2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. Lipopolysaccharides, from S. enterica serotype typhimurium

Lipopolysaccharides, from S. enterica serotype typhimurium  (Synonyms: LPS, from Salmonella enterica (Serotype typhimurium))

Cat. No.: HY-D1056C3
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Lipopolysaccharides, from S. enterica (Salmonella enterica) serotype typhimurium are lipopolysaccharide endotoxins and TLR4 activators derived from serotype typhimurium of Salmonella enterica, and are classified as S-type LPS. Lipopolysaccharides, from S. enterica exhibit a typical three-part structure: O-antigen, core oligosaccharide, and lipid A. Lipopolysaccharides, from S. enterica serotype typhimurium can modulate the fate of bacteria in dendritic cells (DC), determining the uptake, degradation, and activation of immune functions by DC cells against the bacteria.

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Lipopolysaccharides, from S. enterica serotype typhimurium Chemical Structure

Lipopolysaccharides, from S. enterica serotype typhimurium Chemical Structure

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Lipopolysaccharides, from S. enterica serotype typhimurium Related Antibodies

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Description

Lipopolysaccharides, from S. enterica (Salmonella enterica) serotype typhimurium are lipopolysaccharide endotoxins and TLR4 activators derived from serotype typhimurium of Salmonella enterica, and are classified as S-type LPS. Lipopolysaccharides, from S. enterica exhibit a typical three-part structure: O-antigen, core oligosaccharide, and lipid A. Lipopolysaccharides, from S. enterica serotype typhimurium can modulate the fate of bacteria in dendritic cells (DC), determining the uptake, degradation, and activation of immune functions by DC cells against the bacteria[1][2][3][4].

IC50 & Target

TLR-4[2]
In Vitro

Note:
To maintain the integrity of LPS, it is recommended to store LPS solution in silanized containers. This is because LPS can adhere to plastics and certain types of glass, particularly at concentrations below 0.1 mg/mL. If the LPS concentration exceeds 1 mg/mL, this adsorption effect is relatively minimal. If using glass containers, ensure that the solution is thoroughly mixed for at least 30 minutes before use to redissolve any LPS that may have adsorbed to the tube walls.

Lipopolysaccharides, from S. enterica serotype typhimurium are lipopolysaccharides distinct from those secreted by common Salmonella species. The LPS of common Salmonella species has only one wild-type core oligosaccharide structure (the Ra core in serotype Typhimurium), whereas Lipopolysaccharides, from S. enterica serotype typhimurium differ from the Ra core in a single terminal branch of the outer core, which may determine different immunogenicity[1]. S. enterica serotype typhimurium possesses two Wzz proteins: WzzST (which sets the modal range of O-antigen to 16–35 repeat units[RU]) and WzzfepE (which sets the modal value above 100 RU) (RU: sugar repeat units). The Wzz proteins regulate the length of the O-antigen in Lipopolysaccharides, and the number of RUs attached to lipid A is determined by the modal value set by the Wzz proteins. Mutations in the corresponding protein-coding genes lead to the formation of short-chain O-antigens and significantly reduce bacterial pathogenicity[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lipopolysaccharides, from S. enterica serotype typhimurium Related Antibodies
Appearance

Solid

Color

White to off-white

SMILES

[Lipopolysaccharides, from S. enterica serotype typhimurium]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation
References
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Lipopolysaccharides, from S. enterica serotype typhimurium Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lipopolysaccharides, from S. enterica serotype typhimuriumLPS, from Salmonella enterica (Serotype typhimurium)Toll-like Receptor (TLR)Inhibitorinhibitorinhibit

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