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PMM

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Parasite (1) PPAR (1) Small Interfering RNA (siRNA) (2)
By Research Areas:	Infection (1) Inflammation/Immunology (1) Metabolic Disease (1)
Oligonucleotides:	Pre-designed siRNA Sets (2) siRNAs (2)

Inhibitors & Agonists

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Mavodelpar REN001; HPP593	PPAR	Inflammation/Immunology
Mavodelpar (REN001) is a selective PPARδ agonist. Mavodelpar suppresses glomerular injury and renal fibrosis. Mavodelpar can be used for the research of primary mitochondrial myopathies (PMM) and long-chain fatty acid oxidation disorders (LC-FAOD) . Mavodelpar is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Thr101	Others	Metabolic Disease
Thr101 is an inhibitor (IC₅₀=2.9 μM) of phosphomannose isomerase (PMI).PMI can compete with phosphomannose mutase 2 (PMM2) for the binding site of Man-6-P and convert mannose-6-phosphate (Man-6-P) into fructose-6-phosphate (Fru-6-P) .Thr101 only specifically inhibits PMI and not PMM2. Thr101 can be used for research of congenital disorder of glycosylation type Ia (CDG-Ia) .

PMM1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PMM1 Human Pre-designed siRNA Set A contains three designed siRNAs for PMM1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PMM1 Human Pre-designed siRNA Set A PMM1 Human Pre-designed siRNA Set A

PMM2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PMM2 Human Pre-designed siRNA Set A contains three designed siRNAs for PMM2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PMM2 Human Pre-designed siRNA Set A PMM2 Human Pre-designed siRNA Set A

Pheanthine	Parasite	Infection
Pheanthine (Compound 2) is an antiplasmodial agent, that inhibits chloroquine-resistant Plasmodium falciparum K-1 (IC₅₀ is 0.8 μM) and chloroquine-sensitive P. falciparum strain NF54 A19A (IC₅₀ of 0.03 μM). Pheanthine exhibits low cytotoxicity in human lung fibrosblast (MRC-5, IC₅₀ is 11.2 μM) and macrophages (PMM, IC₅₀ is 8 μM) .

Pheanthine	Structural Classification Alkaloids Piperidine Alkaloids Triclisia gilletii (De Wild.) Staner Source classification Plants Menispermaceae	Parasite
Pheanthine (Compound 2) is an antiplasmodial agent, that inhibits chloroquine-resistant Plasmodium falciparum K-1 (IC₅₀ is 0.8 μM) and chloroquine-sensitive P. falciparum strain NF54 A19A (IC₅₀ of 0.03 μM). Pheanthine exhibits low cytotoxicity in human lung fibrosblast (MRC-5, IC₅₀ is 11.2 μM) and macrophages (PMM, IC₅₀ is 8 μM) .

Cat. No.	Compare	Product Name	Species	Source

	PMM2 Protein, Human (His) Phosphomannomutase 2; PMM 2; PMM2	Human	E. coli
	The PMM2 protein is essential for the synthesis of GDP-mannose and polyethylene glycol-phosphate-mannose, which are essential for the mannosyl transfer reaction. Its enzymatic activity is integral to the biosynthesis of mannose-containing glycoconjugates, affects protein glycosylation and contributes to cellular homeostasis. PMM2 Protein, Human (His) is the recombinant human-derived PMM2 protein, expressed by E. coli , with C-6*His labeled tag.

	PMM1 Protein, Human (His) Phosphomannomutase 1; PMM 1; PMMH-22; PMM1; PMMH22	Human	E. coli
	The PMM1 protein is key to the synthesis of GDP-mannose and polyethylene glycol-phosphate-mannose and is essential for the mannosyl transfer reaction. Its enzymatic activity contributes to the biosynthesis of mannose-containing glycoconjugates, which are critical for protein glycosylation and related cellular processes. PMM1 Protein, Human (His) is the recombinant human-derived PMM1 protein, expressed by E. coli , with C-6*His labeled tag. The total length of PMM1 Protein, Human (His) is 262 a.a., with molecular weight of ~49.0 kDa.

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PMM1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
PMM1 Human Pre-designed siRNA Set A contains three designed siRNAs for PMM1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PMM2 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
PMM2 Human Pre-designed siRNA Set A contains three designed siRNAs for PMM2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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