STAT6

Isoforms Recommended:	STAT6

By Targets:	CCR (1) COX (1) Cytochrome P450 (1) HSP (1) Interleukin Related (3) JAK (1) Ligands for Target Protein for PROTAC (1) NF-κB (1) PROTACs (1) Small Interfering RNA (siRNA) (3) STAT (15) TGF-beta/Smad (2)
By Research Areas:	Cancer (7) Endocrinology (1) Inflammation/Immunology (15)
Oligonucleotides:	Pre-designed siRNA Sets (3) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-153991

STAT6-IN-2	STAT	Inflammation/Immunology
STAT6-IN-2 (Comp R-84) is an inhibitor of *STAT6. STAT6-IN-2 inhibits the secretion of chemokine eliciting eosinophil infiltration eotaxin-3. STAT6*-IN-2 can be used for immune disease research .

HY-153992

STAT6-IN-3	STAT	Inflammation/Immunology
STAT6-IN-3 (Compound 18a) is a *STAT6* inhibitor (IC₅₀= 44 nM). STAT6-IN-3 targets the Src Homology 2 (SH2) domain of STAT6. STAT6-IN-3 can be used for research of inflammation such as asthma .

HY-158398

STAT6-IN-4	STAT	Inflammation/Immunology
STAT6-IN-4 (78) is a *STAT6* inhibitor, with an IC₅₀ of 0.34 μM .

HY-148096

STAT6-IN-1	STAT	Inflammation/Immunology Cancer
STAT6-IN-1 (Compound 19a) is a *STAT6* inhibitor with a high affinity for the SH2 domain of *STAT6* (IC₅₀=0.028 µM). STAT6-IN-1 can be used in studies of allergic lung disease, allergic rhinitis, chronic obstructive pulmonary disease or cancer .

HY-RS13896

STAT6 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
STAT6 Human Pre-designed siRNA Set A contains three designed siRNAs for STAT6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

STAT6 Human Pre-designed siRNA Set A STAT6 Human Pre-designed siRNA Set A

HY-RS13897

Stat6 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Stat6 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Stat6 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Stat6 Mouse Pre-designed siRNA Set A Stat6 Mouse Pre-designed siRNA Set A

HY-RS13898

Stat6 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Stat6 Rat Pre-designed siRNA Set A contains three designed siRNAs for Stat6 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Stat6 Rat Pre-designed siRNA Set A Stat6 Rat Pre-designed siRNA Set A

HY-158399

STAT6-IN-5	STAT	Inflammation/Immunology
STAT6-IN-5 (84) is a *STAT6* inhibitor, with an IC₅₀ of 0.24 μM .

HY-169179

AK-1690	PROTACs STAT	Cancer
AK-1690 is a potent and selective STAT6 PROTAC degrader. AK-1690 reduces the levels of STAT6 protein in cells (DC₅₀=1 nM) and depletes STAT6 protein in mouse tissues. AK-1690 can be used for the research of cancer. (Pink: ligand for target protein STAT6 (HY-169182); Black: linker (HY-W459522); Blue: ligand for E3 ligase (HY-131318) .

HY-169182

AK-068	Ligands for Target Protein for PROTAC	Cancer
AK-068 is a *STAT6* ligand, with a K_i of 6 nM and at least >85-fold binding selectivity over STAT5. AK-068 is a ligand for target protein (STAT6) for PROTAC (HY-169179) .

HY-148092

PM-43I	STAT	Inflammation/Immunology Cancer
PM-43I is a potent *STAT6* inhibitor and can reduce STAT6 phosphorylation level. PM-43I can be used in allergic lung disease, allergic rhinitis, chronic pulmonary obstructive disease and cancer research ^[1].

HY-100614

AS1517499 Maximum Cited Publications 29 Publications Verification	STAT	Inflammation/Immunology Cancer
AS1517499 is a potent and brain-permeable *STAT6* phosphorylation inhibitor with an IC₅₀ of 21 nM.

HY-148093

PM-81I	STAT	Inflammation/Immunology Cancer
PM-81I is a potent *STAT6* inhibitor (targeting the SH2 structural domain) that effectively reduces *STAT6* phosphorylation levels. PM-81I can be used in studies of allergic lung disease, allergic rhinitis, chronic obstructive pulmonary disease or cancer ^[1].

HY-P990090

Rademikibart CBP-201	Interleukin Related	Inflammation/Immunology
Rademikibart (CBP-201) is a human monoclonal antibody targeting IL-4Rα with a KD of 20.7 pM when binding to human IL-4Rα epitopes. Rademikibart does not bind to IL-4Rα from other species. Rademikibart inhibits IL-4 and IL-13-mediated STAT6 signaling, TF-1 cell proliferation and TARC production in PBMCs. Rademikibart has the potential for moderate-to-severe Th2 inflammatory diseases research .

HY-162404

Smad2/3-IN-2	STAT TGF-beta/Smad Interleukin Related	Inflammation/Immunology
Smad2/3-IN-2 (Compound 3) is an inhibitor for TGF-β-dependent Smad2/3 and IL-4-dependent STAT6 signaling pathway, with IC₅₀s of 90 and 20 nM, respectively .

HY-162405

Smad2/3-IN-1	STAT TGF-beta/Smad Interleukin Related	Inflammation/Immunology
Smad2/3-IN-2 (Compound 27) is an inhibitor for TGF-β-dependent Smad2/3 and IL-4-dependent STAT6 signaling pathway, with IC₅₀s of 90 and 20 nM, respectively .

HY-134772

AS1810722	STAT Cytochrome P450	Inflammation/Immunology
AS1810722 is an orally active and potent *STAT6* inhibitor with an IC₅₀ of 1.9 nM. AS1810722 shows a good profile of CYP3A4 inhibition. AS1810722, a derivative of fused bicyclic pyrimidine, has the potential for allergic diseases such as asthma and atopic diseases research .

HY-161765

iHSP110-33	HSP STAT	Cancer
iHSP110-33 is an inhibitor for heat shock protein 110 (HSP110). iHSP110-33 exhibits antitumor efficacy agaisnt large B-cell lymphoma and classical Hodgkin lymphoma. iHSP110-33 shows a synergistic effect with Selinexor (HY-17536), inhibits the STAT6 phosphorylation, and enhances its antitumor activity. .

HY-134771

YM-341619 1 Publications Verification AS1617612	STAT	Inflammation/Immunology
YM-341619 (AS1617612) is a potent and orally active *STAT6* inhibitor with an IC₅₀ of 0.70 nM. YM-341619 inhibits Th2 differentiation in mouse spleen T cells induced by IL-4 (IC₅₀=0.28 nM) without affecting Th1 cell differentiation . YM-341619 is a promising compound for the the research of allergic diseases, such as allergic asthma .

HY-125019

iJak-381	JAK STAT	Inflammation/Immunology
iJak-381 is a JAK1/2 inhibitor with anti-inflammatory activity. iJak-381 blocks IL-13 signaling and also inhibits IL-4 and *IL-6* signaling pathways. iJak-381 also reduced p-STAT6 levels and inhibited the influx of inflammatory cells into the lungs of mice. iJak-381 inhibits airway hyperresponsiveness (AHR) .

HY-167692

JI069	Others	Others
JI069 is a novel JAK-STAT inhibitor that demonstrates potent activity in suppressing Th1, Th2, and Th17 differentiation while promoting iTreg differentiation. JI069 effectively inhibits STAT3 activation as well as the activation of other STATs, including STAT1, STAT5, and STAT6. JI069 has shown significant therapeutic potential in alleviating symptoms of collagen-induced arthritis in mice while inhibiting cytokine production from T cells and the phosphorylation of STAT3 in synovial cells.

HY-N2609

7,4'-Dihydroxyflavone 1 Publications Verification	COX CCR NF-κB	Inflammation/Immunology Endocrinology
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor (IC₅₀=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production . 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC₅₀ value of 1.4 µM .

Cat. No.	Product Name

HY-L008

*JAK/STAT* Compound Library**	471 compounds
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is central to signaling by cytokine receptors, a superfamily of more than 30 transmembrane proteins that recognize specific cytokines, and is critical in blood formation and immune response. Canonical JAK/STAT signaling begins with the association of cytokines and their corresponding transmembrane receptors. Activated JAKs then phosphorylate latent STAT monomers, leading to dimerization, nuclear translocation, and DNA binding. In mammals, there are four JAKs (JAK1, JAK2, JAK3, TYK2) and seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6). Since the JAK/STAT pathway plays a major role in many fundamental processes, such as apoptosis and inflammation, dysfunctional proteins in the pathway may lead to a number of diseases. For example, alterations in JAK/STAT signalling can result in cancer and diseases affecting the immune system, such as severe combined immunodeficiency disorder (SCID). MCE provides 471 compounds that can be used in the study of the JAK/STAT signaling pathway and related diseases.

JAK/STAT Compound Library

471 compounds

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is central to signaling by cytokine receptors, a superfamily of more than 30 transmembrane proteins that recognize specific cytokines, and is critical in blood formation and immune response. Canonical JAK/STAT signaling begins with the association of cytokines and their corresponding transmembrane receptors. Activated JAKs then phosphorylate latent STAT monomers, leading to dimerization, nuclear translocation, and DNA binding. In mammals, there are four JAKs (JAK1, JAK2, JAK3, TYK2) and seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6). Since the JAK/STAT pathway plays a major role in many fundamental processes, such as apoptosis and inflammation, dysfunctional proteins in the pathway may lead to a number of diseases. For example, alterations in JAK/STAT signalling can result in cancer and diseases affecting the immune system, such as severe combined immunodeficiency disorder (SCID).

MCE provides 471 compounds that can be used in the study of the JAK/STAT signaling pathway and related diseases.

Cat. No.	Product Name	Target	Research Area

HY-P990090

Rademikibart CBP-201	Interleukin Related	Inflammation/Immunology
Rademikibart (CBP-201) is a human monoclonal antibody targeting IL-4Rα with a KD of 20.7 pM when binding to human IL-4Rα epitopes. Rademikibart does not bind to IL-4Rα from other species. Rademikibart inhibits IL-4 and IL-13-mediated STAT6 signaling, TF-1 cell proliferation and TARC production in PBMCs. Rademikibart has the potential for moderate-to-severe Th2 inflammatory diseases research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2609

7,4'-Dihydroxyflavone 1 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Flavones Leguminosae Source classification Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch. Disease Research Fields Endocrinology	COX CCR NF-κB
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor (IC₅₀=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production . 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC₅₀ value of 1.4 µM .

Species:	Human (4)
Tag:	His (4) Strep (1)
Source:	Sf9 insect cells (1) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P71337

	STAT6 Protein, Human (His) Signal Transducer and Activator of Transcription 6; IL-4 STAT; STAT6	Human	E. coli
	STAT6 is a multifunctional protein that performs dual functions of signal transduction and transcriptional activation. It plays a crucial role in mediating IL4/interleukin-4 and IL3/interleukin-3 induced signaling cascades. STAT6 Protein, Human (His) is the recombinant human-derived STAT6 protein, expressed by E. coli , with C-6*His labeled tag. The total length of STAT6 Protein, Human (His) is 211 a.a., with molecular weight of ~30.0 kDa.

HY-P702835A

	STAT6 Protein, Human (536a.a, His) Signal Transducer and Activator of Transcription 6; IL-4 STAT; STAT6	Human	E. coli
	STAT6 is a multifunctional protein that performs dual functions of signal transduction and transcriptional activation. It plays a crucial role in mediating IL4/interleukin-4 and IL3/interleukin-3 induced signaling cascades. STAT6 Protein, Human (536a.a, His) is the recombinant human-derived STAT6 protein, expressed by E. coli , with N-His labeled tag.

HY-P703579

	STAT6 Protein, Human (sf9, His, Strep) Signal Transducer and Activator of Transcription 6; IL-4 STAT; STAT6	Human	Sf9 insect cells
	STAT6 is a multifunctional protein that performs dual functions of signal transduction and transcriptional activation. It plays a crucial role in mediating IL4/interleukin-4 and IL3/interleukin-3 induced signaling cascades. STAT6 Protein, Human (sf9, His, Strep) is the recombinant human-derived STAT6 protein, expressed by Sf9 insect cells , with C-His; C-Strep labeled tag.

HY-P702835

	STAT6 Protein, Human (Phosphorylated, 536a.a, His) Signal Transducer and Activator of Transcription 6; IL-4 STAT; STAT6	Human	E. coli
	STAT6 is a multifunctional protein that performs dual functions of signal transduction and transcriptional activation. It plays a crucial role in mediating IL4/interleukin-4 and IL3/interleukin-3 induced signaling cascades. STAT6 Protein, Human (Phosphorylated, 536a.a, His) is the recombinant human-derived STAT6 protein, expressed by E. coli , with N-His labeled tag.

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HY-P80347

	STAT6 Antibody 12S1644 antibody; D12S1644 antibody; IL 4 STAT antibody; IL-4 STAT antibody; IL4 STAT antibody; Interleukin 4 Induced antibody; Interleukin 4 Induced Transcription Factor IL4 STAT antibody; Signal transducer and activator of transcription 6 antibody; Signal Transducer And Activator Of Transcription 6 Interleukin 4 Induced antibody; Signal Transducer And Activator Of Transcription 6 Nirs Variant 1 antibody; Signal transducer and activator of transcription 6, interleukin 4 induced antibody; STAT 6 antibody; STAT interleukin4 induced antibody; STAT, interleukin4 induced antibody; STAT6 antibody; STAT6_HUMAN antibody; STAT6B antibody; STAT6C antibody; Transcription factor IL 4 STAT antibody;	WB, ICC/IF, IHC-P, IP	Human, Mouse
	STAT6 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 94 kDa, targeting to STAT6. It can be used for WB,ICC/IF,IHC-P,IP assays with tag free, in the background of Human, Mouse.

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Cat. No.	Product Name		Classification

HY-RS13896

STAT6 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
STAT6 Human Pre-designed siRNA Set A contains three designed siRNAs for STAT6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS13897

Stat6 Mouse Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Stat6 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Stat6 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS13898

Stat6 Rat Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Stat6 Rat Pre-designed siRNA Set A contains three designed siRNAs for Stat6 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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