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Pathways Recommended: Membrane Transporter/Ion Channel
Results for "

Platelet membrane

" in MedChemExpress (MCE) Product Catalog:

18

Inhibitors & Agonists

1

Biochemical Assay Reagents

3

Peptides

2

Natural
Products

1

Isotope-Labeled Compounds

4

Antibodies

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P0074
    GPRP
    1 Publications Verification

    Gly-Pro-Arg-Pro; Pefa 6003

    		 Integrin Cardiovascular Disease
    GPRP (Pefa 6003) is a fibrin polymerization inhibitor that inhibits the interaction of fibrinogen with the platelet membrane glycoprotein IIb/IIIa complex (GPIIb/IIIa) .
    GPRP
  • HY-101833
    YM-264

    		Platelet-activating Factor Receptor (PAFR) Inflammation/Immunology
    YM-264 is a selective, potent and orally active platelet-activating factor (PAF) antagonist with a pKi value of 8.85 for rabbit platelet membranes.
    YM-264
  • HY-118670
    16(S)-Iloprost

    		Others Cardiovascular Disease
    16(S)-Iloprost is a stereoisomer of Iloprost. 16(S)-Iloprost inhibited platelet aggregation with IC50 value of 3.5 nM, and balanced binding with platelet membrane receptors Kd value of 13.4 nM .
    16(S)-Iloprost
  • HY-13511AS
    Rupatadine-d4 fumarate

    UR-12592 D4 fumarate

    		 Isotope-Labeled Compounds Histamine Receptor Autophagy Inflammation/Immunology
    Rupatadine-d4 (fumarate) is a deuterium labeled Rupatadine fumarate. Rupatadine Fumarate (UR-12592 Fumarate) is a potent dual PAF/H1 antagonist with Ki of 0.55/0.1 μM(rabbit platelet membranes/guinea pig cerebellum membranes)[1][2][3].
    Rupatadine-d4 fumarate
  • HY-P3523
    KGDS

    		Integrin Others
    KGDS is synthetic peptides, targeting integrin GPIIb-IIIa located on the membrane of human activated platelets. Amino acid sequence: Lys-Gly-Asp-Ser .
    KGDS
  • HY-N11932
    Piperulin A

    		Platelet-activating Factor Receptor (PAFR) Cancer
    Piperulin A is a potent inhibitor of PAFR. Piperulin A inhibits the specific binding of PAFR on isolated rabbit platelet plasma membranes with an IC50 of 7.3 μM .
    Piperulin A
  • HY-112658
    p-Iodoclonidine hydrochloride

    		Adrenergic Receptor Adenosine Receptor Endocrinology
    p-Iodoclonidine hydrochloride is a partial agonist of α2-adrenergic receptor. p-Iodoclonidine hydrochloride also has minimal agonist activity in inhibiting adenylate cyclase in platelet membranes, and potentiates ADP induced platelet aggregation with an EC50 of 1.5 μM .
    p-Iodoclonidine hydrochloride
  • HY-P0074A
    GPRP acetate
    1 Publications Verification

    Gly-Pro-Arg-Pro acetate; Pefa 6003 acetate

    		 Integrin Cardiovascular Disease
    GPRP acetate (Gly-Pro-Arg-Pro acetate) is a fibrin polymerization inhibitor that inhibits the interaction of fibrinogen with the platelet membrane glycoprotein IIb/IIIa complex (GPIIb/IIIa) .
    GPRP acetate
  • HY-106745
    Elziverine

    Ro 22-4839

    		 Calmodulin Cardiovascular Disease
    Elziverine (Ro 22-4839) is a brain circulation improvement agent with vasospasm antispasmodic effects. Elziverine is a calmodulin antagonist. Elziverine inhibits erythrocyte cell membrane rupture, platelet aggregation and lipid peroxidation .
    Elziverine
  • HY-100957
    Dilazep dihydrochloride

    		Others Cardiovascular Disease
    Dilazep dihydrochloride is an inhibitor of adenosine uptake. Dilazep dihydrochloride has cerebral and coronary vasodilating action through enhancement of effect of adenosine. Dilazep dihydrochloride also inhibits the ischemic damage, platelet aggregation, and membrane transport of nucleosides .
    Dilazep dihydrochloride
  • HY-107867
    (±)-Clopidogrel bisulfate

    		Others Cardiovascular Disease
    Clopidogrel sulfate is an antiplatelet agent. Specifically, Clopidogrel sulfate inhibits the binding of ADP to its receptors on the membranes of platelet cells, and blocks ADP-mediated activation of the glycoprotein GPIIb/IIIa complex. Clopidogrel sulfate can be used for research of heart disease and stroke .
    (±)-Clopidogrel bisulfate
  • HY-108355
    R59949

    		PKC Cancer
    R59949 is a pan diacylglycerol kinase (DGK) inhibitor with an IC50 of 300 nM. R59949 strongly inhibits the activity of type I DGK α and γ and moderately attenuates the activity of type II DGK θ and κ. R59949 activates protein kinase C (PKC) by enhancing the levels of the endogenous ligand diacyl glycerol .
    R59949
  • HY-W046353
    2-Methoxycinnamaldehyde

    o-Methoxycinnamaldehyde

    		 Apoptosis Cancer
    2-Methoxycinnamaldehyde (o-Methoxycinnamaldehyde) is a natural compound of Cinnamomum cassia, with antitumor activity . 2-Methoxycinnamaldehyde inhibits proliferation and induces apoptosis by mitochondrial membrane potential (ΔΨm) loss, activation of both caspase-3 and caspase-9 . 2-Methoxycinnamaldehyde effectively inhibits platelet-derived growth factor (PDGF)-induced HASMC migration .
    2-Methoxycinnamaldehyde
  • HY-113884
    (R)-Coriolic acid

    13(R)-HODE

    		 Endogenous Metabolite Metabolic Disease
    13(R)-HODE is the opposite enantiomer of the 13(S)-HODE produced when linoleic acid is incubated with soybean lipoxygenase. The presence of 13(R)-HODE in the supernatants and membranes of cultured bovine endothelial cells has been attributed to COX metabolism.1 13(R)-HODE is a weak (IC50=2.7 μM) inhibitor of U-46619-induced platelet aggregation.
    (R)-Coriolic acid
  • HY-101654
    Rocepafant

    BN 50730; LAU-8080

    		 Platelet-activating Factor Receptor (PAFR) Cardiovascular Disease Inflammation/Immunology
    Rocepafant (BN 50730) is a specific platelet activating factor (PAF) antagonist. Rocepafant can be used in rheumatoid arthritis and nervous system research .
    Rocepafant
  • HY-125139
    omega-3 Arachidonic acid ethyl ester

    ω-3 Arachidonic acid ethyl ester; (all-Z)-8,11,14,17-Eicosatetraenoic acid ethyl ester

    		 Biochemical Assay Reagents Others
    omega-3 Arachidonic Acid ethyl ester is a rare polyunsaturated fatty acid found in very small amounts in dietary sources. Omega-3 fatty acids are known to be essential for the growth and development of infants, and they protect against heart disease, blood clots, high blood pressure, and inflammatory and autoimmune diseases. In human platelet membranes, omega-3 arachidonic acid inhibits arachidonyl-CoA synthetase with a Ki of 14 μM. It also inhibits arachidonoyl-CoA synthetase in calf brain extract with an IC50 of approximately 5 μM. Omega-3 ethyl arachidonate is the more lipophilic form of the free acid.
    omega-3 Arachidonic acid ethyl ester
  • HY-12716
    BRL-44408

    		Adrenergic Receptor Endocrinology
    BRL-44408 is a selective adrenergic receptor antagonist of α2A/α2B AR. BRL-44408 can effectively antagonize the inhibitory effects of norepinephrine or adrenergic receptor agonist Clonidine (HY-12721) on K +-induced [3H]norepinephrine and [3H]5-hydroxytryptamine release. BRL-44408 has a higher affinity for human platelet membranes containing α2A-adrenoceptors than BRL-41992 and Imiloxan (HY-101337). BRL-44408 may affect the release of norepinephrine and 5-hydroxytryptamine through a mechanism mediated by α2A-adrenoceptors, and has a potential role in the regulation of neurotransmitter release .
    BRL-44408
  • HY-116028
    15-deoxy-Δ12,14-Prostaglandin D2

    15-Deoxy-Δ12,14-PGD2

    		 Endogenous Metabolite Cardiovascular Disease
    15-deoxy-Δ12,14-PGD2 is a metabolite of PGD2. It is an agonist of PGD2 receptor 2 (DP2) that binds DP2 (Ki=50 nM for the mouse receptor expressed in HEK293 cell membranes) and induces activation of eosinophils (EC50=8 nM). It also stimulates the recruitment of steroid receptor coactivator-1 (SRC-1) to peroxisome proliferator-activated receptor γ (PPARγ) and induces PPARγ-mediated transcription in a reporter assay when used at a concentration of 5 μM.1 15-deoxy-Δ12,14-PGD2 is cytotoxic to L1210 murine leukemia cells (IC50=0.3 μg/mL). It inhibits ADP-induced platelet aggregation (IC50=320 ng/ml) less potently than PGD2.
    15-deoxy-Δ12,14-Prostaglandin D2

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