From 11:00 pm to 12:00 pm EST ( 8:00 pm to 9:00 pm PST ) on January 6th, the website will be under maintenance. We are sorry for the inconvenience. Please arrange your schedule properly.
Supinoxin (RX-5902) is an orally active inhibitor of phosphorylated-p68 RNAhelicase (P-p68) and a potent first-in-class anti-cancer agent. Supinoxin interacts with Y593 phosphorylated-p68 and attenuates the nuclear shuttling of β-catenin. Supinoxin induces cell apoptosis and inhibits growth of TNBC cancer cell lines with IC50s ranging from 10 nM to 20 nM .
eIF4A3-IN-8 is a selective ATP-competitive eukaryotic initiation factor 4A3 (eIF4A3) inhibitor. eIF4A3-IN-8 can serve as a valuable chemical probe to elucidate the detailed function of eIF4A3 and EJC (exon junction complex) .
(R)-eIF4A3-IN-2 is a less active enantiomer of eIF4A3-IN-2. eIF4A3-IN-2 is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 (eIF4A3) inhibitor with an IC50 of 110 nM .
Heliquinomycin is an inhibitor of DNA helicase (Ki: 6.8 μM) and inhibits DNA and RNA synthesis. Heliquinomycin is effective against Gram-positive bacteria strains. Heliquinomycin inhibits cancer cell growth .
DHX9-IN-1 (example 160) is an inhibitor of ATP-dependent RNAhelicase A (DHX9), with an EC50 value of 6.94 μM in DHX9 cellular target engagement. DHX9-IN-1 has antitumor activity .
GBM CSCs-IN-1 (Compound (−)-20), a derivative of rocaglate, is a potent inhibitor of glioblastoma stem cells (GBM CSCs) with an EC50 of 45 nM, functioning by targeting the RNAhelicaseDDX3. Furthermore, GBM CSCs-IN-1 is also capable of inducing apoptosis .
Avenanthramide A is a phytoalexin, which can be found in oats (Avena sativa L.). Avenanthramide A targets the RNAhelicaseDDX3, leads to mitochondrial swelling and increased ROS production, and induces apoptosis in CRC cells. Avenanthramide A exhibits antitumor efficacy in mouse model. Avenanthramide A orally active .
KY386 is a potent, selective inhibitor of DHX33 helicase, with the IC50 of 19 nM. KY386 inhibits U251-MG cells (DHX33-overexpressing cancer cell strain) with IC50 of 20 nM.and shows potent anti-cancer activity and moderate metabolic stability .
CMLD012073 is an amidino-rocaglates and is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. CMLD012073 inhibits the growth of NIH/3T3 cells with an IC50 of 10 nM. CMLD012073 inhibits eukaryotic translation initiation by modifying the behavior of the RNAhelicase (eIF4A) .
Fli-1-IN-1 (compound 21) fumarate is a FLI1 targeting agent that directly binds to and inhibits the EWS-FLI1 protein interaction. EWS-FLI1 can bind to RNAhelicase A, and Fli-1-IN-1 fumarate inhibits EWS-FLI1 and has potential anticancer activity .
Fli-1-IN-1 (compound 21) is a FLI1 targeting agent that directly binds to and inhibits the EWS-FLI1 protein interaction. EWS-FLI1 can bind to RNAhelicase A, and Fli-1-IN-1 inhibits EWS-FLI1 and has potential anticancer activity .
TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor . TK216 directly binds EWS-FLI1 and inhibits EWS-FLI1 protein interactions. TK216 blocks the binding between EWS-FLI1 and RNAhelicase A. TK216 has anticancer activity .
Avenanthramide A (Standard) is the analytical standard of Avenanthramide A. This product is intended for research and analytical applications. Avenanthramide A is a phytoalexin, which can be found in oats (Avena sativa L.). Avenanthramide A targets the RNAhelicase DDX3, leads to mitochondrial swelling and increased ROS production, and induces apoptosis in CRC cells. Avenanthramide A exhibits antitumor efficacy in mouse model. Avenanthramide A orally active .
YK-4-279 blocks RNAHelicase A (RHA) binding with EWS-FLI1 (oncogenic protein). YK-4-279 induces apoptosis and shows anti-proliferation activities towards various cancer cells. YK-4-279 has a chiral center and it can be separated into two enantiomers. YK-4-279 can be used for the research of cancer .
CMLD012612 is an amidino-rocaglate containing a hydroxamate group and is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. CMLD012612 inhibits cell translation and is cytotoxic to NIH/3T3 cells with an IC50 value of 2 nM. CMLD012612 inhibits eukaryotic translation initiation by modifying the behavior of the RNAhelicase (eIF4A) and possesses potent anti-neoplastic activity .
Dby HY Peptide (608-622), mouse is a biological active peptide. (Dby HY Peptide, NAGFNSNRANSSRSS, is a HYAb epitope belonging to a well-conserved family of genes coding for known or putative RNAhelicases and containing a core sequence with a DEAD (Asp-Glu-Ala-Asp) box peptide motif, hence the name Dby (Dead box RNAhelicase Y). The single Phenylalanine in the sequence serves as the anchor point while FNSNRANSS most likely is the “core” sequence of this HYAb epitope.)
Avenanthramide A is a phytoalexin, which can be found in oats (Avena sativa L.). Avenanthramide A targets the RNAhelicaseDDX3, leads to mitochondrial swelling and increased ROS production, and induces apoptosis in CRC cells. Avenanthramide A exhibits antitumor efficacy in mouse model. Avenanthramide A orally active .
Avenanthramide A (Standard) is the analytical standard of Avenanthramide A. This product is intended for research and analytical applications. Avenanthramide A is a phytoalexin, which can be found in oats (Avena sativa L.). Avenanthramide A targets the RNAhelicase DDX3, leads to mitochondrial swelling and increased ROS production, and induces apoptosis in CRC cells. Avenanthramide A exhibits antitumor efficacy in mouse model. Avenanthramide A orally active .
DDX5 Protein, Human (His, Myc) is the recombinant human-derived DDX5, expressed by E. coli , with N-10*His, C-Myc labeled tag. The total length of DDX5 Protein, Human (His, Myc) is 614 a.a.,
LGP2 protein is a key regulator of RIGI- and IFIH1/MDA5-mediated antiviral signaling and has dual negative and positive functions affected by factors such as infected viruses and target cells. LGP2 lacks a CARD domain for independent initiation of antiviral signaling and therefore inhibits RIG-I through multiple mechanisms, including competition for RNA binding and obstruction of interaction with MAVS/IPS1. LGP2 Protein, Human (HEK293, FLAG) is the recombinant human-derived LGP2 protein, expressed by HEK293 , with C-Flag labeled tag. The total length of LGP2 Protein, Human (HEK293, FLAG) is 678 a.a., .
DDX41 protein, a probable ATP-dependent RNA helicase, plays a crucial role in post-transcriptional gene expression, suggesting involvement in pre-mRNA splicing. As an ATP-dependent RNA helicase, DDX41 likely contributes to dynamic RNA unwinding, facilitating various aspects of RNA metabolism. Its multifunctional role underscores its significance in the intricate machinery governing gene expression and RNA processing within the cell. DDX41 Protein, Human (His, Strep, Flag) is the recombinant human-derived DDX41 protein, expressed by E. coli , with N-Strep, N-6*His, C-Flag labeled tag.
The DDX19A protein is an ATP-dependent RNA helicase that plays a crucial role in unwinding single- and double-stranded DNA in the 3'-5' direction. It is actively involved in DNA replication and repair by recruiting DNA2 to aid in 5' end resection during double-strand break repair. DDX19A Protein, Human (His-SUMO) is the recombinant human-derived DDX19A protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
POLG proteins play multiple roles in the viral life cycle, contributing to viral RNA packaging, budding, and particle production. It exhibits RNA-binding and RNA chaperone activities, affecting translation initiation through interactions with viral IRES and ribosomal subunits. HCVNS5B Protein, HCV is the recombinant HCVNS5B, expressed by E. coli , with tag Free labeled tag. ,
DDX41 protein, a probable ATP-dependent RNA helicase, plays a crucial role in post-transcriptional gene expression, suggesting involvement in pre-mRNA splicing. As an ATP-dependent RNA helicase, DDX41 likely contributes to dynamic RNA unwinding, facilitating various aspects of RNA metabolism. Its multifunctional role underscores its significance in the intricate machinery governing gene expression and RNA processing within the cell. DDX41 Protein, Human (FLAG) is the recombinant human-derived DDX41 protein, expressed by E. coli , with C-Flag labeled tag. The total length of DDX41 Protein, Human (FLAG) is 622 a.a., .
LGP2 protein is a key regulator of RIGI- and IFIH1/MDA5-mediated antiviral signaling and has dual negative and positive functions affected by factors such as infected viruses and target cells. LGP2 lacks a CARD domain for independent initiation of antiviral signaling and therefore inhibits RIG-I through multiple mechanisms, including competition for RNA binding and obstruction of interaction with MAVS/IPS1. LGP2 Protein, Human (HEK293, His, Strep, FLAG) is the recombinant human-derived LGP2 protein, expressed by HEK293 , with N-Strep, C-Flag, N-8*His labeled tag. The total length of LGP2 Protein, Human (HEK293, His, Strep, FLAG) is 678 a.a., .
The EIF4A1 protein is an ATP-dependent RNA helicase and an important subunit of the eIF4F complex, which is essential for cap recognition and promoting the binding of mRNA to ribosomes. In the translation initiation model, EIF4A1 helps unravel RNA secondary structure in the mRNA 5'-UTR. EIF4A1 Protein, Human is the recombinant human-derived EIF4A1 protein, expressed by E. coli , with tag free. The total length of EIF4A1 Protein, Human is 406 a.a., .
The EIF4A1 protein is an ATP-dependent RNA helicase and an important subunit of the eIF4F complex, which is essential for cap recognition and promoting the binding of mRNA to ribosomes. In the translation initiation model, EIF4A1 helps unravel RNA secondary structure in the mRNA 5'-UTR. EIF4A1 Protein, Human (His, Strep) is the recombinant human-derived EIF4A1 protein, expressed by E. coli , with N-Strep, N-6*His labeled tag. The total length of EIF4A1 Protein, Human (His, Strep) is 406 a.a., .
The DDX39B protein intricately coordinates nuclear mRNA export and is specifically associated with spliced mRNA as a key component of the TREX complex. This coupling of mRNA transcription, processing, and export involves rounds of ATP-dependent hydrolysis, recruiting components such as ALYREF/THOC and CHTOP. DDX39B Protein, Human (GST) is the recombinant human-derived DDX39B protein, expressed by E. coli , with N-GST labeled tag. The total length of DDX39B Protein, Human (GST) is 250 a.a., with molecular weight of ~55.2 kDa.
EIF4A2, an ATP-dependent RNA helicase, is a vital subunit of the eIF4F complex, pivotal in cap recognition and mRNA binding to ribosomes. In translation initiation, EIF4A2 crucially unwinds RNA secondary structures in mRNA 5'-UTRs. This activity facilitates small ribosomal subunit binding and efficient scanning for the initiator codon, orchestrating translation initiation. EIF4A2 Protein, Human (GST) is the recombinant human-derived EIF4A2 protein, expressed by E. coli, with N-GST labeled tag. The total length of EIF4A2 Protein, Human (GST) is 407 a.a., with molecular weight of 73.4 kDa.
The DDX58 protein is an innate immune receptor that detects cytoplasmic viral nucleic acids and initiates a signaling cascade for type I interferon production.It forms ribonucleoprotein complexes with viral RNA and promotes homo-oligomerization.DDX58 Protein, Human (His) is the recombinant human-derived DDX58 protein, expressed by E.coli , with N-6*His labeled tag.
DDX5; G17P1; HELR; HLR1; Probable ATP-dependent RNAhelicase DDX5; DEAD box protein 5; RNAhelicase p68
WB, IHC-F, IHC-P, ICC/IF, IP
Human, Mouse, Rat
DDX5 Antibody (YA2666) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2666), targeting DDX5, with a predicted molecular weight of 69 kDa (observed band size: 69 kDa). DDX5 Antibody (YA2666) can be used for WB, IHC-F, IHC-P, ICC/IF, IP experiment in human, mouse, rat background.
eIF4A1 Antibody (YA774) is a non-conjugated and Mouse origined monoclonal antibody about 46 kDa, targeting to eIF4A1 (6D7). It can be used for WB,IHC-F,IHC-P,ICC/IF assays with tag free, in the background of Human, Mouse, Rat.
Helicard; Hlcd; IDDM19; IFIH1; MDA-5; RH116; RIG I like receptor 2; RLR 2; RNAhelicase DEAD box protein 116
WB, ICC/IF
Human
MDA5 Antibody (YA2399) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2399), targeting MDA5, with a predicted molecular weight of 117 kDa (observed band size: 117 kDa). MDA5 Antibody (YA2399) can be used for WB, ICC/IF experiment in human background.
PIAS1; DDXBP1; E3 SUMO-protein ligase PIAS1; DEAD/H box-binding protein 1; Gu-binding protein; GBP; Protein inhibitor of activated STAT protein 1; RNAhelicase II-binding protein
WB, IHC-P, ICC/IF, FC
Human, Mouse, Rat
PIAS1 Antibody (YA2217) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2217), targeting PIAS1, with a predicted molecular weight of 72 kDa (observed band size: 76 kDa). PIAS1 Antibody (YA2217) can be used for WB, IHC-P, ICC/IF, FC experiment in human, mouse, rat background.
RNA Helicase A Antibody (YA1870) is a biotin-conjugated non-conjugated IgG antibody, targeting RNA Helicase A, with a predicted molecular weight of 141 kDa (observed band size: 141 kDa). RNA Helicase A Antibody (YA1870) can be used for WB experiment in rat background.
Product Comparison
Compare
Clear All
Compare Products
Products
In-stock
-
+
Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample
YesNo
Size
* This product has been "discontinued".
Optimized version of product available:
/
In-stock
-
+
Add to Cart
Get quote
Inquiry Online
Your information is safe with us. * Required Fields.
