Sec61

By Targets:	Sec61 (1) Apoptosis (2) HIV (1) p97 (1) SARS-CoV (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (5) Infection (2) Inflammation/Immunology (1)
Oligonucleotides:	Human Pre-designed siRNA Sets (3) siRNAs (3)

Targets Recommended: Sec61

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-139615

Sec61-IN-1	Sec61	Cancer
Sec61-IN-1 is a potent *sec61* inhibitor (Patent WO2020176863A1, compound A317) .

HY-139616

Sec61-IN-2	Others	Others
Sec61-IN-2 (A347) is a protein secretion inhibitor (extracted from patent WO2020176863) .

HY-139617

Sec61-IN-3	Others	Others
Sec61-IN-2 (A3) is a protein secretion inhibitor (extracted from patent WO2020176863) .

HY-110078

Eeyarestatin I 5 Publications Verification	p97 Apoptosis	Cancer
Eeyarestatin I, a potent endoplasmic reticulum-associated protein degradation (ERAD) inhibitor, is a potent protein translocation inhibitor. Eeyarestatin I inhibits *Sec61* translocon. Eeyarestatin I targets the p97-associated deubiquitinating process (PAD) and inhibits atx3-dependent deubiquitination. Eeyarestatin I interferes at a step prior to proteasomal degradation. Eeyarestatin I induces cell death via the proapoptotic protein NOXA and has anticancer effects .

HY-156355

Sec61-IN-5	Others	Cancer
Sec61-IN-5 (Compound 16c) is a *Sec61* inhibitor. Sec61 shows cytotoxicity in A549 cells (IC₅₀: 0.27 nM). Sec61-IN-5 inhibits Sec61-dependent secretory function (IC₅₀: 0.08 nM) .

HY-156349

Sec61-IN-4	Apoptosis	Others
Sec61-IN-4 (Compound 16b) is a *Sec61* inhibitor (IC₅₀: 0.04 nM in U87-MG cells) .

HY-RS12623

SEC61G Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SEC61G Human Pre-designed siRNA Set A contains three designed siRNAs for SEC61G gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SEC61G Human Pre-designed siRNA Set A SEC61G Human Pre-designed siRNA Set A

HY-RS12622

SEC61B Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SEC61B Human Pre-designed siRNA Set A contains three designed siRNAs for SEC61B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SEC61B Human Pre-designed siRNA Set A SEC61B Human Pre-designed siRNA Set A

HY-RS12621

SEC61A1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SEC61A1 Human Pre-designed siRNA Set A contains three designed siRNAs for SEC61A1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SEC61A1 Human Pre-designed siRNA Set A SEC61A1 Human Pre-designed siRNA Set A

HY-N10661

Ipomoeassin F Ipom-F	SARS-CoV	Infection Cancer
Ipomoeassin F is a potent and selective endoplasmic reticulum (ER) protein-translocation inhibitor by targeting the pore-forming subunit of the Sec61 complex (Sec61α) at the ER membrane. Ipomoeassin F selectively inhibits the ER membrane translocation of SARS-CoV-2 proteins. Ipomoeassin F block the ER translocation of secretory proteins and type I transmembrane proteins (TMPs), but not type III TMPs .

HY-134809

Cyclotriazadisulfonamide CADA	HIV	Infection Inflammation/Immunology
Cyclotriazadisulfonamide (CADA) is a specific CD4-targeted HIV entry inhibitors. Cyclotriazadisulfonamide (CADA) inhibits the co-translational translocation of human CD4 (huCD4) into the ER lumen in a signal peptide (SP)-dependent way. Cyclotriazadisulfonamide is also a *Sec61* translocon inhibitor .

Cat. No.	Product Name	Target	Research Area

HY-P10477

CT-08	Peptides	Cancer
CT-08 (CT8, Compound 3) is a macrocyclic Sec61 modulator, blocks protein secretion in a signal sequence-dependent manner. CT-08 blocks Sec61-mediated translocation of VCAMss-GLuc into the ER, resulting in a loss of luciferase activity. CT-08 inhibits VCAM expression in transfected cells .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N10661

Ipomoeassin F Ipom-F	Structural Classification Natural Products Ipomoea squamosa Choisy Plants Convolvulaceae	SARS-CoV
Ipomoeassin F is a potent and selective endoplasmic reticulum (ER) protein-translocation inhibitor by targeting the pore-forming subunit of the Sec61 complex (Sec61α) at the ER membrane. Ipomoeassin F selectively inhibits the ER membrane translocation of SARS-CoV-2 proteins. Ipomoeassin F block the ER translocation of secretory proteins and type I transmembrane proteins (TMPs), but not type III TMPs .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82080

	SEC61A Antibody (YA1825) fb62c11; HSec61; Sec 61; Sec 61A; Sec61 alpha 1; Sec61; Sec61A1	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	SEC61A Antibody (YA1825) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1825), targeting SEC61A, with a predicted molecular weight of 52 kDa (observed band size: 48 kDa). SEC61A Antibody (YA1825) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human, mouse, rat background.

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Cat. No.	Product Name		Classification

HY-RS12623

SEC61G Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
SEC61G Human Pre-designed siRNA Set A contains three designed siRNAs for SEC61G gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS12622

SEC61B Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
SEC61B Human Pre-designed siRNA Set A contains three designed siRNAs for SEC61B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS12621

SEC61A1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
SEC61A1 Human Pre-designed siRNA Set A contains three designed siRNAs for SEC61A1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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