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Isoforms Recommended:	SGK3

Results for "

SGK3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Autophagy (2) JNK (1) PI3K (1) PROTAC Linkers (4) PROTACs (1) ROCK (1) SGK (3) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (8) Inflammation/Immunology (1) Neurological Disease (1)
Oligonucleotides:	Pre-designed siRNA Sets (3) siRNAs (3)

Inhibitors & Agonists

Recombinant Proteins

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-125878

*PROTAC SGK3* degrader-1** 3 Publications Verification SGK3-PROTAC1	PROTACs SGK	Cancer
PROTAC SGK3 degrader-1 (SGK3-PROTAC1) is a von Hippel-Lindau ligand-based SKG3 PROTAC composed of a PEG3-C4-OBn (HY-130620) alkyl linker, an SGK3 degrader (red structure), and a VHL ligand (HY-150803, blue structure). PROTAC SGK3 degrader-1 (0.3 μM) induced 50% endogenous SGK3 degradation within 2 hours, and 80% SGK3 degradation was observed at 8 hours, accompanied by loss of phosphorylation of NDRG1 (SGK3 substrate) .

HY-130620

PEG3-C4-OBn	PROTAC Linkers	Cancer
PEG3-C4-OBn is a polyethylene glycol (PEG)-based PROTAC linker. PEG3-C4-OBn can be used in the synthesis of the PROTAC SGK3 degrader-1 (HY-125878). PROTAC SGK3 degrader-1 is a potent SKG3 degrader based on PROTAC .

HY-130621

OTs-C6-OBn	PROTAC Linkers	Cancer
OTs-C6-OBn is an alkyl chain-based PROTAC linker can be used in the synthesis of PROTAC SGK3 degrader-1 (HY-125878) .

HY-12795

Vps34-IN-1 Maximum Cited Publications 7 Publications Verification	PI3K Autophagy	Cancer
Vps34-IN-1 is a potent and selective inhibitor of class III Vps34 PI3K. Vps34-IN-1 inhibits phosphorylation of PtdIns by recombinant insect cell expressed Vps34-Vps15 complex with an IC₅₀ of ~25 nM. Vps34-IN-1 can suppress SGK3 activation by reducing PtdIns(3)P levels via lowering phosphorylation of T-loop and hydrophobic motifs. Vps34-IN-1 modulates autophagy ^[3].

HY-145752

HaloPROTAC-E 1 Publications Verification	SGK Autophagy	Cancer
HaloPROTAC-E is a novel HaloPROTAC potent degrader, inducing reversible degradation of two endosomally localized proteins, *SGK3* and VPS34, with a DC₅₀ of 3-10 nM, remarkably selective inducing only degradation of the Halo tagged endogenous VPS34 complex (VPS34, VPS15, Beclin1, and ATG14).

HY-130619

Boc-C1-PEG3-C4-OBn	PROTAC Linkers	Cancer
Boc-C1-PEG3-C4-OBn (PROTAC Linker 15) is a PROTAC linker, which refers to the PEG composition. Boc-C1-PEG3-C4-OBn can be used in the synthesis of a series of PROTACs, such as PROTAC SGK3 degrader-1 (HY-125878). PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins .

HY-RS12802

SGK3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SGK3 Human Pre-designed siRNA Set A contains three designed siRNAs for SGK3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SGK3 Human Pre-designed siRNA Set A SGK3 Human Pre-designed siRNA Set A

HY-RS12803

Sgk3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sgk3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sgk3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sgk3 Mouse Pre-designed siRNA Set A Sgk3 Mouse Pre-designed siRNA Set A

HY-RS12804

SGK3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SGK3 Rat Pre-designed siRNA Set A contains three designed siRNAs for SGK3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

SGK3 Rat Pre-designed siRNA Set A SGK3 Rat Pre-designed siRNA Set A

HY-130770

Ald-CH2-PEG3-CH2-Boc	PROTAC Linkers	Cancer
Ald-CH2-PEG3-CH2-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of SGK3 kinase PROTAC degrader .

HY-167832

PT109	JNK SGK ROCK	Neurological Disease Inflammation/Immunology Cancer
PT109 is a multi-kinase inhibitor. PT109 inhibits JNK (JNK1: IC₅₀=0.143 μM; JNK2: IC₅₀=0.831 μM; *JNK3: IC₅₀=0.285 μM) or other kinases (SGK1:* IC₅₀=1.34 μM; *SGK2: IC₅₀=5.6 μM; SGK3: IC₅₀=26.4 μM; ROCK2: IC₅₀=34 μM) and plays an important role in anti-inflammation, anti-oxidation, neurogenesis, synaptogenesis, etc. In addition, PT109 also reprograms glioblastoma multiforme (GBM) into oligodendrocytes through the PTBP1/PKM1/2* pathway and changes the metabolic pattern of GBM, exerting anti-glioma activity .

Recombinant Proteins Recommended:

Cytokine-independent Survival Kinase (SGK3)

Species:	Human (2)
Tag:	GST (2)
Source:	Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P76063

	SGK3 Protein, Human (sf9, GST) Serine/threonine-protein kinase SGK3; Cytokine-independent survival kinase; SGK3; CISK; SGKL	Human	Sf9 insect cells
	The SGK3 protein is an important serine/threonine protein kinase that complexly controls diverse ion channels, transporters, and key cellular processes, affecting growth, proliferation, survival, and migration. SGK3 exhibits multiple effects by upregulating channels such as Na(+), K(+), epithelial Ca(2+), chloride, and transporters such as creatine. SGK3 Protein, Human (sf9, GST) is the recombinant human-derived SGK3 protein, expressed by Sf9 insect cells , with GST tag.

HY-P703019

	SGK3 Protein, Human (Unactive, sf9, GST) CISK; SGKL	Human	Sf9 insect cells
	The SGK3 protein is an important serine/threonine protein kinase that complexly controls diverse ion channels, transporters, and key cellular processes, affecting growth, proliferation, survival, and migration. SGK3 exhibits multiple effects by upregulating channels such as Na(+), K(+), epithelial Ca(2+), chloride, and transporters such as creatine. SGK3 Protein, Human (Unactive, sf9, GST) is the recombinant human-derived SGK3, expressed by Sf9 insect cells , with GST labeled tag. ,

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SGK3 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
SGK3 Human Pre-designed siRNA Set A contains three designed siRNAs for SGK3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sgk3 Mouse Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Sgk3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sgk3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

SGK3 Rat Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
SGK3 Rat Pre-designed siRNA Set A contains three designed siRNAs for SGK3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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