2. Epigenetics Anti-infection
  3. DNA Methyltransferase Parasite
  4. Nanaomycin A

Nanaomycin A is the first selective DNMT3B inhibitor with an IC50 of 500 nM. Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells. Nanaomycin A inhibits in vitro growth of the human malaria parasite Plasmodium falciparum with an IC80 value of 33.1 nM.

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Nanaomycin A Chemical Structure

Nanaomycin A Chemical Structure

CAS No. : 52934-83-5

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Based on 2 publication(s) in Google Scholar

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Nanaomycin A Related Antibodies

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Description

Nanaomycin A is the first selective DNMT3B inhibitor with an IC50 of 500 nM. Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells[1]. Nanaomycin A inhibits in vitro growth of the human malaria parasite Plasmodium falciparum with an IC80 value of 33.1 nM[2].

IC50 & Target[1]

DNMT3B

500 nM (IC50)

Plasmodium

 

Cellular Effect
Cell Line Type Value Description References
Sf9 IC50
0.5 μM
Compound: 23
Inhibition of His6-tagged human recombinant DNMT3b expressed in insect Sf9 cells assessed as reduction in DNA methyltransferase activity using 5'-biotinylated 45-bp unmethylated or hemimethylated oligonucleotide substrates and [3H]-AdoMet by liquid scinti
Inhibition of His6-tagged human recombinant DNMT3b expressed in insect Sf9 cells assessed as reduction in DNA methyltransferase activity using 5'-biotinylated 45-bp unmethylated or hemimethylated oligonucleotide substrates and [3H]-AdoMet by liquid scinti
[PMID: 25406944]
In Vitro

Nanaomycin A (10-10000 nM; 72 hours) has a distinct cytotoxic effect in all three cell lines[1].
Nanaomycin A (0.5, 5 μM; 72 hours) reveals induction of RASSF1A protein expression in A549 cells[1].
Nanaomycin A (5 μM; 72 hours) has an 18-fold relative induction[1].
Nanaomycin A not affects the enzymatic activity of DNMT1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nanaomycin A Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: HCT116 (colon), A549 (lung), and HL60 (bone marrow) human tumor cell lines
Concentration: 10, 100, 1000, 10000 nM
Incubation Time: 72 hours
Result: Had a distinct cytotoxic effect in all three cell lines.

Western Blot Analysis[1]

Cell Line: A549 cells
Concentration: 0.5, 5 μM
Incubation Time: 72 hours
Result: Revealed induction of RASSF1A protein expression.

RT-PCR[1]

Cell Line: A549 cells
Concentration: 5 μM
Incubation Time: 72 hours
Result: Had an 18-fold relative induction.
Molecular Weight

302.28

Formula

C16H14O6
CAS No.
Appearance

Solid

Color

Yellow to orange

SMILES

O=C(O)C[C@H]1CC(C(C2=C3C(O)=CC=C2)=O)=C(C3=O)[C@H](C)O1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: 98.18%

SDS (480 KB)

COA (249 KB) HNMR (238 KB) RP-HPLC (532 KB) MS (334 KB)

Handling Instructions (2659 KB)
References
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Nanaomycin A Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nanaomycin A52934-83-5DNA MethyltransferaseParasiteDNMTsDNA MTasesDNMT3BantibioticssilencedtumorsuppressorgenesmalariaparasitePlasmodiumfalciparumInhibitorinhibitorinhibit

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