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Results for "

PKLR

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Pyruvate Kinase (4) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cardiovascular Disease (1) Metabolic Disease (4)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Tebapivat AG-946; PKR activator 2	Pyruvate Kinase	Cardiovascular Disease
Tebapivat (PKR activator 2) is a potent pyruvate kinase-R (PKR) activator extracted from patent WO2019035863A1, compound 385 .

Mitapivat 1 Publications Verification AG-348	Pyruvate Kinase	Metabolic Disease
Mitapivat (AG-348) is an orally active pyruvate kinase allosteric activator. Mitapivat increases enzymatic activity, protein stability, and ATP levels over a broad range of *PKLR* genotypes, shows the potential to restore the activity of PK (pyruvate kinase)-deficient glycolytic pathways. Mitapivat can be used in study of PK deficiency .

SBI-993	Others	Metabolic Disease
SBI-993 is a SBI-477 analog with improved potency and suitable pharmacokinetic properties for in vivo bioavailability. SBI-993 stimulates insulin signaling by deactivating the transcription factor MondoA .

PKLR Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PKLR Human Pre-designed siRNA Set A contains three designed siRNAs for PKLR gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PKLR Human Pre-designed siRNA Set A PKLR Human Pre-designed siRNA Set A

Mitapivat hemisulfate AG-348 hemisulfate	Pyruvate Kinase	Metabolic Disease
Mitapivat hemisulfate is an orally active pyruvate kinase allosteric activator. Mitapivat hemisulfate increases enzymatic activity, protein stability, and ATP levels over a broad range of *PKLR* genotypes, shows the potential to restore the activity of PK (pyruvate kinase)-deficient glycolytic pathways. Mitapivat hemisulfate can be used in study of PK deficiency .

Mitapivat hemisulfate sesquihydrate AG-348 hemisulfate sesquihydrate	Pyruvate Kinase	Metabolic Disease
Mitapivat hemisulfate sesquihydrate (AG-348) is an orally active pyruvate kinase allosteric activator. Mitapivat increases enzymatic activity, protein stability, and ATP levels over a broad range of *PKLR* genotypes, shows the potential to restore the activity of PK (pyruvate kinase)-deficient glycolytic pathways. Mitapivat can be used in study of PK deficiency .

Cat. No.	Compare	Product Name	Species	Source

	PKLR Protein, Human (HEK293, His) Pyruvate Kinase Isozymes R/L; Pyruvate Kinase 1; R-Type/L-Type Pyruvate Kinase; Red Cell/Liver Pyruvate Kinase; PKLR; PK1; PKL	Human	HEK293
	The PKLR protein is a key enzyme in cellular metabolism that acts as a pyruvate kinase, converting phosphoenolpyruvate to pyruvate. This process is an integral part of glycolysis, the fundamental pathway for cellular energy production. PKLR Protein, Human (HEK293, His) is the recombinant human-derived PKLR protein, expressed by HEK293 , with C-6*His labeled tag.

	PKLR Protein, Rat (P. pastoris, His) PKLR; pyruvate kinase, liver and RBC; PK1; PKL; PKR; RPK; PKRL; pyruvate kinase isozymes R/L; pyruvate kinase 1; OTTHUMP00000034069; pyruvate kinase type L; pyruvate kinase isozyme R/L; R-type/L-type pyruvate kinase; red cell/liver pyruvate kinase; pyruvate kinase, liver and blood cell; EC 2.7.1.40	Rat	P. pastoris
	The PKLR protein is a pyruvate kinase that plays a critical role in glycolysis, converting phosphoenolpyruvate to pyruvate and producing ATP.As a key enzyme, PKLR mediates the final steps of glycolysis, contributing to energy production.PKLR Protein, Rat (P.pastoris, His) is the recombinant rat-derived PKLR protein, expressed by P.pastoris , with N-6*His labeled tag.

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	Phospho-PKM2(Tyr105)Antibody PKM2 (Phospho Tyr105); PKM2 (Phospho Y105); PK 1; PK 2; PK 3; PK Muscle type; PK1; PK2; Pk3; PKL; PKLR; PKM 2; PKM; PYKM; Pyruvate kinase 1; Pyruvate kinase 2/3; Pyruvate kinase 3; Pyruvate kinase isozyme R/L; Pyruvate kinase isozymes M1/M2; Pyruvate kinase liver and blood cell; Pyruvate kinase liver and RBC; Pyruvate kinase liver and RBC type; Pyruvate kinase M2; Pyruvate kinase muscle; Pyruvate kinase muscle isozyme; Pyruvate kinase type L; R type/L type pyruvate kinase; Red cell/liver pyruvate kinase; RPK; TCB; THBP 1; THBP1; Thyroid hormone binding protein cytosolic; CTHBP; Cytosolic thyroid hormone binding protein; MGC3932; OIP 3; Oip3; Tumor M2-PK; p58; OIP-3.	IHC-P, IHC-F, ICC/IF, FC, ELISA	Human, Rat
	Phospho-PKM2(Tyr105)Antibody is a rabbit-derived non-conjugated IgG antibody, targeting Phospho-PKM2(Tyr105)Antibody, with a predicted molecular weight of 58 kDa. Phospho-PKM2(Tyr105)Antibody can be used for IHC-P, IHC-F, ICC/IF, FC, ELISA experiments in human, rat backgrounds.

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Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

PKLR Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
PKLR Human Pre-designed siRNA Set A contains three designed siRNAs for PKLR gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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