2. GPCR/G Protein Neuronal Signaling
  3. CGRP Receptor
  4. Vazegepant

Vazegepant  (Synonyms: Zavegepant; BHV-3500)

Cat. No.: HY-134992 Purity: 98.92%
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Vazegepant (Zavegepant) is an orally active calcitonin gene-related peptide CGRP receptor antagonist with potential for acute research in migraine, can be administered intranasally. CGRP is an important trigger in migraine pathophysiology.

For research use only. We do not sell to patients.

Vazegepant Chemical Structure

Vazegepant Chemical Structure

CAS No. : 1337918-83-8

Size Price Stock Quantity
1 mg USD 130 In-stock
5 mg USD 290 In-stock
10 mg USD 430 In-stock
25 mg USD 780 In-stock
50 mg USD 1180 In-stock
100 mg USD 1770 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Vazegepant:

Vazegepant Related Antibodies

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Description

Vazegepant (Zavegepant) is an orally active calcitonin gene-related peptide CGRP receptor antagonist with potential for acute research in migraine, can be administered intranasally. CGRP is an important trigger in migraine pathophysiology[1][2][3][4].

Clinical Trial
Molecular Weight

638.80

Formula

C36H46N8O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1CCC(C2=CC3=C(NC2=O)C=CC=C3)CC1)N[C@H](CC4=CC5=C(NN=C5)C(C)=C4)C(N6CCN(C7CCN(C)CC7)CC6)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (78.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5654 mL 7.8272 mL 15.6544 mL
5 mM 0.3131 mL 1.5654 mL 3.1309 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
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μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5654 mL 7.8272 mL 15.6544 mL 39.1359 mL
5 mM 0.3131 mL 1.5654 mL 3.1309 mL 7.8272 mL
10 mM 0.1565 mL 0.7827 mL 1.5654 mL 3.9136 mL
15 mM 0.1044 mL 0.5218 mL 1.0436 mL 2.6091 mL
20 mM 0.0783 mL 0.3914 mL 0.7827 mL 1.9568 mL
25 mM 0.0626 mL 0.3131 mL 0.6262 mL 1.5654 mL
30 mM 0.0522 mL 0.2609 mL 0.5218 mL 1.3045 mL
40 mM 0.0391 mL 0.1957 mL 0.3914 mL 0.9784 mL
50 mM 0.0313 mL 0.1565 mL 0.3131 mL 0.7827 mL
60 mM 0.0261 mL 0.1305 mL 0.2609 mL 0.6523 mL
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Vazegepant Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vazegepant1337918-83-8Zavegepant BHV-3500BHV3500BHV 3500BHV-3500CGRP ReceptorCalcitonin gene-related peptide receptorMigraineInhibitorinhibitorinhibit

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