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SF3B1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	SF3B1 (4) Apoptosis (4) Bcl-2 Family (1) Ceramidase (1) Cuproptosis (1) DYRK (1) LPL Receptor (1) PROTACs (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (5) Neurological Disease (2)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Targets Recommended: SF3B1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

PROTAC-O4I2	PROTACs Apoptosis SF3B1	Cancer
PROTAC-O4I2 is a PROTAC targets splicing factor 3B1 (SF3B1). PROTAC-O4I2 induces FLAG-SF3B1 degradation with an IC₅₀ value of 0.244 μM in K562 cells. PROTAC-O4I2 also induces cellular apoptosis in K562 WT cells .

Pladienolide B	Apoptosis SF3B1	Cancer
Pladienolide B is a potent cancer cell growth inhibitor that targets the *SF3B1* subunit of the spliceosome. Pladienolide B exerts antitumor activities mediated through the inhibition of pre-mRNA splicing. Pladienolide B induces apoptosis .

Spliceostatin A	SF3B1	Cancer
Spliceostatin A, the FR901464 (HY-16212) methylated derivative, is a potent anti-tumor agent. Spliceostatin A inhibits splicing and promotes pre-mRNA accumulation by binding *SF3B1. SF3B1* is a subcomplex of U2 small nuclear ribonucleoprotein in the spliceosome. Spliceostatin A induces Apoptosis in chronic lymphocytic leukemia (CLL) cells .

UM4118	Cuproptosis	Cancer
UM4118 is a copper ionophore that can initiate a mitochondrial-based noncanonical form of cell death known as cuproptosis. UM4118 exhibits high sensitivity in SF3B1-mutated and adverse risk acute myeloid leukemia (AML), and can be used for AML research .

H3B-8800	Apoptosis SF3B1	Cancer
H3B-8800 is a potent and orally active SF3B splicing modulator. H3B-8800 direct interaction with the SF3b complex and shows anti-cancer activity. H3B-8800 has the potential for the research of acute myeloid leukemia (AML) with SF3B1 mutant .

Dyrk1A-IN-5	DYRK	Neurological Disease
Dyrk1A-IN-5 (compound 5j) is a potent and selective DYRK1A inhibitor, with an IC₅₀ of 6 nM. Dyrk1A-IN-5 dose-dependently reduces the phosphorylation of Thr434 in SF3B1, with an IC₅₀ of 0.5 μM. Dyrk1A-IN-5 inhibits phosphorylation of tau at Thr212, with an IC₅₀ of 2.1 μM. Dyrk1A-IN-5 can be used for Down syndrome research .

SF3B1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SF3B1 Human Pre-designed siRNA Set A contains three designed siRNAs for SF3B1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SF3B1 Human Pre-designed siRNA Set A SF3B1 Human Pre-designed siRNA Set A

SACLAC	Ceramidase Bcl-2 Family LPL Receptor Apoptosis	Neurological Disease
SACLAC, a Ceramide analog, is a potent and covalent acid ceramidase (ASAH1; AC) inhibitor with a K_i of 97.1 nM. SACLAC effectively blocks AC activity and induces a decrease in sphingosine 1-phosphate (S1P) and total ceramide levels. SACLAC reduces the levels of splicing factor SF3B1 and alternative Mcl-1 mRNA splicing, increases pro-apoptotic Mcl-1S levels to induce apoptosis in acute myeloid leukemia (AML) cells. SACLAC reduces the leukemic burden in human AML xenograft mouse models .

Cat. No.	Compare	Product Name	Application	Reactivity

	SF3B1 Antibody (YA2256) SF3B1; SAP155; Splicing factor 3B subunit 1; Pre-mRNA-splicing factor SF3b 155 kDa subunit; SF3B155; Spliceosome-associated protein 155; SAP 155	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	SF3B1 Antibody (YA2256) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2256), targeting SF3B1, with a predicted molecular weight of 146 kDa (observed band size: 155 kDa). SF3B1 Antibody (YA2256) can be used for WB, IHC-P, ICC/IF, FC experiment in human, mouse, rat background.

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SF3B1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
SF3B1 Human Pre-designed siRNA Set A contains three designed siRNAs for SF3B1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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