2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  3. HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species
  4. Adaptaquin

Adaptaquin is a BBB-penatrable HIF-PHDs inhibitor. Adaptaquin has anti-inflammatory and neuroprotective effects. Adaptaquin can effectively inhibit lipid peroxidation, maintain mitochondrial function, and reduce neuronal death. Adaptaquin can be used in the research of nervous system diseases such as Parkinson's disease.

For research use only. We do not sell to patients.

Adaptaquin Chemical Structure

Adaptaquin Chemical Structure

CAS No. : 385786-48-1

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Based on 1 publication(s) in Google Scholar

Adaptaquin Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Adaptaquin

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HIF-1α HIF

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Description

Adaptaquin is a BBB-penatrable HIF-PHDs inhibitor. Adaptaquin has anti-inflammatory and neuroprotective effects. Adaptaquin can effectively inhibit lipid peroxidation, maintain mitochondrial function, and reduce neuronal death. Adaptaquin can be used in the research of nervous system diseases such as Parkinson's disease[1][2][3].

In Vitro

Adaptaquin (0.5-5 μM; 4-15 h) can increase the viability of glutamate-treated HT-22 cells and inhibit lipid peroxidation and ROS production[1].
Adaptaquin (0.1-5 μM; 24-48 h) can significantly protect PC12 cells and ventral midbrain dopaminergic neurons from cell death induced by Oxidopamine (HY-B1081) (6-OHDA) and MPP+ (HY-W008719) and maintain cell morphology[2].
Adaptaquin (0.5 μM; 8-16 h) can inhibit the expression of Trib3, ATF4, and CHOP induced by 6-OHDA/MPP+ and maintain the Parkin protein level in PC12 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Adaptaquin Related Antibodies

Real Time qPCR[2]

Cell Line: 6-OHDA/ MPP+ treated PC12
Concentration: 0.5 μM
Incubation Time: 8 h/16 h
Result: Reduced the mRNA levels of Trib3, ATF4 and CHOP.
In Vivo

Adaptaquin (30 mg/kg; intraperitoneal injection; 7 days) has a protective effect in a mouse model of Parkinson's disease[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male C57BL/6 mice (10-12 weeks) treated 6-OHDA hydrobromide (HY-B1081A)[2]
Dosage: 30 mg/kg
Administration: Intraperitoneal injection; 7 days
Result: Enhanced survival of dopaminergic neurons and substantially protected their striatal projections.
Significantly enhanced retention of nigrostriatal function.
Molecular Weight

377.82

Formula

C21H16ClN3O2
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

OC1=C2N=CC=CC2=CC=C1C(C3=CC=C(Cl)C=C3)NC4=NC=CC=C4O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (264.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6468 mL 13.2338 mL 26.4676 mL
5 mM 0.5294 mL 2.6468 mL 5.2935 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6468 mL 13.2338 mL 26.4676 mL 66.1691 mL
5 mM 0.5294 mL 2.6468 mL 5.2935 mL 13.2338 mL
10 mM 0.2647 mL 1.3234 mL 2.6468 mL 6.6169 mL
15 mM 0.1765 mL 0.8823 mL 1.7645 mL 4.4113 mL
20 mM 0.1323 mL 0.6617 mL 1.3234 mL 3.3085 mL
25 mM 0.1059 mL 0.5294 mL 1.0587 mL 2.6468 mL
30 mM 0.0882 mL 0.4411 mL 0.8823 mL 2.2056 mL
40 mM 0.0662 mL 0.3308 mL 0.6617 mL 1.6542 mL
50 mM 0.0529 mL 0.2647 mL 0.5294 mL 1.3234 mL
60 mM 0.0441 mL 0.2206 mL 0.4411 mL 1.1028 mL
80 mM 0.0331 mL 0.1654 mL 0.3308 mL 0.8271 mL
100 mM 0.0265 mL 0.1323 mL 0.2647 mL 0.6617 mL
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Adaptaquin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Adaptaquin385786-48-1HIF/HIF Prolyl-HydroxylaseReactive Oxygen SpeciesHypoxia-inducible factorsHIFsHIF-PHHT-22PC12VM DA neuronsPD modelInhibitorinhibitorinhibit

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