Search Result

Results for "

UC,

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) E1/E2/E3 Enzyme (2) Endogenous Metabolite (2) Epoxide Hydrolase (2) ERK (1) Glucocorticoid Receptor (2) HIV (1) IAP (1) Interleukin Related (5) Isotope-Labeled Compounds (1) MDM-2/p53 (1) NO Synthase (2) PKC (2) PROTACs (1) Ras (1) ROR (1) SARS-CoV (1) STAT (1) TET Protein (1) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (1) Endocrinology (3) Infection (3) Inflammation/Immunology (15) Metabolic Disease (7)

Inhibitors & Agonists

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-153775

UC-764864	E1/E2/E3 Enzyme	Cancer
UC-764864 is a UBE2N inhibitor. UC-764864 inhibits UBE2N enzymatic activity. UC-764864 has cytotoxic effects and inhibition of UBE2N-dependent signaling in leukemic cells. UC-764864 blocks ubiquitination of innate immune- and inflammatory-related substrates in human AML cell lines .

HY-120395

UC-514321	STAT Apoptosis TET Protein	Inflammation/Immunology Cancer
UC-514321, a structural analog of NSC370284 with higher activity, directly targets STAT3/5 and represses TET1 expression, but not TET2 or TET3. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low toxicity .

HY-114266

UC-1728 t-TUCB	Epoxide Hydrolase	Cardiovascular Disease Inflammation/Immunology
UC-1728 is a potent rabbit soluble epoxide hydrolase (sEH) inhibitor, with an IC₅₀ of 2 nM on rabbit liver.

HY-112780

UC2288 3 Publications Verification	MDM-2/p53	Cancer
UC2288 is a novel, cell-permeable, and orally active p21 attenuator (relatively selective activity for p21), which is synthesized based Sorafenib (HY-10201). UC2288 decreases p21 mRNA expression independently of p53, and attenuates p21 protein levels with minimal effect on p21 protein stability. UC2288 has no inhibition of VEGFR2 and Raf kinases even at 10 μM .

HY-P99201

Zilovertamab UC-961; Cirmtuzumab	ROR	Cancer
Zilovertamab (UC-961) is a humanised monoclonal antibody against ROR1 that blocks Wnt5a-induced ROR1 signalling .

HY-12842

UC-112	IAP Apoptosis	Cancer
UC-112 is a novel potent IAP(Inhibitor of apoptosis) inhibitor; potently inhibit cell growth in two human melanoma (A375 and M14) and two human prostate (PC-3 and DU145) cancer cell lines(IC50=0.7-3.4 uM).

HY-124514

UC-857993	Ras ERK	Cancer
UC-857993 is a selective SOS1-Ras inhibitor (K_d=14.7 μM, His₆-SOS1_cat), suppressing catalytic activity. UC-857993 also inhibits ERK and Ras activation, suppresses the growth of mouse embryonic fibroblasts (MEFs) .

HY-15351

UC-781 NSC 675186	HIV	Infection
UC-781 (NSC 675186) is a highly potent and selective nonnucleoside reverse transcriptase inhibitor (NNRTI) of HIV-1 with an IC₅₀ value of 5 nM. UC-781 is stable under low PH or various temperatures conditions. UC-781 has antiviral activity and resistance .

HY-147215

UC-1V150	Toll-like Receptor (TLR)	Inflammation/Immunology
UC-1V150 is a specific TLR7 (Toll-like receptor) agonist that stimulates cellular immune responses and has anti-tumor activity. UC-1V150 can be used to synthesize ISAC (Immune-Stimulating Antibody Conjugates) molecule .

HY-151988

SARS-CoV-2-IN-36	SARS-CoV	Infection
SARS-CoV-2-IN-36 is a potent SARS-CoV-2 Mpro (SARS-CoV) inhibitor with an IC₅₀ of 2.37 μM and a K_d of 1.19 μM in enzymatic assays. SARS-CoV-2-IN-36 shows antiviral activity against UC-1074, RG2674, and NVDBB-2220 SARS-CoV-2 variants in Vero cells .

HY-108013

Armillarisin A	Interleukin Related	Inflammation/Immunology
Armillarisin A has the potential for the ulcerative colitis (UC) study. Armillarisin A increases IL-4 and lower IL-1β .

HY-159494

PROTAC sEH-degrader-1	PROTACs Epoxide Hydrolase	Metabolic Disease
sEH-degrader-1 (Compound 8) serves as an inhibitor for sEH, with IC₅₀ values of 3.8 nM and 210 nM against hsEH and msEH respectively. sEH-degrader-1 can effectively degrade sEH in mouse liver and brown adipose tissue (Red: UC-1728 (HY-114266), black: linker (HY-W248248), Blue: Thalidomide-5-piperazine (HY-W834174)) .

HY-116374A

Glycolithocholic acid sodium Lithocholylglycine sodium	Others	Metabolic Disease
Glycolithocholic acid (Lithocholylglycine) sodium is the sodium salt of Glycolithocholic acid. Glycolithocholic acid is a glycine-conjugated secondary bile acid. Glycolithocholic acid can be used to diagnose ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC) .

HY-116374

Glycolithocholic acid Lithocholylglycine	Endogenous Metabolite	Inflammation/Immunology
Glycolithocholic acid (Lithocholylglycine), an endogenous metabolite, is a glycine-conjugated secondary bile acid. Glycolithocholic acid can be used to diagnose ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC) .

HY-P99439

Anrukinzumab IMA-638	Interleukin Related	Inflammation/Immunology
Anrukinzumab (IMA-638) is a humanized anti-IL-13 monoclonal antibody. Anrukinzumab effectively reduces lung inflammation in a cynomolgus monkey model. Anrukinzumab can be used in studies of ulcerative colitis (UC) as well as asthma .

HY-116833

4-Chloro-3,5-dimethylphenoxyacetic acid	Others	Metabolic Disease
4-Chloro-3,5-dimethylphenoxyacetic acid (compound 602 UC) is a product of masked amide bond hydrolysis of auxin analog 602 (compound 602).602 can effectively stimulate hypocotyl growth in wild-type seedlings .

HY-116374S

Glycolithocholic acid-d4 Lithocholylglycine-d4	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
Glycolithocholic acid-d₄ is the deuterium labeled Glycolithocholic acid. Glycolithocholic acid, an endogenous metabolite, is a glycine-conjugated secondary bile acid and can be used to diagnose ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC) [1][2][3][4].

HY-B1402B

Hydrocortisone hemisuccinate sodium 1 Publications Verification Hydrocortisone 21-hemisuccinate sodium	Glucocorticoid Receptor	Metabolic Disease
Hydrocortisone hemisuccinate sodium is an orally active physiological glucocorticoid. Hydrocortisone hemisuccinate sodium inhibits proinflammatory cytokine activity, with IC₅₀s of 6.7 and 21.4 μM for IL-6 and IL-3, respectively. Hydrocortisone hemisuccinate sodium can be used for the research of ulcerative colitis (UC) .

HY-N0278

Anemonin Pulsatilla camphor; Anemonine; trans-Anemonin	PKC NO Synthase	Inflammation/Immunology
Anemonin (Pulsatilla camphor), a selective iNOS inhibitor, is also a PKC-θ inhibitor. Anemonin can significantly inhibit the translation or protein stability of PKC-θ protein. Anemonin also ameliorates dextran sodium sulfate-induced acute ulcerative colitis (UC) in mice. Anemonin can be used in the research of inflammation-related diseases .

HY-B1402A

Hydrocortisone hemisuccinate hydrate Hydrocortisone 21-hemisuccinate hydrate	Interleukin Related	Inflammation/Immunology Endocrinology
Hydrocortisone hemisuccinate hydrate (Hydrocortisone 21-hemisuccinate hydrate), a glucocorticoid, is an orally active steroidal anti-inflammatory agent (SAID) with anti-inflammatory and immunomodulatory activities. Hydrocortisone hemisuccinate hydrate inhibits the bioactivity of IL-6 and IL-3 with IC₅₀ values of 6.7 and 21.4 μM, respectively. Hydrocortisone hemisuccinate hydrate can be used in the study of ulcerative colitis (UC) and recurrent oral ulcers .

HY-N0278A

(Rac)-Anemonin (Rac)-Pulsatilla camphor; (Rac)-Anemonine	PKC NO Synthase	Inflammation/Immunology
(Rac)-Anemonin ((Rac)-Pulsatilla camphor) is the diastereoisomer of Anemonin (HY-N0278). Anemonin (Pulsatilla camphor), a selective iNOS inhibitor, is also a PKC-θ inhibitor. Anemonin can significantly inhibit the translation or protein stability of PKC-θ protein. Anemonin also ameliorates dextran sodium sulfate-induced acute ulcerative colitis (UC) in mice. Anemonin can be used in the research of inflammation-related diseases .

HY-B1402

Hydrocortisone hemisuccinate 1 Publications Verification Hydrocortisone 21-hemisuccinate	Interleukin Related	Metabolic Disease Inflammation/Immunology Endocrinology
Hydrocortisone hemisuccinate (Hydrocortisone 21-hemisuccinate), a glucocorticoid, is an orally active steroidal anti-inflammatory agent (SAID) with anti-inflammatory and immunomodulatory activities. Hydrocortisone hemisuccinate inhibits the bioactivity of IL-6 and IL-3 with IC₅₀ values of 6.7 and 21.4 μM, respectively. Hydrocortisone hemisuccinate can be used in the study of ulcerative colitis (UC) and recurrent oral ulcers .

HY-115497

BRD5529	E1/E2/E3 Enzyme	Infection Inflammation/Immunology
BRD5529 is an effective dose-dependent CARD9-TRIM62 protein–protein interaction (PPI) inhibitor with an IC₅₀ value of 8.6 μM. BRD5529 has potency and complete inhibition of CARD9 ubiquitinylation in vitro, also has favorable solubility. BRD5529 can be used for the research of inflammatory bowel disease (IBD) such as Crohn’s disease (CD) and ulcerative colitis (UC) .

HY-B1402R

Hydrocortisone hemisuccinate (Standard) Hydrocortisone 21-hemisuccinate (Standard)	Glucocorticoid Receptor Interleukin Related	Metabolic Disease Inflammation/Immunology Endocrinology
Hydrocortisone hemisuccinate (Standard) is the analytical standard of Hydrocortisone hemisuccinate. This product is intended for research and analytical applications. Hydrocortisone hemisuccinate (Hydrocortisone 21-hemisuccinate), a physiological glucocorticoid, is an orally active steroidal anti-in ammatory agent (SAID). Hydrocortisone hemisuccinate inhibits proinflammatory cytokine activity, with IC50s of 6.7 and 21.4 μM for IL-6 and IL-3, respectively. Hydrocortisone hemisuccinate can be used for the research of ulcerative colitis (UC).

Zilovertamab UC-961; Cirmtuzumab	ROR	Cancer
Zilovertamab (UC-961) is a humanised monoclonal antibody against ROR1 that blocks Wnt5a-induced ROR1 signalling .

Anrukinzumab IMA-638	Interleukin Related	Inflammation/Immunology
Anrukinzumab (IMA-638) is a humanized anti-IL-13 monoclonal antibody. Anrukinzumab effectively reduces lung inflammation in a cynomolgus monkey model. Anrukinzumab can be used in studies of ulcerative colitis (UC) as well as asthma .

Anti-Mouse TCR gamma/delta Antibody (UC7-13D5)	Inhibitory Antibodies	Inflammation/Immunology
Anti-Mouse TCR gamma/delta Antibody is an anti-mouse TCR gamma/delta IgG antibody inhibitor derived from host Armenian Hamster.

Anti-Mouse TCR V gamma 2 Antibody (UC3-10A6)	Inhibitory Antibodies	Inflammation/Immunology
Anti-Mouse TCR V gamma 2 Antibody is an anti-mouse TCR V gamma 2 IgG antibody inhibitor derived from host Armenian Hamster.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-P99201

Zilovertamab UC-961; Cirmtuzumab	Classification of Application Fields Disease Research Fields Cancer	ROR
Zilovertamab (UC-961) is a humanised monoclonal antibody against ROR1 that blocks Wnt5a-induced ROR1 signalling .

HY-108013

Armillarisin A	Monophenols Microorganisms Classification of Application Fields Source classification Coumarins Phenols Phenylpropanoids Disease Research Fields Inflammation/Immunology	Interleukin Related
Armillarisin A has the potential for the ulcerative colitis (UC) study. Armillarisin A increases IL-4 and lower IL-1β .

HY-116374

Glycolithocholic acid Lithocholylglycine	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Steroids	Endogenous Metabolite
Glycolithocholic acid (Lithocholylglycine), an endogenous metabolite, is a glycine-conjugated secondary bile acid. Glycolithocholic acid can be used to diagnose ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC) .

HY-N0278

Anemonin Pulsatilla camphor; Anemonine; trans-Anemonin	Structural Classification Natural Products Source classification Ranunculaceae Clematis crassifolia Benth. Plants	PKC NO Synthase
Anemonin (Pulsatilla camphor), a selective iNOS inhibitor, is also a PKC-θ inhibitor. Anemonin can significantly inhibit the translation or protein stability of PKC-θ protein. Anemonin also ameliorates dextran sodium sulfate-induced acute ulcerative colitis (UC) in mice. Anemonin can be used in the research of inflammation-related diseases .

HY-N0278A

(Rac)-Anemonin (Rac)-Pulsatilla camphor; (Rac)-Anemonine	Structural Classification Natural Products Ranunculaceae Source classification Clematis crassifolia Benth. Plants	PKC NO Synthase
(Rac)-Anemonin ((Rac)-Pulsatilla camphor) is the diastereoisomer of Anemonin (HY-N0278). Anemonin (Pulsatilla camphor), a selective iNOS inhibitor, is also a PKC-θ inhibitor. Anemonin can significantly inhibit the translation or protein stability of PKC-θ protein. Anemonin also ameliorates dextran sodium sulfate-induced acute ulcerative colitis (UC) in mice. Anemonin can be used in the research of inflammation-related diseases .

Cat. No.	Product Name	Chemical Structure

HY-116374S

Glycolithocholic acid-d4
Glycolithocholic acid-d₄ is the deuterium labeled Glycolithocholic acid. Glycolithocholic acid, an endogenous metabolite, is a glycine-conjugated secondary bile acid and can be used to diagnose ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC) [1][2][3][4].

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

UC,

Inhibitors & Agonists

Inhibitory Antibodies

NaturalProducts

Isotope-Labeled Compounds

Natural
Products