UCHL1

Isoforms Recommended:	UCHL1

By Targets:	Apoptosis (2) Caspase (2) Deubiquitinase (9) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (9) Neurological Disease (2)
Click Chemistry:	Azide (1) Alkynes (3)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-161378

UCHL1-IN-1	Deubiquitinase	Cancer
UCHL1-IN-1 (Compound 46) is an inhibitor for Ubiquitin C-terminal Hydrolase L1 (UCHL1), with an IC₅₀ of 5.1 μM. UCHL1-IN-1 can be used for cancer research ^[1].

HY-133118

6RK73 2 Publications Verification	Deubiquitinase	Cancer
6RK73 is a covalent irreversible and specific *UCHL1* inhibitor with an IC₅₀ of 0.23 µM. 6RK73 shows almost no inhibition of UCHL3 (IC₅₀=236 µM). 6RK73 specifically inhibit UCHL1 activity in breast cancer ^[1].

HY-154914

GK16S	Deubiquitinase	Others
GK16S is a *UCHL1* chemogenomic probe. GK16S can be used as a complement to GK13S. GK16S and GK13S can be used to study UCHL1 function in cells ^[1]. GK16S is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-153627

GK13S	Deubiquitinase	Cancer
G13KS is a deubiquitinase *UCHL1* ligand and inhibitor. G13KS inhibits recombinant and cellular UCHL1. G13KS reduces levels of monoubiquitin in human glioblastoma cells ^[1]. GK13S is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-16658

Z-VAD(OMe)-FMK 160+ Cited Publications Z-Val-Ala-Asp(OMe)-FMK	Caspase	Cancer
Z-VAD(OMe)-FMK (Z-Val-Ala-Asp(OMe)-FMK) is a cell-permeable and irreversible pan-caspase inhibitor ^[1]. Z-VAD(OMe)-FMK is an ubiquitin carboxy-terminal hydrolase L1 (UCHL1) inhibitor. Z-VAD(OMe)-FMK irreversibly modifies UCHL1 by targeting the active site of UCHL1 .

HY-138995

IMP-1710	Deubiquitinase	Cancer
IMP-1710 is a potent and selective deubiquitylating enzyme UCHL1 inhibitor with an IC₅₀ value of 38 nM. IMP-1710 has antifibrotic activity. IMP-1710 is a UCHL1 probe to identify and quantify target proteins in intact human cells ^[1]. IMP-1710 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-12989

LDN-91946	Deubiquitinase	Neurological Disease Cancer
LDN-91946 is a potent, selective and uncompetitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor with a K_{i app} of 2.8 μM ^[1].

HY-16658B

Z-VAD-FMK Maximum Cited Publications 381 Publications Verification Z-VAD(OH)-FMK	Caspase Apoptosis	Cancer
Z-VAD-FMK (Z-VAD(OH)-FMK) is a well-know pan caspase inhibitor, which does not inhibit ubiquitin carboxy-terminal hydrolase L1 (UCHL1) activity even at concentrations as high as 440 μM ^[1].

HY-RS15400

UCHL1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
UCHL1 Human Pre-designed siRNA Set A contains three designed siRNAs for UCHL1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

UCHL1 Human Pre-designed siRNA Set A UCHL1 Human Pre-designed siRNA Set A

HY-D1726

8RK59	Deubiquitinase	Cancer
8RK59, a Bodipy probe, is a potent *UCHL1* (ubiquitin C-terminal hydrolase L1) inhibitor, with an IC₅₀ close to 1 μM. 8RK59 could penetrate and label living cells. BodipyFL-alkyne is coupled to the azide of 8RK64 (HY-148254) using copper(I)-mediated click chemistry, resulting in compound 8RK59 ^[1].

HY-18637

LDN-57444 10+ Cited Publications	Deubiquitinase Apoptosis	Neurological Disease
LDN-57444 is a reversible, competitive and site-directed inhibitor of ubiquitin C-terminal hydrolase L1 (UCH-L1), with an IC₅₀ of 0.88 μM and a K_i of 0.40 μM; LDN-57444 also suppresses UCH-L3 activity, with an IC₅₀ of 25 μM.

HY-148254

8RK64	Deubiquitinase	Cancer
8RK64 is a covalent *UCHL1* inhibitor (IC₅₀: 0.32 μM) ^[1]. 8RK64 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Cat. No.	Product Name	Type

HY-D1726

8RK59	Fluorescent Dyes/Probes
8RK59, a Bodipy probe, is a potent *UCHL1* (ubiquitin C-terminal hydrolase L1) inhibitor, with an IC₅₀ close to 1 μM. 8RK59 could penetrate and label living cells. BodipyFL-alkyne is coupled to the azide of 8RK64 (HY-148254) using copper(I)-mediated click chemistry, resulting in compound 8RK59 ^[1].

Recombinant Proteins Recommended:

UCH-L1

Species:	Human (1) Mouse (1) Rat (1)
Tag:	His (3)
Source:	E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P73466

	UCHL1 Protein, Mouse (His) Ubiquitin carboxyl-terminal hydrolase isozyme L1; UCH-L1; UCHL1; PGP9.5	Mouse	E. coli
	UCHL1 Protein, a ubiquitin carboxyl-terminal hydrolase, plays a crucial role in protein degradation and regulation of cellular processes.It is involved in maintaining neuronal integrity and has been linked to neurodegenerative diseases.UCHL1 Protein's potential as a biomarker and therapeutic target in neurodegenerative disorders makes it a subject of intense research in the field of neuroscience.UCHL1 Protein, Mouse (His) is the recombinant mouse-derived UCHL1 protein, expressed by E.coli , with N-His labeled tag.

HY-P71096

	UCHL1 Protein, Human (His) Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L1; UCH-L1; Neuron Cytoplasmic Protein 9.5; PGP 9.5; PGP9.5; Ubiquitin Thioesterase L1; UCHL1	Human	E. coli
	The UCHL1 protein is a multifunctional deubiquitinase that regulates a variety of cellular processes. It maintains synaptic and cardiac function, modulates inflammatory responses, and influences osteoclastogenesis. UCHL1 Protein, Human (His) is the recombinant human-derived UCHL1 protein, expressed by E. coli , with C-6*His labeled tag. The total length of UCHL1 Protein, Human (His) is 223 a.a., with molecular weight of ~26.0 kDa.

HY-P74483

	UCHL1 Protein, Rat (His) Ubiquitin carboxyl-terminal hydrolase isozyme L1; UCH-L1; UCHL1; PGP9.5	Rat	E. coli
	The UCHL1 protein is a ubiquitin proteolytic enzyme essential for processing ubiquitin precursors and hydrolyzing ubiquitinated proteins. As a thiol protease, it specifically cleaves the C-terminal glycine of ubiquitin. UCHL1 Protein, Rat (His) is the recombinant rat-derived UCHL1 protein, expressed by E. coli , with N-10*His labeled tag. The total length of UCHL1 Protein, Rat (His) is 222 a.a., with molecular weight of ~28 kDa.

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HY-P80785

	PGP9.5 Antibody UCHL1 / PGP9.5; UCHL1; B220; CD 45; CD45; cd45 antigen; ec3.1.3.48; GP 180; GP180; Human homolog of severe combined immunodeficiency due to PTPRC deficiency; L CA; L-CA; lca; Leukocyte common antigen; LY 5; LY5; Protein tyrosine phosphatase receptor type	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	PGP9.5 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 25 kDa, targeting to PGP9.5. It can be used for WB,IHC-F,IHC-P,ICC/IF,IP assays with tag free, in the background of Human, Mouse, Rat.

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Cat. No.	Product Name		Classification

HY-154914

GK16S		Alkynes
GK16S is a *UCHL1* chemogenomic probe. GK16S can be used as a complement to GK13S. GK16S and GK13S can be used to study UCHL1 function in cells ^[1]. GK16S is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-153627

GK13S		Alkynes
G13KS is a deubiquitinase *UCHL1* ligand and inhibitor. G13KS inhibits recombinant and cellular UCHL1. G13KS reduces levels of monoubiquitin in human glioblastoma cells ^[1]. GK13S is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-138995

IMP-1710		Alkynes
IMP-1710 is a potent and selective deubiquitylating enzyme UCHL1 inhibitor with an IC₅₀ value of 38 nM. IMP-1710 has antifibrotic activity. IMP-1710 is a UCHL1 probe to identify and quantify target proteins in intact human cells ^[1]. IMP-1710 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-148254

8RK64		Azide
8RK64 is a covalent *UCHL1* inhibitor (IC₅₀: 0.32 μM) ^[1]. 8RK64 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Cat. No.	Product Name		Classification

HY-RS15400

UCHL1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
UCHL1 Human Pre-designed siRNA Set A contains three designed siRNAs for UCHL1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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