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Prolyl Hydroxylase 2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	HIF/HIF Prolyl-Hydroxylase (9)
By Research Areas:	Cancer (2) Cardiovascular Disease (1) Inflammation/Immunology (1) Metabolic Disease (2) Neurological Disease (2)

9

Inhibitors & Agonists

2

Natural
Products

1

Recombinant Proteins

Targets Recommended: HIF/HIF Prolyl-Hydroxylase Prolyl Endopeptidase (PREP) Tryptophan Hydroxylase Tyrosine Hydroxylase Dopamine β-hydroxylase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Dencichine Dencichin; ODAP	HIF/HIF Prolyl-Hydroxylase	Neurological Disease
Dencichin is a non-protein amino acid originally extracted from Panax notoginseng, and can inhibit *HIF-prolyl* hydroxylase-2 (PHD-2)** activity.

FG-2216 4 Publications Verification IOX3; YM311	HIF/HIF Prolyl-Hydroxylase	Metabolic Disease
FG-2216 (IOX3) is a potent and orally active inhibitor of *HIF prolyl* hydroxylase-2 (PHD2), with an IC₅₀** of 3.9 μM. FG-2216 induces robust erythropoietin and modest fetal hemoglobin in vivo .

IOX2 Maximum Cited Publications 13 Publications Verification	HIF/HIF Prolyl-Hydroxylase	Cancer
IOX2 is a specific prolyl hydroxylase-2 (PHD2) inhibitor with IC₅₀ of 22 nM. IOX2 regulates platelet function and arterial thrombosis by upregulating HIF-1α expression and inhibiting ROS production. IOX2 can be used in the study of thrombotic diseases .

BNS	HIF/HIF Prolyl-Hydroxylase	Others
BNS is a cell penetrant, potent and selective PHD2 (prolyl-hydroxylase 2) inhibitor .

Adaptaquin 1 Publications Verification	HIF/HIF Prolyl-Hydroxylase	Metabolic Disease
Adaptaquin is an inhibitor of *hypoxia-inducible factor prolyl* hydroxylase 2 (HIF-PHD2), with an IC₅₀** of 2 μM. Adaptaquin can inhibit lipid peroxidation and maintain mitochondrial function .

IOX4 5+ Cited Publications	HIF/HIF Prolyl-Hydroxylase	Neurological Disease Inflammation/Immunology
IOX4 is a selective HIF prolyl-hydroxylase 2 (PHD2) inhibitor with an IC₅₀ value of 1.6 nM, induces HIFα in cells and in wildtype mice with marked induction in the brain tissue. IOX4 competes with and displaces 2-oxoglutarate (2OG) at the active site of PHD2 .

(Rac)-Dencichine (Rac)-Dencichin; (Rac)-ODAP	HIF/HIF Prolyl-Hydroxylase	Others
(Rac)-Dencichine ((Rac)-Dencichin) is the racemate of Dencichin. Dencichin is a non-protein amino acid originally extracted from Panax notoginseng, and can inhibit HIF-prolyl hydroxylase-2 (PHD-2) activity .

IOX2 sodium	HIF/HIF Prolyl-Hydroxylase	Cardiovascular Disease Cancer
IOX2 sodium is a specific prolyl hydroxylase-2 (PHD2) inhibitor with IC₅₀ of 22 nM. IOX2 sodium regulates platelet function and arterial thrombosis by upregulating HIF-1α expression and inhibiting ROS production. IOX2 sodium can be used in the study of thrombotic diseases .

PHD2-IN-1	HIF/HIF Prolyl-Hydroxylase	Others
PHD2-IN-1 is a potent and orally active inhibitor of *HIF prolyl* hydroxylase 2 (PHD2) with an IC₅₀** of 22.53 nM. PHD2-IN-1 can be used for anemia research .

Cat. No.	Compare	Product Name	Species	Source

	EGLN1 Protein, Human (His) C1orf12; PNAS-118; PNAS-137; Egl nine homolog 1; Hypoxia-inducible factor Prolyl Hydroxylase 2 (HIF-PH2; HIF-Prolyl Hydroxylase 2; HPH-2); Prolyl Hydroxylase domain-containing protein 2 (PHD2)	Human	E. coli
	EGLN1 Protein, Human (His) is the recombinant human-derived EGLN1, expressed by E. coli , with His labeled tag. The total length of EGLN1 Protein, Human (His) is 246 a.a.,

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