Lipopolysaccharides, from S. enterica serotype typhimurium (Synonyms: LPS, from Salmonella enterica (Serotype typhimurium))

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Lipopolysaccharides, from S. enterica serotype typhimurium, are a kind of lipid-polysaccharide endotoxin. Smooth Gram-negative bacteria's lipopolysaccharides are made up of three components: lipid A, core oligosaccharide, and O antigen (OAg). The O antigen is a polymer of sugar repeat units (RUs); the Wzz protein regulates the length of the O antigen in lipopolysaccharides, and the number of RUs attached to lipid A is determined by the modal value set by the Wzz protein. S. enterica typhimurium has two Wzz proteins: Wzz_ST (which makes the modal range of the O antigen between 16 and 35 RUs) and Wzz_fepE (which makes the modal value over 100 RUs). Mutating the genes corresponding to these two proteins causes the formation of short-chain O antigen chains and significantly reduces bacterial pathogenicity.

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Lipopolysaccharides, from S. enterica serotype typhimurium Chemical Structure

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Other Forms of Lipopolysaccharides, from S. enterica serotype typhimurium:

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Description	Lipopolysaccharides, from S. enterica serotype typhimurium, are a kind of lipid-polysaccharide endotoxin. Smooth Gram-negative bacteria's lipopolysaccharides are made up of three components: lipid A, core oligosaccharide, and O antigen (OAg). The O antigen is a polymer of sugar repeat units (RUs); the Wzz protein regulates the length of the O antigen in lipopolysaccharides, and the number of RUs attached to lipid A is determined by the modal value set by the Wzz protein. S. enterica typhimurium has two Wzz proteins: Wzz_ST (which makes the modal range of the O antigen between 16 and 35 RUs) and Wzz_fepE (which makes the modal value over 100 RUs). Mutating the genes corresponding to these two proteins causes the formation of short-chain O antigen chains and significantly reduces bacterial pathogenicity^[1]^[2]^[3]^[4]^[5]^[6].
IC₅₀ & Target	TLR-4^[2]
SMILES	[Lipopolysaccharides, from S. enterica serotype typhimurium]
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (264 KB) Handling Instructions (2659 KB)
References	[1]. Kabanov DS, et al. Structural analysis of lipopolysaccharides from Gram-negative bacteria. Biochemistry (Mosc). 2010 Apr;75(4):383-404. [Content Brief] [2]. Cai KC, et al. Age and sex differences in immune response following LPS treatment in mice. Brain Behav Immun. 2016 Nov;58:327-337. [Content Brief] [3]. Heinrichs DE, et al. Molecular basis for structural diversity in the core regions of the lipopolysaccharides of Escherichia coli and Salmonella enterica. Mol Microbiol. 1998 Oct;30(2):221-32. [Content Brief] [4]. Ying Liu, et al. Podocyte-Released Migrasomes in Urine Serve as an Indicator for Early Podocyte Injury. Kidney Dis (Basel). 2020 Nov;6(6):422-433. [Content Brief] [5]. Guard-Bouldin J,et al. Subpopulation characteristics of egg-contaminating Salmonella enterica serovar Enteritidis as defined by the lipopolysaccharide O chain[J]. Applied and environmental microbiology, 2004, 70(5): 2756-2763. [6]. Murray G L, et al. Altering the length of the lipopolysaccharide O antigen has an impact on the interaction of Salmonella enterica serovar Typhimurium with macrophages and complement[J]. Journal of bacteriology, 2006, 188(7): 2735-2739.

Lipopolysaccharides, from S. enterica serotype typhimurium Related Classifications

Inflammation/Immunology

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lipopolysaccharides, from S. enterica serotype typhimuriumLPS, from Salmonella enterica (Serotype typhimurium)Toll-like Receptor (TLR)Inhibitorinhibitorinhibit

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