2. Cell Cycle/DNA Damage
  3. Deubiquitinase
  4. LDN-91946

LDN-91946 is a potent, selective and uncompetitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor with a Ki app of 2.8 μM.

For research use only. We do not sell to patients.

LDN-91946 Chemical Structure

LDN-91946 Chemical Structure

CAS No. : 439946-22-2

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 55 In-stock
Solution
10 mM * 1 mL in DMSO USD 55 In-stock
Solid
5 mg USD 32 In-stock
10 mg USD 50 In-stock
50 mg USD 120 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

LDN-91946 Related Antibodies

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View All Deubiquitinase Isoform Specific Products:

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USP1 USP2 USP7 USP8 USP30 UCHL1

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Description

LDN-91946 is a potent, selective and uncompetitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor with a Ki app of 2.8 μM[1].

IC50 & Target

Ki app: 2.8 μM (UCH-L1)[1]
In Vitro

LDN-91946 is inactive against UCH-L3 at 20 μM. LDN-91946 demonstrates no activity against TGase 2, Papain, and Caspase-3 at 40 μM[1].
There is no cytotoxicity when serum-starved Neuro 2A (N2A) cells are treated with LDN-91946 at concentrations as high as 0.1 mM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LDN-91946 Related Antibodies
Molecular Weight

314.32

Formula

C15H10N2O4S
CAS No.
Appearance

Solid

Color

Light brown to brown

SMILES

OC(C1=CC2=C(SC(C(C3=CC=CC=C3)=O)=C2N)NC1=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (265.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1815 mL 15.9074 mL 31.8147 mL
5 mM 0.6363 mL 3.1815 mL 6.3629 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1815 mL 15.9074 mL 31.8147 mL 79.5368 mL
5 mM 0.6363 mL 3.1815 mL 6.3629 mL 15.9074 mL
10 mM 0.3181 mL 1.5907 mL 3.1815 mL 7.9537 mL
15 mM 0.2121 mL 1.0605 mL 2.1210 mL 5.3025 mL
20 mM 0.1591 mL 0.7954 mL 1.5907 mL 3.9768 mL
25 mM 0.1273 mL 0.6363 mL 1.2726 mL 3.1815 mL
30 mM 0.1060 mL 0.5302 mL 1.0605 mL 2.6512 mL
40 mM 0.0795 mL 0.3977 mL 0.7954 mL 1.9884 mL
50 mM 0.0636 mL 0.3181 mL 0.6363 mL 1.5907 mL
60 mM 0.0530 mL 0.2651 mL 0.5302 mL 1.3256 mL
80 mM 0.0398 mL 0.1988 mL 0.3977 mL 0.9942 mL
100 mM 0.0318 mL 0.1591 mL 0.3181 mL 0.7954 mL
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LDN-91946 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LDN-91946439946-22-2LDN91946LDN 91946DeubiquitinaseDUBsUbiquitinUCH-L1selectiveInhibitorinhibitorinhibit

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