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Topoisomerase 1

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By Targets:	Topoisomerase (11) Antibiotic (3) Apoptosis (8) DNA/RNA Synthesis (3) Drug-Linker Conjugates for ADC (1) ERK (2) FAK (2) HIV (1) NF-κB (2) p38 MAPK (2) Parasite (2) PARP (1) Peptide-Drug Conjugates (PDCs) (1) STAT (2)
By Research Areas:	Cancer (10) Infection (1) Inflammation/Immunology (3)

11

Inhibitors & Agonists

1

Peptides

3

Natural
Products

2

Recombinant Proteins

1

Antibodies

Targets Recommended: Topoisomerase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Rabdosiin (+)-Rabdosiin	HIV Topoisomerase	Infection Inflammation/Immunology
Rabdosiin is a tetramer of caffeic acid isolated from the stem of Ocimum sanctum. Rabdosiin possess anti-allergic activity, anti-HIV activity and inhibition on DNA topoisomerase .

Pyrazoloacridine NSC 366140; PD 115934	Topoisomerase Apoptosis	Cancer
Pyrazoloacridine (NSC 366140), an intercalating agent with anti-cancer activity, inhibits the activity of *topoisomerases* 1 and 2. Pyrazoloacridine (NSC 366140) exhibits an IC₅₀ of 1.25 μM in K562 myeloid leukemia cells for 24 h treatment .

Epirubicin hydrochloride Maximum Cited Publications 28 Publications Verification 4'-Epidoxorubicin hydrochloride	DNA/RNA Synthesis Topoisomerase Apoptosis Antibiotic	Cancer
Epirubicin hydrochloride (4'-Epidoxorubicin hydrochloride), a semisynthetic L-arabino derivative of doxorubicin, has an antineoplastic agent by inhibiting *Topoisomerase* . Epirubicin hydrochloride inhibits DNA and RNA synthesis. Epirubicin hydrochloride is a Forkhead box protein p3 (Foxp3) inhibitor and inhibits regulatory T cell activity .

Epirubicin (hydrochloride) (Standard)	DNA/RNA Synthesis Topoisomerase Apoptosis Antibiotic	Cancer
Epirubicin (hydrochloride) (Standard) is the analytical standard of Epirubicin (hydrochloride). This product is intended for research and analytical applications. Epirubicin hydrochloride (4'-Epidoxorubicin hydrochloride), a semisynthetic L-arabino derivative of doxorubicin, has an antineoplastic agent by inhibiting Topoisomerase . Epirubicin hydrochloride inhibits DNA and RNA synthesis. Epirubicin hydrochloride is a Forkhead box protein p3 (Foxp3) inhibitor and inhibits regulatory T cell activity .

Nitidine chloride 3 Publications Verification	Parasite Apoptosis STAT Topoisomerase ERK FAK p38 MAPK NF-κB	Inflammation/Immunology Cancer
Nitidine chloride, a potential anti-malarial lead compound derived from Zanthoxylum nitidum (Roxb) DC, exerts potent anticancer activity through diverse pathways, including inducing apoptosis, inhibiting STAT3 signaling cascade, *DNA topoisomerase 1* and 2A, ERK and c-Src/FAK associated signaling pathway, also has anti-inflammatory activity. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kB** pathway .

Topoisomerase inhibitor 4	Topoisomerase Apoptosis	Cancer
Topoisomerase inhibitor 4 (compound 45) is a potent *Topoisomerase1/2* inhibitor. Topoisomerase inhibitor 4 causes cell cycle arrest in the G2/M phase by inducing Apoptosis. Topoisomerase inhibitor 4 has antitumor activity .

Epirubicin 4'-Epidoxorubicin	DNA/RNA Synthesis Topoisomerase Apoptosis Antibiotic	Cancer
Epirubicin (4'-Epidoxorubicin), a semisynthetic L-arabino derivative of doxorubicin, has an antineoplastic agent by inhibiting *Topoisomerase* . Epirubicin inhibits DNA and RNA synthesis. Epirubicin is a Forkhead box protein p3 (Foxp3) inhibitor and inhibits regulatory T cell activity .

CBX-12	Peptide-Drug Conjugates (PDCs) Topoisomerase	Cancer
CBX-12 is a PDC (peptide drug conjugate) that targets tumors in an antigen-independent manner and exhibits antitumor activity. CBX-12 consists of a pH-sensitive peptide (pHLIP), a self-immolating linker, and a topoisomerase 1 (TOP1) inhibitor Exatecan (HY-13631) .

TOPOI/PARP-1-IN-2	PARP Topoisomerase Apoptosis	Cancer
TOPOI/PARP-1-IN-2 (compound 6c) is a dual PARP-1 and **topoisomerase 1 (TOPO-1) inhibitor with IC₅₀*s of 32.2 nM and 46.2 nM, respectively. TOPOI/PARP-1-IN-2 shows a selectivity for PARP-1 over PARP-2. TOPOI/PARP-1-IN-2 disrupts the cell cycle at the S phase and induces apoptosis* in NCI-60 cancer cell lines .

Nitidine chloride (Standard)	Parasite Apoptosis STAT Topoisomerase ERK FAK p38 MAPK NF-κB	Inflammation/Immunology Cancer
Nitidine (chloride) (Standard) is the analytical standard of Nitidine (chloride). This product is intended for research and analytical applications. Nitidine chloride, a potential anti-malarial lead compound derived from Zanthoxylum nitidum (Roxb) DC, exerts potent anticancer activity through diverse pathways, including inducing apoptosis, inhibiting STAT3 signaling cascade, DNA topoisomerase 1 and 2A, ERK and c-Src/FAK associated signaling pathway. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kB pathway .

MC-GGFG-AM-(10Me-11F-Camptothecin)	Drug-Linker Conjugates for ADC Topoisomerase	Cancer
MC-GGFG-AM-(10Me-11F-Camptothecin) is a linker-payload conjugate used to synthesize ZW251. ZW251 an antibody-drug conjugate (ADC) targeting human GPC3. ZW251 consists of a humanized IgG1 antibody conjugated to a novel camptothecin-based *topoisomerase 1* inhibitor, ZD06519, via a linker. The linker is the maleimide anchor and a glycyl glycyl phenylalanyl glycine (GGFG)-aminomethyl (AM) cleavable linker. ZW251 has high affinity with human and cynomolgus monkey GPC3. ZW251 displays rapid internalization in GPC3-expressing HCC cell lines, and bystander-mediated killing of GPC3 negative cancer cells .

Cat. No.	Product Name	Target	Research Area

CBX-12	Peptide-Drug Conjugates (PDCs) Topoisomerase	Cancer
CBX-12 is a PDC (peptide drug conjugate) that targets tumors in an antigen-independent manner and exhibits antitumor activity. CBX-12 consists of a pH-sensitive peptide (pHLIP), a self-immolating linker, and a topoisomerase 1 (TOP1) inhibitor Exatecan (HY-13631) .

Species:	Human (2)
Tag:	His (2)
Source:	Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source

	TOP1 Protein, Human (765a.a, sf9, His) DNA Topoisomerase 1; TOP1	Human	Sf9 insect cells
	The TOP1 protein is critical in cellular processes, mitigating DNA supercoiling and torsional tension during replication and transcription. It does this by transiently cutting and rejoining a DNA strand, introducing breaks through transesterification. TOP1 Protein, Human (765a.a, sf9, His) is the recombinant human-derived TOP1 protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of TOP1 Protein, Human (765a.a, sf9, His) is 765 a.a., with molecular weight of ~93.1 kDa.

	TOP1 Protein, Human (575a.a, sf9, His) DNA Topoisomerase 1; TOP1	Human	Sf9 insect cells
	The TOP1 protein is critical in cellular processes, mitigating DNA supercoiling and torsional tension during replication and transcription. It does this by transiently cutting and rejoining a DNA strand, introducing breaks through transesterification. TOP1 Protein, Human (575a.a, sf9, His) is the recombinant human-derived TOP1 protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of TOP1 Protein, Human (575a.a, sf9, His) is 575 a.a., with molecular weight of ~70.4 kDa.

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	Topoisomerase I Antibody (YA2237) TOP1; DNA Topoisomerase 1; DNA Topoisomerase I	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	Topoisomerase I Antibody (YA2237) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2237), targeting Topoisomerase I, with a predicted molecular weight of 91 kDa (observed band size: 91 kDa). Topoisomerase I Antibody (YA2237) can be used for WB, IHC-F, IHC-P, ICC/IF experiment in human, mouse, rat background.

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