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Results for "

UGT1A10

" in MedChemExpress (MCE) Product Catalog:

5

Inhibitors & Agonists

2

Isotope-Labeled Compounds

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-RS15427
    UGT1A10 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    UGT1A10 Human Pre-designed siRNA Set A contains three designed siRNAs for UGT1A10 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    UGT1A10 Human Pre-designed siRNA Set A
    UGT1A10 Human Pre-designed siRNA Set A
  • HY-135582
    Raloxifene 4'-glucuronide

    		Estrogen Receptor/ERR Endocrinology
    Raloxifene 4'-glucuronide is a primary metabolite of Raloxifene. Raloxifene 4'-glucuronide formation is mediated mostly by UGT1A10 and UGT1A8. Raloxifene 4'-glucuronide binds to estrogen receptor with an IC50 of 370 μM. . Raloxifene is a selective estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression .
    Raloxifene 4'-glucuronide
  • HY-135582S
    Raloxifene 4'-glucuronide-d4

    		Estrogen Receptor/ERR Isotope-Labeled Compounds Endocrinology
    Raloxifene 4'-glucuronide-d4 is deuterated labeled Raloxifene 4'-glucuronide (HY-135582). Raloxifene 4'-glucuronide is a primary metabolite of Raloxifene. Raloxifene 4'-glucuronide formation is mediated mostly by UGT1A10 and UGT1A8. Raloxifene 4'-glucuronide binds to estrogen receptor with an IC50 of 370 μM. . Raloxifene is a selective estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression .
    Raloxifene 4'-glucuronide-d4
  • HY-135582S1
    Raloxifene 4'-glucuronide-d4 lithium

    		Isotope-Labeled Compounds Estrogen Receptor/ERR Endocrinology
    Raloxifene 4'-glucuronide-d4 (lithium) is deuterium labeled Raloxifene 4'-glucuronide. Raloxifene 4'-glucuronide is a primary metabolite of Raloxifene. Raloxifene 4'-glucuronide formation is mediated mostly by UGT1A10 and UGT1A8. Raloxifene 4'-glucuronide binds to estrogen receptor with an IC50 of 370 μM. [1][2]. Raloxifene is a selective estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression[3].
    Raloxifene 4'-glucuronide-d4 lithium
  • HY-135541
    Darexaban maleate

    YM150 maleate

    		 Endogenous Metabolite Cardiovascular Disease
    Darexaban maleate (YM150 maleate) is a direct factor Xa inhibitor with activity in preventing venous thromboembolism. The major metabolite of Darexaban maleate in humans is Darexaban glucitol, which acts pharmacologically. The glucitolation reaction of Darexaban maleate is mainly catalyzed by UGT1A9 and UGT1A10 in the human liver and intestine. The K(m) value of Darexaban maleate glucitolation in the liver is greater than 250 μM, while in the intestine it exhibits substrate inhibition kinetics with a K(m) value of 27.3 μM. The unbound K(m) value of Darexaban maleate is significantly reduced by the influence of fatty acid-free bovine serum albumin in both HLM and UGT1A9 .
    Darexaban maleate

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