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PhI

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (3) Apoptosis (1) Bacterial (5) Biochemical Assay Reagents (1) EGFR (1) Endogenous Metabolite (1) Ferroptosis (3) FLT3 (1) Fluorescent Dye (1) GCGR (1) HIF/HIF Prolyl-Hydroxylase (3) HIV (1) Na+/H+ Exchanger (NHE) (3) Na+/HCO3- Cotransporter (1) NOD-like Receptor (NLR) (3) Potassium Channel (3) Pyroptosis (3) Sodium Channel (1) Src (1) Wnt (3) β-catenin (3)
By Research Areas:	Cancer (9) Cardiovascular Disease (4) Infection (4) Inflammation/Immunology (1) Metabolic Disease (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-Y1312

2-Phenylimidazole PhI; 2PZ	Biochemical Assay Reagents	Others
2-Phenylimidazole (PhI) is a corrosion inhibitor for brass and can be used to prepare complexes with ruthenium (III) .

HY-153857

Lasmotinib PhI-101	FLT3	Cancer
Lasmotinib is an orally active FLT3 inhibitor that overcomes resistance to multiple drug-resistant mutations. Lasmotinib potently inhibits FLT3 single activating mutations (ITD or TKD mutants) and has inhibitory activity against FLT3 double (ITD/D835Y or ITD/F691L) and triple (ITD/D835Y/F691L) resistance mutations. Lasmotinib has potential for research in relapsed or refractory acute myeloid leukemia (AML) .

HY-146127A

Grb2 SH2 domain inhibitor 1 TFA	Src	Others
Grb2 SH2 domain inhibitor 1 TFA is a conformationally restricted cyclic cell penetrating peptide (CPP) containing d-pro-l-pro motif ring (AF Φ Rpprrfq) (where Φ It is L-naphthylalanine, R is D-arginine, P is D-proline), which is mainly used as a cyclic peptide inhibitor.

HY-P6012A

SAIRGA TFA	Bacterial	Others
SAIRGA (TFA), derived from the phages phi3T, can recognize phAimR in the bacterial cytosol to induce lysogeny .

HY-D0075

DHPDS disodium salt	Fluorescent Dye	Others
DHPDS disodium salt is a pH-sensitive fluorescent dye. DHPDS disodium salt is used to measure intracellular pH (pHi) from the surface fluorescence of the isolated perfused rat liver .

HY-13426

Roxadustat 40+ Cited Publications FG-4592	HIF/HIF Prolyl-Hydroxylase Ferroptosis	Cancer
Roxadustat is an orally active hypoxia-inducible factor (HIF) prolyl-hydroxylase (PHD) inhibitor (HIF-PHI) that promotes erythropoiesis through increasing endogenous erythropoietin, improving iron regulation, and reducing hepcidin .

HY-100302

FR183998 free base	Na+/H+ Exchanger (NHE)	Cardiovascular Disease Inflammation/Immunology
FR183998 free base is a potent Na ⁺/H ⁺-exchange inhibitor, with IC₅₀s of 0.3 nM, 3.1 nM and 6.5 nM by measurement of pH_i change in rat lymphocytes, rat and human platelets, respectively.

HY-P2880

PHI-27 (porcine)	GCGR	Others
PHI-27 (porcine) is a 27 amino acid peptide.PHI-27 (porcine) is used to find peptide hormones and other active peptides .

HY-146127

Grb2 SH2 domain inhibitor 1	EGFR	Others
Grb2 SH2 domain inhibitor 1 is a conformationally restricted cyclic cell penetrating peptide (CPP) containing d-pro-l-pro motif ring (AF Φ Rpprrfq) (where Φ It is L-naphthylalanine, R is D-arginine, P is D-proline), which is mainly used as a cyclic peptide inhibitor.

HY-P6012

SAIRGA	Bacterial	Others
SAIRGA, derived from the phages phi3T, can recognize phAimR in the bacterial cytosol to induce lysogeny .

HY-13426S

Roxadustat-d5	HIF/HIF Prolyl-Hydroxylase Ferroptosis	Cancer
Roxadustat-d₅ is deuterium labeled Roxadustat. Roxadustat is an oral hypoxia-inducible factor prolyl-hydroxylase inhibitor (HIF-PHI) that promotes erythropoiesis through increasing endogenous erythropoietin, improving iron regulation, and reducing hepcidin[1].

HY-15529

S0859 1 Publications Verification	Na+/HCO3- Cotransporter	Cardiovascular Disease
S0859 is a selective, high-affinity generic Na ⁺/HCO₃ ^- transporter (NBC) inhibitor. S0859 reversibly inhibits NBC-mediated intracellular pH (pHi) recovery (K_i=1.7 μM, full inhibition at approximately 30 μM).

HY-13426R

Roxadustat (Standard)	HIF/HIF Prolyl-Hydroxylase Ferroptosis	Cancer
Roxadustat (Standard) is the analytical standard of Roxadustat. This product is intended for research and analytical applications. Roxadustat is an orally active hypoxia-inducible factor (HIF) prolyl-hydroxylase (PHD) inhibitor (HIF-PHI) that promotes erythropoiesis through increasing endogenous erythropoietin, improving iron regulation, and reducing hepcidin .

HY-P2918

Phosphoglucose Isomerase, Rabbit muscle GPI; Phosphoglucose Isomerase	Endogenous Metabolite	Metabolic Disease Cancer
Phosphoglucose Isomerase, Rabbit muscle (GPI), i.e., phosphoglucose isomerase/phosphoglucoisomerase (PGI) or phosphohexose isomerase (PHI), is often used in biochemical studies. Glucose 6-phosphate isomeras is a highly conserved glycolytic and dimeric enzyme. Glucose 6-phosphate isomeras catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate .

HY-100381

Nigericin sodium salt Maximum Cited Publications 142 Publications Verification	Potassium Channel NOD-like Receptor (NLR) Bacterial Antibiotic Pyroptosis Wnt β-catenin	Infection Cancer
Nigericin sodium salt is an antibiotic derived from Streptomyces hygroscopicus that act as a K ⁺/H ⁺ ionophore, promoting K ⁺/H ⁺ exchange across mitochondrial membranes. Nigericin sodium salt is a NLRP3 activator. Nigericin sodium salt shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt/β-catenin signals. Nigericin sodium salt induces pyroptosis through caspase 1/GSDMD in TNBC .

HY-127019

Nigericin Maximum Cited Publications 142 Publications Verification	Potassium Channel NOD-like Receptor (NLR) Bacterial Antibiotic Pyroptosis Wnt β-catenin	Infection Cancer
Nigericin is an antibiotic derived from Streptomyces hygroscopicus that act as a K ⁺/H ⁺ ionophore, promoting K ⁺/H ⁺ exchange across mitochondrial membranes. Nigericin is a NLRP3 activator. Nigericin shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt/β-catenin signals. Nigericin induces pyroptosis through caspase 1/GSDMD in TNBC .

HY-100381R

Nigericin (sodium salt) (Standard)	Potassium Channel NOD-like Receptor (NLR) Bacterial Antibiotic Pyroptosis Wnt β-catenin	Infection Cancer
Nigericin (sodium salt) (Standard) is the analytical standard of Nigericin (sodium salt). This product is intended for research and analytical applications. Nigericin sodium salt is an antibiotic derived from Streptomyces hygroscopicus that act as a K ⁺/H ⁺ ionophore, promoting K ⁺/H ⁺ exchange across mitochondrial membranes. Nigericin sodium salt is a NLRP3 activator. Nigericin sodium salt shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt/β-catenin signals. Nigericin sodium salt induces pyroptosis through caspase 1/GSDMD in TNBC .

HY-18071A

BI-9627 hydrochloride 2 Publications Verification	Na+/H+ Exchanger (NHE)	Cardiovascular Disease
BI-9627 hydrochloride is potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor, with IC50s of 6 and 31 nM in intracellular pH recovery (pHi) and human platelet swelling assays, respectively. BI-9627 hydrochloride displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. BI-9627 hydrochloride shows low DDI (agent-agent interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury .

HY-18071

BI-9627 2 Publications Verification	Na+/H+ Exchanger (NHE)	Cardiovascular Disease
BI-9627 is potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor, with IC₅₀s of 6 and 31 nM in intracellular pH recovery (pHi) and human platelet swelling assays, respectively. BI-9627 displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. BI-9627 shows low DDI (agent-agent interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury .

HY-128067

5-(N,N-Hexamethylene)-amiloride 2 Publications Verification Hexamethylene amiloride; HMA	Sodium Channel HIV Apoptosis	Infection Cancer
5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) derives from an amiloride and is a potent Na ⁺/H ⁺ exchanger inhibitor, which decreases the intracellular pH (pH_i) and induces apoptosis in leukemic cells. 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) is also an inhibitor of the HIV-1 Vpu virus ion channel and inhibits mouse hepatitis virus (MHV) replication and human coronavirus 229E (HCoV229E) replication in cultured L929 cells with EC₅₀s of 3.91 μM and 1.34 μM, respectively .

Cat. No.	Product Name	Type

HY-D0075

DHPDS disodium salt	Fluorescent Dyes/Probes
DHPDS disodium salt is a pH-sensitive fluorescent dye. DHPDS disodium salt is used to measure intracellular pH (pHi) from the surface fluorescence of the isolated perfused rat liver .

Cat. No.	Product Name	Target	Research Area

HY-146127A

Grb2 SH2 domain inhibitor 1 TFA	Src	Others
Grb2 SH2 domain inhibitor 1 TFA is a conformationally restricted cyclic cell penetrating peptide (CPP) containing d-pro-l-pro motif ring (AF Φ Rpprrfq) (where Φ It is L-naphthylalanine, R is D-arginine, P is D-proline), which is mainly used as a cyclic peptide inhibitor.

HY-P6012A

SAIRGA TFA	Bacterial	Others
SAIRGA (TFA), derived from the phages phi3T, can recognize phAimR in the bacterial cytosol to induce lysogeny .

HY-P2880

PHI-27 (porcine)	GCGR	Others
PHI-27 (porcine) is a 27 amino acid peptide.PHI-27 (porcine) is used to find peptide hormones and other active peptides .

HY-P3040

PHI-27 (rat)	Peptides	Others
PHI-27 (rat) is a 27 amino acid peptide.PHI-27 (rat) is used to find peptide hormones and other active peptides .

HY-146127

Grb2 SH2 domain inhibitor 1	EGFR	Others
Grb2 SH2 domain inhibitor 1 is a conformationally restricted cyclic cell penetrating peptide (CPP) containing d-pro-l-pro motif ring (AF Φ Rpprrfq) (where Φ It is L-naphthylalanine, R is D-arginine, P is D-proline), which is mainly used as a cyclic peptide inhibitor.

HY-P6012

SAIRGA	Bacterial	Others
SAIRGA, derived from the phages phi3T, can recognize phAimR in the bacterial cytosol to induce lysogeny .

Cat. No.	Product Name

HY-KE8001

Phi29 DNA Polymerase
Phi29 DNA Polymerase is a mesophilic DNA polymerase cloned from Bacillus subtilis phage Phi29.

HY-KE8011

Phi29 DNA Polymerase（mutant）
Phi29 DNA polymerase is a protein-engineered Phi29 DNA polymerase expressed in E. coli and then purified and isolated multiple times. Compared with wild-type Phi29 DNA polymerase, it has higher amplification efficiency and sensitivity, and can greatly shorten the reaction time.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-100381

Nigericin sodium salt 140+ Cited Publications	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Disease Research Disease Research Fields Other Antibiotics Cancer	Potassium Channel NOD-like Receptor (NLR) Bacterial Antibiotic Pyroptosis Wnt β-catenin
Nigericin sodium salt is an antibiotic derived from Streptomyces hygroscopicus that act as a K ⁺/H ⁺ ionophore, promoting K ⁺/H ⁺ exchange across mitochondrial membranes. Nigericin sodium salt is a NLRP3 activator. Nigericin sodium salt shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt/β-catenin signals. Nigericin sodium salt induces pyroptosis through caspase 1/GSDMD in TNBC .

HY-100381R

Nigericin (sodium salt) (Standard)	Structural Classification Microorganisms Antibiotics Source classification Disease Research Other Antibiotics	Potassium Channel NOD-like Receptor (NLR) Bacterial Antibiotic Pyroptosis Wnt β-catenin
Nigericin (sodium salt) (Standard) is the analytical standard of Nigericin (sodium salt). This product is intended for research and analytical applications. Nigericin sodium salt is an antibiotic derived from Streptomyces hygroscopicus that act as a K ⁺/H ⁺ ionophore, promoting K ⁺/H ⁺ exchange across mitochondrial membranes. Nigericin sodium salt is a NLRP3 activator. Nigericin sodium salt shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt/β-catenin signals. Nigericin sodium salt induces pyroptosis through caspase 1/GSDMD in TNBC .

Species:	Human (1) Mouse (2)
Tag:	His (3) B2M (1)
Source:	P. pastoris (1) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P71738

	Glucose-6-phosphate isomerase Protein, Mouse (P.pastoris, His) Gpi; Gpi1Glucose-6-phosphate isomerase; GPI; AMF; Neuroleukin; NLK; PhI	Mouse	P. pastoris
	Glucose-6-phosphate isomerase protein exists in the cytoplasm and has dual functions. It converts glucose-6-phosphate into fructose-6-phosphate, playing a vital role in glycolysis and gluconeogenesis. Glucose-6-phosphate isomerase Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived Glucose-6-phosphate isomerase protein, expressed by P. pastoris , with N-6*His labeled tag.

HY-P71680

	Glucose-6-phosphate isomerase Protein, Human (His) AMF; Aurocrine motility factor; Autocrine motility factor; DKFZp686C13233; EC 5.3.1.9; Neuroleukin; NLK; Oxoisomerase; PGI; PhI; Phosphoglucose isomerase; SA-36; SA36; Sperm antigen 36	Human	E. coli
	Glucose-6-phosphate isomerase protein is a key player in glycolysis, catalyzing the conversion of glucose-6-phosphate into fructose-6-phosphate in the cytoplasm. It carries out this reaction reversibly during gluconeogenesis. Glucose-6-phosphate isomerase Protein, Human (His) is the recombinant human-derived Glucose-6-phosphate isomerase protein, expressed by E. coli , with N-6*His labeled tag.

HY-P72210

	Glucose-6-phosphate isomerase Protein, Mouse (His-B2M) Gpi; Gpi1Glucose-6-phosphate isomerase; GPI; EC 5.3.1.9; Autocrine motility factor; AMF; Neuroleukin; NLK; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PhI	Mouse	E. coli
	Glucose-6-phosphate isomerase protein exists in the cytoplasm and has dual functions. It converts glucose-6-phosphate into fructose-6-phosphate, playing a vital role in glycolysis and gluconeogenesis. Glucose-6-phosphate isomerase Protein, Mouse (His-B2M) is the recombinant mouse-derived Glucose-6-phosphate isomerase protein, expressed by E. coli , with N-6*His, B2M labeled tag. The total length of Glucose-6-phosphate isomerase Protein, Mouse (His-B2M) is 557 a.a., with molecular weight of ~76.6 kDa.

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HY-13426S

Roxadustat-d5
Roxadustat-d₅ is deuterium labeled Roxadustat. Roxadustat is an oral hypoxia-inducible factor prolyl-hydroxylase inhibitor (HIF-PHI) that promotes erythropoiesis through increasing endogenous erythropoietin, improving iron regulation, and reducing hepcidin[1].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82032

	AMF Antibody (YA1777) GPI; Glucose-6-phosphate isomerase; GPI; Autocrine motility factor; AMF; Neuroleukin; NLK; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PhI; Sperm antigen 36; SA-36	WB, IHC-P, ICC/IF, FC	Human
	AMF Antibody (YA1777) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1777), targeting AMF, with a predicted molecular weight of 63 kDa (observed band size: 63 kDa). AMF Antibody (YA1777) can be used for WB, IHC-P, ICC/IF, FC experiment in human background.

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PhI

Inhibitors & Agonists

Fluorescent Dye

Peptides

MCE Kits

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Natural
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