RING1

By Targets:	Bradykinin Receptor (1) E1/E2/E3 Enzyme (3) Endogenous Metabolite (1) Estrogen Receptor/ERR (1) PROTACs (3) Reverse Transcriptase (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (5) Endocrinology (1) Inflammation/Immunology (2) Metabolic Disease (1)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-139514

RB-3	E1/E2/E3 Enzyme	Cancer
RB-3, a polycomb repressive complex 1 (PRC1) inhibitor, binds to *RING1B-BMI1f, with a K_d* of 2.8 μM ^[1].

HY-103291

Sar-[D-Phe8]-des-Arg9-Bradykinin	Bradykinin Receptor	Inflammation/Immunology Endocrinology
Sar-[D-Phe8]-des-Arg9-Bradykinin is a agonist of B1 receptor. Sar-[D-Phe8]-des-Arg9-Bradykinin selectively amplifies the contractile response when incubation with human recombinant interleukin-1 β (IL-1 β) in rabbit aortic rings .

HY-158239

MS181	PROTACs E1/E2/E3 Enzyme	Cancer
MS181 (compound 1) is a potent cereblon (CRBN)-recruiting and EED-binding polycomb repressive complex 1 (PRC1) PROTAC degrader. MS181 decreases the expression of EED, EZH2, SUZ12, BMI1 and RING1B. MS181 shows antiproliferative activity (Strtucture Note: Red, EED binder (HY-158771); Blue, CRBN ligand (HY-41547); Black, Linker HY-131717) ^[1].

HY-RS11985

RING1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RING1 Human Pre-designed siRNA Set A contains three designed siRNAs for RING1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RING1 Human Pre-designed siRNA Set A RING1 Human Pre-designed siRNA Set A

HY-138140

Desertomycin A	Others	Others
Desertomycin A is an aminopolyol polyketide containing a macrolactone ring .

HY-116918

N,N-Diphenylacetamide N-Acetyldiphenylamine	Others	Others
N,N-Diphenylacetamide (N-Acetyldiphenylamine) has N,N-disubstituted amide group and can be used as a mono- as well as a bidentate ligand generating four-membered chelate rings .

HY-160924

MS147	PROTACs E1/E2/E3 Enzyme	Cancer
MS147 is a VHL-based PROTAC degrader of *PRC1* (Polycomb Repressive Complex 1). The dissociation constants (Kd) of MS147 for EED (Embryonic Ectoderm Development) and VHL (Von Hippel-Lindau) are 3.0 μM and 450 nM, respectively. MS147 specifically binds to the EED protein through its EED-binding moiety; EED is a core component of PRC2 (Polycomb Repressive Complex 2) and interacts with the core components of *PRC1, BMI1* (B-lymphoma Mo-MLV insertion region 1 homolog) and *RING1B* (Ring Finger Protein 1B). By this binding, MS147 is able to recruit *BMI1* and *RING1B* near to VHL. Through the degradation of *BMI1* and *RING1B, MS147 reduces the level of H2AK119ub (histone H2A lysine 119 ubiquitination), affecting the proliferation of cancer cells. (Blue: VHL ligand (HY-125845), Black: linker ; Pink: PRC1* ligand (HY-158771)) ^[1].

HY-129665

GS-389 (±)-O,O-Dimethylcoclaurine	Endogenous Metabolite	Metabolic Disease
GS 389 ((±)-O,O-Dimethylcoclaurine) is a tetrahydroisoquinoline. GS-389 inhibites Cyclic AMP and cyclic AMP dependent phosphodiesterases from rat atrial and ventricular tissue. GS-389 relaxes the contraction induced by phenylephrine and high K ⁺ in rat aortic rings .

HY-160562

PROTAC ERα Degrader-7	PROTACs Estrogen Receptor/ERR	Cancer
PROTAC ERα Degrader-7 (compound i-320) is a potent estrogen receptor alpha(ERα) PROTAC degrader with a DC₅₀ value of 0.000006 µM. PROTAC ERα Degrader-7 comprises a cereblon-binding moiety LBM linked to a ligand ERBM that binds ERα and comprises a benzofused partially saturated 6-membered carbocyclic or heterocyclic ring .

HY-117664

PNR-7-02	Reverse Transcriptase	Inflammation/Immunology Cancer
PNR-7-02 inhibits Pol η function with an IC₅₀ value of near 8 μM, which binds to the little finger domain. PNR-7-02 is also an inhibitor against *hRev1* and hpol lambda (λ). PNR-7-02 acts synergistically with Cisplatin (HY-17394) to kill chronic myeloid leukaemia and ovarian cancer cell lines. PNR-7-02 is an indole thio-barbituric acid (ITBA) derivative with both N-napthoyl moiety and 5-chloro substituent on the indole ring .

Cat. No.	Product Name

HY-L0122V

Asinex CNS Macrocycles Library	1,122 compounds
Several CNS multi-parameter scoring approaches have been reported: CNS-MPO, CNS-MPO V.2, CNS-TEMPO, which suggesting an algorithm to predict CNS-ike properties of new chemical entities. We have applied these scoring algorithms to select macrocycles satisfying multiple cut-offs and structural desirability criteria. The resulting set consists of 1,122 macrocyclic compounds with CNS-MPO > 4, CNS-MPO.v2 > 4, and CNS-TEMPO < 4 for CNS-related drug discovery and research.

Asinex CNS Macrocycles Library

1,122 compounds

Several CNS multi-parameter scoring approaches have been reported: CNS-MPO, CNS-MPO V.2, CNS-TEMPO, which suggesting an algorithm to predict CNS-ike properties of new chemical entities. We have applied these scoring algorithms to select macrocycles satisfying multiple cut-offs and structural desirability criteria. The resulting set consists of 1,122 macrocyclic compounds with CNS-MPO > 4, CNS-MPO.v2 > 4, and CNS-TEMPO < 4 for CNS-related drug discovery and research.

Cat. No.	Product Name	Target	Research Area

HY-103291

Sar-[D-Phe8]-des-Arg9-Bradykinin	Bradykinin Receptor	Inflammation/Immunology Endocrinology
Sar-[D-Phe8]-des-Arg9-Bradykinin is a agonist of B1 receptor. Sar-[D-Phe8]-des-Arg9-Bradykinin selectively amplifies the contractile response when incubation with human recombinant interleukin-1 β (IL-1 β) in rabbit aortic rings .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-138140

Desertomycin A	Natural Products Microorganisms Classification of Application Fields Source classification Other Diseases Disease Research Fields	Others
Desertomycin A is an aminopolyol polyketide containing a macrolactone ring .

HY-129665

GS-389 (±)-O,O-Dimethylcoclaurine	Structural Classification Alkaloids Source classification Cocculus laurifolius DC. Plants Isoquinoline Alkaloids Menispermaceae	Endogenous Metabolite
GS 389 ((±)-O,O-Dimethylcoclaurine) is a tetrahydroisoquinoline. GS-389 inhibites Cyclic AMP and cyclic AMP dependent phosphodiesterases from rat atrial and ventricular tissue. GS-389 relaxes the contraction induced by phenylephrine and high K ⁺ in rat aortic rings .

Species:	Human (2)
Tag:	His (2) GST (1)
Source:	Sf9 insect cells (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P74590

	RYBP Protein, Human (sf9, His-GST) RING1 and YY1-binding protein; APAP-1; RYBP; DEDAF; YEAF1	Human	Sf9 insect cells
	RYBP Protein, a crucial regulatory factor, complexes with metalloproteinases like collagenases, inhibiting their activity by irreversibly binding to catalytic zinc cofactors.This interaction, notably with MMP-1, MMP-2, MMP-3, MMP-7, and MMP-9, highlights RYBP's pivotal role in finely regulating extracellular matrix remodeling and proteolytic processes across diverse physiological contexts.RYBP Protein, Human (sf9, His-GST) is the recombinant human-derived RYBP protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P703186

	RNF2 Protein, Human (His) BAP1; DING; HIPI3; RING1B	Human	E. coli
	RNF2 Protein, Human (His) is the recombinant human-derived RNF2, expressed by E. coli , with His labeled tag. ,

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HY-P82606

	RING1 Antibody (YA2351) RING1A; RING1; RING1A; Rnf1	WB, IHC-P, ICC/IF	Human
	RING1 Antibody (YA2351) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2351), targeting RING1, with a predicted molecular weight of 42 kDa (observed band size: 50 kDa). RING1 Antibody (YA2351) can be used for WB, IHC-P, ICC/IF experiment in human background.

HY-P83585

	RING2 Antibody (YA3330) BAP1; DING; BAP-1; HIPI3; RING2; RING1B	WB, IHC-P	Human
	RING2 Antibody (YA3330) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3330), targeting RING2, with a predicted molecular weight of 38 kDa (observed band size: 38 kDa). RING2 Antibody (YA3330) can be used for WB, IHC-P experiment in human background.

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Cat. No.	Product Name		Classification

HY-RS11985

RING1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
RING1 Human Pre-designed siRNA Set A contains three designed siRNAs for RING1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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