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Relative binding affinity

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9

Inhibitors & Agonists

1

Fluorescent Dye

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-108637A
    PhiKan 083 hydrochloride

    		MDM-2/p53 Cancer
    PhiKan 083 hydrochloride is a carbazole derivative, which binds to the surface cavity and stabilizes Y220C (a p53 mutant), with a Kd of 167 μM , and a relative binding affinity (Kd) of 150 μM in Ln229 cells .
    PhiKan 083 hydrochloride
  • HY-120959
    DAUDA

    		Fluorescent Dye Parasite Others
    DAUDA (11-(dansylamino) undecanoic acid) is an environment-sensitive fluorescent fatty acid analogue. DAUDA alters its intensities and fluorescent emission spectra on entry into binding proteins. DAUDA is used to determine the relative affinity of natural fatty acids for polymorphs of the Schistosoma mansoni Sm14 fatty acid-binding protein[1].
    DAUDA
  • HY-100689
    Propyl pyrazole triol
    10+ Cited Publications

    PPT

    		 Estrogen Receptor/ERR Cancer
    Propyl pyrazole triol (PPT) is a selective estrogen receptor alpha (ERα) agonist. The relative binding affinity of Propyl pyrazole triol for ERα (ERα: 49%) around 410 times higher compared with estrogen receptor beta (ERβ: 0.12%) .
    Propyl pyrazole triol
  • HY-16023B
    (Rac)-Acolbifene

    EM-343; (Rac)-EM-652

    		 Estrogen Receptor/ERR Cancer
    (Rac)-Acolbifene (EM-343; (Rac)-EM-652) is the racemic form of EM652 (estrogen receptor?antagonist), has anti-estrogenic and estrogenic activities. (Rac)-Acolbifene (EM-343; (Rac)-EM-652) contains a piperidine ring, shows good pharmacological profile,relative binding affinity (RBA)=380 .
    (Rac)-Acolbifene
  • HY-103451
    (R,R)-THC

    		Estrogen Receptor/ERR Metabolic Disease
    (R,R)-THC is an ERα agonist and an ERβ antagonist, with Kis of 9.0 nM and 3.6 nM for ERα and ERβ, respectively. (R,R)-THC has higher relative binding affinity for ERβ than ERα with the values of 25 and 3.6 .
    (R,R)-THC
  • HY-103451A
    rel-(R,R)-THC

    		Estrogen Receptor/ERR Metabolic Disease
    rel-(R,R)-THC is the relative configuration of (R,R)-THC (HY-103451). (R,R)-THC is an ERα agonist and an ERβ antagonist, with Kis of 9.0 nM and 3.6 nM for ERα and ERβ, respectively. (R,R)-THC has higher relative binding affinity for ERβ than ERα with the values of 25 and 3.6 .
    rel-(R,R)-THC
  • HY-168759
    11α-Hydroxytestosterone

    		Progesterone Receptor Drug Derivative Metabolic Disease Cancer
    11α-Hydroxytestosterone is a deriviative of Hydrocortisone (HY-N0583), with the relative binding affinity to progesterone receptor of 9% (comparing to R5020 (HY-119384) 100%). 11α-Hydroxytestosterone inhibits the growth and differentiation of human decidual cells in culture .
    11α-Hydroxytestosterone
  • HY-117953
    RU 59063

    		Prostaglandin Receptor Endocrinology
    RU 59063 is an N-substituted arylthiohydantoin compound with antiandrogenic activity and high relative binding affinity for the rat androgen receptor. RU 59063 is a nonsteroidal androgen receptor that functions as a radioactive AR radioprobe (Ki: 0.71 nM, rAR) when its trifluoromethyl group is replaced by a similar hydrophobic iodine atom .
    RU 59063
  • HY-131543
    22-Hydroxy mifepristone

    RU 42698

    		 Endogenous Metabolite Glucocorticoid Receptor Metabolic Disease
    22-Hydroxy Mifepristone (RU 42698) is an orally active hydroxylated alcoholic metabolite with antiprogestational and antiglucocorticoidal activities, which contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. The relative binding affinity of 22-Hydroxy Mifepristone to the human glucocorticoid receptor is 48% .
    22-Hydroxy mifepristone

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