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Results for "

cholesterol synthesis

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (1) Apoptosis (9) Autophagy (8) Bacterial (2) Biochemical Assay Reagents (2) Drug Metabolite (1) Endogenous Metabolite (20) Enterovirus (1) Estrogen Receptor/ERR (1) Fatty Acid Synthase (FASN) (2) Ferroptosis (1) Fungal (2) Glucosidase (1) Hedgehog (1) HMG-CoA Reductase (HMGCR) (9) Isotope-Labeled Compounds (6) Ligands for Target Protein for PROTAC (1) Liposome (2) LXR (1) MicroRNA (2) Mitophagy (7) p38 MAPK (1) PPAR (1) Reactive Oxygen Species (2) TRP Channel (2)
By Research Areas:	Cancer (15) Cardiovascular Disease (11) Endocrinology (2) Infection (5) Inflammation/Immunology (2) Metabolic Disease (30) Neurological Disease (10)
Oligonucleotides:	Cholesterol (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: DNA/RNA Synthesis Acyltransferase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W020033

Lanosterol 3 Publications Verification	Endogenous Metabolite	Neurological Disease
Lanosterol is an intermediate of cholesterol synthesis and use of lanosterol induces ubiquitination and degradation of a rate-controlling enzyme of cholesterol synthesis, i.e., HMG CoA reductase. Lanosterol suppresses the aggregation and cytotoxicity of misfolded proteins linked with neurodegenerative diseases .

HY-N3925

Ganoderol A	Bacterial	Infection Metabolic Disease Inflammation/Immunology
Ganoderol A is a terpenoid extracted from Ganoderma lucidum with antimicrobial activities. Ganoderol A inhibits cholesterol synthesis pathway and has significant anti-inflammatory activity and protection against ultraviolet A (UVA) damage .

HY-125713

Ganoderic acid Y	Glucosidase Enterovirus	Infection
Ganoderic acid Y is a α-glucosidase inhibitor with an IC₅₀ of 170 μM for yeast α-glucosidase. Ganoderic acid Y inhibits enterovirus 71 (EV71) replication through blocking EV71 uncoating .

HY-113486S

(S)-Lathosterol-d4	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
(S)-Lathosterol-d₄ is the deuterium labeled (S)-Lathosterol. Lathosterol is a cholesterol-like molecule. Serum Lathosterol concentration is an indicator of whole-body cholesterol synthesis[1].

HY-113486

Lathosterol 2 Publications Verification	Endogenous Metabolite	Metabolic Disease
Lathosterol is a cholesterol-like molecule. Serum Lathosterol concentration is an indicator of whole-body cholesterol synthesis.

HY-17502

Simvastatin Maximum Cited Publications 48 Publications Verification MK 733	HMG-CoA Reductase (HMGCR) Autophagy Mitophagy Apoptosis Ferroptosis	Cardiovascular Disease Cancer
Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a K_i of 0.2 nM.

HY-W020033S

Lanosterol-d6	Isotope-Labeled Compounds Endogenous Metabolite	Neurological Disease
Lanosterol-d₆ is deuterium labeled Lanosterol. Lanosterol is an intermediate of cholesterol synthesis and use of lanosterol induces ubiquitination and degradation of a rate-controlling enzyme of cholesterol synthesis, i.e., HMG CoA reductase. Lanosterol s

HY-156197

Biotin-cholesterol	Liposome Estrogen Receptor/ERR Endogenous Metabolite Bacterial	Cancer
Biotin-cholesterol is a biotinylated form of Cholesterol (HY-N0322). Biotin-cholesterol can be used in the synthesis of biotin-conjugated liposomes and micelles for drug delivery .

HY-113486S1

lathosterol-d7	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
lathosterol-d₇ is deuterium labeled lathosterol. Lathosterol is a cholesterol-like molecule. Serum Lathosterol concentration is an indicator of whole-body cholesterol synthesis[1].

HY-167016

Cholesterol-undecanoate-glucose conjugate	Liposome	Others
Cholesterol-undecanoate-glucose conjugate is a cholesterol conjugate used in the synthesis of intranasal liposomal vaccines. Cholesterol-undecanoate-glucose conjugate can be used in drug delivery studies .

HY-124265

4β-Hydroxycholesterol	Endogenous Metabolite	Metabolic Disease
4β-hydroxy Cholesterol is a major oxysterol cholesterol metabolite and a precursor in the synthesis of bile acids that is found in human circulation .

HY-N2221

Ganoderal A	Others	Metabolic Disease
Ganoderal A, an oxygenated sterol from G. lucidum, is a cholesterol synthesis inhibitor .

HY-121795

Pravastatin lactone	HMG-CoA Reductase (HMGCR)	Cardiovascular Disease
Pravastatin lactone is a potent HMG-CoA inhibitor. Pravastatin Lactone is a metabolite of pravastatin. Pravastatin lactone reduces blood cholesterol levels by inhibiting cholesterol synthesis .

HY-16166

Dalvastatin RG-12561	HMG-CoA Reductase (HMGCR)	Inflammation/Immunology
Dalvastatin (RG-12561) inhibitor of HMG-CoA reductase and cholesterol-lowering synthesis .

HY-125666

Agistatin B	Others	Infection
Agistatin B, isolated from fungus, is a mycotoxin. Agistatin B inhibits **cholesterol synthesis** .

HY-113486R

Lathosterol (Standard)	Endogenous Metabolite	Metabolic Disease
Lathosterol (Standard) is the analytical standard of Lathosterol. This product is intended for research and analytical applications. Lathosterol is a cholesterol-like molecule. Serum Lathosterol concentration is an indicator of whole-body cholesterol synthesis.

HY-121413

Clinolamide	Others	Others
Clinolamide is an N-cyclohexyl linoleamide. In a rat cholesterol metabolism study, feeding it at a dose of 0.3% for 21 days had no significant effect on serum, liver or kidney cholesterol levels, but had different effects on cholesterol synthesis in liver slices under different substrates and concentrations.

HY-114294A

DL-3-Hydroxy-3-methylglutaryl coenzyme A disodium hydrate HMG-CoA disodium hydrate	Biochemical Assay Reagents	Metabolic Disease
DL-3-Hydroxy-3-methylglutaryl coenzyme A disodium hydrate is a disodium salt compound of HMG-CoA, is a intermediate of terpenes and ketone bodies. DL-3-Hydroxy-3-methylglutaryl coenzyme A disodium also involves in ester metabolism in vivo, as a precursor for cholesterol synthesis, and regulates cholesterol synthesis by coupling LDL receptor .

HY-167936

cis-AY 9944	Others	Neurological Disease
cis-AY 9944 is a cholesterol synthesis inhibitor, exhibiting anticonvulsant activity that influences the dynamics of spike and wave discharges in EEG recordings.

HY-129098

DMHCA 1 Publications Verification	LXR	Metabolic Disease
DMHCA, a potent and selective LXR agonist, specifically activates the cholesterol efflux arm of the LXR pathway without stimulating triglyceride synthesis. DMHCA has anti-inflammatory effects?and can be used for the research of cholesterol homeostasis diabetes .

HY-104081

Cholestyramine 5+ Cited Publications Cholestyramine resin; Colestyramine	Others	Cardiovascular Disease Cancer
Cholestyramine (Colestyramine) is a bile acid binding resin and can inhibit intestinal bile acid absorption which results in the increasing bile acid synthesis from cholesterol.

HY-124265S2

4β-Hydroxycholesterol-d4	Endogenous Metabolite	Metabolic Disease
4β-Hydroxycholesterol-d₄ is the deuterium labeled 4β-Hydroxycholesterol. 4β-hydroxy Cholesterol is a major oxysterol cholesterol metabolite and a precursor in the synthesis of bile acids that is found in human circulation[1][2].

HY-113037C

Farnesyl pyrophosphate ammonium Farnesyl diphosphate ammonium	TRP Channel Endogenous Metabolite	Neurological Disease
Farnesyl pyrophosphate ammonium salt, a 15-carbon isoprenoid, is a metabolic intermediate of the mevalonate (MVA) pathway. Farnesyl pyrophosphate ammonium salt is a TRPM2 (TRP Channel) agonist, and activates TRPM2 opening for ion influx. Farnesyl pyrophosphate ammonium salt is a key branch substrate for cholesterol synthesis, ubiquinones synthesis, protein farnesylation decoration, and geranyl-geranyl pyrophosphate (GGPP) synthesis .

HY-N1214

Squalene Super Squalene; trans-Squalene; AddaVax	Endogenous Metabolite Reactive Oxygen Species Fungal	Infection Cardiovascular Disease Cancer
Squalene (Super Squalene) is an intermediate product in the synthesis of cholesterol, and shows several pharmacological properties such as hypolipidemic, hepatoprotective, antiatherosclerotic, cardioprotective, antioxidant, and antitumour activity .

HY-N0686

Pseudoprotodioscin 1 Publications Verification	Fatty Acid Synthase (FASN) MicroRNA	Metabolic Disease
Pseudoprotodioscin, a furostanoside, inhibits SREBP1/2 and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides .

HY-113342

7-Ketocholesterol 1 Publications Verification	Endogenous Metabolite p38 MAPK	Cardiovascular Disease Metabolic Disease
7-Ketocholesterol is an oxidation product of cholesterol, widely present in atherosclerotic plaques, and has a stronger atherogenic effect than cholesterol. 7-Ketocholesterol can inhibit the rate-limiting enzymes involved in bile acid and cholesterol synthesis, such as cholesterol 7α-hydroxylase and HMG-CoA reductase. 7-Ketocholesterol exhibits pro-inflammatory effects both in vivo and in vitro and can induce cell apoptosis (apoptosis) .

HY-124265S1

4β-Hydroxycholesterol-d5	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
4β-Hydroxycholesterol-d₅ is the deuterium labeled 4β-Hydroxycholesterol (HY-124265). 4β-hydroxy Cholesterol is a major oxysterol cholesterol metabolite and a precursor in the synthesis of bile acids that is found in human circulation[1][2].

HY-106539

Colesevelam hydrochloride	Others	Metabolic Disease Cancer
Colesevelam (hydrochloride) is a bile acid sequestrant that bind bile acids in the gut. Colesevelam (hydrochloride) inhibits bile acid reabsorption, leading to increased bile acid synthesis and reduced cholesterol levels in patients with cholestatic pruritus and Crohn’s disease.

HY-113037

(E/Z)-Farnesyl pyrophosphate (E/Z)-Farnesyl diphosphate	TRP Channel Endogenous Metabolite	Neurological Disease
(E/Z)-Farnesyl pyrophosphate ((E/Z)-Farnesyl diphosphate), a 15-carbon isoprenoid, is a metabolic intermediate of the mevalonate (MVA) pathway. (E/Z)-Farnesyl pyrophosphate is a TRPM2 (TRP Channel) agonist, activates TRPM2 opening for ion influx. (E/Z)-Farnesyl pyrophosphate is a key branch substrate for cholesterol synthesis, ubiquinones synthesis, protein farnesylation decoration, and geranyl-geranyl pyrophosphate (GGPP) synthesis .

HY-123349

5α-Hydroxy-6-keto cholesterol	Drug Metabolite	Cardiovascular Disease
5α-Hydroxy-6-keto cholesterol is major metabolite of β-epoxide (5α,6β-epoxycholesterol) during direct exposure of intact cultured human bronchial epithelial cells (16-HBE) to ozone. 5α-Hydroxy-6-keto cholesterol inhibits *cholesterol* synthesis with an IC₅₀ of 350 nM .

HY-P5282

ApoA-I mimetic peptide	Acyltransferase	Others
ApoA-I mimetic peptide (PVLDLFRELLNELLEALKQKLK) has good lecithin:cholesterol acyl transferase (LCAT) activation potency. ApoA-I mimetic peptide can be used for synthesis of peptide/lipid complex .

HY-B0144AS1

Pitavastatin-d5 sodium NK-104-d₅ sodium	Apoptosis HMG-CoA Reductase (HMGCR) Mitophagy Autophagy	Metabolic Disease Cancer
Pitavastatin-d₅ (sodium) is the deuterium labeled Pitavastatin sodium. Pitavastatin (NK-104) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. Pitavastatin is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Anti-cancer activity.

HY-163452

Squalene synthase-IN-2	Others	Metabolic Disease
Squalene synthase-IN-2 (comppund isomer A-(1S, 3R)-14i) is an orally active squalene synthase inhibitor with IC₅₀ values of 3.4, 99 nM for squalene synthase and cholesterol synthesis, respectively. Squalene synthase-IN-2 reduces plasma cholesterol and triglyceride .

HY-N1214S

Squalene-d6 Super Squalene-d₆; trans-Squalene-d₆; AddaVax-d₆	Isotope-Labeled Compounds	Others
Squalene-d6 is a deuterium labeled Squalene. Squalene (Super Squalene) is an intermediate product in the synthesis of cholesterol, and shows several pharmacological properties such as hypolipidemic, hepatoprotective, antiatherosclerotic, cardioprotective, antioxidant, and antitumour activity .

HY-135383B

(Z)-Pitavastatin calcium	Others	Metabolic Disease
(Z)-Pitavastatin calcium is the Z-Isomer of Pitavastatin hemicacium. Pitavastatin calcium is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin calcium inhibits cholesterol synthesis from acetic acid with an IC₅₀ of 5.8 nM in HepG2 cells .

HY-137089

Azacosterol dihydrochloride 20.25-Diazacholesterol dihydrochloride	Others	Endocrinology
Azacosterol (SC-12937) dihydrochloride is a chemosterilant which in-hibits reproduction in the pigeon. Azacosterol (SC-12937) dihydrochloride exerts its inhibitory effect through the blocking of the synthesis of cholesterol, thought to be a vital component in the formation of egg yolks .

HY-N1214R

Squalene (Standard)	Endogenous Metabolite Reactive Oxygen Species Fungal	Infection Cardiovascular Disease
Squalene (Standard) is the analytical standard of Squalene. This product is intended for research and analytical applications. Squalene (Super Squalene) is an intermediate product in the synthesis of cholesterol, and shows several pharmacological properties such as hypolipidemic, hepatoprotective, antiatherosclerotic, cardioprotective, antioxidant, and antitumour activity .

HY-N0686R

Pseudoprotodioscin (Standard)	Fatty Acid Synthase (FASN) MicroRNA	Metabolic Disease
Pseudoprotodioscin (Standard) is the analytical standard of Pseudoprotodioscin. This product is intended for research and analytical applications. Pseudoprotodioscin, a furostanoside, inhibits SREBP1/2 and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides .

HY-W749520

Zymosterone	Others	Metabolic Disease
Zymosterone is converted into zymosterol, an intermediate in cholesterol synthesis, through the action of the enzyme hydroxysteroid (17β) dehydrogenase 7 (HSD17B7), and this transformation, catalyzed by 3-keto sterol reductase (ERG27), plays a crucial role in the biosynthesis of ergosterol in yeast.

HY-B0144A

Pitavastatin 5+ Cited Publications NK-104	HMG-CoA Reductase (HMGCR) Autophagy Mitophagy Apoptosis	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Pitavastatin (NK-104) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin inhibits cholesterol synthesis from acetic acid with an IC₅₀ of 5.8 nM in HepG2 cells. Pitavastatin is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Pitavastatin also possesses anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective and reno-protective effects .

HY-B0144B

Pitavastatin sodium NK-104 sodium	HMG-CoA Reductase (HMGCR) Autophagy Mitophagy Apoptosis	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Pitavastatin (NK-104) sodium is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin sodium inhibits cholesterol synthesis from acetic acid with an IC₅₀ of 5.8 nM in HepG2 cells. Pitavastatin sodium is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Pitavastatin sodium also possesses anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective and reno-protective effects .

HY-16620

DF 461	Others	Metabolic Disease
DF 461 is a sterol synthase inhibitor with significant inhibitory activity. DF 461 shows high selectivity for the liver and can effectively inhibit cholesterol synthesis in rat liver. DF 461 has shown the effect of lowering plasma lipids in repeated dosing studies in non-rodents .

HY-B0144S

Pitavastatin-d4 hemicalcium NK-104-d₄ hemicalcium; Pitavastatin-d₄ hemicalcium	Isotope-Labeled Compounds HMG-CoA Reductase (HMGCR) Autophagy Mitophagy Apoptosis	Metabolic Disease Cancer
Pitavastatin-d₄ (hemicalcium) is deuterium labeled Pitavastatin (Calcium). Pitavastatin Calcium (NK-104 hemicalcium) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin Calcium (NK-104 hemicalcium) inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. Pitavastatin Calcium is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Anti-cancer activity[1][2][3].

HY-N7392

Acetoacetyl-CoA	Biochemical Assay Reagents	Metabolic Disease
Acetoacetyl CoA is the precursor of HMG-CoA in the mevalonate pathway. Acetoacetyl-CoA thiolase catalyzes the reaction to form acetoacetyl-CoA from two acetyl-CoA molecules. Acetoacetyl CoA is essential for cholesterol biosynthesis. Acetoacetyl-CoA is also a intermediate in the biological breakdown and synthesis of fatty acids .

HY-B0144

Pitavastatin Calcium 5+ Cited Publications NK-104 hemicalcium; Pitavastatin hemicalcium	HMG-CoA Reductase (HMGCR) Autophagy Mitophagy Apoptosis	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Pitavastatin Calcium (NK-104 hemicalcium) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin Calcium (NK-104 hemicalcium) inhibits cholesterol synthesis from acetic acid with an IC₅₀ of 5.8 nM in HepG2 cells. Pitavastatin Calcium is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Pitavastatin Calcium also possesses anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective and reno-protective effects .

HY-B0144R

Pitavastatin Calcium (Standard)	HMG-CoA Reductase (HMGCR) Autophagy Mitophagy Apoptosis	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Pitavastatin (Calcium) (Standard) is the analytical standard of Pitavastatin (Calcium). This product is intended for research and analytical applications. Pitavastatin Calcium (NK-104 hemicalcium) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin Calcium (NK-104 hemicalcium) inhibits cholesterol synthesis from acetic acid with an IC₅₀ of 5.8 nM in HepG2 cells. Pitavastatin Calcium is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Pitavastatin Calcium also possesses anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective and reno-protective effects .

HY-W587530

6-Oxolithocholic acid 6-Ketolithocholic acid	Endogenous Metabolite Apoptosis	Endocrinology
6-Oxolithocholic acid is a bile acid metabolite derived from Lithocholic acid (HY-B0172). 6-Oxolithocholic acid has high cytotoxicity and can induce apoptosis, especially in hepatocytes. 6-Oxolithocholic acid can participate in the regulation of bile acid metabolism and synthesis and affect the metabolic pathway of cholesterol. 6-Oxolithocholic acid can be used to study the role of bile acids in health and disease, especially in the context of digestive and liver diseases .

HY-150407

TSPO ligand-1	Ligands for Target Protein for PROTAC Autophagy	Others Neurological Disease Cancer
TSPO ligand-1 is the ligand of AUTAC4 (HY-134640) that can be used in the synthesis of PROTACs. TSPO ligand-1 is a mitochondrial outer membrane transmembrane structural domain protein can bind to AUTAC4 and regulate mitochondrial autophagy to promote targeted mitochondrial renewal. TSPO ligand-1 is also involved in the transport of cholesterol from the outer to inner mitochondrial membrane and serves as a sensitive biomarker of brain injury and neurodegeneration .

HY-113081R

1-Methyladenosine (Standard)	Endogenous Metabolite PPAR Hedgehog	Cancer
1-Methyladenosine (Standard) is the analytical standard of 1-Methyladenosine. This product is intended for research and analytical applications. 1-Methyladenosine is an RNA modification that can serve as a tumor marker, with elevated levels in the body associated with cancer development. Following 1-methyladenosine methylation, upregulation of PPARδ expression regulates cholesterol metabolism and activates Hedgehog signaling pathway, driving liver tumorigenesis . In Vitro:Compared to surrounding tumor tissues, 1-methyladenosine methylation in RNA is aberrantly elevated in hepatocellular carcinoma (HCC) cell lines and liver cancer stem cells (CSCs). Methylated 1-methyladenosine can promote cholesterol synthesis and activate the Hedgehog signaling pathway by enhancing the translation of PPARδ in liver CSCs, ultimately driving the self-renewal and tumorigenesis of liver cancer stem cells .

HY-19671

Apomine SR-45023A; SR 9223i; SK&F-99085	Apoptosis	Cancer
Apomine (SR-45023A) is an antineoplastic agent that inhibits the mevalonate/isoprenoid pathway in cholesterol synthesis. Apomine can accelerate the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR). Apomine can also inhibit the growth of various types of cancer cells, including lung cancer, colon cancer, breast cancer, and skin cancer. In addition, Apomine is able to induce apoptosis in tumor cell lines derived from leukemia, colon cancer, liver cancer, ovarian cancer, and breast cancer .

Cat. No.	Product Name	Type

HY-114294A

DL-3-Hydroxy-3-methylglutaryl coenzyme A disodium hydrate HMG-CoA disodium hydrate	Enzyme Substrates
DL-3-Hydroxy-3-methylglutaryl coenzyme A disodium hydrate is a disodium salt compound of HMG-CoA, is a intermediate of terpenes and ketone bodies. DL-3-Hydroxy-3-methylglutaryl coenzyme A disodium also involves in ester metabolism in vivo, as a precursor for cholesterol synthesis, and regulates cholesterol synthesis by coupling LDL receptor .

HY-P5282

ApoA-I mimetic peptide	Drug Delivery
ApoA-I mimetic peptide (PVLDLFRELLNELLEALKQKLK) has good lecithin:cholesterol acyl transferase (LCAT) activation potency. ApoA-I mimetic peptide can be used for synthesis of peptide/lipid complex .

HY-167016

Cholesterol-undecanoate-glucose conjugate	Drug Delivery
Cholesterol-undecanoate-glucose conjugate is a cholesterol conjugate used in the synthesis of intranasal liposomal vaccines. Cholesterol-undecanoate-glucose conjugate can be used in drug delivery studies .

HY-N7392

Acetoacetyl-CoA	Biochemical Assay Reagents
Acetoacetyl CoA is the precursor of HMG-CoA in the mevalonate pathway. Acetoacetyl-CoA thiolase catalyzes the reaction to form acetoacetyl-CoA from two acetyl-CoA molecules. Acetoacetyl CoA is essential for cholesterol biosynthesis. Acetoacetyl-CoA is also a intermediate in the biological breakdown and synthesis of fatty acids .

Cat. No.	Product Name	Target	Research Area

HY-P5282

ApoA-I mimetic peptide	Acyltransferase	Others
ApoA-I mimetic peptide (PVLDLFRELLNELLEALKQKLK) has good lecithin:cholesterol acyl transferase (LCAT) activation potency. ApoA-I mimetic peptide can be used for synthesis of peptide/lipid complex .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W020033

Lanosterol 3 Publications Verification	Triterpenes Structural Classification Human Gut Microbiota Metabolites Microorganisms Terpenoids Source classification Endogenous metabolite	Endogenous Metabolite
Lanosterol is an intermediate of cholesterol synthesis and use of lanosterol induces ubiquitination and degradation of a rate-controlling enzyme of cholesterol synthesis, i.e., HMG CoA reductase. Lanosterol suppresses the aggregation and cytotoxicity of misfolded proteins linked with neurodegenerative diseases .

HY-N3925

Ganoderol A	Triterpenes Classification of Application Fields Terpenoids Source classification Polyporaceae Metabolic Disease Plants Disease Research Fields Inflammation/Immunology	Bacterial
Ganoderol A is a terpenoid extracted from Ganoderma lucidum with antimicrobial activities. Ganoderol A inhibits cholesterol synthesis pathway and has significant anti-inflammatory activity and protection against ultraviolet A (UVA) damage .

HY-125713

Ganoderic acid Y	Infection Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Polyporaceae Plants Disease Research Fields	Glucosidase Enterovirus
Ganoderic acid Y is a α-glucosidase inhibitor with an IC₅₀ of 170 μM for yeast α-glucosidase. Ganoderic acid Y inhibits enterovirus 71 (EV71) replication through blocking EV71 uncoating .

HY-113486

Lathosterol 2 Publications Verification	Structural Classification Microorganisms Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
Lathosterol is a cholesterol-like molecule. Serum Lathosterol concentration is an indicator of whole-body cholesterol synthesis.

HY-124265

4β-Hydroxycholesterol	Structural Classification Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
4β-hydroxy Cholesterol is a major oxysterol cholesterol metabolite and a precursor in the synthesis of bile acids that is found in human circulation .

HY-N2221

Ganoderal A	Triterpenes Structural Classification Classification of Application Fields Terpenoids Polyporaceae Source classification Metabolic Disease Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants Disease Research Fields	Others
Ganoderal A, an oxygenated sterol from G. lucidum, is a cholesterol synthesis inhibitor .

HY-113037C

Farnesyl pyrophosphate ammonium Farnesyl diphosphate ammonium	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	TRP Channel Endogenous Metabolite
Farnesyl pyrophosphate ammonium salt, a 15-carbon isoprenoid, is a metabolic intermediate of the mevalonate (MVA) pathway. Farnesyl pyrophosphate ammonium salt is a TRPM2 (TRP Channel) agonist, and activates TRPM2 opening for ion influx. Farnesyl pyrophosphate ammonium salt is a key branch substrate for cholesterol synthesis, ubiquinones synthesis, protein farnesylation decoration, and geranyl-geranyl pyrophosphate (GGPP) synthesis .

HY-N1214

Squalene Super Squalene; trans-Squalene; AddaVax	Cardiovascular Disease Triterpenes Structural Classification Classification of Application Fields Source classification Plants Endogenous metabolite Human Gut Microbiota Metabolites Microorganisms other families Animals Terpenoids Disease Research Fields	Endogenous Metabolite Reactive Oxygen Species Fungal
Squalene (Super Squalene) is an intermediate product in the synthesis of cholesterol, and shows several pharmacological properties such as hypolipidemic, hepatoprotective, antiatherosclerotic, cardioprotective, antioxidant, and antitumour activity .

HY-125666

Agistatin B	Infection Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Others
Agistatin B, isolated from fungus, is a mycotoxin. Agistatin B inhibits **cholesterol synthesis** .

HY-113486R

Lathosterol (Standard)	Structural Classification Microorganisms Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
Lathosterol (Standard) is the analytical standard of Lathosterol. This product is intended for research and analytical applications. Lathosterol is a cholesterol-like molecule. Serum Lathosterol concentration is an indicator of whole-body cholesterol synthesis.

HY-N0686

Pseudoprotodioscin 1 Publications Verification	Structural Classification Natural Products Classification of Application Fields Dioscorea nipponica Makino Source classification Metabolic Disease Plants Disease Research Fields Dioscoreaceae	Fatty Acid Synthase (FASN) MicroRNA
Pseudoprotodioscin, a furostanoside, inhibits SREBP1/2 and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides .

HY-113342

7-Ketocholesterol 1 Publications Verification	Triterpenes Structural Classification Terpenoids Source classification Endogenous metabolite	Endogenous Metabolite p38 MAPK
7-Ketocholesterol is an oxidation product of cholesterol, widely present in atherosclerotic plaques, and has a stronger atherogenic effect than cholesterol. 7-Ketocholesterol can inhibit the rate-limiting enzymes involved in bile acid and cholesterol synthesis, such as cholesterol 7α-hydroxylase and HMG-CoA reductase. 7-Ketocholesterol exhibits pro-inflammatory effects both in vivo and in vitro and can induce cell apoptosis (apoptosis) .

HY-113037

(E/Z)-Farnesyl pyrophosphate (E/Z)-Farnesyl diphosphate	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	TRP Channel Endogenous Metabolite
(E/Z)-Farnesyl pyrophosphate ((E/Z)-Farnesyl diphosphate), a 15-carbon isoprenoid, is a metabolic intermediate of the mevalonate (MVA) pathway. (E/Z)-Farnesyl pyrophosphate is a TRPM2 (TRP Channel) agonist, activates TRPM2 opening for ion influx. (E/Z)-Farnesyl pyrophosphate is a key branch substrate for cholesterol synthesis, ubiquinones synthesis, protein farnesylation decoration, and geranyl-geranyl pyrophosphate (GGPP) synthesis .

HY-N1214R

Squalene (Standard)	Triterpenes Structural Classification Human Gut Microbiota Metabolites Microorganisms other families Animals Terpenoids Source classification Plants Endogenous metabolite	Endogenous Metabolite Reactive Oxygen Species Fungal
Squalene (Standard) is the analytical standard of Squalene. This product is intended for research and analytical applications. Squalene (Super Squalene) is an intermediate product in the synthesis of cholesterol, and shows several pharmacological properties such as hypolipidemic, hepatoprotective, antiatherosclerotic, cardioprotective, antioxidant, and antitumour activity .

HY-N0686R

Pseudoprotodioscin (Standard)	Structural Classification Natural Products Dioscorea nipponica Makino Source classification Plants Dioscoreaceae	Fatty Acid Synthase (FASN) MicroRNA
Pseudoprotodioscin (Standard) is the analytical standard of Pseudoprotodioscin. This product is intended for research and analytical applications. Pseudoprotodioscin, a furostanoside, inhibits SREBP1/2 and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides .

HY-N7392

Acetoacetyl-CoA	Human Gut Microbiota Metabolites Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Biochemical Assay Reagents
Acetoacetyl CoA is the precursor of HMG-CoA in the mevalonate pathway. Acetoacetyl-CoA thiolase catalyzes the reaction to form acetoacetyl-CoA from two acetyl-CoA molecules. Acetoacetyl CoA is essential for cholesterol biosynthesis. Acetoacetyl-CoA is also a intermediate in the biological breakdown and synthesis of fatty acids .

HY-113081R

1-Methyladenosine (Standard)	Alkaloids Structural Classification Microorganisms Immune System Disorder Source classification Disease markers Endogenous metabolite Cancer	Endogenous Metabolite PPAR Hedgehog
1-Methyladenosine (Standard) is the analytical standard of 1-Methyladenosine. This product is intended for research and analytical applications. 1-Methyladenosine is an RNA modification that can serve as a tumor marker, with elevated levels in the body associated with cancer development. Following 1-methyladenosine methylation, upregulation of PPARδ expression regulates cholesterol metabolism and activates Hedgehog signaling pathway, driving liver tumorigenesis . In Vitro:Compared to surrounding tumor tissues, 1-methyladenosine methylation in RNA is aberrantly elevated in hepatocellular carcinoma (HCC) cell lines and liver cancer stem cells (CSCs). Methylated 1-methyladenosine can promote cholesterol synthesis and activate the Hedgehog signaling pathway by enhancing the translation of PPARδ in liver CSCs, ultimately driving the self-renewal and tumorigenesis of liver cancer stem cells .

HY-113259

7α-Hydroxy-4-cholesten-3-one	Structural Classification Microorganisms Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
7α-Hydroxy-4-cholesten-3-one is an intermediate in synthesis of bile acids from cholesterol. 7α-Hydroxy-4-cholesten-3-one is a pregnane X receptor (PXR) agonist. 7α-Hydroxy-cholest-4-en-3-one is a biomarker for bile acid loss, irritable bowel syndrome, and other diseases associated with defective bile acid biosynthesis. 7α-Hydroxy-cholest-4-en-3-one is the physiological substrate for CYP8B1 .

HY-113259R

7α-Hydroxy-4-cholesten-3-one (Standard)	Structural Classification Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
7α-Hydroxy-4-cholesten-3-one (Standard) is the analytical standard of 7α-Hydroxy-4-cholesten-3-one. This product is intended for research and analytical applications. 7α-Hydroxy-4-cholesten-3-one is an intermediate in synthesis of bile acids from cholesterol. 7α-Hydroxy-4-cholesten-3-one is a pregnane X receptor (PXR) agonist. 7α-Hydroxy-cholest-4-en-3-one is a biomarker for bile acid loss, irritable bowel syndrome, and other diseases associated with defective bile acid biosynthesis. 7α-Hydroxy-cholest-4-en-3-one is the physiological substrate for CYP8B1 .

Cat. No.	Product Name	Chemical Structure

HY-113486S

(S)-Lathosterol-d4
(S)-Lathosterol-d₄ is the deuterium labeled (S)-Lathosterol. Lathosterol is a cholesterol-like molecule. Serum Lathosterol concentration is an indicator of whole-body cholesterol synthesis[1].

HY-W020033S

Lanosterol-d6
Lanosterol-d₆ is deuterium labeled Lanosterol. Lanosterol is an intermediate of cholesterol synthesis and use of lanosterol induces ubiquitination and degradation of a rate-controlling enzyme of cholesterol synthesis, i.e., HMG CoA reductase. Lanosterol s

HY-124265S2

4β-Hydroxycholesterol-d4
4β-Hydroxycholesterol-d₄ is the deuterium labeled 4β-Hydroxycholesterol. 4β-hydroxy Cholesterol is a major oxysterol cholesterol metabolite and a precursor in the synthesis of bile acids that is found in human circulation[1][2].

HY-B0144AS1

Pitavastatin-d5 sodium
Pitavastatin-d₅ (sodium) is the deuterium labeled Pitavastatin sodium. Pitavastatin (NK-104) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. Pitavastatin is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Anti-cancer activity.

HY-N1214S

Squalene-d6
Squalene-d6 is a deuterium labeled Squalene. Squalene (Super Squalene) is an intermediate product in the synthesis of cholesterol, and shows several pharmacological properties such as hypolipidemic, hepatoprotective, antiatherosclerotic, cardioprotective, antioxidant, and antitumour activity .

HY-113259S

7α-Hydroxy-4-cholesten-3-one-d7

7α-Hydroxy-4-cholesten-3-one-d₇ is the deuterium labeled 7α-Hydroxy-4-cholesten-3-one. 7α-Hydroxy-4-cholesten-3-one is an intermediate in synthesis of bile acids from cholesterol. 7α-Hydroxy-4-cholesten-3-one is a pregnane X receptor (PXR) agonist. 7α-Hydroxy-cholest-4-en-3-one is a biomarker for bile acid loss, irritable bowel syndrome, and other diseases associated with defective bile acid biosynthesis. 7α-Hydroxy-cholest-4-en-3-one is the physiological substrate for CYP8B1[1][2].

HY-113486S1

lathosterol-d7
lathosterol-d₇ is deuterium labeled lathosterol. Lathosterol is a cholesterol-like molecule. Serum Lathosterol concentration is an indicator of whole-body cholesterol synthesis[1].

HY-124265S1

4β-Hydroxycholesterol-d5
4β-Hydroxycholesterol-d₅ is the deuterium labeled 4β-Hydroxycholesterol (HY-124265). 4β-hydroxy Cholesterol is a major oxysterol cholesterol metabolite and a precursor in the synthesis of bile acids that is found in human circulation[1][2].

HY-B0144S

Pitavastatin-d4 hemicalcium

Pitavastatin-d₄ (hemicalcium) is deuterium labeled Pitavastatin (Calcium). Pitavastatin Calcium (NK-104 hemicalcium) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin Calcium (NK-104 hemicalcium) inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. Pitavastatin Calcium is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Anti-cancer activity[1][2][3].

Cat. No.	Product Name		Classification

HY-156197

Biotin-cholesterol		Cholesterol
Biotin-cholesterol is a biotinylated form of Cholesterol (HY-N0322). Biotin-cholesterol can be used in the synthesis of biotin-conjugated liposomes and micelles for drug delivery .

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