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Results for "

Quinone reductase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (1) Akt (1) AMPK (2) Antibiotic (5) Apoptosis (3) Aryl Hydrocarbon Receptor (1) Autophagy (3) Bacterial (11) Biochemical Assay Reagents (1) Btk (1) Caspase (1) Cytochrome P450 (1) DNA Alkylator/Crosslinker (1) DNA Methyltransferase (1) DNA/RNA Synthesis (2) Endogenous Metabolite (9) Enterovirus (2) Ferroptosis (1) Fluorescent Dye (1) Fungal (4) Glutathione S-transferase (1) HIV (1) Influenza Virus (2) Isotope-Labeled Compounds (4) JAK (1) Microtubule/Tubulin (2) Mitochondrial Metabolism (5) mTOR (1) NF-κB (2) Nuclear Factor of activated T Cells (NFAT) (1) P-glycoprotein (2) p38 MAPK (2) Parasite (7) PDHK (1) Phosphatase (1) Phospholipase (1) Photosystem II (2) PI3K (1) Pyroptosis (1) Reactive Oxygen Species (3) Reverse Transcriptase (1) STAT (1)
By Research Areas:	Cancer (30) Cardiovascular Disease (5) Infection (22) Inflammation/Immunology (10) Metabolic Disease (3) Neurological Disease (4)

By Targets:

ADC Cytotoxin (1)

Akt (1)

AMPK (2)

Antibiotic (5)

Apoptosis (3)

Aryl Hydrocarbon Receptor (1)

Autophagy (3)

Bacterial (11)

Biochemical Assay Reagents (1)

Btk (1)

Caspase (1)

Cytochrome P450 (1)

DNA Alkylator/Crosslinker (1)

DNA Methyltransferase (1)

DNA/RNA Synthesis (2)

Endogenous Metabolite (9)

Enterovirus (2)

Ferroptosis (1)

Fluorescent Dye (1)

Fungal (4)

Glutathione S-transferase (1)

HIV (1)

Influenza Virus (2)

Isotope-Labeled Compounds (4)

JAK (1)

Microtubule/Tubulin (2)

Mitochondrial Metabolism (5)

mTOR (1)

NF-κB (2)

Nuclear Factor of activated T Cells (NFAT) (1)

P-glycoprotein (2)

p38 MAPK (2)

Parasite (7)

PDHK (1)

Phosphatase (1)

Phospholipase (1)

Photosystem II (2)

PI3K (1)

Pyroptosis (1)

Reactive Oxygen Species (3)

Reverse Transcriptase (1)

STAT (1)

By Research Areas:

Cancer (30)

Cardiovascular Disease (5)

Infection (22)

Inflammation/Immunology (10)

Metabolic Disease (3)

Neurological Disease (4)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Targets Recommended: Glutathione Reductase Aldose Reductase 5 alpha Reductase Dihydrofolate reductase (DHFR) HMG-CoA Reductase (HMGCR) TrxR GSNOR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100196

Pyrroloquinoline quinone 3 Publications Verification PQQ; Methoxatin	Endogenous Metabolite	Inflammation/Immunology
Pyrroloquinoline quinone (PQQ), a redox co-factor, is an anionic, redox-cycling orthoquinone. Pyrroloquinoline quinone is isolated from cultures of methylotropic bacteria and tissues of mammals. Pyrroloquinoline quinone is an essential nutrient for mammals and is important for immune function .

HY-152039S

*6PPD-quinone-d5*	Isotope-Labeled Compounds	Others
6PPD-quinone-d₅ is the deuterium labeled 6PPD-quinone[1].

HY-100196A

*Pyrroloquinoline quinone* disodium salt** 3 Publications Verification PQQ disodium salt; Methoxatin disodium salt	Endogenous Metabolite	Inflammation/Immunology
Pyrroloquinoline quinone disodium salt, a redox co-factor, is an anionic, redox-cycling orthoquinone. Pyrroloquinoline quinone disodium salt is isolated from cultures of methylotropic bacteria and tissues of mammals. Pyrroloquinoline quinone disodium salt is an essential nutrient for mammals and is important for immune function .

HY-108544

INCA-6 1 Publications Verification Triptycene-1,4-Quinone	Nuclear Factor of activated T Cells (NFAT)	Cardiovascular Disease
INCA-6 (Triptycene-1,4-quinone) is a cell-permeable NFAT inhibitor. INCA-6 specifically blocks targeting of NFAT(P) substrate to the ?calcineurin (CN) phosphatase site and is an effective inhibitor of CN-NFAT signaling .

HY-153169

6PPD-Q 6PPD-Quinone	Endogenous Metabolite	Others
6PPD-Q (6PPD-Quinone) is an endogenous metabolite that can be found in human urine and can also commonly found in the environment .

HY-100196R

*Pyrroloquinoline quinone* (Standard)**	Endogenous Metabolite	Inflammation/Immunology
Pyrroloquinoline quinone (Standard) is the analytical standard of Pyrroloquinoline quinone. This product is intended for research and analytical applications. Pyrroloquinoline quinone (PQQ), a redox co-factor, is an anionic, redox-cycling orthoquinone. Pyrroloquinoline quinone is isolated from cultures of methylotropic bacteria and tissues of mammals. Pyrroloquinoline quinone is an essential nutrient for mammals and is important for immune function .

HY-N10563

Coleon-U-quinone	P-glycoprotein	Cancer
Coleon-U-quinone is a potent P-gp inhibitor. Coleon-U-quinone can inhibit cancer cells viability and sensitize multidrug resistance cancer cells to Doxorubicin (HY-15142A) .

HY-167746

*Nevirapine quinone* methide**	Others	Infection
Nevirapine quinone methide is an active metabolite of Nevirapine, serving as a non-nucleoside reverse transcriptase inhibitor (NNRTI) for the treatment of HIV-1 infection and AIDS. Nevirapine quinone methide is associated with severe skin and liver injuries due to its metabolic activation pathways. Nevirapine quinone methide has been shown to inhibit CYP3A4, which could contribute to its hepatic toxicity.

HY-157744

*Coumarin–quinone* conjugate**	Others	Cancer
Coumarin–quinone conjugate is a fluorescent substrate for NADH:ubiquinone oxidoreductases which consists of a coumarin fluorophore and a ubiquinone analog. Coumarin–quinone conjugate can be used to measure the kinetic parameters of AIFM2/FSP1 for researches such as ferroptosis .

HY-N10564

8α,9α-Epoxycoleon-U-quinone	P-glycoprotein	Cancer
8α,9α-Epoxycoleon-U-quinone (compound 3) is a p-glycoprotein (P-gp) regulator that is selective for cancer cells (SI=2.0). 8α,9α-Epoxycoleon-U-quinone effectively inhibits P-gp activity in NCI-H460/R cells. 8α,9α-Epoxycoleon-U-quinone also reverses the resistance of cancer cells to Doxorubicin (DOX) (HY-15142A) and enhances the anticancer effect of DOX .

HY-100196S1

*Pyrroloquinoline quinone-13C3 sodium* PQQ-¹³C₃ sodium; Methoxatin-¹³C₃ sodium	Endogenous Metabolite	Inflammation/Immunology
Pyrroloquinoline quinone-13C3 (sodium) is an isotope of Pyrroloquinoline quinone. Pyrroloquinoline quinone (PQQ), a redox co-factor, is an anionic, redox-cycling orthoquinone. Pyrroloquinoline quinone is isolated from cultures of methylotropic bacteria and tissues of mammals. Pyrroloquinoline quinone is an essential nutrient for mammals and is important for immune function .

HY-152039S1

6PPD-Q-13C6 6PPD-Quinone-¹³C₆	Isotope-Labeled Compounds	Others
6PPD-quinone- ¹³C₆ is the ¹³C labeled 6PPD-quinone[1].

HY-16772

EPI-743 α-Tocotrienol Quinone; PTC-743; VatiQuinone; NCT04378075	Mitochondrial Metabolism Ferroptosis	Neurological Disease
EPI-743 (Vatiquinone; α-Tocotrienol quinone; PTC-743; NCT04378075) is a potent cellular oxidative stress protectant, inhibits ferroptosis in cells, which could be used for the study for mitochondrial diseases. EPI-743 is a synthetic analog of vitamin E with oral activity, targets repletion of reduced intracellular glutathione .

HY-N9942

Physalin A	Apoptosis Autophagy NF-κB p38 MAPK PI3K Akt mTOR STAT JAK	Inflammation/Immunology Cancer
Physalin A is a biologically active withanolide. Physalin A shows anti-inflammatory, antifibrotic and ameliorative effects on autophagy in models of disc degeneration. Physalin A has antitumor activity and can induce apoptosis, ROS production and G2/M phase cell cycle arrest. Besides. Physalin A can significantly increase the activity of quinone reductase and increase the expression of detoxifying enzymesc .

HY-128369

Acid Yellow 36 Metanil Yellow	Cytochrome P450	Others
Acid Yellow 36 (Metanil Yellow) is an azo dye and a pH indicator. Acid Yellow 36 changes its color from red at pH 1.2 to yellow at pH 2.3. Acid Yellow 36 is used in the leather, paper and textile industries. Acid Yellow 36 acts as a bifunctional inducer of specific isozymes of P-450 and cytosolic enzymes .

HY-N7638

Dihydrolapachenole	Others	Others
Dihydrolapachenole is a naturally occurring quinone .

HY-N1319

Salvisyrianone	Others	Others
Salvisyrianone is a Quinones product that can be isolated from the herbs of Salvia syriaca L. .

HY-119528

Mansonone F	Bacterial	Infection
Mansonone F is a potent anti-MRSA sesquiterpenoid quinone that can be found in Thespesia populnea .

HY-111441

1,4-Chrysenequinone Chrysene-1,4-dione	Aryl Hydrocarbon Receptor	Cancer
1,4-Chrysenequinone, a polycyclic aromatic quinone, acts as an activator of aryl hydrocarbon receptor (AhR).

HY-N3385

Licorisoflavan A 7-O-Methyllicorisoflavan B	Others	Others
Licorisoflavan A (7-O-Methyllicorisoflavan B) is a isoflavan-quinone, that can be isolated from Glycyrrhiza uralensis .

HY-N11789

3-Hydroxyirisquinone	Others	Others
3-Hydroxyirisquinone is a quinone derivative, which can isolated from the seeds of Iris bungei Maxim .

HY-W667667

5-Hydroxyalizarin 1-methyl ether	Others	Others
5-Hydroxyalizarin 1-methyl ether is a quinone compound isolated from Hymenodictyon excelsum .

HY-118588

Diminutol	Microtubule/Tubulin	Others
Diminutol is an inhibitor for NADP-dependent quinone oxidoreductase (NQO1), that is involved in microtubule morphogenesis and cell devision .

HY-N2797

9-Methoxy-α-lapachone	Others	Others
9-Methoxy-α-lapachone is a Quinones product that can be isolated from the stems of Catalpa ovata .

HY-N1551

Przewaquinone A	Others	Cardiovascular Disease
Przewaquinone A, a lipophilic diterpene quinone present only in Salvia przewalskii, induces a potent inhibitory action on vascular contraction .

HY-W015816

2,6-Dimethylbenzoquinone 2,6-DMBQ	Others	Others
2,6-Dimethylbenzoquinone (2,6-DMBQ) is a quinone compound that can accept photosynthetic electrons downstream of photosystem II .

HY-135771

Avarone (+)-Avarone	Others	Cancer
Avarone ((+)-Avarone) is a sesquiterpenoidal quinone that can be isolated from Dysidea avara. Avarone shows cytotoxicity. Avarone shows antileukemic activity .

HY-N6724

Altertoxin I Dihydroalterperylenol	Others	Metabolic Disease
Altertoxin I (Dihydroalterperylenol) is a quinone-type mycotoxin produced by Alternaria alternata fungi, which is mutagenic and cytotoxic, and can weakly disrupts metabolic communication .

HY-125027

Isobutyl-deoxynyboquinone IB-DNQ	Others	Cancer
Isobutyl-deoxynyboquinone (IB-DNQ) is a selective substrate for NAD(P)H:quinone oxidoreductase (NQO1). Isobutyl-deoxynyboquinone can be used for the research of anticancer .

HY-111968

Orysastrobin	Fungal	Infection
Orysastrobin, a “quinone outside inhibitor” (QoI)-type fungicide, has excellent fungicidal efficacy against leaf and panicle blast and against sheath blight in rice .

HY-B1848

Hexaflumuron	Others	Others
Hexazinone is a nonselective herbicide from the triazine family. Hexazinone binds to the D-1 quinone protein of the electron transport chain in photosystem II to inhibit the photosynthesis .

HY-B1849

Hexazinone	Others	Infection
Hexazinone is a nonselective herbicide from the triazine family. Hexazinone binds to the D-1 quinone protein of the electron transport chain in photosystem II to inhibit the photosynthesis .

HY-N10394

Metachromins X	Others	Cancer
Metachromins X is a sesquiterpene quinone that arrests the cell cycle progression of HeLa/Fucci2 cells at S/G2/M phase .

HY-N0645

Dicoumarol Maximum Cited Publications 8 Publications Verification Dicumarol	PDHK	Cancer
Dicoumarol is an inhibitor of both *NAD(P)H:quinone* oxidoreductase 1 (NQO1) and PDK1 with IC₅₀**s of 0.37 and 19.42 μM, respectively.

HY-125999

EPI-589	Others	Neurological Disease
EPI-589, a quinone derivative, is a safe and well tolerated oxidoreductase enzyme inhibitor. EPI-589 has the potential for the treatment of amyotrophic lateral sclerosis (ALS) .

HY-138645A

5-Iminodaunorubicin hydrochloride	DNA/RNA Synthesis	Cancer
5-Iminodaunorubicin hydrochloride is a quinone-modified anthracycline that retains antitumor activity . 5-Iminodaunorubicin hydrochloride produces protein-concealed DNA strand breaks in cancer cells .

HY-138645

5-Iminodaunorubicin	DNA/RNA Synthesis	Cancer
5-Iminodaunorubicin is a quinone-modified anthracycline that retains antitumor activity . 5-Iminodaunorubicin produces protein-concealed DNA strand breaks in cancer cells .

HY-103667

2-HBA 3 Publications Verification	Caspase	Cancer
2-HBA is a potent inducer of *NAD(P)H:quinone* acceptor oxidoreductase 1 (NQO1) which can also activate caspase-3 and caspase-10**.

HY-116726

Crambene	Glutathione S-transferase	Cancer
Crambene is an orally active cyanide compound isolated from cruciferous vegetables. Crambene has a cancer-preventive effect and induces significant upregulation of quinone reductase and glutathione S-transferase in vitro and in vivo .

HY-125134

Alloaromadendrene	Parasite	Inflammation/Immunology
Alloaromadendrene, an antioxidant, can be isolated from the leaves of mixed-type C. osmophloeum. Alloaromadendrene protects C. elegans against oxidative stress induced by walnut quinone and prolongs the life of C. elegans .

HY-131722

EA4	Phospholipase	Cardiovascular Disease
EA4, a derivative of quinone, is an inhibitor for both rPLA and cPLA. EA4 can inhibit rPLA₂ with a K_i value of 130 μM. EA4 can be used for the research of hemostasis, thrombosis, and erythropoiesis .

HY-N9680

Coenzyme Q8 UbiQuinone 8	Endogenous Metabolite	Metabolic Disease
Coenzyme Q8 (Ubiquinone 8) is an isoprenoid quinone that mediates electron transfer within the aerobic respiratory chain and mitigates oxidative stress. Coenzyme Q8 enhances nonspecific resistance to bacterial infections .

HY-122482

β-Rubromycin	HIV Reverse Transcriptase Antibiotic	Inflammation/Immunology
β-Rubromycin is a potent and selective inhibitor of human immunodeficiency virus-1 (HIV-1) RNA-directed DNA polymeras (reverse transcriptase). β-Rubromycin is a class of quinone antibacterials .

HY-123436

Sarubicin B	Antibiotic Bacterial	Infection
Sarubicin B is an active product that can be isolated from the culture filtrate of a Streptomyces strain JA 2861. Sarubicin B is a quinone antibiotic that inhibit Gram-positive bacteria and not active against Gram-negative microorganisms .

HY-144439

HTS07545	Others	Cardiovascular Disease
HTS07545 is a potent *sulfide:quinone* oxidoreductase (SQOR) inhibitor with an IC₅₀** of 30 nM. HTS07545 decrease the rate of breakdown of hydrogen sulfide (H2S). HTS07545 can be used for heart failure research .

HY-N4033

Horminone 7α-Hydroxyroyleanone	Bacterial	Infection
Horminone is an abietan diterpene quinone that can be isolated from Labiatae family. Horminone increases of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) serum levels in vivo. Horminone inhibits the growth of Trypanosoma cruzi and shows antibacterial activity .

HY-N5018

Nepodin Musizin	Parasite AMPK	Infection
Nepodin (Musizin) is a quinone oxidoreductase (PfNDH2) inhibitor isolate from Rumex crispus .Nepodin (Musizin) stimulates the translocation of GLUT4 to the plasma membrane by activation of AMPK .Nepodin (Musizin) has antidiabetic and antimalarial activities.

HY-N10344

Glucoarabin	Others	Cancer
Glucoarabin is a bioactive glucosinolate. In Hepa1c1c7 cells, hydrolyzed Glucoarabin (hGSL 9) upregulates the phase II detoxification enzyme quinone reductase (NQO1), with no effect on cytochrome P450 (CYP) 1A1 activity .

HY-N2853

D-α-Tocopherylquinone α-TocopherylQuinone	Others	Cancer
D-α-Tocopherylquinone (α-Tocopherylquinone) is a quinone, can be isolated from Phaeodactylum tricornutum. D-α-Tocopherylquinone is a oxidation product of α-Tocopherol (vitamin E). D-α-Tocopherylquinone can act as an anticoagulant and as an antioxidant .

HY-B1849S

Hexazinone-d6	Isotope-Labeled Compounds	Infection
Hexazinone-d₆ is the deuterium labeled Hexazinone[1]. Hexazinone is a nonselective herbicide from the triazine family. Hexazinone binds to the D-1 quinone protein of the electron transport chain in photosystem II to inhibit the photosynthesis[2].

Cat. No.	Product Name

HY-L021L

Natural Product-like Compound Library

629 compounds

Natural products are an attractive source with varied structures that exhibit potent biological activities, and desirable pharmacological profiles. The core scaffold of a natural product can also provide a biologically validated framework upon which to display diverse functional groups. Inspired by bioactive natural products, natural product-like compounds, occupying the same chemical space, are ideally suited to explore and to facilitate understanding of biological pathways.

MCE provides a unique collection of 629 natural product-like compounds that are structurally like Steroids, Tannins, Flavonoids, Quinones, Isoquinolines, etc. This library is an important source of lead compounds for drug discovery.

HY-L021

Natural Product Library

4,689 compounds

Natural products are small molecules produced naturally by any organism including primary and secondary metabolites. Natural sources may lead to basic research on potential bioactive components for commercial development as lead compounds in drug discovery.

Nature has been a source of medicinal agents for thousands of years, and an impressive number of modern drugs have been isolated from natural sources, many based on their use in traditional medicine. With the development of new molecular targets, there is an increasing demand for novel molecular diversity for screening. Natural products will play a crucial role in meeting this demand through the continued investigation of world’s bio-diversity, much of which remains unexplored.

MCE provides a unique collection of 4,689 natural compounds that contain Saccharides and Glycosides, Phenylpropanoids, Quinones, Flavonoids, Terpenoids and Glycosides, Steroids, Alkaloid, Phenols, Acids and Aldehydes. Natural Product Library is a useful tool for drug discovery that can be used for high throughput screening (HTS) and high content screening (HCS).

HY-L021P

Natural Product Library Plus

5,540 compounds

MCE provides a unique collection of 5,540 natural compounds that contains Saccharides and Glycosides, Phenylpropanoids, Quinones, Flavonoids, Terpenoids and Glycosides, Steroids, Alkaloid, Phenols, Acids and Aldehydes. Natural Product Library Plus, with more powerful screening capability, further complements Natural Product Library (HY-L021) by adding some compounds with low solubility or solution stability (Part B) to this library. All those supplementary are supplied in powder form.

HY-L163

FDA-Approved Traditional Chinese Medicine Active Compound Library

332 compounds

Traditional Chinese medicine provides abundant natural resources for medicinal compounds, which are often considered effective and safe for drug discovery. Traditional Chinese medicine is based on the principle of "multiple components, multiple targets, and multiple pathways", and naturally has multiple pharmacological effects. As herbal medicine, the secondary plant metabolites in Chinese herbal medicine play an important role in alleviating many diseases in Traditional medicine and folk use. Therefore, the identification of traditional Chinese medicine derived compounds is also an important process in drug development and a necessary factor in dissecting the overall mechanism of action of traditional Chinese medicine. FDA listed compounds have completed extensive preclinical and clinical studies, exhibiting good biological activity, safety, and bioavailability.

MCE designs a unique collection of 332 FDA-approved traditional Chinese medicine active compounds, including flavonoids, polyphenols, alkaloids, terpenoids, and other structural types. It is a good tool for drug reuse and screening drugs from traditional Chinese medicine sources.

HY-L200

RO5 Drug-like Natural Product Library

2,713 compounds

Natural products are small molecular compounds that occur in nature and come from any organism, including primary and secondary metabolites. Natural products have potential biological activity and can be used as lead compounds for drug discovery. Nature has been a source of medicines for thousands of years, and a large number of drugs have been isolated from nature, many based on their use in traditional medicine. With the development of compound targets, there is an increasing need to screen for compound diversity. Through ongoing research into natural biodiversity, much of which remains to be exploited, natural products will play a key role in meeting this demand. The Lipinski rule of 5 is used to describe the drug-like properties of a molecule, molecules that adhere to the rule of 5 have higher drug potential. Based on MCE natural product library, MCE selects the molecules that obey the rule of 5, which makes the efficiency of drug screening higher.

MCE designs a unique collection of 2,713 RO5 drug-like natural products, which is an important tool for drug discovery.

HY-L065

Traditional Chinese Medicine Active Compound Library

2,918 compounds

Chinese herbal therapy is an important part of Traditional Chinese Medicine (TCM). It has been used for centuries in China, where herbs are considered fundamental therapy for many acute and chronic conditions. Many studies indicated TCM exerted an overall regulatory effect via multi-component and multi-target network. Active components from Traditional Chinese Medicine possess many medicinal properties such as antioxidant, anti-cancer, and anti-bacterial effects, which makes it an important source of new drugs. Nearly 200 modern medicines have been developed either directly or indirectly from the plants used as medicines in China. For example, artemisinin, used in multidrug resistant malaria, was first isolated from the Chinese herb Artemisia annua L. Today, scientists continue to identify compounds in Chinese herbal remedies that may be useful in the development of new therapeutic agents applicable in Western medicine.

MCE designs a unique collection of 2,918 active compounds of Chinese Herbal Medicines. MCE Traditional Chinese Medicine Active Compound Library is a useful tool for discovery new drugs from TCM.

Cat. No.	Product Name	Type

HY-128369

Acid Yellow 36 Metanil Yellow	Dyes
Acid Yellow 36 (Metanil Yellow) is an azo dye and a pH indicator. Acid Yellow 36 changes its color from red at pH 1.2 to yellow at pH 2.3. Acid Yellow 36 is used in the leather, paper and textile industries. Acid Yellow 36 acts as a bifunctional inducer of specific isozymes of P-450 and cytosolic enzymes .

Cat. No.	Product Name	Type

HY-15929

TBHBA 2,4,6-Tribromo-3-hydroxybenzoic acid	Biochemical Assay Reagents
The Boehringer Mannheim cholesterol esterase/cholesterol oxidase/peroxidase/3,4-dichlorophenol kinetic reagent was modified by the inclusion of TBHBA (2,4,6-Tribromo-3-hydroxybenzoic acid) which reacts with hydrogen peroxide and 4-aminophenazone to produce a quinone-imine dye with a greater molar absorptivity than that produced with phenol.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-100196

Pyrroloquinoline quinone 3 Publications Verification PQQ; Methoxatin	Quinones Structural Classification Microorganisms Animals Classification of Application Fields Source classification Benzene Quinones Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
Pyrroloquinoline quinone (PQQ), a redox co-factor, is an anionic, redox-cycling orthoquinone. Pyrroloquinoline quinone is isolated from cultures of methylotropic bacteria and tissues of mammals. Pyrroloquinoline quinone is an essential nutrient for mammals and is important for immune function .

HY-100196A

*Pyrroloquinoline quinone* disodium salt** 3 Publications Verification PQQ disodium salt; Methoxatin disodium salt	Quinones Structural Classification Microorganisms Classification of Application Fields Source classification Benzene Quinones Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
Pyrroloquinoline quinone disodium salt, a redox co-factor, is an anionic, redox-cycling orthoquinone. Pyrroloquinoline quinone disodium salt is isolated from cultures of methylotropic bacteria and tissues of mammals. Pyrroloquinoline quinone disodium salt is an essential nutrient for mammals and is important for immune function .

HY-153169

6PPD-Q 6PPD-Quinone	Quinones Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Other Diseases Benzene Quinones Endogenous metabolite Disease Research Fields	Endogenous Metabolite
6PPD-Q (6PPD-Quinone) is an endogenous metabolite that can be found in human urine and can also commonly found in the environment .

HY-N9942

Physalin A	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Alkekengi officinarum var. franchetii (Mast.) R.J.Wang Source classification Solanaceae Plants Disease Research Fields Cancer	Apoptosis Autophagy NF-κB p38 MAPK PI3K Akt mTOR STAT JAK
Physalin A is a biologically active withanolide. Physalin A shows anti-inflammatory, antifibrotic and ameliorative effects on autophagy in models of disc degeneration. Physalin A has antitumor activity and can induce apoptosis, ROS production and G2/M phase cell cycle arrest. Besides. Physalin A can significantly increase the activity of quinone reductase and increase the expression of detoxifying enzymesc .

HY-N7638

Dihydrolapachenole	Natural Products other families Classification of Application Fields Source classification Other Diseases Plants Disease Research Fields	Others
Dihydrolapachenole is a naturally occurring quinone .

HY-100196R

*Pyrroloquinoline quinone* (Standard)**	Quinones Structural Classification Microorganisms Animals Source classification Benzene Quinones Endogenous metabolite	Endogenous Metabolite
Pyrroloquinoline quinone (Standard) is the analytical standard of Pyrroloquinoline quinone. This product is intended for research and analytical applications. Pyrroloquinoline quinone (PQQ), a redox co-factor, is an anionic, redox-cycling orthoquinone. Pyrroloquinoline quinone is isolated from cultures of methylotropic bacteria and tissues of mammals. Pyrroloquinoline quinone is an essential nutrient for mammals and is important for immune function .

HY-N10563

Coleon-U-quinone	Structural Classification Ketones, Aldehydes, Acids Labiatae Smallanthus uvedalia (Linnaeus) Mackenzie Plants	P-glycoprotein
Coleon-U-quinone is a potent P-gp inhibitor. Coleon-U-quinone can inhibit cancer cells viability and sensitize multidrug resistance cancer cells to Doxorubicin (HY-15142A) .

HY-N10564

8α,9α-Epoxycoleon-U-quinone	Structural Classification Ketones, Aldehydes, Acids Labiatae Smallanthus uvedalia (Linnaeus) Mackenzie Plants	P-glycoprotein
8α,9α-Epoxycoleon-U-quinone (compound 3) is a p-glycoprotein (P-gp) regulator that is selective for cancer cells (SI=2.0). 8α,9α-Epoxycoleon-U-quinone effectively inhibits P-gp activity in NCI-H460/R cells. 8α,9α-Epoxycoleon-U-quinone also reverses the resistance of cancer cells to Doxorubicin (DOX) (HY-15142A) and enhances the anticancer effect of DOX .

HY-N1319

Salvisyrianone	Quinones Structural Classification Salvia syriaca L. other families Source classification Plants	Others
Salvisyrianone is a Quinones product that can be isolated from the herbs of Salvia syriaca L. .

HY-119528

Mansonone F	Structural Classification Natural Products Source classification Plants Ulmaceae Ulmus davidiana Planch.	Bacterial
Mansonone F is a potent anti-MRSA sesquiterpenoid quinone that can be found in Thespesia populnea .

HY-N3385

Licorisoflavan A 7-O-Methyllicorisoflavan B	Structural Classification Flavonoids Leguminosae Source classification Plants Other Flavonoids Glycyrrhiza uralensis Fisch.	Others
Licorisoflavan A (7-O-Methyllicorisoflavan B) is a isoflavan-quinone, that can be isolated from Glycyrrhiza uralensis .

HY-N11789

3-Hydroxyirisquinone	Quinones Structural Classification Iridaceae Source classification Benzene Quinones Plants Iris bungei Maxim.	Others
3-Hydroxyirisquinone is a quinone derivative, which can isolated from the seeds of Iris bungei Maxim .

HY-W667667

5-Hydroxyalizarin 1-methyl ether	Quinones Structural Classification Anthraquinones Source classification Rubiaceae Plants	Others
5-Hydroxyalizarin 1-methyl ether is a quinone compound isolated from Hymenodictyon excelsum .

HY-N2797

9-Methoxy-α-lapachone	Quinones Structural Classification Catalpa ovata G. Don Source classification Bignoniaceae Plants	Others
9-Methoxy-α-lapachone is a Quinones product that can be isolated from the stems of Catalpa ovata .

HY-N1551

Przewaquinone A	Natural Products Labiatae Source classification Diterpenoids Plants Vachellia nilotica (L.) P. J. H. Hurter & Mabb.	Others
Przewaquinone A, a lipophilic diterpene quinone present only in Salvia przewalskii, induces a potent inhibitory action on vascular contraction .

HY-135771

Avarone (+)-Avarone	Structural Classification Natural Products Marine natural products Source classification	Others
Avarone ((+)-Avarone) is a sesquiterpenoidal quinone that can be isolated from Dysidea avara. Avarone shows cytotoxicity. Avarone shows antileukemic activity .

HY-N6724

Altertoxin I Dihydroalterperylenol	Seeds of Cassia tora Linn. Natural Products other families Microorganisms Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Metabolic Disease Plants Disease Research Fields	Others
Altertoxin I (Dihydroalterperylenol) is a quinone-type mycotoxin produced by Alternaria alternata fungi, which is mutagenic and cytotoxic, and can weakly disrupts metabolic communication .

HY-N10394

Metachromins X	Quinones Structural Classification Classification of Application Fields Animals Terpenoids Sesquiterpenes Marine natural products Benzene Quinones Sponge Disease Research Fields Cancer	Others
Metachromins X is a sesquiterpene quinone that arrests the cell cycle progression of HeLa/Fucci2 cells at S/G2/M phase .

HY-N0645

Dicoumarol Maximum Cited Publications 8 Publications Verification Dicumarol	Structural Classification Melilotus officinalis (L.) Pall. Classification of Application Fields Leguminosae Source classification Coumarins Phenylpropanoids Plants Disease Research Fields Biological Pesticide Research Cancer Agricultural Research	PDHK
Dicoumarol is an inhibitor of both *NAD(P)H:quinone* oxidoreductase 1 (NQO1) and PDK1 with IC₅₀**s of 0.37 and 19.42 μM, respectively.

HY-125134

Alloaromadendrene	Structural Classification Natural Products Cinnamomum osmophloeum Kanehira Source classification Plants Lauraceae	Parasite
Alloaromadendrene, an antioxidant, can be isolated from the leaves of mixed-type C. osmophloeum. Alloaromadendrene protects C. elegans against oxidative stress induced by walnut quinone and prolongs the life of C. elegans .

HY-N9680

Coenzyme Q8 UbiQuinone 8	Structural Classification Natural Products Leguminosae Source classification Pisum sativum Linn Plants	Endogenous Metabolite
Coenzyme Q8 (Ubiquinone 8) is an isoprenoid quinone that mediates electron transfer within the aerobic respiratory chain and mitigates oxidative stress. Coenzyme Q8 enhances nonspecific resistance to bacterial infections .

HY-123436

Sarubicin B	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Bacterial
Sarubicin B is an active product that can be isolated from the culture filtrate of a Streptomyces strain JA 2861. Sarubicin B is a quinone antibiotic that inhibit Gram-positive bacteria and not active against Gram-negative microorganisms .

HY-N4033

Horminone 7α-Hydroxyroyleanone	Quinones Structural Classification Verbenaceae Source classification Verbena officinalis Linn. Plants Phenanthrenequinones	Bacterial
Horminone is an abietan diterpene quinone that can be isolated from Labiatae family. Horminone increases of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) serum levels in vivo. Horminone inhibits the growth of Trypanosoma cruzi and shows antibacterial activity .

HY-N5018

Nepodin Musizin	Rumex crispus Linn. Infection Structural Classification Classification of Application Fields Polygonaceae Source classification Phenols Polyphenols Rumex japonicus Houtt. Plants Disease Research Fields	Parasite AMPK
Nepodin (Musizin) is a quinone oxidoreductase (PfNDH2) inhibitor isolate from Rumex crispus .Nepodin (Musizin) stimulates the translocation of GLUT4 to the plasma membrane by activation of AMPK .Nepodin (Musizin) has antidiabetic and antimalarial activities.

HY-N10344

Glucoarabin	Structural Classification Natural Products Classification of Application Fields Source classification Camelina sativa (L.) Crantz Glucosinolates Plants Brassicaceae Disease Research Fields Cancer	Others
Glucoarabin is a bioactive glucosinolate. In Hepa1c1c7 cells, hydrolyzed Glucoarabin (hGSL 9) upregulates the phase II detoxification enzyme quinone reductase (NQO1), with no effect on cytochrome P450 (CYP) 1A1 activity .

HY-N2853

D-α-Tocopherylquinone α-TocopherylQuinone	Quinones Microorganisms Classification of Application Fields Source classification Benzene Quinones Disease Research Fields Cancer	Others
D-α-Tocopherylquinone (α-Tocopherylquinone) is a quinone, can be isolated from Phaeodactylum tricornutum. D-α-Tocopherylquinone is a oxidation product of α-Tocopherol (vitamin E). D-α-Tocopherylquinone can act as an anticoagulant and as an antioxidant .

HY-122961

Dehydromiltirone 1,2-Didehydromiltirone	Terpenoids Labiatae Samanea saman (Jacq.) Merr. Diterpenoids Plants	NF-κB p38 MAPK
Dehydromiltirone (1,2-Didehydromiltirone) is a diterpenoid quinone with an anti-inflammatory effect. Dehydromiltirone prevents liver injury by modifying the MAPK and NF-κB signaling pathways, reducing neuroinflammatory responses, and inhibiting platelet aggregation. Dehydromiltirone can be used for osteoporosis research .

HY-106338

Polyketomycin	Infection Quinones Structural Classification Microorganisms Classification of Application Fields Source classification Phenols Polyphenols Naphthalene Quinones Disease Research Fields	Bacterial ADC Cytotoxin Parasite
Polyketomycin is a tetracyclic quinone glycoside antibiotic isolated from Streptomyces sp. or Streptomyces diastatochromogenes. Polyketomycin inhibits growth of Gram-positive bacteria, and its MIC values is less than 0.2 µg/mL. Polyketomycin has antibacterial, anticancer, antimalarial activities .

HY-N1066

Xanthohumol D 1 Publications Verification	Structural Classification Chalcones Flavonoids Classification of Application Fields Humulus lupulus L. Source classification Phenols Polyphenols Plants Moraceae Disease Research Fields Cancer	Others
Xanthohumol D, isolated from hops, is an inhibitor of quinone reductase-2 (QR-2) with the IC₅₀ value of 110 μM, and binds to the active site of QR-2. Xanthohumol D shows antiproliferative activity on human cancer cell lines in vitro .

HY-110013

Terreic acid	Microorganisms Source classification	Btk Antibiotic
Terreic acid, a quinone epoxide antibiotic, acts as an effective Btk inhibitor. Terreic acid blocks the interaction between PKC and the pleckstrin homology domain of Btk. Terreic acid inhibits the binding of GST-BtkPH to PKC in lysates of HMC-1 human mast cells with an IC₅₀ of approximately 100 μM .

HY-125365

Rifamycin S 1 Publications Verification	Infection Quinones Structural Classification Monophenols Microorganisms Classification of Application Fields Source classification Phenols Naphthalene Quinones Disease Research Fields	Bacterial Reactive Oxygen Species Antibiotic
Rifamycin S, a quinone, is an antibiotic against Gram-positive bacteria (including MRSA). Rifamycin S is the oxidized forms of a reversible oxidation-reduction system involving two electrons. Rifamycin S generates reactive oxygen species (ROS) and inhibits microsomal lipid peroxidation. Rifamycin S can be used for tuberculosis and leprosy .

HY-145379

Miaosporone A	Infection Quinones Structural Classification Monophenols Classification of Application Fields Anthraquinones Source classification Phenols Endogenous metabolite Disease Research Fields	Parasite Endogenous Metabolite
Miaosporone A, an angucyclic quinone, exhibits antimalarial activity against Plasmodium falciparum K1 and antibacterial activity against Mycobacterium tuberculosis with respective IC₅₀ values of 2.5 and 2.4 μM and displays cytotoxic activities against both cancerous (MCF-7 and NCI-H187) and nonmalignant (Vero) cells .

HY-N10611

Elsinochrome A	Structural Classification Natural Products Microorganisms Source classification	Reactive Oxygen Species Apoptosis Autophagy Fungal Fluorescent Dye
Elsinochrome A is a perylene quinone photosensitizer, and can generate reactive oxygen species (ROS) to induce apoptosis and autophagy under light excitation. Elsinochrome A also shows antifungal activity against C. albicans biofilm through photodynamic antimicrobial chemotherapy (PACT). Elsinochrome A can be used for research of photodynamic therapy (PDT) (Ex: 460 nm) .

HY-N5018R

Nepodin (Standard)	Rumex crispus Linn. Structural Classification Polygonaceae Source classification Phenols Polyphenols Rumex japonicus Houtt. Plants	Parasite AMPK
Nepodin (Standard) is the analytical standard of Nepodin. This product is intended for research and analytical applications. Nepodin (Musizin) is a quinone oxidoreductase (PfNDH2) inhibitor isolate from Rumex crispus .Nepodin (Musizin) stimulates the translocation of GLUT4 to the plasma membrane by activation of AMPK .Nepodin (Musizin) has antidiabetic and antimalarial activities.

HY-N11709

Theasaponin E1	Triterpenes Structural Classification Terpenoids Source classification Plants Camellia sinensis (L.) O. Ktze. Theaceae	Others
Theasaponin E1 is a tea saponin isolated from tea seeds. Theasaponin E1 exhibits potential antitumor activity against human tumor cell lines K562 and HL60. Theasaponin E1 also has quinone reductase (QR)-inducing activity and can act as an anti-tumor agent for cancer prevention .

HY-N11894

1,3,6-Trihydroxy-2-methyl-9,10-anthraquinone-3-O-(6'-O-acetyl)-beta-D-xylopyranosyl-(1->2)-beta-D-glucopyranoside	Quinones Structural Classification Rubia podantha Anthraquinones Source classification Rubiaceae Plants	Others
1,3,6-Trihydroxy-2-methyl-9,10-anthraquinone-3-O-(6'-O-acetyl)-beta-D-xylopyranosyl-(1->2)-beta-D-glucopyranoside ( Compound 20) is a quinone compound that can be isolated from the roots and rhizomes of Madder .

HY-N10800

1,2,6,7,8,9-Hexahydro-1,6,6-trimethyl-3,11-dioxanaphth[2,1-e]azulene-10,12-dione	Structural Classification Terpenoids Labiatae Source classification Samanea saman (Jacq.) Merr. Diterpenoids Plants	Others
1,2,6,7,8,9-Hexahydro-1,6,6-trimethyl-3,11-dioxanaphth[2,1-e]azulene-10,12-dione is a kind of chemical constituents of Salvia miltiorrhiza f. alba. The dihydroisotanshinone with a para-quinone moiety shows cytotoxicity and anti-tumor activity .

HY-125365R

Rifamycin S (Standard)	Quinones Structural Classification Monophenols Microorganisms Source classification Phenols Naphthalene Quinones	Bacterial Reactive Oxygen Species Antibiotic
Rifamycin S (Standard) is the analytical standard of Rifamycin S. This product is intended for research and analytical applications. Rifamycin S, a quinone, is an antibiotic against Gram-positive bacteria (including MRSA). Rifamycin S is the oxidized forms of a reversible oxidation-reduction system involving two electrons. Rifamycin S generates reactive oxygen species (ROS) and inhibits microsomal lipid peroxidation. Rifamycin S can be used for tuberculosis and leprosy .

HY-N6802

Tigloylgomisin H	Structural Classification Classification of Application Fields Source classification Lignans Phenylpropanoids Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill. Cancer	Others
Tigloylgomisin H is a lignan isolated from the fruits of S. chinensis, can induce quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells. Tigloylgomisin H functions as a monofunctional inducer that specifically upregulates phase II detoxification enzyme NQO1 through the NF-E2-related factor 2 (Nrf2)-ARE pathway, thus represents a potential liver cancer prevention agent .

HY-N6715

Tenuazonic acid	Infection Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields Biological Pesticide Research Agricultural Research	Influenza Virus Bacterial Enterovirus Photosystem II
Tenuazonic acid is a nonhost-selective mycotoxin belonging to the tetramic acids family. Tenuazonic acid inhibits protein biosynthesis on ribosomes by suppressing the release of new protein. Tenuazonic acid is acutely toxic, and oral LD₅₀ is set between 81-186 mg/kg in rats and mice. Tenuazonic acid blocks electron transport beyond the primary quinone receptor (QA) by interacting with the D1 protein and is a *photosystem II (PSII)* inhibitor. In addition, Tenuazonic acid has antiviral effects on measles virus, enterovirus, respiratory virus and so on. Tenuazonic acid has an inhibitory effect on skin cancer .

HY-N6715R

Tenuazonic acid (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Influenza Virus Bacterial Enterovirus Photosystem II
Tenuazonic acid (Standard) is the analytical standard of Tenuazonic acid. This product is intended for research and analytical applications. Tenuazonic acid is a nonhost-selective mycotoxin belonging to the tetramic acids family. Tenuazonic acid inhibits protein biosynthesis on ribosomes by suppressing the release of new protein. Tenuazonic acid is acutely toxic, and oral LD₅₀ is set between 81-186 mg/kg in rats and mice. Tenuazonic acid blocks electron transport beyond the primary quinone receptor (QA) by interacting with the D1 protein and is a *photosystem II (PSII)* inhibitor. In addition, Tenuazonic acid has antiviral effects on measles virus, enterovirus, respiratory virus and so on. Tenuazonic acid has an inhibitory effect on skin cancer .

Species:	Human (4) Mouse (1)
Tag:	His (4) Tag Free (1)
Source:	P. pastoris (1) E. coli (4)

Cat. No.	Compare	Product Name	Species	Source

HY-P74405A

	Azoreductase/NQO1 Protein, Human NQO1; DIA4; NAD(P)H dehydrogenase [Quinone] 1; Azoreductase; DTD; QR1	Human	E. coli
	Azo reductase/NQO1 protein is a flavin-containing quinone reductase that uses NADH or NADPH to catalyze the two-electron reduction of quinone to hydroquinone. It regulates cellular redox status by detoxifying quinones and reducing plasma membrane redox components. Azoreductase/NQO1 Protein, Human is the recombinant human-derived Azoreductase/NQO1 protein, expressed by E. coli , with tag free. The total length of Azoreductase/NQO1 Protein, Human is 274 a.a., with molecular weight of ~33 kDa.

HY-P74405

	Azoreductase/NQO1 Protein, Human (His) NQO1; DIA4; NAD(P)H dehydrogenase [Quinone] 1; Azoreductase; DTD; QR1	Human	E. coli
	Azo reductase/NQO1 protein is a flavin-containing quinone reductase that uses NADH or NADPH to catalyze the two-electron reduction of quinone to hydroquinone. It regulates cellular redox status by detoxifying quinones and reducing plasma membrane redox components. Azoreductase/NQO1 Protein, Human (His) is the recombinant human-derived Azoreductase/NQO1 protein, expressed by E. coli , with N-His labeled tag. The total length of Azoreductase/NQO1 Protein, Human (His) is 274 a.a., with molecular weight of ~33 kDa.

HY-P71831

	Azoreductase/NQO1 Protein, Mouse (P.pastoris, His) Nqo1; Dia4; Nmo1; Nmor1; NAD(P)H dehydrogenase [Quinone] 1; EC 1.6.5.2; Azoreductase; DT-diaphorase; DTD; PhylloQuinone reductase; Quinone reductase 1; QR1	Mouse	P. pastoris
	The azoreductase/NQO1 protein reduces quinones to hydroquinone using NADH or NADPH as an electron donor.Azoreductase/NQO1 Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived Azoreductase/NQO1 protein, expressed by P.pastoris , with N-6*His labeled tag.

HY-P74632

	PIG3 Protein, Human (His) Quinone oxidoreductase PIG3; TP53I3; PIG3	Human	E. coli
	PIG3 is a key player in cellular processes, functioning as an enzyme that catalyzes NADPH-dependent quinone reduction. It exhibits moderate enzymatic activity towards β-naphthoquinone, with the para -quinone isomer (1,2-β-naphthoquinone) compared to the para -isomer (1,4-β-naphthoquinone). Obvious preference. PIG3 Protein, Human (His) is the recombinant human-derived PIG3 protein, expressed by E. coli , with N-6*His labeled tag. The total length of PIG3 Protein, Human (His) is 332 a.a., with molecular weight of ~37.5 kDa.

HY-P78957

	Dihydroorotate Dehydrogenase Protein, Human (His) Dihydroorotate dehydrogenase (Quinone), mitochondrial; DHODH; DHOdehase; Dihydroorotate oxidase; Dihydroorotate Dehydrogenase	Human	E. coli
	Dihydroorotate dehydrogenase is a key enzyme that utilizes quinones as electron acceptors to catalyze the key conversion of dihydroorotate to orotic acid. This enzyme activity is essential for the de novo biosynthesis of UMP (uridine monophosphate), an essential component of nucleotide metabolism. Dihydroorotate Dehydrogenase Protein, Human (His) is the recombinant human-derived Dihydroorotate Dehydrogenase protein, expressed by E. coli , with N-His labeled tag. The total length of Dihydroorotate Dehydrogenase Protein, Human (His) is 365 a.a., with molecular weight of ~41 kDa.

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Cat. No.	Product Name	Chemical Structure

HY-152039S

*6PPD-quinone-d5*
6PPD-quinone-d₅ is the deuterium labeled 6PPD-quinone[1].

HY-152039S1

6PPD-Q-13C6
6PPD-quinone- ¹³C₆ is the ¹³C labeled 6PPD-quinone[1].

HY-B1849S

Hexazinone-d6
Hexazinone-d₆ is the deuterium labeled Hexazinone[1]. Hexazinone is a nonselective herbicide from the triazine family. Hexazinone binds to the D-1 quinone protein of the electron transport chain in photosystem II to inhibit the photosynthesis[2].

HY-100196S1

*Pyrroloquinoline quinone-13C3 sodium*
Pyrroloquinoline quinone-13C3 (sodium) is an isotope of Pyrroloquinoline quinone. Pyrroloquinoline quinone (PQQ), a redox co-factor, is an anionic, redox-cycling orthoquinone. Pyrroloquinoline quinone is isolated from cultures of methylotropic bacteria and tissues of mammals. Pyrroloquinoline quinone is an essential nutrient for mammals and is important for immune function .

HY-N1944S

Nerolidol-d4

Nerolidol-d₄ is deuterated labeled Tenuazonic acid (HY-N6715). Tenuazonic acid, belonging to tetramic acids that are the largest family of natural products, is a putative nonhost-selective mycotoxin isolated from Alternaria alternate . Tenuazonic acid blocks electron transport beyond primary quinone acceptor (QA) by interacting with D₁ protein and it is a broad-spectrum and effective photosystem II (PSII) inhibitor .

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