2 Human Pre-designed siRNA Set A contains three designed siRNAs for PKD2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pkd2 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Pkd2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Pkd2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pkd2 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Pkd2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pkd2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

PKD2L1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
PKD2L1 Human Pre-designed siRNA Set A contains three designed siRNAs for PKD2L1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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