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Vitiligo

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By Targets:	Apoptosis (2) Cytochrome P450 (3) DNA Alkylator/Crosslinker (2) DNA/RNA Synthesis (2) Drug Metabolite (1) EGFR (2) GSK-3 (1) Melanocortin Receptor (1) Microtubule/Tubulin (1) Tyrosinase (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (2) Inflammation/Immunology (8) Metabolic Disease (1)

12

Inhibitors & Agonists

6

Natural
Products

1

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Monobenzone 1 Publications Verification	Apoptosis DNA/RNA Synthesis	Cancer
Monobenzone is a potent skin depigmenting agent. Monobenzone induces depigmentation and exhibits good potential for vitiligo research. Monobenzone is a potent inhibitor of RNR (Ribonucleotide reductase) enzyme activity by targeting RRM2 (a regulatory small subunit M2 of RNR) protein, and thus has significant anti-leukemia efficacy in vitro and in vivo. Monobenzone inhibits acute myeloid leukemia (AML) cells proliferation and DNA synthesis, induces cell cycle arrest, and Apoptosis .

Trioxsalen 2 Publications Verification Trisoralen; Trioxysalen; TMP	DNA Alkylator/Crosslinker	Inflammation/Immunology
Trioxsalen (Trisoralen), a psoralen derivative, is a photochemical DNA crosslinker. Trioxsalen only works after photoactivation with near ultraviolet light. Trioxsalen is a photosensitizer that can be used for the research of vitiligo and hand eczema. Trioxsalen is used for visualization of genomic interstrand cross-links localized by laser photoactivation .

5-Hydroxy-8-methoxypsoralen 1 Publications Verification 5-Hydroxyxanthotoxin	Drug Metabolite	Inflammation/Immunology
5-Hydroxy-8-methoxypsoralen (5-Hydroxyxanthotoxin) is a metabolite of Xanthotoxin. Xanthotoxin is a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight .

Methoxsalen Maximum Cited Publications 12 Publications Verification 8-Methoxypsoralen; Xanthotoxin; 8-MOP	Cytochrome P450	Inflammation/Immunology Cancer
Methoxsalen (8-Methoxypsoralen) is a furanocoumarin compound used in psoralen, used in studies of psoriasis, eczema, vitiligo and some sun-exposed cutaneous lymphomas, and is a P450 inhibitor.

Khellin 1 Publications Verification	EGFR	Cardiovascular Disease Cancer
Khellin is a furochromone that can be isolated from Ammi visnuga L.. Khellin is an EGFR inhibitor with an IC₅₀ of 0.15 µM. Khelline has anti-proliferative activity in vitro. Khellin has antispasmodic and coronary vasodilator effects .

Monobenzone (Standard)	DNA/RNA Synthesis Apoptosis	Inflammation/Immunology
Monobenzone (Standard) is the analytical standard of Monobenzone. This product is intended for research and analytical applications. Monobenzone is a potent skin depigmenting agent. Monobenzone induces depigmentation and active human vitiligo and exhibits good potential for vitiligo research .

6-Methoxy-4-methylcoumarin	Melanocortin Receptor GSK-3	Metabolic Disease Cancer
6-Methoxy-4-methylcoumarin is a 4-methylcoumarin derivative with an antitumor activity. 6-Methoxy-4-methylcoumarin activates melanin synthesis in B16F10 melanoma cells. 6-Methoxy-4-methylcoumarin is a pigmentation stimulator, and can be used for the study of skin conditions such as vitiligo .

Trioxsalen (Standard)	DNA Alkylator/Crosslinker	Inflammation/Immunology
Trioxsalen (Standard) is the analytical standard of Trioxsalen. This product is intended for research and analytical applications. Trioxsalen (Trisoralen), a psoralen derivative, is a photochemical DNA crosslinker. Trioxsalen only works after photoactivation with near ultraviolet light. Trioxsalen is a photosensitizer that can be used for the research of vitiligo and hand eczema. Trioxsalen is used for visualization of genomic interstrand cross-links localized by laser photoactivation .

Methoxsalen (Standard)	Cytochrome P450	Inflammation/Immunology Cancer
Methoxsalen (Standard) is the analytical standard of Methoxsalen. This product is intended for research and analytical applications. Methoxsalen (8-Methoxypsoralen) is a furanocoumarin compound used in psoralen, used in studies of psoriasis, eczema, vitiligo and some sun-exposed cutaneous lymphomas, and is a P450 inhibitor.

Methoxsalen-d3 8-Methoxypsoralen-d₃; Xanthotoxin-d₃; 8-MOP-d₃	Cytochrome P450	Inflammation/Immunology
Methoxsalen-d₃ is the deuterium labeled Methoxsalen[1]. Methoxsalen (8-Methoxypsoralen) is a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight[2].

Khellin (Standard)	EGFR	Cardiovascular Disease Cancer
Khellin (Standard) is the analytical standard of Khellin. This product is intended for research and analytical applications. Khellin is a furochromone that can be isolated from Ammi visnuga L.. Khellin is an EGFR inhibitor with an IC50 of 0.15 μM. Khelline has anti-proliferative activity in vitro. Khellin has antispasmodic and coronary vasodilator effects .

PPL agonist-1	Tyrosinase Microtubule/Tubulin	Inflammation/Immunology
PPL agonist-1 is a highly selective Periplakin (PPL) agonist that increases cAMP levels by regulating PPL, thereby enhancing MITF expression and promoting melanin synthesis. Furthermore, PPL agonist-1 facilitates melanin production by regulating tryptophan metabolism. Compared to Ruxolitinib (HY-50856), PPL agonist-1 demonstrates superior efficacy. PPL agonist-1 holds potential for research into vitiligo treatment .

Cat. No.	Product Name	Category	Target	Chemical Structure

5-Hydroxy-8-methoxypsoralen 1 Publications Verification 5-Hydroxyxanthotoxin	Saussurea medusa Maxim. Structural Classification Monophenols Classification of Application Fields Source classification Coumarins Phenols Phenylpropanoids Umbelliferae Plants Inflammation/Immunology Disease Research Fields	Drug Metabolite
5-Hydroxy-8-methoxypsoralen (5-Hydroxyxanthotoxin) is a metabolite of Xanthotoxin. Xanthotoxin is a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight .

Methoxsalen Maximum Cited Publications 12 Publications Verification 8-Methoxypsoralen; Xanthotoxin; 8-MOP	Structural Classification other families Classification of Application Fields Source classification Coumarins Phenylpropanoids Plants Disease Research Fields Cancer	Cytochrome P450
Methoxsalen (8-Methoxypsoralen) is a furanocoumarin compound used in psoralen, used in studies of psoriasis, eczema, vitiligo and some sun-exposed cutaneous lymphomas, and is a P450 inhibitor.

Khellin 1 Publications Verification	Cardiovascular Disease Structural Classification Classification of Application Fields Artemisia cana Pursh Source classification Lignans Phenylpropanoids Umbelliferae Plants Disease Research Fields	EGFR
Khellin is a furochromone that can be isolated from Ammi visnuga L.. Khellin is an EGFR inhibitor with an IC₅₀ of 0.15 µM. Khelline has anti-proliferative activity in vitro. Khellin has antispasmodic and coronary vasodilator effects .

6-Methoxy-4-methylcoumarin	Structural Classification Citrus × aurantium Linnaeus Source classification Rutaceae Coumarins Phenylpropanoids Plants Daphniphyllum macropodum Miq.	Melanocortin Receptor GSK-3
6-Methoxy-4-methylcoumarin is a 4-methylcoumarin derivative with an antitumor activity. 6-Methoxy-4-methylcoumarin activates melanin synthesis in B16F10 melanoma cells. 6-Methoxy-4-methylcoumarin is a pigmentation stimulator, and can be used for the study of skin conditions such as vitiligo .

Methoxsalen (Standard)	Structural Classification other families Source classification Coumarins Phenylpropanoids Plants	Cytochrome P450
Methoxsalen (Standard) is the analytical standard of Methoxsalen. This product is intended for research and analytical applications. Methoxsalen (8-Methoxypsoralen) is a furanocoumarin compound used in psoralen, used in studies of psoriasis, eczema, vitiligo and some sun-exposed cutaneous lymphomas, and is a P450 inhibitor.

Khellin (Standard)	Structural Classification Artemisia cana Pursh Source classification Lignans Phenylpropanoids Umbelliferae Plants	EGFR
Khellin (Standard) is the analytical standard of Khellin. This product is intended for research and analytical applications. Khellin is a furochromone that can be isolated from Ammi visnuga L.. Khellin is an EGFR inhibitor with an IC50 of 0.15 μM. Khelline has anti-proliferative activity in vitro. Khellin has antispasmodic and coronary vasodilator effects .

Cat. No.	Product Name	Chemical Structure

Methoxsalen-d3
Methoxsalen-d₃ is the deuterium labeled Methoxsalen[1]. Methoxsalen (8-Methoxypsoralen) is a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight[2].

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