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Sodium/hydrogen Exchanger

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Na+/H+ Exchanger (NHE) (10) Biochemical Assay Reagents (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (7) Metabolic Disease (2) Neurological Disease (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Targets Recommended: Na+/H+ Exchanger (NHE) Sodium Channel Apical Sodium-Dependent Bile Acid Transporter Na+/Ca2+ Exchanger SGLT Na+/K+ ATPase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-118778

KR-32568	Na+/H+ Exchanger (NHE)	Cardiovascular Disease
KR-32568 is a *sodium/hydrogen* exchanger-1 (NHE-1) inhibitor with an IC₅₀** of 230 nM. KR-32568 has cardioprotective effects .

HY-15991

Tenapanor 4 Publications Verification AZD1722; RDX5791	Na+/H+ Exchanger (NHE)	Metabolic Disease
Tenapanor (AZD1722) is a potent and orally active *sodium/hydrogen* exchanger isoform 3 (NHE3)** inhibitor. Tenapanor reduces intestinal phosphate absorption predominantly through reduction of passive paracellular phosphate flux. Tenapanor has the potential for the research of hyperphosphatemia .

HY-15991A

Tenapanor hydrochloride 4 Publications Verification AZD1722 hydrochloride; RDX5791 hydrochloride	Na+/H+ Exchanger (NHE)	Metabolic Disease
Tenapanor (AZD1722) hydrochloride is a potent and orally active *sodium/hydrogen* exchanger isoform 3 (NHE3)** inhibitor. Tenapanor hydrochloride reduces intestinal phosphate absorption predominantly through reduction of passive paracellular phosphate flux. Tenapanor hydrochloride has the potential for the research of hyperphosphatemia .

HY-75070

(+)-1-(1-Naphthyl)ethylamine	Biochemical Assay Reagents	Others
(+)-1-(1-Naphthyl)ethylamine ((+)-1-(1-NEA)) is a chiral modifier used to introduce enantioselectivity in catalytic hydrogenation reactions. 1-NEA can undergo H-D exchange with D2 in solution to form N?D bonds. That is, 1-NEA can complete Pt surface adsorption and protonation through amine N atoms, indicating that NEA molecules have the potential to impart enantioselectivity to Pt hydrogenation catalysts .

HY-105064D

Zoniporide hydrochloride hydrate 1 Publications Verification CP-597396 hydrochloride hydrate	Na+/H+ Exchanger (NHE)	Cardiovascular Disease
Zoniporide (CP-597396) hydrochloride hydrate is a potent and selective inhibitor of *sodium-hydrogen* exchanger type 1 (NHE-1). Zoniporide hydrochloride hydrate inhibits human NHE-1 (IC₅₀**=14 nM), and has >150-fold selectivity versus other NHE isoforms. Zoniporide hydrochloride hydrate potently inhibits ex vivo NHE-1-dependent swelling of human platelets (IC₅₀=59 nM) .

HY-18071

BI-9627 1 Publications Verification	Na+/H+ Exchanger (NHE)	Cardiovascular Disease
BI-9627 is potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor, with IC₅₀s of 6 and 31 nM in intracellular pH recovery (pHi) and human platelet swelling assays, respectively. BI-9627 displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. BI-9627 shows low DDI (agent-agent interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury .

HY-122525B

Sabiporide mesylate BIIB 722 mesylate	Others	Cardiovascular Disease
Sabiporide (BIIB 722 mesylate) mesylate is a selective inhibitor of sodium-hydrogen exchange, known for its cardioprotective properties, making it a valuable tool for investigating myocardial ischemia and myocardial infarction.

HY-W704968

2-Oxo-zoniporide hydrochloride	Na+/H+ Exchanger (NHE)	Cardiovascular Disease
2-Oxo-zoniporide hydrochloride is an oral active sodium-hydrogen exchanger type 1 (NHE-1) inhibitor and can be used for study of myocardial ischemic injury .

HY-105064C

Zoniporide dihydrochloride CP-597396 dihydrochloride	Na+/H+ Exchanger (NHE)	Cancer
Zoniporide dihydrochloride (CP-597396 dihydrochloride) is a potent and selective inhibitor of highly water-soluble sodium hydrogen exchange type 1 (NHE-1). Zoniporide dihydrochloride inhibits NHE1 dependent 22Na ⁺ uptake in vitro with an IC₅₀ of 14 nM. Zoniporide has antitumor activity .

HY-105064B

Zoniporide hydrochloride CP-597396 hydrochloride	Na+/H+ Exchanger (NHE)	Cardiovascular Disease
Zoniporide (CP-597396) hydrochloride is a potent and selective inhibitor of *sodium-hydrogen* exchanger type 1 (NHE-1). Zoniporide hydrochloride inhibits human NHE-1 (IC₅₀**=14 nM), and has >150-fold selectivity versus other NHE isoforms. Zoniporide hydrochloride potently inhibits ex vivo NHE-1-dependent swelling of human platelets (IC₅₀=59 nM) .

HY-18071A

BI-9627 hydrochloride 1 Publications Verification	Na+/H+ Exchanger (NHE)	Cardiovascular Disease
BI-9627 hydrochloride is potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor, with IC50s of 6 and 31 nM in intracellular pH recovery (pHi) and human platelet swelling assays, respectively. BI-9627 hydrochloride displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. BI-9627 hydrochloride shows low DDI (agent-agent interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury .

HY-120623

BMS-284640	Na+/H+ Exchanger (NHE)	Neurological Disease
BMS-284640 is a synthetic sodium hydrogen exchange isomer-1 (NHE-1) inhibitor. BMS-284640 has a more than 380-fold higher NHE-1 inhibitory activity (IC50: 9 nM) compared to cariporide (HY-19693) and is more selective for NHE-1 over NHE-2 (IC50: 1.8 μM) and NHE-5 (IC50: 3.36 μM). BMS-284640 and its analogs also exhibit enhanced oral bioavailability and prolonged plasma half-life in rats. .

Cat. No.	Product Name	Type

HY-75070

(+)-1-(1-Naphthyl)ethylamine	Biochemical Assay Reagents
(+)-1-(1-Naphthyl)ethylamine ((+)-1-(1-NEA)) is a chiral modifier used to introduce enantioselectivity in catalytic hydrogenation reactions. 1-NEA can undergo H-D exchange with D2 in solution to form N?D bonds. That is, 1-NEA can complete Pt surface adsorption and protonation through amine N atoms, indicating that NEA molecules have the potential to impart enantioselectivity to Pt hydrogenation catalysts .

(+)-1-(1-Naphthyl)ethylamine

Biochemical Assay Reagents

(+)-1-(1-Naphthyl)ethylamine ((+)-1-(1-NEA)) is a chiral modifier used to introduce enantioselectivity in catalytic hydrogenation reactions. 1-NEA can undergo H-D exchange with D2 in solution to form N?D bonds. That is, 1-NEA can complete Pt surface adsorption and protonation through amine N atoms, indicating that NEA molecules have the potential to impart enantioselectivity to Pt hydrogenation catalysts .

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