2. MAPK/ERK Pathway Stem Cell/Wnt Immunology/Inflammation
  3. MEK ERK AP-1
  4. TERT activator-1

TERT activator-1 is a small molecule activator of telomerase reverse transcriptase (TERT). TERT activator-1 promotes TERT transcription through the MEK/ERK/AP-1 signaling cascade. TERT activator-1 promotes adult neurogenesis and enhances neuromuscular function. TERT activator-1 reduces cellular senescence and systemic inflammation in aged mice, and can be used in the study of aging.

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TERT activator-1 Chemical Structure

TERT activator-1 Chemical Structure

CAS No. : 666699-46-3

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10 mM * 1 mL in DMSO USD 126 In-stock
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10 mg USD 185 In-stock
25 mg USD 375 In-stock
50 mg USD 600 In-stock
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Based on 1 publication(s) in Google Scholar

TERT activator-1 Related Antibodies

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c-Fos c-Jun

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Description

TERT activator-1 is a small molecule activator of telomerase reverse transcriptase (TERT). TERT activator-1 promotes TERT transcription through the MEK/ERK/AP-1 signaling cascade. TERT activator-1 promotes adult neurogenesis and enhances neuromuscular function. TERT activator-1 reduces cellular senescence and systemic inflammation in aged mice, and can be used in the study of aging[1].

IC50 & Target[1]

MEK1

 

MEK2

 

ERK1

 

ERK2

 

In Vitro

TERT activator-1 (0-10 μM; 0-4 h) specifically activates TERT transcription in MRC-5 cells via the MEK/ERK/AP-1 pathway and can alter chromatin status in the TERT promoter region[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TERT activator-1 Related Antibodies

Real Time qPCR[1]

Cell Line: MRC-5 human fibroblasts cells
Concentration: 0, 0.05, 0.1, 0.5, 1, 5 and 10 μM
Incubation Time: 4 h
Result: Reduced the mRNA levels of TERT.
In Vivo

TERT activator-1 (6 mg/kg; intraperitoneal injection; 1-6 weeks) alleviates aging and promotes adult neurogenesis in naturally aging mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice aged 10-12 weeks old[1]
Dosage: 6 mg/kg
Administration: Intraperitoneal injection (i.p.); 1 week
Result: Significantly increased the level of TERT protein.
Reduced aging genetic traits including cell-cycle arrest and PML body.
Suppressed p16Ink4a and other senescence-associated secretory phenotype (SASP) components.
Induced signatures of organism growth and natural killer cell activation.
Increased in the levels of mBDNF in adult hippocampus.
Animal Model: Naturally aged C57BL/6 mice aged 20-21 months old[1]
Dosage: 6 mg/kg
Administration: Intraperitoneal injection (i.p.); 3 times a week; 6 months
Result: Improves hippocampal-dependent cognitive function.
Enhances neuromuscular function.
Did not result in any overt adverse consequences.
Molecular Weight

331.77

Formula

C14H12ClF2NO2S
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=S(NC1=CC=C(C(Cl)=C1)F)(C2=CC(C)=C(F)C(C)=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: 99.50%

COA (249 KB) HNMR (219 KB) RP-HPLC (251 KB) LCMS (143 KB)

Handling Instructions (2659 KB)
References
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TERT activator-1 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TERT activator-1666699-46-3TERT activator1TERT activator 1MEKERKAP-1Mitogen-activated protein kinase kinaseMAPKKMAP2KExtracellular signal regulated kinasesActivator Protein 1TERT activatorAgingAdult neurogenesisInhibitorinhibitorinhibit

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