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Results for "

acute migraine

" in MedChemExpress (MCE) Product Catalog:

7

Inhibitors & Agonists

2

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-134992
    Vazegepant

    Zavegepant; BHV-3500

    		 CGRP Receptor Neurological Disease
    Vazegepant (Zavegepant) is an orally active calcitonin gene-related peptide CGRP receptor antagonist with potential for acute research in migraine, can be administered intranasally. CGRP is an important trigger in migraine pathophysiology .
    Vazegepant
  • HY-12366
    Ubrogepant

    MK-1602

    		 CGRP Receptor Cardiovascular Disease Neurological Disease
    Ubrogepant (MK-1602) is an orally active and selective antagonist of calcitonin gene-related peptide receptor (CGRP). Ubrogepant has high affinity for CGRP receptors in human and rhesus monkeys, and can effectively block the cAMP response stimulated by α-CGRP. Ubrogepant can be used in the study of acute migraine .
    Ubrogepant
  • HY-117694
    MK-8825

    		CGRP Receptor Neurological Disease Inflammation/Immunology
    MK-8825 is an orally active, potent and selective CGRP receptor antagonist, which shows concentration-dependent inhibition of Capsaicin (HY-10448)-evoked dermal blood flow with an EC50 value of about 7.4 μM. MK-8825 inhibits CGRP-induced spontaneous nociceptive facial grooming behaviors, neuronal activation in the trigeminal nucleus, and systemic release of pro-inflammatory cytokines in a mouse model of acute orofacial masseteric muscle pain. MK-8825 is promising for research of acute migraine .
    MK-8825
  • HY-145353
    HTL22562

    		CGRP Receptor Neurological Disease
    HTL22562 is a calcitonin gene-related peptide (CGRP) receptor antagonist for acute research of migraine.
    HTL22562
  • HY-134992S
    (Rac)-Vazegepant-13C,d3

    		Isotope-Labeled Compounds Others
    (Rac)-Vazegepant- 13C,d3 is the C13 and deuterium labeled (Rac)-Vazegepant. Vazegepant (HY-134992) is the first intranasal CGRP receptor antagonist for the study the acute research of migraine .
    (Rac)-Vazegepant-13C,d3
  • HY-12366R
    Ubrogepant (Standard)

    MK-1602 (Standard)

    		 CGRP Receptor Cardiovascular Disease Neurological Disease
    Ubrogepant (Standard) is the analytical standard of Ubrogepant. This product is intended for research and analytical applications. Ubrogepant (MK-1602) is an orally active and selective antagonist of calcitonin gene-related peptide receptor (CGRP). Ubrogepant has high affinity for CGRP receptors in human and rhesus monkeys, and can effectively block the cAMP response stimulated by α-CGRP. Ubrogepant can be used in the study of acute migraine .
    Ubrogepant (Standard)
  • HY-12366S
    Ubrogepant-d5

    MK-1602-d5

    		 Isotope-Labeled Compounds CGRP Receptor Cardiovascular Disease Neurological Disease
    Ubrogepant-d5 (MK-1602-d5) is deuterium labeled Ubrogepant. Ubrogepant (MK-1602) is an orally active and selective antagonist of calcitonin gene-related peptide receptor (CGRP). Ubrogepant has high affinity for CGRP receptors in human and rhesus monkeys, and can effectively block the cAMP response stimulated by α-CGRP. Ubrogepant can be used in the study of acute migraine .
    Ubrogepant-d5

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