2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. Khellin

Khellin is a furochromone that can be isolated from Ammi visnuga L.. Khellin is an EGFR inhibitor with an IC50 of 0.15 µM. Khelline has anti-proliferative activity in vitro. Khellin has antispasmodic and coronary vasodilator effects.

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Khellin Chemical Structure

Khellin Chemical Structure

CAS No. : 82-02-0

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Based on 1 publication(s) in Google Scholar

Khellin Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Khellin

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • Biological Activity

  • Purity & Documentation

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Description

Khellin is a furochromone that can be isolated from Ammi visnuga L.. Khellin is an EGFR inhibitor with an IC50 of 0.15 µM. Khelline has anti-proliferative activity in vitro. Khellin has antispasmodic and coronary vasodilator effects[1][2].

IC50 & Target

IC50: 0.15 µM (EGFR)[1]
In Vitro

Khelline exhibits anti-proliferative activity for MCF-7 cells and Hela cells[1].
Khellin inhibits the pathways of Ca2+ influx which are activated by both noradrenaline and high K+[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Khellin Related Antibodies
Molecular Weight

260.24

Formula

C14H12O5
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C1C=C(C)OC2=C(OC)C(OC=C3)=C3C(OC)=C12
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 16.67 mg/mL (64.06 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8426 mL 19.2130 mL 38.4261 mL
5 mM 0.7685 mL 3.8426 mL 7.6852 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.8426 mL 19.2130 mL 38.4261 mL 96.0652 mL
5 mM 0.7685 mL 3.8426 mL 7.6852 mL 19.2130 mL
10 mM 0.3843 mL 1.9213 mL 3.8426 mL 9.6065 mL
15 mM 0.2562 mL 1.2809 mL 2.5617 mL 6.4043 mL
20 mM 0.1921 mL 0.9607 mL 1.9213 mL 4.8033 mL
25 mM 0.1537 mL 0.7685 mL 1.5370 mL 3.8426 mL
30 mM 0.1281 mL 0.6404 mL 1.2809 mL 3.2022 mL
40 mM 0.0961 mL 0.4803 mL 0.9607 mL 2.4016 mL
50 mM 0.0769 mL 0.3843 mL 0.7685 mL 1.9213 mL
60 mM 0.0640 mL 0.3202 mL 0.6404 mL 1.6011 mL
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Khellin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Khellin82-02-0EGFREpidermal growth factor receptorErbB-1HER1vascularsmoothmusclevitiligoanalgesicInhibitorinhibitorinhibit

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