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Results for "

cGAS/STING

" in MedChemExpress (MCE) Product Catalog:

17

Inhibitors & Agonists

1

Peptides

3

Natural
Products

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-160406
    SNX281

    		STING Cancer
    SNX281 is a systemically active STING agonist that binds to the STING protein, promotes signal transduction of the cGAS-STING pathway, and increases cellular responses to tumor cells. SNX281 can be used in the study of anti-tumor immunity .
    SNX281
  • HY-P1680
    Astin C

    Asterin

    		 STING Inflammation/Immunology Cancer
    Astin C (Asterin) is a cyclic pentapeptide with anticancer and anti-inflammatory properties, as well as an inhibitor of cGAS-STING .
    Astin C
  • HY-131454
    SR-717
    Maximum Cited Publications
    13 Publications Verification

    		 STING Inflammation/Immunology Cancer
    SR-717 is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 is a stable cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic. Antitumor activity .
    SR-717
  • HY-131454A
    SR-717 free acid
    Maximum Cited Publications
    13 Publications Verification

    		 STING Inflammation/Immunology Cancer
    SR-717 free acid is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 free acid is a stable cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic. Antitumor activity .
    SR-717 free acid
  • HY-162967
    MS8588

    		PROTACs STING Cancer
    MS8588 is the first DUBTACs for cGAS, a key component of the cGAS-STING pathway.
    MS8588
  • HY-N15159
    Cladophorol A

    		Cyclic GMP-AMP Synthase STING
    Cladophorol A is a cGAS inhibitor that binds to the conserved adenosine nucleobase binding site of cGAS, thereby blocking its activity. At non-cytotoxic concentrations, Cladophorol A effectively inhibits the overactivation of the cGAS-STING pathway with an IC50 of 370 nM. Cladophorol A holds potential for research on inflammatory diseases related to the overactivation of the cGAS-STING pathway .
    Cladophorol A
  • HY-162966
    MS7829

    		Cyclic GMP-AMP Synthase Cancer
    MS7829 is a cGAS inhibitor-based deubiquitinase-targeted chimera (DUBTAC), a targeted protein stabilization (TPS) technology. cGAS is a key component in the cGAS-STING pathway. .
    MS7829
  • HY-162133
    MSA-2-Pt

    		STING Cancer
    MSA-2-Pt is an orally active STING agonist that has good cell membrane permeability. MSA-2-Pt can induce cell death by Pt, which may release damaged DNA to activate the cGAS-STING pathway. Besides, MSA-2-Pt can activate the STING pathway directly by MSA-2. MSA-2-Pt can be used for the research of cancer .
    MSA-2-Pt
  • HY-N12507
    Eupenicisirenin C

    		STING NF-κB Others
    Eupenicisirenin C (compound 1) is a sirenin derivative. Eupenicisirenin C has strong NF-κB inhibitory activities. Eupenicisirenin C suppresses effects on cGAS-STING pathway. Eupenicisirenin C inhibits RANKL-induced osteoclast differentiation in bone marrow macrophage cells .
    Eupenicisirenin C
  • HY-158126
    G-quadruplex ligand 2

    		DNA/RNA Synthesis Cancer
    G-quadruplex ligand 2 (compound A3) is a triphenylamine-based ligand that targets mitochondrial DNA G4s. G-quadruplex ligand 2 activates the cGAS-STING pathway. G-quadruplex ligand 2 inhibits tumor growth and metastasis via regulation of TME .
    G-quadruplex ligand 2
  • HY-163461
    4F-DDC

    		PARP Cancer
    4F-DDC is a novel PARP1 inhibitor with an IC50 value of 82 nM. 4F-DDC induces DNA damage and activates the cGAS–STING pathway. 4F-DDC inhibits the growth of HCC-1937-derived tumor xenografts .
    4F-DDC
  • HY-144329
    STING agonist-11

    		STING Inflammation/Immunology Cancer
    STING agonist-11 (Compound 92) is a potent small molecule cyclic urea activator of STING with EC50 of 18 nM. Activation of STING is a highly promising approach in immunotherapy .
    STING agonist-11
  • HY-144328
    STING agonist-10

    		STING Inflammation/Immunology Cancer
    STING agonist-10 (Compound 91) is a potent small molecule cyclic urea activator of STING with the EC50 of 2600 nM. Activation of STING is a highly promising approach in immunotherapy .
    STING agonist-10
  • HY-139056
    SU0268
    1 Publications Verification

    		 Glycosyltransferase Infection Inflammation/Immunology Cancer
    SU0268 is a potent and specific inhibitor of 8-Oxoguanine DNA glycosylase 1 (OGG1). SU0268 regulates inflammatory responses during Pseudomonas aeruginosa infection .
    SU0268
  • HY-13735H
    Quinacrine acetate

    Acriquine acetate

    		 Parasite Sodium Channel DNA Stain Apoptosis Cancer
    Quinacrine (Acriquine) acetate is a small molecule modulator of the cGAS-STING-TBK1 signaling pathway, possessing immune stimulatory activity. Quinacrine acetate has been explored for its potential therapeutic applications in enhancing anti-tumor immunity. Quinacrine acetate can improve the effectiveness of cancer immunotherapies by addressing the poor immunogenicity of various tumors. Quinacrine acetate also presents a promising strategy for overcoming the limitations associated with immune checkpoint inhibitors in cancer treatment.
    Quinacrine acetate
  • HY-158045
    PROTAC PARP1 degrader-1

    		PROTACs PARP Inflammation/Immunology Cancer
    PROTAC PARP1 degrader-1 (Compound CN0) is a PROTAC degrader of PARP1. PROTAC PARP1 degrader-1 activates the cGAS/STING immunity pathway and eventually enhances T cell killing of tumor cells. PROTAC PARP1 degrader-1 inhibits DNA damage repair, resulting in highly efficient accumulation of cytosolic DNA fragments (Blue: CRBN ligand, Black: linker; Pink: PARP1 inhibitor) .
    PROTAC PARP1 degrader-1
  • HY-162944
    NA-Ir

    		Ferroptosis Mitochondrial Metabolism STING Autophagy Cancer
    NA-Ir is a Ferroptosis inducer. NA-Ir targets mitochondrial DNA (mtDNA) and activates the cGAS-STING pathway to induce ferritinophagy (Autophagy), while also generating reactive oxygen species (ROS) through photodynamic therapy (PDT), depleting glutathione (GSH), and downregulating glutathione peroxidase 4 (GPX4), thereby triggering lipid peroxidation and Ferroptosis. NA-Ir exhibits higher anticancer activity under light exposure and selectively inhibits cancer cells with high H2S levels .
    NA-Ir

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