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S. Typhimurium

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (1) Bacterial (5) Caspase (1) DNA/RNA Synthesis (2) Endogenous Metabolite (3) Fungal (1) Isotope-Labeled Compounds (1) Parasite (1) TNF Receptor (1) Toll-like Receptor (TLR) (3)
By Research Areas:	Cancer (3) Infection (8) Inflammation/Immunology (4) Metabolic Disease (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N5054

(R)-5,7-Dimethoxyflavanone	TNF Receptor	Inflammation/Immunology
(R)-5,7-Dimethoxyflavanone shows potent antimutagenic activity against MeIQ mutagenesis in Ames test using the S. typhimurium TA100 and TA98 strains . And (R)-5,7-Dimethoxyflavanone significantly and dose-dependently inhibits the inflammatory mediato .

HY-N8060A

Orotidine 5′-monophosphate trisodium Orotidine monophosphate trisodium; Orotidylic acid trisodium	Endogenous Metabolite DNA/RNA Synthesis	Metabolic Disease
Orotidine 5'-monophosphate trisodium is a pyrimidine nucleotide. Orotidine 5'-monophosphate trisodium is synthesized via the de novo synthesis pathway for DNA synthesis in a large number of microorganisms including M. tuberculosis, S. cerevisiae, S. typhimurium and P. falciparum to name a few. The synthesis of orotidine 5'-monophosphate trisodium uses phosphoribosyl pyrophosphate (PRPP) and orotic acid (OA) as the substrates catalyzed by orotate phosphoribosyltransferase (OPRT) .

HY-NP134

Flagellin from S. typhimurium	Toll-like Receptor (TLR)	Cancer
Flagellin from S. typhimurium is a potent TLR5 agonist. Flagellin activates immune cells and inhibits melanoma cells activity .

HY-D1056C3

Lipopolysaccharides, from S. enterica serotype typhimurium LPS, from Salmonella enterica (Serotype Typhimurium)	Toll-like Receptor (TLR)	Inflammation/Immunology
Lipopolysaccharides, from S. enterica serotype typhimurium, are a kind of lipid-polysaccharide endotoxin. Smooth Gram-negative bacteria's lipopolysaccharides are made up of three components: lipid A, core oligosaccharide, and O antigen (OAg). The O antigen is a polymer of sugar repeat units (RUs); the Wzz protein regulates the length of the O antigen in lipopolysaccharides, and the number of RUs attached to lipid A is determined by the modal value set by the Wzz protein. S. enterica typhimurium has two Wzz proteins: Wzz_ST (which makes the modal range of the O antigen between 16 and 35 RUs) and Wzz_fepE (which makes the modal value over 100 RUs). Mutating the genes corresponding to these two proteins causes the formation of short-chain O antigen chains and significantly reduces bacterial pathogenicity .

HY-P5016

CRAMP-18 (mouse)	Antibiotic Bacterial Fungal	Infection Cancer
CRAMP-18 (mouse) is an antibiotic peptide without hemolytic activity. CRAMP-18 (mouse) has good inhibitory activity against Gram-negative bacteria, such as S. typhimurium and P. aeruginosa. CRAMP-18 (mouse) has the potential to study antifungal, antibacterial and antitumor .

HY-P5565

RP-1	Bacterial	Infection
RP-1 is an antimicrobial peptide, and is active against S. aureus, S. typhimurium, E. coli, and C. albicans .

HY-120002

Proclonol Kilacar; R 8284	Parasite	Infection
Proclonol (Kilacar) is an insecticide-acaricide. Proclonol is a weak mutagen in the TA97 strain of S. typhimurium .

HY-N3616

trans-Coniferyl aldehyde	DNA/RNA Synthesis Endogenous Metabolite	Cancer
trans-Coniferyl aldehyde (compound 2) is a natural compound isolated from the buds of clove (Syzygium aromaticum).trans-Coniferyl aldehyde suppresses 63% of the UV mutable gene expression at 1.20 μM, and with an ID₅₀ value of 0.76 μM,and has the antimutagenic activities against furylfuramide, Trp-P-1, and activated Trp-P-1 .

HY-P5122

Z-LEED-FMK	Caspase	Inflammation/Immunology
Z-LEED-FMK is a caspase-13 and caspase-4 inhibitor. Z-LEED-FMK also inhibits caspase-1 processing in S. typhimurium-infected macrophages .

HY-N2980

Ocotillone Cabraleone	Bacterial	Infection
Ocotillone ((24S)-20,24-Epoxy-25-hydroxydammaran-3-one) is a triterpenoids that can be isolated from the fruits of Dysoxylum richii. Ocotillone has antibacterial activities against P. aeruginosa and S. typhimurium without hemolytic activity .

HY-W001189

1,3-Dithiane	Bacterial Endogenous Metabolite	Infection
1,3-Dithiane is a protected formaldehyde anion equivalent that could serve as a useful labeled synthon . 1,3-Dithiane is also a sulfur-containing Maillard reaction products (MRPs) found in boiled beef extracts. 1,3-Dithiane shows a potent direct-acting mutagenicity toward *S. typhimurium* TA98 and TA100** .

HY-D1056C1

Lipopolysaccharides, from S. enterica serotype enteritidis LPS, from Salmonella enterica (Serotype enteritidis)	Toll-like Receptor (TLR)	Inflammation/Immunology
Lipopolysaccharides, from S. enterica serotype enteritidis is a lipopolysaccharide endotoxin that causes gastrointestinal disease in humans and can be transmitted through contaminated eggs or foods based on eggs and poultry meat products. S. enterica serotype enteritidis is capable of producing high molecular weight LPS-O antigen chains, Lipopolysaccharides, from S. enterica serotype typhimurium (HY-D1056C3) did not. S. enterica serotype enteritidis is similar to other pathogenic Salmonella. Lipopolysaccharides, from S. enterica serotype enteritidis' O antigen is associated with phage attachment in the early stages of phage infection S. Enteritidis .

HY-W099540

OES2-0017	Others	Infection
OES2-0017 shows potent synergy with polyamines and growth-inhibitory effects at the low micromolar range. OES2-0017 inhibits spermine/spermidine acetyltransferase (SpeG) (IC₅₀: 34.82 μM ) and other polyamine detoxification enzymes in low concentrations, perturbed the bacterial membrane in higher concentrations .

HY-N8256

(–)-Mycousnine Mycousunin	Others	Infection
(–)-Mycousnine is a microbial metabolite and derivative of Usnic Acid (HY-N0656) originally isolated from M. nawae that has antibacterial and antifungal activities. It is active against the Gram-positive bacteria B. subtilis, K. rhizophila, and S. aureus (MICs=4, 8, and 4 g/ml, respectively) but not the Gram-negative bacteria E. coli, S. typhimurium, and K. pneumoniae (MICs=>128 g/ml for all).2 (–)-Mycousnine is also active against the fungi T. mentagrophytes, T. rubrum, and C. albicans (MICs=25, 25, and 100 μg/mL, respectively).

HY-W001189S

1,3-Dithiane-d2	Isotope-Labeled Compounds Bacterial	Infection
1,3-Dithiane-d2 is the deuterium labeled 1,3-Dithiane (HY-W001189). 1,3-Dithiane is a protected formaldehyde anion equivalent that could serve as a useful labeled synthon . 1,3-Dithiane is also a sulfur-containing Maillard reaction products (MRPs) found in boiled beef extracts. 1,3-Dithiane shows a potent direct-acting mutagenicity toward *S. typhimurium* TA98 and TA100** .

Cat. No.	Product Name	Type

HY-NP134

Flagellin from S. typhimurium	Native Proteins
Flagellin from S. typhimurium is a potent TLR5 agonist. Flagellin activates immune cells and inhibits melanoma cells activity .

HY-D1056C3

Lipopolysaccharides, from S. enterica serotype typhimurium LPS, from Salmonella enterica (Serotype Typhimurium)	Carbohydrates
Lipopolysaccharides, from S. enterica serotype typhimurium, are a kind of lipid-polysaccharide endotoxin. Smooth Gram-negative bacteria's lipopolysaccharides are made up of three components: lipid A, core oligosaccharide, and O antigen (OAg). The O antigen is a polymer of sugar repeat units (RUs); the Wzz protein regulates the length of the O antigen in lipopolysaccharides, and the number of RUs attached to lipid A is determined by the modal value set by the Wzz protein. S. enterica typhimurium has two Wzz proteins: Wzz_ST (which makes the modal range of the O antigen between 16 and 35 RUs) and Wzz_fepE (which makes the modal value over 100 RUs). Mutating the genes corresponding to these two proteins causes the formation of short-chain O antigen chains and significantly reduces bacterial pathogenicity .

Lipopolysaccharides, from S. enterica serotype typhimurium

LPS, from Salmonella enterica (Serotype Typhimurium)

Carbohydrates

Lipopolysaccharides, from S. enterica serotype typhimurium, are a kind of lipid-polysaccharide endotoxin. Smooth Gram-negative bacteria's lipopolysaccharides are made up of three components: lipid A, core oligosaccharide, and O antigen (OAg). The O antigen is a polymer of sugar repeat units (RUs); the Wzz protein regulates the length of the O antigen in lipopolysaccharides, and the number of RUs attached to lipid A is determined by the modal value set by the Wzz protein. S. enterica typhimurium has two Wzz proteins: Wzz_ST (which makes the modal range of the O antigen between 16 and 35 RUs) and Wzz_fepE (which makes the modal value over 100 RUs). Mutating the genes corresponding to these two proteins causes the formation of short-chain O antigen chains and significantly reduces bacterial pathogenicity .

HY-D1056C1

Lipopolysaccharides, from S. enterica serotype enteritidis LPS, from Salmonella enterica (Serotype enteritidis)	Carbohydrates
Lipopolysaccharides, from S. enterica serotype enteritidis is a lipopolysaccharide endotoxin that causes gastrointestinal disease in humans and can be transmitted through contaminated eggs or foods based on eggs and poultry meat products. S. enterica serotype enteritidis is capable of producing high molecular weight LPS-O antigen chains, Lipopolysaccharides, from S. enterica serotype typhimurium (HY-D1056C3) did not. S. enterica serotype enteritidis is similar to other pathogenic Salmonella. Lipopolysaccharides, from S. enterica serotype enteritidis' O antigen is associated with phage attachment in the early stages of phage infection S. Enteritidis .

Lipopolysaccharides, from S. enterica serotype enteritidis

LPS, from Salmonella enterica (Serotype enteritidis)

Carbohydrates

Lipopolysaccharides, from S. enterica serotype enteritidis is a lipopolysaccharide endotoxin that causes gastrointestinal disease in humans and can be transmitted through contaminated eggs or foods based on eggs and poultry meat products. S. enterica serotype enteritidis is capable of producing high molecular weight LPS-O antigen chains, Lipopolysaccharides, from S. enterica serotype typhimurium (HY-D1056C3) did not. S. enterica serotype enteritidis is similar to other pathogenic Salmonella. Lipopolysaccharides, from S. enterica serotype enteritidis' O antigen is associated with phage attachment in the early stages of phage infection S. Enteritidis .

Cat. No.	Product Name	Target	Research Area

HY-P5016

CRAMP-18 (mouse)	Antibiotic Bacterial Fungal	Infection Cancer
CRAMP-18 (mouse) is an antibiotic peptide without hemolytic activity. CRAMP-18 (mouse) has good inhibitory activity against Gram-negative bacteria, such as S. typhimurium and P. aeruginosa. CRAMP-18 (mouse) has the potential to study antifungal, antibacterial and antitumor .

HY-P5565

RP-1	Bacterial	Infection
RP-1 is an antimicrobial peptide, and is active against S. aureus, S. typhimurium, E. coli, and C. albicans .

HY-P5122

Z-LEED-FMK	Caspase	Inflammation/Immunology
Z-LEED-FMK is a caspase-13 and caspase-4 inhibitor. Z-LEED-FMK also inhibits caspase-1 processing in S. typhimurium-infected macrophages .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N5054

(R)-5,7-Dimethoxyflavanone	Structural Classification Flavonoids other families Classification of Application Fields Flavonones Source classification Plants Inflammation/Immunology Disease Research Fields	TNF Receptor
(R)-5,7-Dimethoxyflavanone shows potent antimutagenic activity against MeIQ mutagenesis in Ames test using the S. typhimurium TA100 and TA98 strains . And (R)-5,7-Dimethoxyflavanone significantly and dose-dependently inhibits the inflammatory mediato .

HY-N8060A

Orotidine 5′-monophosphate trisodium Orotidine monophosphate trisodium; Orotidylic acid trisodium	Alkaloids Structural Classification Classification of Application Fields Other Alkaloids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite DNA/RNA Synthesis
Orotidine 5'-monophosphate trisodium is a pyrimidine nucleotide. Orotidine 5'-monophosphate trisodium is synthesized via the de novo synthesis pathway for DNA synthesis in a large number of microorganisms including M. tuberculosis, S. cerevisiae, S. typhimurium and P. falciparum to name a few. The synthesis of orotidine 5'-monophosphate trisodium uses phosphoribosyl pyrophosphate (PRPP) and orotic acid (OA) as the substrates catalyzed by orotate phosphoribosyltransferase (OPRT) .

HY-W001189

1,3-Dithiane	Infection Structural Classification Natural Products Animals Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Bacterial Endogenous Metabolite
1,3-Dithiane is a protected formaldehyde anion equivalent that could serve as a useful labeled synthon . 1,3-Dithiane is also a sulfur-containing Maillard reaction products (MRPs) found in boiled beef extracts. 1,3-Dithiane shows a potent direct-acting mutagenicity toward *S. typhimurium* TA98 and TA100** .

HY-N3616

trans-Coniferyl aldehyde	Structural Classification Monophenols Simple Phenylpropanols Source classification Phenols Myrtaceae Syzygium aromaticum (L.) Merr. & L.M.Perry Phenylpropanoids Plants	DNA/RNA Synthesis Endogenous Metabolite
trans-Coniferyl aldehyde (compound 2) is a natural compound isolated from the buds of clove (Syzygium aromaticum).trans-Coniferyl aldehyde suppresses 63% of the UV mutable gene expression at 1.20 μM, and with an ID₅₀ value of 0.76 μM,and has the antimutagenic activities against furylfuramide, Trp-P-1, and activated Trp-P-1 .

HY-N2980

Ocotillone Cabraleone	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	Bacterial
Ocotillone ((24S)-20,24-Epoxy-25-hydroxydammaran-3-one) is a triterpenoids that can be isolated from the fruits of Dysoxylum richii. Ocotillone has antibacterial activities against P. aeruginosa and S. typhimurium without hemolytic activity .

Cat. No.	Product Name	Chemical Structure

HY-W001189S

1,3-Dithiane-d2
1,3-Dithiane-d2 is the deuterium labeled 1,3-Dithiane (HY-W001189). 1,3-Dithiane is a protected formaldehyde anion equivalent that could serve as a useful labeled synthon . 1,3-Dithiane is also a sulfur-containing Maillard reaction products (MRPs) found in boiled beef extracts. 1,3-Dithiane shows a potent direct-acting mutagenicity toward *S. typhimurium* TA98 and TA100** .

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S. Typhimurium

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

NaturalProducts

Isotope-Labeled Compounds

Natural
Products