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TERT activator

" in MedChemExpress (MCE) Product Catalog:

12

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Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-402361
    TERT activator-1

    		MEK ERK AP-1 Neurological Disease Inflammation/Immunology
    TERT activator-1 is a small molecule activator of telomerase reverse transcriptase (TERT). TERT activator-1 promotes TERT transcription through the MEK/ERK/AP-1 signaling cascade. TERT activator-1 promotes adult neurogenesis and enhances neuromuscular function. TERT activator-1 reduces cellular senescence and systemic inflammation in aged mice, and can be used in the study of aging .
    TERT activator-1
  • HY-100489
    TBHQ
    90+ Cited Publications

    TERT-Butylhydroquinone

    		 Keap1-Nrf2 ERK Autophagy Apoptosis Ferroptosis Cancer
    TBHQ (tert-Butylhydroquinone) is a widely used Nrf2 activator, protects against Doxorubicin (DOX)-induced cardiotoxicity through activation of Nrf2 . TBHQ (tert-Butylhydroquinone) is also an ERK activator; rescues Dehydrocorydaline (DHC)-induced cell proliferation inhibitionin melanoma .
    TBHQ
  • HY-100489R
    TBHQ (Standard)

    TERT-Butylhydroquinone (Standard)

    		 Keap1-Nrf2 ERK Autophagy Apoptosis Ferroptosis Cancer
    TBHQ (Standard) is the analytical standard of TBHQ. This product is intended for research and analytical applications. TBHQ (tert-Butylhydroquinone) is a widely used Nrf2 activator, protects against Doxorubicin (DOX)-induced cardiotoxicity through activation of Nrf2 . TBHQ (tert-Butylhydroquinone) is also an ERK activator; rescues Dehydrocorydaline (DHC)-induced cell proliferation inhibitionin melanoma .
    TBHQ (Standard)
  • HY-W014589
    2,4-Di-tert-butylphenol
    1 Publications Verification

    2,4-DTBP

    		 Endogenous Metabolite Fungal Apoptosis RAR/RXR Infection Inflammation/Immunology Cancer
    2,4-Di-tert-butylphenol (2,4-DTBP) is an orally active RXRα activator and a human estrogen receptor ligand with anti-inflammatory and antioxidant activities, which can induce apoptosis in tumor cells. 2,4-Di-tert-butylphenol can activate the RXRα subtype in LXRα/RXRα, PPARγ/RXRα, and hormone receptor β/RXRα. 2,4-Di-tert-butylphenol also has antiviral and antifungal activities. 2,4-Di-tert-butylphenol can be used as an intermediate in the preparation of antioxidants and UV stabilizers, and is also used in the manufacture of medicines and fragrances .
    2,4-Di-tert-butylphenol
  • HY-W131541
    N-Boc-undecane-1,11-diamine

    		PROTAC Linkers Cancer
    tert-Butyl (11-aminoundecyl)carbamate is an alkane chain with terminal amine and Boc-protected amino groups. tert-Butyl (11-aminoundecyl)carbamate can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. Amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.
    N-Boc-undecane-1,11-diamine
  • HY-42773
    tert-Butyl (8-aminooctyl)carbamate

    1-Boc-1,8-diaminooctane

    		 PROTAC Linkers Cancer
    tert-Butyl (8-aminooctyl)carbamate (1-Boc-1,8-diaminooctane) can be used as a PROTAC linker in the synthesis of PROTACs. tert-butyl (8-aminooctyl)carbamate is an alkane chain with terminal amine and Boc-protected amino groups. Amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.
    tert-Butyl (8-aminooctyl)carbamate
  • HY-W047688
    tert-Butyl (10-aminodecyl)carbamate

    1-Boc-1,10-diaminodecane

    		 PROTAC Linkers Cancer
    tert-Butyl (10-aminodecyl)carbamate (1-Boc-1,10-diaminodecane) can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. tert-Butyl (10-aminodecyl)carbamate is an alkane chain with terminal amine and Boc-protected amino groups. Amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.
    tert-Butyl (10-aminodecyl)carbamate
  • HY-169518
    TERT activator-2

    		Telomerase Cancer
    TERT activator-2 (Compound 1030) is a telomerase reverse transcriptase (TERT) activator that can increase the expression of TERT in cells. TERT activator-2 can be used in telomere-related cell lifespan research .
    TERT activator-2
  • HY-163012
    Dicamba-6-amino-6-oxohexanoic acid

    		Biochemical Assay Reagents Inflammation/Immunology
    Dicamba-6-amino-6-oxohexanoic acid (DCh) is an immunizing and heterologous hapten, activated before removing the 1-tert-butyl-benzoate moiety .
    Dicamba-6-amino-6-oxohexanoic acid
  • HY-W101722
    tert-Butyl (9-aminononyl)carbamate

    		PROTAC Linkers Cancer
    tert-Butyl (9-aminononyl)carbamate is an alkane chain with terminal amine and Boc-protected amino groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. Amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.
    tert-Butyl (9-aminononyl)carbamate
  • HY-14562
    TBPB

    		mAChR Amyloid-β Neurological Disease Inflammation/Immunology
    TBPB (tert-butyl peroxybenzoate) is a highly selective, blood-brain-permeable M1 mAChR allosteric agonist (EC50=289 nM) with anti-schizophrenia and anti-inflammatory activities. TBPB can enhance the sensitivity of M1 receptors to acetylcholine, activate downstream signaling pathways, and inhibit the release of pro-inflammatory cytokines (TNF-α, IL-6). TBPB can regulate the processing of amyloid and can be used in the study of neurodegenerative diseases (such as Alzheimer's disease) and inflammation-related diseases (such as sepsis) .
    TBPB
  • HY-162816
    PROTAC HPK1 Degrader-3

    		PROTACs MAP4K Cancer
    PROTAC HPK1 Degrader-3 (compound C3) is an orally effective PROTAC targeting HPK1 (DC50=21.26 nM). HPK1 is a negative regulator of T cell receptors, which can lead to T cell dysfunction after abnormal activation. PROTAC HPK1 Degrader-3 can inhibit SLP76 and NF-κB signaling pathways and inhibit MAPK signal transduction, and has anticancer activity and immune activation. PROTAC HPK1 Degrader-3 has a certain oral bioavailability and can be combined with PD-L1 antibody therapy to achieve a tumor growth inhibition rate of 65.58%. PROTAC HPK1 Degrader-3 is composed of E3 ligase ligand Thalidomide (HY-14658; blue part), PROTAC linker tert-Butyl 3-oxoazetidine-1-carboxylate (HY-40146; black part), and target protein ligand HPK1-IN-51 (HY-162842; red part); the activity control of the target protein ligand can be HPK1 ligand 1 (HY-162841) [1] .
    PROTAC HPK1 Degrader-3