2. Anti-infection PI3K/Akt/mTOR Epigenetics
  3. Parasite AMPK
  4. Nepodin

Nepodin (Musizin) is a quinone oxidoreductase (PfNDH2) inhibitor isolate from Rumex crispus.Nepodin (Musizin) stimulates the translocation of GLUT4 to the plasma membrane by activation of AMPK.Nepodin (Musizin) has antidiabetic and antimalarial activities.

For research use only. We do not sell to patients.

Nepodin Chemical Structure

Nepodin Chemical Structure

CAS No. : 3785-24-8

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5 mg USD 160 In-stock
10 mg USD 260 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Nepodin:

Nepodin Related Antibodies

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NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Nepodin (Musizin) is a quinone oxidoreductase (PfNDH2) inhibitor isolate from Rumex crispus[1].Nepodin (Musizin) stimulates the translocation of GLUT4 to the plasma membrane by activation of AMPK[2].Nepodin (Musizin) has antidiabetic and antimalarial activities.

IC50 & Target

Plasmodium

 

In Vitro

Nepodin (Musizin) exhibits significant IC50 values that are 0.74 and 0.79 μg/ml against P. falciparum chloroquine-sensitive (3D7) and P. falciparum chloroquine-resistant (S20), respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nepodin Related Antibodies
In Vivo

Nepodin (Musizin) (orally administration; 2-10 mg/kg; 4 weeks) improves the impaired glucose tolerance of db/db mice, also decreases an increase in plasma insulin concentration of db/db mice in a dose-dependent manner[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/KsJ-db/db mice[2]
Dosage: 2 mg/kg; 10 mg/kg
Administration: Orally administration; 2-10 mg/kg; 4 weeks
Result: Had antihyperglycemic potential and improved insulin resistance.
Molecular Weight

216.23

Formula

C13H12O3
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

CC(C1=C(C)C=C2C=CC=C(O)C2=C1O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (578.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6247 mL 23.1235 mL 46.2471 mL
5 mM 0.9249 mL 4.6247 mL 9.2494 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.71%

COA (254 KB) HNMR (277 KB) LCMS (265 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.6247 mL 23.1235 mL 46.2471 mL 115.6176 mL
5 mM 0.9249 mL 4.6247 mL 9.2494 mL 23.1235 mL
10 mM 0.4625 mL 2.3124 mL 4.6247 mL 11.5618 mL
15 mM 0.3083 mL 1.5416 mL 3.0831 mL 7.7078 mL
20 mM 0.2312 mL 1.1562 mL 2.3124 mL 5.7809 mL
25 mM 0.1850 mL 0.9249 mL 1.8499 mL 4.6247 mL
30 mM 0.1542 mL 0.7708 mL 1.5416 mL 3.8539 mL
40 mM 0.1156 mL 0.5781 mL 1.1562 mL 2.8904 mL
50 mM 0.0925 mL 0.4625 mL 0.9249 mL 2.3124 mL
60 mM 0.0771 mL 0.3854 mL 0.7708 mL 1.9270 mL
80 mM 0.0578 mL 0.2890 mL 0.5781 mL 1.4452 mL
100 mM 0.0462 mL 0.2312 mL 0.4625 mL 1.1562 mL
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Nepodin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nepodin3785-24-8MusizinParasiteAMPKAMP-activated protein kinaseInhibitorinhibitorinhibit

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