Search Result

Results for "

b7h3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Antibody (2) ADC Cytotoxin (1) Akt (1) Antibody-Drug Conjugates (ADCs) (1) Autophagy (1) CD276/B7-H3 (4) CD3 (2) mTOR (1) Topoisomerase (1)
By Research Areas:	Cancer (9) Inflammation/Immunology (2)

Inhibitors & Agonists

Inhibitory Antibodies

Recombinant Proteins

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-156617

Cyclopropaneacetamide-Exatecan	ADC Cytotoxin Topoisomerase	Cancer
Cyclopropaneacetamide-Exatecan (Compound 2-A) is an ADC Cytotoxin and an Exatecan analogue. Cyclopropaneacetamide-Exatecan can be used in the synthesis of ADC such as anti-B7H3 antibody-Exatecan analogue conjugate (compound ADC-2) .

HY-P9966

Enoblituzumab MGA271	CD276/B7-H3	Cancer
Enoblituzumab (MGA271) is a humanized IgG1κ monoclonal antibody recognizing human *B7-H3* protein, a member of the B7 family of immune regulators .

HY-P99367

Ifinatamab	CD3	Inflammation/Immunology Cancer
Ifinatamab is monoclonal immunoglobulin G1-kappa with anti-human B7 homolog 3 protein (Human B7-H3). Ifinatamab is a glycoforme α immunomodulateur .

HY-P99762

Obrindatamab MGD009	CD3	Cancer
Obrindatamab is a humanized anti-B7-H3/CD3 bispecific antibody. Obrindatamab binds to B7-H3 and CD3, thereby mediating redirected cytotoxic T-lymphocyte (CTL) activity against B7-H3-expressing cancer cells. Obrindatamab can be used in research of cancer .

HY-155747

FDW028	Autophagy Akt mTOR	Cancer
FDW028 a potent and highly selective FUT8 inhibitor. FUT8 exhibits potent anti-tumor activity by defucosylation and impelling lysosomal degradation of B7-H3 through the chaperone-mediated autophagy (CMA) pathway. FDW028 can be used for metastatic colorectal cancer (mCRC) research .

HY-P99157

Omburtamab	CD276/B7-H3	Cancer
Omburtamab is an anti-CD276 (also known as *B7-H3*) monoclonal antibody, CD276 is a B7/CD28 immunoglobulin superfamily member expressed among solid human tumours. Omburtamab can bind tumor tissues and be used in various cancers research .

HY-P99101

Vobramitamab AEX-4089	ADC Antibody	Cancer
Vobramitamab is a humanized *B7-H3* monoclonal antibody (mAb). Vobramitamab conjugated with prodrug seco-DUBA (HY-132180A) via a cleavable linker, to form antibody-drug conjugate (ADC), the MGC018. MGC018 displays potent antitumor activity in preclinical tumor models of breast, ovarian, and lung cancer, as well as melanoma .

HY-P99740

Mirzotamab	CD276/B7-H3 ADC Antibody	Cancer
Mirzotamab is an IgG1κ monoclonal antibody targeting to *CD276/B7-H3* with anti-tumor activity. Mirzotamab conjugates with Clezutoclax (HY-137774), a BCL inhibitor to form Mirzotamab clezutoclax (HY-P99741), involving in research with taxane research in relapsed/refractory solid tumors. Mirzotamab clezutoclax (ABBV-155) is a targeted antibody drug conjugate (ADC) .

HY-P3371

Ifinatamab deruxtecan DS-7300a; MABX-9001a	Antibody-Drug Conjugates (ADCs)	Cancer
Ifinatamab deruxtecan (DS-7300a) is an ADC that binds an anti-B7-H3 antibody to the DNA topoisomerase I inhibitory anti-tumor drug DXd. Ifinatamab deruxtecan has antitumor activity .

HY-P990340

*Anti-B7-H3/CD276 Antibody*	CD276/B7-H3	Inflammation/Immunology
Anti-B7-H3/CD276 Antibody is a CHO-expressed human antibody targeting *B7-H3/CD276. Anti-B7-H3/CD276 Antibody has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for Anti-B7-H3*/CD276 Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

Cat. No.	Product Name	Target	Research Area

HY-P9966

Enoblituzumab MGA271	CD276/B7-H3	Cancer
Enoblituzumab (MGA271) is a humanized IgG1κ monoclonal antibody recognizing human *B7-H3* protein, a member of the B7 family of immune regulators .

HY-P99367

Ifinatamab	CD3	Inflammation/Immunology Cancer
Ifinatamab is monoclonal immunoglobulin G1-kappa with anti-human B7 homolog 3 protein (Human B7-H3). Ifinatamab is a glycoforme α immunomodulateur .

HY-P99762

Obrindatamab MGD009	CD3	Cancer
Obrindatamab is a humanized anti-B7-H3/CD3 bispecific antibody. Obrindatamab binds to B7-H3 and CD3, thereby mediating redirected cytotoxic T-lymphocyte (CTL) activity against B7-H3-expressing cancer cells. Obrindatamab can be used in research of cancer .

HY-P99157

Omburtamab	CD276/B7-H3	Cancer
Omburtamab is an anti-CD276 (also known as *B7-H3*) monoclonal antibody, CD276 is a B7/CD28 immunoglobulin superfamily member expressed among solid human tumours. Omburtamab can bind tumor tissues and be used in various cancers research .

HY-P99101

Vobramitamab AEX-4089	ADC Antibody	Cancer
Vobramitamab is a humanized *B7-H3* monoclonal antibody (mAb). Vobramitamab conjugated with prodrug seco-DUBA (HY-132180A) via a cleavable linker, to form antibody-drug conjugate (ADC), the MGC018. MGC018 displays potent antitumor activity in preclinical tumor models of breast, ovarian, and lung cancer, as well as melanoma .

HY-P990279

*Anti-Mouse CD276/B7-H3* Antibody (MJ18)**	Inhibitory Antibodies	Others
Anti-Mouse CD276/B7-H3 Antibody (MJ18) is a rat-derived IgG1, κ type antibody inhibitor, targeting to mouse CD276/B7-H3.

HY-P99740

Mirzotamab	CD276/B7-H3 ADC Antibody	Cancer
Mirzotamab is an IgG1κ monoclonal antibody targeting to *CD276/B7-H3* with anti-tumor activity. Mirzotamab conjugates with Clezutoclax (HY-137774), a BCL inhibitor to form Mirzotamab clezutoclax (HY-P99741), involving in research with taxane research in relapsed/refractory solid tumors. Mirzotamab clezutoclax (ABBV-155) is a targeted antibody drug conjugate (ADC) .

HY-P3371

Ifinatamab deruxtecan DS-7300a; MABX-9001a	Antibody-Drug Conjugates (ADCs)	Cancer
Ifinatamab deruxtecan (DS-7300a) is an ADC that binds an anti-B7-H3 antibody to the DNA topoisomerase I inhibitory anti-tumor drug DXd. Ifinatamab deruxtecan has antitumor activity .

HY-P990340

*Anti-B7-H3/CD276 Antibody*	CD276/B7-H3	Inflammation/Immunology
Anti-B7-H3/CD276 Antibody is a CHO-expressed human antibody targeting *B7-H3/CD276. Anti-B7-H3/CD276 Antibody has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for Anti-B7-H3*/CD276 Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

Recombinant Proteins Recommended:

B7-H3

Species:	Human (11) Rat (2) Mouse (1) Cynomolgus (2)
Tag:	His (9) Avi (4) Myc (1) Fc (7)
Source:	HEK293 (16)

Cat. No.	Compare	Product Name	Species	Source

HY-P74314

	*CD276/B7-H3* Protein, Rat (HEK293, His)** b7h3; B7-H3B7 homolog 3; CD276; Costimulatory molecule	Rat	HEK293
	CD276/B7-H3 Protein regulates T-cell-mediated immune responses and transplant rejection. It also promotes bone formation, functioning at the bone-immune interface. Additionally, it activates immune responses against tumors, eliminating them through natural killer cells and CD8 T-cells. Its interaction with TREML2 enhances T-cell activation, highlighting its role in immune regulation. CD276/B7-H3 Protein, Rat (HEK293, His) is the recombinant rat-derived CD276/B7-H3 protein, expressed by HEK293 , with C-His labeled tag.

HY-P700880

	*CD276/B7-H3* Protein, Human (Biotinylated, HEK293, C-His-Avi)** b7h3; B7-H3; CD276; PSEC0249; UNQ309; PRO352; B7 homolog 3; CD276	Human	HEK293
	CD276/B7-H3 protein can regulate T cell-mediated immune responses and act as a protective factor for tumor cells by inhibiting natural killer-mediated cell lysis. It also functions as a neuroblastoma cell marker, plays a role in acute and chronic transplant rejection, and modulates lymphocyte activity at mucosal surfaces. CD276/B7-H3 Protein, Human (Biotinylated, HEK293, C-His-Avi) is the recombinant human-derived CD276/B7-H3 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of CD276/B7-H3 Protein, Human (Biotinylated, HEK293, C-His-Avi) is 217 a.a., with molecular weight of 40-50 kDa.

HY-P70125

	*CD276/B7-H3* Protein, Cynomolgus (HEK293, His)** rCynCD276/B7-H3, His; CD276 antigen; CD276; B7 homolog 3; B7-H3; CD276; Cynomolgus CD276	Cynomolgus	HEK293
	CD276/B7-H3 protein can regulate T cell-mediated immune responses and act as a protective factor for tumor cells by inhibiting natural killer-mediated cell lysis. It also functions as a neuroblastoma cell marker, plays a role in acute and chronic transplant rejection, and modulates lymphocyte activity at mucosal surfaces. CD276/B7-H3 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CD276/B7-H3 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P7327

	*CD276/B7-H3* Protein, Human (HEK293, His)** rHuB7-H3/ICOSLG, His; b7h3; B7 homolog 3; CD276	Human	HEK293
	CD276/B7-H3 Protein, Human (HEK293, His) is a polypeptide chain containing the C-termimal His tag produced in HEK293 cells. B7-H3 is an immune checkpoint from the B7 family of molecules.

HY-P70126

	*CD276/B7-H3* Protein, Cynomolgus (HEK293, Fc)** rCynCD276/B7-H3, Fc; CD276 antigen; CD276; B7 homolog 3; B7-H3; CD276; Cynomolgus CD276 Molecule	Cynomolgus	HEK293
	CD276/B7-H3 protein can regulate T cell-mediated immune responses and act as a protective factor for tumor cells by inhibiting natural killer-mediated cell lysis. It also functions as a neuroblastoma cell marker, plays a role in acute and chronic transplant rejection, and modulates lymphocyte activity at mucosal surfaces. CD276/B7-H3 Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived CD276/B7-H3 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P7639

	*CD276/B7-H3* Protein, Mouse (HEK293, His)** rMuB7-H3, His; CD276 antigen; CD276; B7 homolog 3; B7-H3; CD276	Mouse	HEK293
	CD276/B7-H3 Protein, Mouse (HEK293, His) is induced upon T cell activation. B7-H3 selectively increases the production of IFN-γ.

HY-P74315

	*CD276/B7-H3* Protein, Rat (HEK293, Fc)** b7h3; B7-H3B7 homolog 3; CD276; Costimulatory molecule	Rat	HEK293
	CD276/B7-H3 Protein regulates T-cell-mediated immune responses and transplant rejection. It also promotes bone formation, functioning at the bone-immune interface. Additionally, it activates immune responses against tumors, eliminating them through natural killer cells and CD8 T-cells. Its interaction with TREML2 enhances T-cell activation, highlighting its role in immune regulation. CD276/B7-H3 Protein, Rat (HEK293, Fc) is the recombinant rat-derived CD276/B7-H3 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P77538

	*CD276/B7-H3* Protein, Human (Biotinylated, HEK293, His)** b7h3; B7-H3B7 homolog 3; CD276; Costimulatory molecule	Human	HEK293
	CD276/B7-H3 protein can regulate T cell-mediated immune responses and act as a protective factor for tumor cells by inhibiting natural killer-mediated cell lysis. It also functions as a neuroblastoma cell marker, plays a role in acute and chronic transplant rejection, and modulates lymphocyte activity at mucosal surfaces. CD276/B7-H3 Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived CD276/B7-H3 protein, expressed by HEK293 , with C-His labeled tag.

HY-P77578

	*CD276/B7-H3* Protein, Human (217a.a, HEK293, Fc)** b7h3; B7-H3; CD276; PSEC0249; UNQ309; PRO352; B7 homolog 3; CD276	Human	HEK293
	CD276/B7-H3 protein can regulate T cell-mediated immune responses and act as a protective factor for tumor cells by inhibiting natural killer-mediated cell lysis. It also functions as a neuroblastoma cell marker, plays a role in acute and chronic transplant rejection, and modulates lymphocyte activity at mucosal surfaces. CD276/B7-H3 Protein, Human (217a.a, HEK293, Fc) is the recombinant human-derived CD276/B7-H3 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD276/B7-H3 Protein, Human (217a.a, HEK293, Fc) is 217 a.a., with molecular weight of 60-70 kDa.

HY-P700448

	*CD276/B7-H3* Protein, Human (HEK293, Myc-hFc)** CD276; CD276 molecule; CD276 antigen; B7 H3; b7h3; B7RP 2; B7 homolog 3; costimulatory molecule; B7-H3; B7RP-2; 4Ig-B7-H3	Human	HEK293
	CD276/B7-H3 protein can regulate T cell-mediated immune responses and act as a protective factor for tumor cells by inhibiting natural killer-mediated cell lysis. It also functions as a neuroblastoma cell marker, plays a role in acute and chronic transplant rejection, and modulates lymphocyte activity at mucosal surfaces. CD276/B7-H3 Protein, Human (HEK293, Myc-hFc) is the recombinant human-derived CD276/B7-H3 protein, expressed by HEK293 , with C-Myc, C-hFc labeled tag.

HY-P70652

	*CD276/B7-H3* Protein, Human (433a.a, HEK293, His)** CD276; b7h34Ig-B7-H3; B7-H3; B7 homolog 3; CD276 antigen; CD276 molecule; Costimulatory molecule	Human	HEK293
	CD276/B7-H3 protein can regulate T cell-mediated immune responses and act as a protective factor for tumor cells by inhibiting natural killer-mediated cell lysis. It also functions as a neuroblastoma cell marker, plays a role in acute and chronic transplant rejection, and modulates lymphocyte activity at mucosal surfaces. CD276/B7-H3 Protein, Human (433a.a, HEK293, His) is the recombinant human-derived CD276/B7-H3 protein, expressed by HEK293 , with C-His labeled tag.

HY-P7326

	*CD276/B7-H3* Protein, Human (435a.a, HEK293, Fc)** rHuB7-H3/ICOSLG, Fc Chimera; b7h3; B7 homolog 3; CD276	Human	HEK293
	CD276/B7-H3 Protein, Human (HEK293, Fc) is a polypeptide chain containing the C-termimal His tag produced in HEK293 cells. B7-H3 is an immune checkpoint from the B7 family of molecules.

HY-P78930

	*CD276/B7-H3* Protein, Human (Biotinylated, HEK293, Fc-Avi)** B7-H3; CD276; B7 homolog 3	Human	HEK293
	CD276/B7-H3 Protein may regulate T-cell-mediated immune responses, acting as a protective factor in tumor cells by inhibiting natural-killer-mediated cell lysis. It also serves as a neuroblastoma cell marker and plays a role in acute and chronic transplant rejection, regulating lymphocytic activity at mucosal surfaces. Crucially, CD276/B7-H3 may provide an immunologically suitable environment for the placenta and fetus during pregnancy. Both isoforms modulate CD4 T-cell responses, with isoform 2 enhancing cytotoxic T-cells and selectively stimulating interferon-gamma production. Interaction with TREML2 enhances T-cell activation, highlighting CD276/B7-H3's diverse roles in immune regulation and cellular responses. CD276/B7-H3 Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived CD276/B7-H3 protein, expressed by HEK293, with C-Avi, C-hFc labeled tag. The total length of CD276/B7-H3 Protein, Human (Biotinylated, HEK293, Fc-Avi) is 217 a.a., with molecular weight of 63-70 kDa.

HY-P78391

	*CD276/B7-H3* Protein, Human (HEK293, His-Avi)** B7-H3; CD276; PSEC0249; 4Ig-B7-H3; UNQ309; PRO352; B7 homolog 3; CD276	Human	HEK293
	CD276/B7-H3 protein can regulate T cell-mediated immune responses and act as a protective factor for tumor cells by inhibiting natural killer-mediated cell lysis. It also functions as a neuroblastoma cell marker, plays a role in acute and chronic transplant rejection, and modulates lymphocyte activity at mucosal surfaces. CD276/B7-H3 Protein, Human (HEK293, His-Avi) is the recombinant human-derived CD276/B7-H3 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P78074

	*CD276/B7-H3* Protein, Human (Biotinylated, HEK293, His-Avi)** B7-H3; CD276; PSEC0249; 4Ig-B7-H3; UNQ309; PRO352; B7 homolog 3; CD276	Human	HEK293
	CD276/B7-H3 protein can regulate T cell-mediated immune responses and act as a protective factor for tumor cells by inhibiting natural killer-mediated cell lysis. It also functions as a neuroblastoma cell marker, plays a role in acute and chronic transplant rejection, and modulates lymphocyte activity at mucosal surfaces. CD276/B7-H3 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived CD276/B7-H3 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P701302

	*FITC-Labeled CD276/B7-H3* Protein, Human (435a.a, HEK293, Fc)** 4Ig-B7-H3; B7-H3; CD276; PSEC0249; UNQ309; PRO352; B7 homolog 3	Human	HEK293
	CD276/B7-H3 protein can regulate T cell-mediated immune responses and act as a protective factor for tumor cells by inhibiting natural killer-mediated cell lysis. It also functions as a neuroblastoma cell marker, plays a role in acute and chronic transplant rejection, and modulates lymphocyte activity at mucosal surfaces. FITC-Labeled CD276/B7-H3 Protein, Human (435a.a, HEK293, Fc) is the recombinant human-derived FITC-Labeled CD276/B7-H3 protein, expressed by HEK293 , with Fc labeled tag.

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81534

	CD276 Antibody (YA1279) CD276; b7h3; PSEC0249; CD276 antigen; 4Ig-B7-H3; B7 homolog 3; B7-H3; Costimulatory molecule; CD276	IHC-P	Human
	CD276 Antibody (YA1279) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1279), targeting CD276. CD276 Antibody (YA1279) can be used for IHC-P experiment in human background.

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